非相干成像双目视觉系统的误差分析

影响双目视觉系统测量精度的因素很多,目前系统结构参数对测量精度的影响主要有光轴与基线的夹角、基线距离、水平视角、物距以及透镜焦距等。由于孔径尺寸直接影响成像分辨率,是决定双目视觉测量精度的核心因素,因此依据非相干成像理论,对双目成像过程进行仿真和实验,采用加速鲁棒特征算法对所成的图像对进行特征提取与匹配,获取其视差值,并且计算其视差均方根误差来表征系统误差。研究结果表明,系统误差随着透镜孔径大小的增大而减小,并且趋于饱和。该研究可以为双目系统设计过程中系统参数和孔径尺寸的选取提供理论和实验依据。     

X射线成像系统点扩展函数理论模型及其实验验证

X射线成像系统点扩展函数是影响X射线成像空间分辨率和密度分辨率的决定性因素,在系统分析X射线成像物理过程基础上,建立了X射线成像系统点扩展函数的一种数学解析模型,推导出了射束有效宽度计算公式,最后通过实验验证了模型的正确性。该模型为X射线成像系统空间分辨率和密度分辨率的初步设计和评定提供了理论依据,可作为X射线图像恢复算法中模糊函数的先验信息。     

Toward an optimal distribution of b values for intravoxel incoherent motion imaging

The intravoxel incoherent motion (IVIM) theory provides a framework for the separation of perfusion and diffusion effects in diffusion-weighted imaging (DWI). To measure the three free IVIM parameters, DWIs with several diffusion weightings b must be acquired. To date, the used b value distributions are chosen heuristically and vary greatly among researchers. In this work, optimal b value distributions for the three parameter fit are determined using Monte-Carlo simulations for the measurement of a low, medium and high IVIM perfusion regime. The first 16 b values of a b value distribution, which was optimized to be appropriate for all three regimes, are {0, 40, 1000, 240, 10, 750, 90, 390, 170, 10, 620, 210, 100, 0, 530 and 970} in units of seconds per square meter. This distribution performed well for all organs and outperformed a distribution frequently used in the literature. In case of limited acquisition time, the b values should be chosen in the given order, but at least 10 b values should be used for current clinical settings. The overall parameter estimation quality depends strongly and nonlinearly on the signal-to-noise ratio (SNR): it is essential that the SNR is considerably higher than a critical SNR. This critical SNR is about 8 for medium and high IVIM perfusion and 50 for the low IVIM perfusion regime. Initial in vivo IVIM measurements were performed in the abdomen and were in keeping with the numerically simulated results.     

相位板装配倾斜对波前编码系统点扩散函数的影响

分析了装配误差引起的相位板倾斜对波前编码系统的影响,通过坐标变换推导了相应条件下的广义光瞳函数。结果表明:倾斜因子对系统的相位板系数具有放大效果,其随倾斜角绝对值的增大而增大,而与倾斜角的正负无关。相位板倾斜会放大系统点扩散函数包络面的两条直角边,相应地降低其光学传递函数值。在子午倾斜的条件下,子午方向的相位板系数放大效果大于弧矢方向,从而导致点扩散函数包络面在子午方向的放大效果大于弧矢方向,子午方向光学传递函数值的降低效果大于弧矢方向。采用MATLAB以及商用光学软件进行仿真实验,验证了上述结论。     

用基于厚度估计的卷积算法校正X线图像散射的方法

在数字X线摄影中,散射-眩光造成了图像对比度的下降,为了提高数字X线图像的质量,本方法使用曝光参数和图像灰阶值对图像中的每个像素确定等价的有机玻璃厚度,然后在像素-像素的基础上使用厚度信息估计散射-眩光强度。这里我们把60kV和80kV两种参考状态进行线性组合求校正系数,避免了片面性。为了测试本方法估计散射-眩光强度的能力,把它应用在对志愿者胸部所拍摄的图像中,并获得了一定的结果。本方法为解决数字X线图像中的散射校正问题提供了一种有效的手段。     

