微波辐射下一步合成9-芳基-1,2,3,4,5,6,7,8,9,10-十氢-1,8-吖啶二酮

以芳醛、1,3-环己二酮、醋酸铵为原料在无溶剂条件下经微波辐射合成了一系列9-芳基-1,2,3,4,5,6,7,8,9,10-十 氢-1,8-吖啶二酮. 该反应的反应时间短、产率高、环境友好、后处理方便. 产物的结构经红外光谱、核磁共振谱表征, 3d的结构经单晶X射线衍射进一步确证.     

微波辐射下合成3-芳基-9-氨基-1,2,3,4-四氢吖啶-1-酮衍生物

在微波辐射和对甲基苯磺酸的催化作用下, 5-芳基-1,3-环己二酮与邻氨基苯甲腈进行缩合反应, 得到了N-取代的2-氨基苯甲腈衍生物, 在K₂CO₃和Cu₂Cl₂的催化作用下进一步合环, 得到3-芳基-9-氨基-1,2,3,4-四氢吖啶-1-酮衍生物, 用LiAlH₄还原羰基得到3-芳基-9-氨基-1,2,3,4-四氢吖啶-1-醇衍生物. 新合成化合物的结构均经元素分析、红外光谱和核磁共振光谱予以确认.     

可膨胀石墨催化合成3,3,6,6-四甲基-9-芳基-1,2,3,4,5,6,7,8-八氢化氧杂蒽-1,8-二酮

在可膨胀石墨催化下, 由芳香醛和5,5-二甲基-1,3-环己二酮缩合制备了3,3,6,6-四甲基-9-芳基-1,2,3,4,5,6,7,8-八氢化氧杂蒽-1,8-二酮. 在乙醇-水介质中回流反应2.5 h, 反应产率可达87%～93%. 该方法不仅反应时间短, 产率高, 而且催化剂价廉易得、对环境友好, 催化剂经简单过滤后可重复使用.     

水介质中9,10-二芳基吖啶的洁净合成

水介质中在十二烷基磺酸钠(SDS)催化下, 席夫碱与双甲酮反应合成了一系列9,10-二芳基吖啶衍生物, 同时分离得到一种中间产物. 所有产物的结构通过红外光谱和1H NMR光谱确定, 产物10-(4-氯苯基)-9-(4-甲氧基苯基)-3,3,6,6-四甲基-3,4,6,7,9,10-六氢化吖啶-1,8(2H,5H)-二酮(3i)和中间产物2-{4-氯苯基-[2-(4-甲氧基苯基氨基)-4,4-二甲基-6-氧代环已-1-烯基]甲基}-3-羟基-5,5-二甲基环已-2-烯酮(4h)的结构还通过单晶X射线衍射分析确证.     

无溶剂条件下利用微波促进下的多组分反应对2,6-二芳基-4-苯乙烯基吡啶化合物进行非预期的绿色简易合成

在无溶剂条件下,通过微波促进下的3-芳基丙烯醛肟、1-芳基乙酮及醋酸铵的多组分反应,非预期地实现了2,6-二芳基-4-苯乙烯基吡啶化合物的绿色简易合成。该方法具有环境友好、反应时间短、产率高、成本低、操作简便以及适用范围广等优点。     

水相回流条件下N-取代吖啶二酮衍生物的合成

在水相回流条件下,以芳香醛、5,5-二甲基-1,3-环己二酮（达米酮）和苯胺/对甲苯胺为原料,经过多组分一锅反应,合成了一系列N-取代吖啶二酮衍生物,收率在69%~90%之间。 该过程以水作为溶剂,无有机溶剂污染,而且操作简单,后处理方便。     

3,6-二甲基-9-芳基-2,7-二氧杂-1,2,7,8,9,10-六氢-1,8-吖啶二酮衍生物的一步合成

以芳醛、6-甲基-4-羟基-2-吡喃酮、醋酸铵为原料, 醋酸为溶剂, 一步合成了一系列3,6-二甲基-9-芳基-2,7-二氧 杂-1,2,7,8,9,10-六氢-1,8-吖啶二酮, 产物的结构经红外、核磁、元素分析进行了表征, 并对反应过程提出了可能的机理.     

