SYNTHESIS AND CRYSTAL STRUCTURE OF 5, 10, 15, 20, 22, 24-HEXAHYDRO-5, 5, 10, 10, 15, 15, 20, 20-OCTAMETHYL-PORPHINE

<正> The title com pound (HHOMP) has been synthesized with the pho-toinduced condensation of acetone and pyrrole in the presence of iodoaromatic hydrocarbons, and its molecular and crystal structures have been determined by X-ray analysis. C28H36N4, Mr = 428. 63, triclinic; space group P1; a =10. 165(3), b = 10. 185(2), c=13. 012(3)(?); α=85. 41(2), β=67. 84(2), γ= 89. 75(2)°; V = 1243 (?)3; Z = 2; D = 1. 145g. cm-3; μ= 0. 635cm-1; F (000) = 464. Although the HHOMP molecule twists, it is found that the four nitrogen atoms are still in a plane.     

Synthesis and Resolution of 10, 11-Dihydro- 10-hydroxycyproheptadine

10, 11-Dihydro-10-hydroxycyproheptadine was synthesized in a new and facile synthetic route and resolved by L-(-)-2-(1, 3)-dioxo-1, 3-dihydroisoindol-2-yl)-propionic acid and D-( )-tartaric acid, respectively. The free base of the two enantiomers has the same absolute specific rotation value.     

Photo-induced Coupling Reaction of 1, 1-Diphenyl-2, 2-dicyanoethylene with 10-Methyl-9, 10-dihydroacridine

In a previous communication1, we reported a novel photo-induced coupling of 9-fluorenylidenemalononitrile 1 with the coenzyme NADH model 10-methyl-9, 10-dihydroacridine (AcrH2) to give 9-dicyanomethyl-9-(10-methyl-9-acridinyl)fluorene and proposed a mechanism involving photo-induced electron transfer-proton transfer and radical coupling. This is a scarce mechanism for the reaction of NADH models2, which usually takes place by a formal hydride transfer pathway3. In view of the novelty of t…     

反式9, 10-二氢-9, 10-二苯基-9, 10-菲二醇包结性能的研究

合成了一种具有螯形结构的反式-9, 10-二氢-9, 10-二苯基-9,10-菲二醇(1)作为主体分子。它能与许多有机小分子化合物, 诸如DMF, DMSO, 吡啶, 哌啶, 喹啉, 异喹啉等形成包结化合物。本文还报道了这些包结化合物的IR, 粉末XRD的表征, 用^1H NMR谱测定了它们的分子摩尔比。DMF包结物的单晶四圆X衍射结果表明主体分子1与客体分子形成的包结物为配位笼状包合物。     

Author Index Vol.10, 1999

ANC.C.(0781)ANJ.(0697)BAID.L.(0281)BAID.L.(0733)BAIF.L.(0953)BAOX.H.(0083)BEIJ.Z.(0327)BIS.P.(0247)BIANJ.(0697)CAIJ.C.(0201)CAIL.T(1045)CAIM.S.(0027)CAIQ.(0335)CAIT.X.(0083)CAIZ.G.(0257)CAIZ.T(0325)CAOC.N.(1003)CAOG.F(0441)CAOH.Y(0731)CAOS.Q.(0193)CENW.(0111)EENW.(0547)CENY.Z.(0401)CHANGJ.B.(0273)CHANGJ.B.(0341)CHANGJ.B.(0357)CHANGW.B.(0495)CHENC.F.(0059)CHENC.X.(0033)CHENC.X.(0131)CHENC.X.(0391)CHENG.(0247)CHENH.(0147)CHENH.(…     

Keyword Index Vol.10, 1999

A_2BO_4-typecompound(1049)Abinitio(0511)Abinitio(1053)Abinitiocalculation(0321)Abinitiocalculation(0941)Abeotaxane(0043)Absorption(0161)Acetals(0199)Acetophenone(1053)7-O-[6-O-(4-O-Acetyl-α-L-(0295)rhamnosyl]1-3-β-D-glu-rhamnosyl]-6-O-acetyl-β-D-glucosyl]-6-O-actetyl-β-D-gluAcetylene(0803)Acrylatepolymer(0667)Acrylicacid(0601)Acylchloride(0009)5-Acyl-2-furancarboxaldehyde(0011)2-Acyl-5-dichloromethylfuran(0011)Acylatedtriterpenoidssaponin(0033)Acylation(0347)3-Acylcamphor(0347)A…     

