具有潜伏期和免疫应答的HIV感染模型的全局稳定性

本文考虑具有CTL免疫应答和细胞内部潜伏阶段的HIV感染数学模型,得到其基本再生数,通过构造适用的Lyapunov函数,研究该模型的健康平衡点和感染平衡点的稳定性.当基本再生数不大于1时,健康平衡点在可行域上是全局稳定的,即HIV在个体体内最终灭绝;当基本再生数大于1时,模型存在惟一的感染平衡点在可行域上是全局稳定的,即HIV在个体体内呈现持续存在状态,且其浓度最终趋于一个常数.     

具有潜伏期和免疫应答的时滞病毒感染模型的全局稳定性

研究了具有潜伏期和CTL免疫应答的时滞病毒感染模型的动力学行为.模型描述了病毒和两类靶细胞的相互作用:CD4+T淋巴细胞与巨噬细胞.通过构造适当的Lyapunov泛函,使用La Salle不变性原理,证明了CD4+T淋巴细胞和巨噬细胞的基本再生总数R0,CD4+T淋巴细胞和巨噬细胞的CTL免疫再生总数R*决定了模型的全局性态.若R0≤1,病毒在体内清除.若R01,正解在R*≤1时趋于无免疫平衡点,在R*1时趋于正平衡点.获得了无病平衡点、无免疫平衡点和正平衡点全局渐近稳定的充分条件.     

具有Logistic增长和年龄结构的SIS模型

讨论具有Logistic增长和年龄结构的SIS流行病模型.运用微分、积分方程理论,得到了当再生数R0<1时,无病平衡点E0是全局渐近稳定的;当R0>1时,地方病平衡点E*是局部渐近稳定的.     

具有染病年龄结构的SEIR流行病模型的稳定性

建立和研究了一类具有染病年龄结构的SEIR流行病模型.得到了该模型的基本再生数R0的表达式.证明了当R0<1时,无病平衡点E0不仅局部渐近稳定,而且全局吸引;当R0>1时,无病平衡点E0不稳定,此时存在稳定的地方病平衡点.     

一类具有Logistic增长和病程的SIR模型

研究具有Logistic增长和病程的SIR流行病模型.运用微分、积分方程理论,得到再生数R0<1时,无病平衡点E0是全局渐近稳定的;而当R0>1时,地方病平衡点E*是局部渐近稳定的.     

具有隔离和不完全治疗的传染病模型的全局稳定性

该文建立了一类具有隔离和不完全治疗的传染病模型.在模型中考虑了无意识和有意识的易感人群,通过基本再生数确定了模型的传播动力学,当R0≤1时,无病平衡点是全局渐近稳定的,当R0＞1时,地方病平衡点是全局渐近稳定的,并通过数值模拟说明了理论分析的正确性.     

一类具有时滞和接种疫苗年龄的SIS模型

研究具有时滞和接种疫苗年龄的SIS流行病模型.运用微分、积分方程理论,得到再生数R(ψ)<1,且γτ1时,地方病平衡点E*的存在性.     

带有体检和免疫的乙肝动力学模型分析

研究了一类同时带有体检和免疫的乙肝传染病问题.通过分析体检和免疫对乙肝的影响,建立了合理的动力学模型,证明了模型地方病平衡点的存在性条件,计算了基本再生数R₀,并证明了当R₀≤1时,无病平衡点是全局渐近稳定的,当R₀> 1时,地方病平衡点是全局渐近稳定的.最后通过数值模拟证明了结果的正确性,分析比较了体验和免疫分别对乙肝感染的影响效果.强调了体检和免疫对防控乙肝感染的重要性.     

基于两斑块和人口流动的SIR传染病模型的稳定性

根据传染病动力学原理,考虑人口在两斑块上流动且具有非线性传染率,建立了一类基于两斑块和人口流动的SIR传染病模型.利用常微分方程定性与稳定性方法,分析了模型永久持续性和非负平衡点的存在性,通过构造适当的Lyapunov函数和极限系统理论,获得无病平衡点和地方病平衡点全局渐近稳定的充分条件.研究结果表明:基本再生数是决定疾病流行与否的阈值,当基本再生数小于等于1时,感染者逐渐消失,病毒趋于灭绝;当基本再生数大于1并满足永久持续条件时,感染者持续存在且病毒持续流行并将成为一种地方病.     

一类采取隔离措施的非线性传染率传染病模型的全局稳定性

讨论一类采取隔离措施的非线性传染率传染病的数学模型,得到了基本再生数Rθ的表达式,当Rθ<1时,仅存在无病平衡点,是全局渐近稳定的;当Rθ>1时,存在两个平衡点,其中无病平衡点不稳定,地方病平衡点全局渐近稳定.     

具有饱和发生率和免疫响应的病毒感染模型的稳定性分析

提出了具有饱和发生率和免疫响应的病毒感染数学模型,得到了基本再生数R_0的表达式.当R_01时,证明了无病平衡点是全局渐近稳定的;当R_01时,得到了免疫耗竭平衡点和持续带毒平衡点局部渐近稳定的条件.     