微波辐射下9-芳基-10-对甲苯基多氢吖啶衍生物的合成

芳醛、5,5-二甲基-1，3-环已二酮（达米酮）与对甲基苯胺在以乙二醇为溶剂 ，微波辐射下反应生成一素列新的3，3，6，6-四甲基-1，8-二氧代-9-芳基-10-对 甲基苯基-1，2，3，4，5，6，7，8，9，10-十氢吖啶，产物的结构通过单晶X射线 衍射分析确证。     

无溶剂条件下新型N-羟乙基-9-取代十氢吖啶-1,8-二酮衍生物的合成

通过芳香醛、达米酮和乙醇胺的"一锅法"无溶剂反应将羟乙基引入吖啶二酮的氮原子上,合成了一系列新型的吖啶二酮衍生物,收率29%~83%,其结构经1H NMR,13C NMR,IR和MS表征。并对其反应机理进行推测。     

微波促进下4-芳基亚氨基-1,2,4-三唑的合成

无溶剂;无催化剂;微波辐射;取代基-巯基-芳基亚氨基三唑     

2,3-二氢-1,4-酞嗪二酮的微波合成

以邻苯二甲酸酐和肼类化合物为原料,用微波辐射合成了6种2,3-二氢-1,4-酞嗪二酮类化合物,其结构经^1H NMR和^13C NMR表征。     

Synthesis and Crystal Structure of N-cyclopropyl-9 -（3,4-dicholophenyl）- 1,2,3,4,5,6,7,8,9,10-decahydroacridine -1,8-dione under Microwave Irradiation

1 INTRODUCTION aryl or methyl group to the nitrogen atom of these compounds leads to enhanced activities of fluo- A lot of natural and synthetic compounds con- rescence[7, . Since the pyridine scaffold is included 8] taining acridine skeletons display interesting biolo- in decahydroacridine-1,8-dione, a question is whether gical and physical activities[1]. Acridinedione, for the same modification on the nitrogen atom of de- example, has been identified as antimalarial and cahydroacridine-1…     

Synthesis and Crystal Structure of N-methyl- 9- （4-bromophenyl）-1,2,3,4,5,6,7,8,9,10- decahydroacridine- 1,8-dione under Microwave Irradiation

1 INTRODUCTION Since the discovery of pharmacological effectsof 1,4-dihydropyridine (1,4-DHPs) as calcium mo-dulators[1], a great deal of work has been directedtowards the synthesis of 1,4-DHPs acting as cal-cium antagonists[2]. The chemical modifications onthe DHP ring, such as the introduction of differentsubstituents on heteroatoms[3], have allowed theexpansion of researches on structure-activity rela-tionship to have new insight into the molecularinteractions at the receptor l…     

CHLOROSULFONATION OF 9-ARYLOCTAHYDROXANTHEN-1,8-DIONES

The 9-aryloctahydroxanthen-1,8-diones (3, 4– 24) were prepared by reaction of cyclohexan-1,3-dione (1) with selected arylaldehydes. The xanthendiones (4– 9, 11, 12, 18, 21, 22) were successfully reacted with chlorosulfonic acid, and the crude sulfonyl chlorides were converted into 15 sulfonamides (26– 40) for screening as potential pesticides. Attempted chlorosulfonation of the xanthendiones (13– 17) was unsuccessful. α-Methylcinnamaldehyde was reacted with cyclohexandione (1) to yield the corresponding xanthendione derivative (23). On the other hand, with o-methoxycinnamaldehyde an impure product formed and the p-methoxy isomer afforded the corresponding 2-arylpyran (25). The NMR spectral data of the compounds are briefly discussed.     

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.     

Novel heterocyclic systems. Synthesis of 2,7-dimethyl-10-oxa-1,8-diaza-anthracen-9-one and derivatives

Synthesis of novel heterocycles, which contain the unique 10-oxa-1,8-diazaanthracen-9-one tricyclic core, is reported. The core structure was assembled via a dehydrative-cyclization strategy.     

无溶剂条件下氨基磺酸锂催化合成氧杂蒽化合物

在无溶剂条件下,芳香醛与5,5-二甲基-1,3-环己二酮或1,3-环己二酮经氨基磺酸锂催化缩合反应合成了氧杂蒽.结果表明,当催化剂用量为3％(摩尔分数)时,在120℃反应40～70 min,产率高达90％以上.此外,探讨了该反应的氨基磺酸锂催化机理.该合成方法具有操作简单、反应时间短、产率高及对环境友好等优点,是现有氧杂蒽化合物合成方法的一个重要补充.     

无催化剂条件下经微波辐射一步合成9-芳基-3,4,5,6,7,9-六氢-1H-氧杂蒽-1,8(2H)-二酮

微波辐射下以芳醛、1,3-环己二酮为原料在无催化剂条件下合成了一系列9-芳基-3,4,5,6,7,9-六氢-1H-氧杂蒽-1,8(2H)-二酮, 该反应时间短、产率高、后处理方便、环境友好.     

Clean and atom-economic synthesis of octahydroacridines: application to essential oil of citronella

A green and efficient method for the synthesis of octahydroacridine (OHA) has been developed by a simple one-pot hetero-Diels-Alder reaction starting from (+)-citronellal and N-arylamines in the presence of a solid supported catalyst (SiO₂/ZnCl₂), under MW irradiation and without any solvent. The method was used in the direct preparation of OHA from citronella oil in good yield.