The Crystal Structure of 1, 4, 7, 10- Tetraazacyclododecane Hydrate Triperchlorate

1=mTRODUCTIONMacroazacyclicligandisofwideinterestbecauseofitsstructuralsimilaritywiththeskeletonofPOrphyrinringinsomebibectivesubstancessuchaschlorophyllandhemeetc.tl1.Asametalsimulationenzyme,macroazacyclicligandcoordinatedwithtransitionmetalhasbeeninvestigatedthoroghlyinkinetic,dynamicandstructuralcharactert2.3).Butthere'isnorePOrtaboutthecrystalstructureof1,4,7,1o-tetraaza-cyclododecanehydratetriperchlorate.2EXPERIMENTAL2-lSynthesisoftheTitleComplexTetraazacycldodecanewassynthes…     

Theoretical study of dodecahydro-closo-decaborane B10H12, the diprotonated boron cluster B10H 10 2−

The electronic and geometric structures of different isomers of the closo-B₁₀H₁₂ boron cluster have been calculated by the density functional theory method (in the B3LYP/6-311++G**//B3LYP/6-31G* approximation). The compound is considered to be the diprotonated (H*) analogue of the well-studied B₁₀H ₁₀ ^2? anion and serves as a model system. The increase in the relative energies of isomers and the preferred location of the extra H* protons near the opposite B(1) and B(10) “poles” are consistent with the charge separation (in the framework of the Mulliken population analysis) between B(1) and B(10). The reactions of migration of one or simultaneously two H* protons in B₁₀H₁₂ over the boron polyhedron have been considered, and the corresponding energies of elementary events E and activation barriers h have been estimated. The elementary events have been predicted in which both H* protons simultaneously move along the trajectories near the opposite B(1) and B(10) poles of the B₁₀H ₁₀ ^2? polyhedron with the same or opposite changes in the angles determining the H* position with respect to the B(1)–B(10) axis. The activation barrier to the “opposite” migration of the H* protons has been assessed to be h ～ 1.2 kcal/mol, whereas for the migration of the H* protons in the same direction, h ～ 1.4 kcal/mol. The H* proton transfer from the position near the B(1) pole to the position near the opposite B(10) pole is hindered, and higher activation barriers on the order of h ～ 13–15 kcal/mol should be overcome for this transfer to occur.     

Structural examination of 1-vinylphenothiazine, 10-vinylphenothiazine S-oxide, 10-vinylcarbazole, 9-vinylcarbazole,and 9-vinyl-β-carboline by 1H and 13C NMR

According to ¹H and ¹³C NMR, the vinyl group in 10-vinylphenothiazine is coplanar with the plane orthogonal to the axis of the lone pair on nitrogen, as a result of bending of the ring along the S-N axis. In 10-vinylphenothiazine S-oxide, this bending does not occur, and as a result of the steric influence of the heterocycle the vinyl group is located nearly orthogonally to the heterocycle, and is analogous to the spatial structure of 10-vinylacridone. In 9-vinylcarbazole, the N-C torsion angle is 60°, increasing to 75° in 9-vinyl-1-methyl--carboline.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 408–415, March, 1992.     

Synthetische Versuche in der Gruppe hypotensiv wirksamer Alkaloide, 13. Mitt.: Synthese vondl-10-Methyldeserpidin,dl-10-Äthoxydeserpidin unddl-10-Methylmercapto-deserpidin

Zusammenfassung Die durch Umsetzung von 5-Methyltryptamin, 5-Äthoxytryptamin und 5-Methylmercapto-tryptamin (I, R=CH₃, OC₂H₅ bzw. SCH₃) mit dem racemischen Aldehyd-Ester II entstandenenSchiffschen Basen wurden durch Natriumborhydrid-Reduktion in Methanol unter gleichzeitiger Cyclisierung und Desacetylierung in die entsprechenden 10-substituiertendl-Methyl-2,3-seco-3-oxodeserpidate (IV) übergeführt. Die bei der Einwirkung von 3,4,5-Trimethoxybenzoylchlorid in Pyridin erhaltenen Ester V wurden weiter mit Phosphoroxychlorid cyclisiert und die Produkte als Perchlorate (VI) mit Zink in sauerer Lösung zu den entsprechenden 10-substituiertendl-Deserpidinen (VII, R=CH₃, OC₂H₅ bzw. SCH₃) reduziert. Mit Hilfe der Chromatographie gelang es in zwei Fällen, aus den Rohprodukten auch die entsprechendendl-3-Isodeserpidine (VIII, R=CH₃ bzw. OC₂H₅) zu isolieren. Zum Unterscheiden der Produkte der normalen Reihe (VII) und der 3-Iso-Reihe (VIII) wurden IR-Spektren und die Papierchromatographie angewendet.Mit 2 Abbildungen     