具有预防接种免疫力的双线性传染率SIR流行病模型全局稳定性

研究一类具有预防接种免疫力的双线性传染率 SIR流行病模型全局稳定性 ,找到了决定疾病灭绝和持续生存的阈值——基本再生数 R0 .当 R0 ≤ 1时 ,仅存在无病平衡态 E0 ;当 R0 >1时 ,存在唯一的地方病平衡态 E* 和无病平衡态 E0 .利用 Hurwitz判据及 Liapunov-Lasalle不变集原理可以得知 :当 R0 <1时 ,无病平衡态 E0 全局渐近稳定 ;当 R0 >1时 ,地方病平衡态 E*全局渐近稳定 ,无病平衡态 E0 不稳定 ;当 R0 =1时 ,计算机数值模拟结果显示 ,无病平衡态 E0 有可能是稳定的     

Global and Bifurcation Analysis of an HIV Pathogenesis Model with Saturated Reverse Function

In this paper, an HIV dynamics model with the proliferation of CD4 T cells is proposed. The authors consider nonnegativity, boundedness, global asymptotic stability of the solutions and bifurcation properties of the steady states. It is proved that the virus is cleared from the host under some conditions if the basic reproduction number R_0 is less than unity. Meanwhile, the model exhibits the phenomenon of backward bifurcation. We also obtain one equilibrium is semi-stable by using center manifold theory. It is proved that the endemic equilibrium is globally asymptotically stable under some conditions if R_0 is greater than unity. It also is proved that the model undergoes Hopf bifurcation from the endemic equilibrium under some conditions. It is novelty that the model exhibits two famous bifurcations,backward bifurcation and Hopf bifurcation. The model is extended to incorporate the specific Cytotoxic T Lymphocytes(CTLs) immune response. Stabilities of equilibria and Hopf bifurcation are considered accordingly. In addition, some numerical simulations for justifying the theoretical analysis results are also given in paper.     

Global properties for virus dynamics model with Beddington–DeAngelis functional response

This paper investigates the global stability of virus dynamics model with Beddington–DeAngelis infection rate. By constructing Lyapunov functions, the global properties have been analysed. If the basic reproductive ratio of the virus is less than or equal to one, the uninfected steady state is globally asymptotically stable. If the basic reproductive ratio of the virus is more than one, the infected steady state is globally asymptotically stable. The conditions imply that the steady states are always globally asymptotically stable for Holling type II functional response or for a saturation response.     

具有免疫应答和吸收效应的病毒感染模型分析

研究了具有免疫应答和吸收效应的病毒动力学模型的动力学行为.通过构造适当的Lyapunov泛函,使用LaSalle不变性原理,证明了基本再生数、CTL免疫再生数、抗体免疫再生数、CTL免疫竞争再生数和抗体免疫竞争再生数决定了模型的全局性态.若基本再生数小于等于1,病毒在体内清除.若基本再生数大于1,正解在满足条件max{...     

Global dynamics of an age‐structured virus model with saturation effects

An infection‐age virus dynamics model for human immunodeficiency virus (or hepatitis B virus) infections with saturation effects of infection rate and immune response is investigated in this paper. It is shown that the global dynamics of the model is completely determined by two critical values R ₀, the basic reproductive number for viral infection, and R ₁, the viral reproductive number at the immune‐free infection steady state (R ₁<R ₀). If R ₀<1, the uninfected steady state E ⁰ is globally asymptotically stable; if R ₀>1 > R ₁, the immune‐free infected steady state E ^? is globally asymptotically stable; while if R ₁>1, the antibody immune infected steady state is globally asymptotically stable. Moreover, our results show that ignoring the saturation effects of antibody immune response or infection rate will result in an overestimate of the antibody immune reproductive number. Copyright © 2016 John Wiley & Sons, Ltd.     

一类潜伏期和染病期均具有传染性的手足口病模型

根据手足口病的病理特性及传播特点,建立一类描述其传播的数学模型并对模型的动力学性态进行分析.首先利用再生矩阵的方法定义了模型的基本再生数R_0,同时通过构造Lyapunov函数和Routh-Hurwitz判据证明了当R_0≤1时无病平衡点E_0的金局渐近稳定性,R_0>1时地方病平衡点E_*的局部渐近稳定性,并进一步证明了在一定条件下地方病平衡点的全局渐近稳定性.     

GLOBAL STABILITY IN A VIRAL INFECTION MODEL

This paper investigates the global stability of a viral infection model with lytic immune response. If the basic reproductive ratio of the virus is less than or equal to one, by the LaSalle's invariance principle, the disease-free steady state is globally asymptotically stable. If the basic reproductive ratio of the virus is greater than one but less than or equal to a constant, which is defined by the parameters of the model, then the immune-exhausted steady state is globally asymptotically stable. The endemic steady state is globally asymptotically stable if the inverse is valid.     

Threshold dynamics for compartmental epidemic models with impulses

The basic reproductive number and its calculation for general impulsive compartmental epidemic models, with pulses on both the infected and the uninfected compartments, are established. Theoretical results show that the basic reproductive number serves as a threshold parameter: the disease dies out if the basic reproductive number is smaller than unity, and breaks out if it is larger than unity. The global dynamics of a viral dynamical model with impulsive immune response is analyzed to study how the vaccination strength and the vaccination interval affect the basic reproductive number and virus progression.     

Global properties of a class of HIV infection models with Beddington–DeAngelis functional response

In this paper, the global properties of a class of human immunodeficiency virus (HIV) models with Beddington–DeAngelis functional response are investigated. Lyapunov functions are constructed to establish the global asymptotic stability of the uninfected and infected steady states of three HIV infection models. The first model considers the interaction process of the HIV and the CD4 ⁺ T cells and takes into account the latently and actively infected cells. The second model describes two co‐circulation populations of target cells, representing CD4 ⁺ T cells and macrophages. The third model is a two‐target‐cell model taking into account the latently and actively infected cells. We have proven that if the basic reproduction number R₀ is less than unity, then the uninfected steady state is globally asymptotically stable, and if R₀ > 1, then the infected steady state is globally asymptotically stable. Copyright © 2012 John Wiley & Sons, Ltd.