用于成像侦察的CCD探测器成像分辨力的探讨

通过对CCD探测器成像过程的模拟,分析了CCD成像在像元几何尺寸及成像灰度方面的数字离散化特征对CCD成像分辨力的影响,给出了CCD成像分辨力与CCD像元分辨力的关系,同时也给出了在相应情况下的调制度传递函数(MTF)的数值。     

中子散射成像探测角分辨研究

中子散射成像技术是近年来国外正在发展的一项新型辐射成像技术, 在深空宇宙探测、核材料监控等方面具有广阔的应用前景. 角分辨是衡量该技术成像能力的一项重要参数. 研究了位置不确定度和能量分辨对角分辨的影响. 理论分析表明: 以不同角度散射, 成像的角分辨不同; 位置不确定不仅直接影响角分辨, 还通过影响能量不确定度对角分辨间接贡献; 位置分辨主要来源于探测器的结构尺寸, 当探测器尺寸小于5 cm, 影响角分辨的主要来源是能量不确定度. 利用所获得的理论结果指导设计了原理探测系统, 并对设计的原理系统开展了初步实验研究. 结果表明, 分析结果与实验得到的角分辨参数基本一致.     

相位板装配倾斜对波前编码系统点扩散函数的影响

分析了装配误差引起的相位板倾斜对波前编码系统的影响,通过坐标变换推导了相应条件下的广义光瞳函数。结果表明：倾斜因子对系统的相位板系数具有放大效果,其随倾斜角绝对值的增大而增大,而与倾斜角的正负无关。相位板倾斜会放大系统点扩散函数包络面的两条直角边,相应地降低其光学传递函数值。在子午倾斜的条件下,子午方向的相位板系数放大效果大于弧矢方向,从而导致点扩散函数包络面在子午方向的放大效果大于弧矢方向,子午方向光学传递函数值的降低效果大于弧矢方向。采用MATLAB以及商用光学软件进行仿真实验,验证了上述结论。     

Intravoxel incoherent motion imaging of the kidney: alterations in diffusion and perfusion in patients with renal dysfunction

Purpose

To investigate the relationship between estimated glomerular filtration rate (eGFR) and parameters calculated using intravoxel incoherent motion (IVIM) imaging of the kidneys.

Materials and Methods

We studied 365 patients, divided into 4 groups based on eGFR levels (mL/min/1.73 m²): group 1, eGFR ≥ 80(n = 80); group 2, eGFR 60–80 (n = 156); group 3, eGFR 30–60 (n = 114); and group 4 ,eGFR < 30 (n = 15). IVIM imaging was used to acquire diffusion-weighted images at 12 b values. The diffusion coefficient of pure molecular diffusion (D), the diffusion coefficient of microcirculation or perfusion (D*), and perfusion fraction (f) were compared among the groups using group 1 as control.

Results

In the renal cortex, D* values were significantly lower in groups 2, 3, and 4 than in group 1. The D value of renal cortex was significantly low in only group 3. In the renal medulla, the D* and D values were significantly lower only in groups 2 and 3, respectively.

Conclusion

As renal dysfunction progresses, renal perfusion might be reduced earlier and affected more than molecular diffusion in the renal cortex. These changes are effectively detected by IVIM MR imaging.     

点扩散函数高斯拟合估计与遥感图像恢复

为了减轻或消除航天遥感相机成像过程中图像退化造成的模糊,突出图像的特征目标,对获取的图像进行了恢复处理。首先,采用陷波滤波器在频率域对遥感图像进行了去噪预处理。然后,通过图像中具有刀刃边缘的地物估计成像系统的退化函数,即点扩散函数;同时,利用高斯拟合对估计的点扩散函数进行校正。最后,利用拟合后的点扩散函数,采用自适应维纳滤波对图像进行恢复。实验结果表明：陷波滤波器基本消除了图像中叠加的条带噪声。与原图相比,细节图像恢复后其方差增大4.395,灰度平均梯度增大1.799,Laplacian梯度增大10.014,图像目视效果更清晰。高斯拟合的点扩散函数用于遥感图像恢复,减轻了图像模糊,使图像细节突出,纹理清晰,利于图像的判读和分析。     

