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1.
The effect of WO3 on thermal behaviour and thermal stability of ZnO–P2O5–WO3 glasses prepared in compositional series (100 ? x)[0.5ZnO–0.5P2O5] ? xWO3 (x = 0–60) was investigated by heating microscopy and the results were correlated with the results determined by conventional thermodilatometry and differential thermal analysis. Thermoanalytical studies showed that the glass transformation temperature and dilatation softening temperature increase with increasing WO3 content while thermal expansion coefficient decreases. The highest stability towards crystallization possess glasses containing 20–30 mol% WO3. Major compounds formed by the crystallization of the glasses were Zn(PO3)2, WO3 and W18P2O59. The values of sphere temperature, hemisphere temperature and flow temperature obtained using heating microscopy were strongly influenced by the degree of crystallization process at the sintering.  相似文献   

2.
A derivation of the Williams–Landel–Ferry equation for the temperature dependence of relaxation time τ(T) in the glass transition range is proposed. This derivation is of a general character and is not related to any particular form of the functional dependence τ(T), in contrast to the known approaches. The modification of the Williams–Landel–Ferry equation and examples of its practical applications are considered.  相似文献   

3.
Many biological processes depend on protein-based interactions, which are governed by central regions with higher binding affinities, the hot-spots. The O-ring theory or the “Water Exclusion” hypothesis states that the more deeply buried central regions are surrounded by areas, the null-spots, whose role would be to shelter the hot-spots from the bulk solvent. Although this theory is well-established for protein–protein interfaces, its applicability to other protein interfaces remains unclear. Our goal was to verify its applicability to protein–DNA interfaces. We performed Molecular Dynamics simulations in explicit solvent of several protein–DNA complexes and measured a variety of solvent accessible surface area (SASA) features, as well as, radial distribution functions of hot-spots and null-spots. Our aim was to test the influence of water in their coordination sphere. Our results show that hot-spots tend to have fewer water molecules in their neighborhood when compared to null-spots, and higher values of ΔSASA, which confirms their occlusion from solvent. This study provides evidence in support of the O-ring theory with its applicability to a new type of protein-based interface: protein–DNA.  相似文献   

4.
The influence of the ratio of the acrylamide, acrylonitrile, and 2-acrylamido-2-methylpropanesulfonic acid monomeric units in the terpolymer on its resistance to elevated temperatures and sensitivity to calcium salts was studied. The influence of the terpolymer composition on the chemical transformations occurring under the conditions of thermal and hydrothermal treatment was studied by TGA and IR spectroscopy. The degree of hydrolysis of the terpolymers influences their resistance to CaCl2. The resistance of the terpolymers to CaCl2 additions at their concentrations of up to 7 wt % is preserved at the content of 2-acrylamido-2-methylpropanesulfonic acid units higher than 20 mol %. The revealed features allow optimization of the structure of polymer systems used in drilling lubricants.  相似文献   

5.
Synthetic oleananes and seco-oleananes form a group of promising anti-inflammatory and cancer chemopreventive agents with an excellent safety profile. These compounds are usually prepared by semi-synthesis from natural oleanane triterpenoids. Since a taraxer-14-ene was reported to be rearranged into an olean-12-ene under mild reaction conditions, a rapid synthesis of seco-oleananes from taraxerone, which is a readily available starting material, was explored by us. Treatment of taraxerone with m-chloroperoxybenzoic acid gave 14,15-epoxy lactones, which underwent the taraxerane–oleanane rearrangement leading to new seco-oleanane triterpenoids.  相似文献   