反式-9, 10-二氢-9, 10-二(1-萘基)-9, 10-菲二醇的包合现象 与晶体结构

按文献方法合成了一个螯形主体分子,反式-9,10-二氢-9,10-二(1-萘基)-9,10-菲二醇。研究发现该主体可以和一些含氮杂环化合物形成一定比例的晶体包合物。用X-射线衍射分析二环己胺包合物的晶体结构表明,包合物中主客体之间存在O-H…N氢键相互作用,客体分子包合在主体分子形成的空腔中。     

7~th Natural Gas Conversion Symposium, Dalian, China, June 6-10, 2004 Second Circular

About the symposiumThe 7th Natural Gas Conversion Symposium will be held June 6-10, 2004 at a five-star hotel in Dalian, China. The symposium continues the tradition set by six previous meetings.1987 - Auckland, New Zealand1990 - Oslo, Norway1993 - Sydney, Australia1995 - Kruger National Park, South Africa1998 - Taormina, Italy2001 - Girdwood, Alaska, USAThe symposium will focus on recent developments and novel aspects of the conversion of natural gas.     

Protein recognition by bivalent, ‘turn-on’ fluorescent molecular probes

We show that the conversion of a known intercalating dye (i.e., thiazole orange) into a bivalent protein binder could lead to the realization of a novel class of ‘turn-on’ fluorescent molecular probes that detect proteins with high affinity, selectivity, and a high signal-to-noise (S/N) ratio. The feasibility of the approach is demonstrated with monomolecular probes that light-up in the presence of three different proteins: acetylcholinesterase (AChE), glutathione-s-transferase (GST), or avidin (Av) at low concentrations and with minimal background signal. The way by which such probes can be used to detect individual protein isoforms and be applied in inhibitor screening, cell imaging, and biomarker detection is described.     

中国科学院新当选院士简介(2001年,化学部,10人)

曹镛 (Cao Yong)　男 ,汉族 ,高分子化学家 ,华南理工大学教授、高分子光电材料与器件研究所所长。1941年出生于湖南长沙。196 5年毕业于原苏联列宁格勒大学化学系。 1987年获日本东京大学理学博士学位。曹镛是国内最早从事导电高分子研究的科学家之一。与他人合作用稀土催化剂合成了有新的结构和形貌特色的聚乙炔。率先合成苯胺及噻吩的齐聚物 ,并对其进行掺杂和研究其结构与性能关系。他在用有机质子酸掺杂聚苯胺制备可溶性的聚合物的基础上 ,提出“对阴离子诱导加工性”的概念 ,解决了导电高分子的高导电性与加工性不能同时并存的难题 ,…     

A Facile Synthetic Method for （3Z, 6Z, 9S, 10R）-9, 10-Epoxy-3, 6- heneicosadiene, Sex Pheromone Component of Hyphantria Cunea （Drug）

Total synthesis of (3Z, 6Z, 9S, 10R)-9, 10-epoxy-3, 6-heneicosadiene, sex pheromone component of Hyphantria cunea (Drug), was achieved using Sharpless AE kinetic resolution and alkylative epoxide rearrangement as key steps.     

Studies on Selena-Macrocyclic Amides Synthesis and Structural Characterization of 7-Phenyl-5, 9-dioxo-1-selena-4, 7, 10-triazacyclododecane and 6-(4-Nitrobenzyl )-5, 9-dioxo-1, 4, 7, 10-selenatriazacyclododecane

lmTR0DUCTI0NSincetheseleniumcoronandswereachivevedin1989tli,thesynthesisandcoor-dinationchemistrystudyofthismacrocycliccomPOundshavereceivedwideattentionowingtotheirstrongcomplexingabilitiestowardssoft.transiti0nandheavymetals.InourprevibuspaPer,wereP0rtedthecrystalstructureoftw0selenacrownethers(2'3)andaPd(1)complexwith10'selenabenzo-15-crown-5t4i.Duetothedifficultyofthepreparationsofselenium-nitr0genmixeddonorc0n-..tainingmacrocycles,thestudyontheseligandsisconsiderablyscarce.Thesynthes…