基于相位差混合处理方法的高分辨力成像技术

为了提高成像系统的分辨能力, 并尽量减小系统的复杂度, 本文将相位差波前探测技术和相位差图像恢复技术结合起来构成相位差混合处理方法, 给出了点目标和扩展目标情况下混合处理方法的数值仿真结果, 并针对点目标情况进行了实验验证. 实验表明, 在像差较大的情况下, 直接用事后处理方法无法得到满意的结果. 在三种湍流强度下, 经混合方法处理后得到光斑的半高宽分别由自适应光学系统校正后的5.1, 5.1和5.0个像素减小到3.3, 3.2和3.0个像素. 可以看出, 利用相位差混合处理方法得到的图像明显优于单独的事后图像处理方法和自适应光学校正, 相位差混合处理方法在高分辨力成像领域有着巨大的应用潜力.     

An integrated phase-resolved fluorescence imaging system with sub-nanosecond lifetime resolution

In this paper, a novel configuration of an integrated phase-resolved (PR) fingerprint fluorescence imaging system is proposed and implemented. In this integrated PR imaging system, a current modulated 402 nm dual diode laser is proposed to be the light source, to obtain both high laser power and easy modulability. To estimate the lifetime resolution of this PR imaging system, a novel method of using distance-selective suppression of fluorescence signals from two identical fluorescing samples is proposed. Detailed theoretical and experimental analyses are presented. The experimental results demonstrate that this integrated PR imaging system has a lifetime resolution of 0.1 ns. Fingerprint detection experiments are also carried out using this system with latent fingerprints deposited on substrates of aluminum foil and currency.     

全反射式高分辨率傅里叶成像光谱仪的研究

提出了一种基于分波前干涉结构的全反射式高分辨率傅里叶变换成像光谱仪。其中前置望远系统及干涉成像系统都采用了反射式光学元件,反射表面镀金属反射膜,使系统可应用与很宽的光谱范围内。分析和讨论了光谱仪的工作原理及光学结构,设计了两种可行的光路结构图,并通过初步实验验证了系统的基本性能。     

0.14 THz高分辨力成像雷达信号处理

为适应0.14 THz超高分辨雷达实时成像的需求,开发了基于CPU+GPU+FPGA的硬件架构和成像处理算法,算法以距离-多普勒为原型,引入L类维格纳分布变换提高横向分辨力,用Keystone变换方法对越距离单元徙动进行校正,并开发了系统非线性补偿算法。在载频0.14 THz、带宽5 GHz雷达样机上进行了逆合成孔径雷达成像试验,获得了3 cm3 cm的成像分辨力和实时成像能力,验证了信号处理方法的有效性。     

距离选通成像系统分辨力模拟测试装置的设计

距离选通成像系统采用的是脉冲激光主动照明与ICCD选通技术相结合的方法。为了在室内模拟测试在一定大气条件下距离选通成像系统的分辨力,设计了一套模拟测试装置。以辐射传输理论为基础,建立了大气距离选通成像系统后向散射光和信号光的模型。该模型给出了后向散射光和信号光在光电阴极面上照度随时间的变化规律。采用两个模拟光源,分别模拟了信号光和后向散射光。采用阴极面等效辐射照度法,给出了模拟光源功率的方法。以S 20光电阴极的像增强器与CCD的耦合为例,计算了模拟光源的功率。     

纳米分辨相干反斯托克斯拉曼散射显微成像

采用附加探测光声子耗尽法来实现超衍射极限相干反斯托克斯拉曼散射显微成像. 此方法引入一束环形分布的附加探测光来消耗点扩展函数周边的相干声子, 实现点扩展函数的改造, 从而达到超越衍射极限的空间分辨率. 为了获得更高的空间分辨率和更佳的相位匹配条件, 通常需采用高数值孔径物镜对抽运光、斯托克斯光和探测光进行聚焦, 此时标量衍射理论不再成立. 基于矢量衍射理论, 分析了线偏振光、圆偏振光先后经过螺旋相位片和高数值孔径物镜后的光强分布, 结果表明: 圆偏振光在高数值孔径物镜后焦平面的光强分布呈中心对称状, 较线偏振环形光更适合作为附加探测光. 此外, 采用全量子理论分析了附加探测光声子耗尽法. 结果表明: 当附加探测光与探测光强度比为80时, 成像系统的横向空间分辨率可以达到45 nm; 继续提高附加探测光强度, 空间分辨将进一步提高.     

Intravoxel incoherent motion diffusion-weighted imaging in head and neck squamous cell carcinoma: Assessment of perfusion-related parameters compared to dynamic contrast-enhanced MRI

Purpose

To investigate the correlation between perfusion-related parameters obtained with intravoxel incoherent motion (IVIM) and classical perfusion parameters obtained with dynamic contrast-enhanced (DCE) magnetic resonance imaging in patients with head and neck squamous cell carcinoma (HNSCC), and to compare direct and asymptotic fitting, the pixel-by-pixel approach, and a region of interest (ROI)-based approach respectively for IVIM parameter calculation.

Materials and methods

Seventeen patients with HNSCC were included in this retrospective study. All magnetic resonance (MR) scanning was performed using a 3 T MR unit. Acquisition of IVIM was performed using single-shot spin-echo echo-planar imaging with three orthogonal gradients with 12 b-values (0, 10, 20, 30, 50, 80, 100, 200, 400, 800, 1000, and 2000). Perfusion-related parameters of perfusion fraction ‘f’ and the pseudo-diffusion coefficient ‘D*’ were calculated from IVIM data by using least square fitting with the two fitting methods of direct and asymptotic fitting, respectively. DCE perfusion was performed in a total of 64 dynamic phases with a 3.2-s phase interval. The two-compartment exchange model was used for the quantification of tumor blood volume (TBV) and tumor blood flow (TBF). Each tumor was delineated with a polygonal ROI for the calculation of f, f ? D* performed using both the pixel-by-pixel approach and the ROI-based approach. In the pixel-by-pixel approach, after fitting each pixel to obtain f, f ? D* maps, the mean value in the delineated ROI on these maps was calculated. In the ROI-based approach, the mean value of signal intensity was calculated within the ROI for each b-value in IVIM images, and then fitting was performed using these values. Correlations between f in a total of four combinations (direct or asymptotic fitting and pixel-by-pixel or ROI-based approach) and TBV were respectively analyzed using Pearson's correlation coefficients. Correlations between f ? D* and TBF were also similarly analyzed.

Results

In all combinations of f and TBV, f ? D* and TBF, there was a significant correlation. In the comparison of f and TBV, a moderate correlation was observed only between f obtained by direct fitting with the pixel-by-pixel approach, whereas a good correlation was observed in the comparisons using the other three combinations. In the comparison of f ? D* and TBF, a good correlation was observed only with f ? D* obtained by asymptotic fitting with the ROI-based approach. In contrast, moderate correlations were observed in the comparisons using the other three combinations.

Conclusion

IVIM was found to be feasible for the analysis of perfusion-related parameters in patients with HNSCC. Especially, the combination of asymptotic fitting with the ROI-based approach was better correlated with DCE perfusion.     

太赫兹极高分辨力雷达成像试验研究

给出了一种载频0.14 THz、带宽5 GHz的极高分辨力太赫兹雷达成像系统样机。系统采用Ka波段毫米波信号二倍频后作为样机收发链路的谐波混频本振,以线性调频连续波信号作为发射信号,接收时采用去斜接收。利用该太赫兹雷达进行了成像试验并得到了1维距离像与逆合成孔径雷达（ISAR）成像结果。结果表明,THz雷达样机实现了3 cm的高分辨力,其ISAR像清晰,反映了目标的细微特征。     

Resolution enhancement techniques for optical lithography and optical imaging theory

Production of a fine pattern is necessary to get a high integration degree of integrated circuits. The conventional methods which utilize high numerical aperture and short wavelength exposure are limited by designing and manufacturing of a practical lens and make the focus depth narrow. Resolution enhancement techniques (RETs) have, therefore, been required and proposed. This paper introduces a phase-shifting mask, a typical RET, points out the problems and inconsistencies of conventional optical imaging theory and explains the image formation concept of expansion of plane waves. Essentially using this concept, an attempt is also made to describe some other typical RETs with potential.