6.
7.
First-line drugs (rifampicin, RIF; isoniazid, INH; ethambutol, ETA; and pyrazinamide, PZA) recommended in conventional treatment of tuberculosis were analyzed in 1:1 w/w binary mixtures with microcrystalline cellulose MC 101 (CEL) and lactose supertab® (LAC) by differential scanning calorimetry (DSC), thermogravimetry (TG), differential thermal analysis (DTA), and Fourier transformed infrared analysis (FTIR) as part of development of fixed dose combination (FDC) tablets. Evidence of interaction between drug and pharmaceutical excipients was supposed when peaks disappearance or shifting were observed on DTA and DSC curves, as well as decreasing of decomposition temperature onset and TG profiles, comparing to pure species data submitted to the same conditions. LAC was showed to interact with RIF (absence of drug fusion and recrystallization events on DSC/DTA curves); INH (thermal events of the mixtures different from those observed for drug and excipient pure in DSC/DTA curves); PZA (decrease on drug fusion peak in DSC/DTA curves), and ETA (shift on drug onset fusion and absence of pure LAC events on DSC/DTA curves). In all cases, an important decrease on the temperature of drug decomposition was verified for the mixtures (TG analysis). However, FTIR analysis showed good correlation between theoretical and experimental drug-LAC spectra except for INH–LAC mixture, evidencing high incompatibility between these two species and suggesting that those interactions with PZA and RIF were thermally induced. No evidence of incompatibilities in CEL mixtures was observed to any of the four-studied drugs.  相似文献   

8.
In the present paper we suggest a new concept to overcome some of the so far unsolved problems of the structure–property relationship of methylcellulose, the most important nonionic cellulose ether industrially produced in large scale. Not only from the viewpoint of scientific understanding, but also from that of the peculiar and application-determining behavior, the aggregation in aqueous solution and phase separation on heating are the most important questions. As a part of the concept, we had prepared amphiphilic block co-oligomers of tri-O-methylated and unmodified cello-oligosaccharides as structural models of typical sequences in methylcellulose chains. Now static and dynamic light scattering measurements and transmission electron microscopy (TEM) were carried out using solutions of the oligomers in water. Ellipsoidal particles with dimensions of about 50 nm for the semi-major axis and of circa 25 nm for the semi-minor one could be detected. These findings agree with the radii of gyration and the hydrodynamic radii, determined by static and dynamic light scattering. The data preliminary obtained demonstrate the strong aggregation tendency of block-like methylated cello-oligosaccharides.  相似文献   

9.
10.
Glass transition effect of mixed network AlPO4–BPO4–SiO2 glasses was studied. DTA/DSC and TMA measurements has been applied in the research. It has been found that glass transition effect has structurally sensitive properties. Glass transition temperature T g, changes of specific heat (Δc p)and thermal expansion coefficient (α) accompanying the process depend on the nature and the number of components forming the glassy framework. Character of chemical bonds combining them into the glass structure has an influence on the glass transition effect. Its course is dependent on the flexibility of the structure of glasses. This revised version was published online in July 2006 with corrections to the Cover Date.  相似文献   

11.
The mixture {yNaCl + (1 – y)CaCl2}(aq) has been studied with the hygrometric method at the temperature 25°C. The water activities were measured at total molalities from 0.25 mol-kg–1 to near saturation for different ionic-strength fractions y of NaCl with y = 0.33, 0.50, and 0.67. The obtained data allow the calculation of osmotic coefficients. The experimental results are compared with the predictions of the Zdanovskii–Stokes–Robinson (ZSR), Kusik and Meissner (KM), Robinson and Stokes (RS), Lietzke and Stoughton (LS II), Reilly–Wood–Robinson (RWR), and Pitzer models. From the measured osmotic coefficients, the Pitzer ionic mixing parameters Na Ca and Na Ca Cl are determined and are used to predict the solute activity coefficients in the mixtures. The excess Gibbs energy is also determined. These results are compared with those given in the literature.  相似文献   

12.
《中国化学快报》2023,34(1):107273
In this study, through direct pyrolysis of a nitrogen-rich metal-organic framework of Fe-BTT at different temperatures and followed by acid treatment, we prepared a series of Fe–N–CT (T = 800–1000 °C) composite catalysts with uniform cubic morphology and homogeneously distributed active sites. Acid leaching leads to the removal of excess Fe NPs and the exposure of more pyridinic N and porphyrin-like Fe–Nx sites and creates a higher specific surface area. Structural and electrochemical performance test results showed that Fe–N–C900 catalyst exhibited the highest selectivity for CO product at –1.2 V vs. Ag/AgCl, with 496 mV of overpotential and 86.8% of Faraday efficiency, as well as excellent long-term stability, due to the good inheritance from rich-N Fe–BTT precursor.  相似文献   

13.
14.
SiO2–Al2O3 aerogels and xerogels with a Si to Al molar ratio r Si/Al varying from 0.25 to 20, were made by sol-gel process in acidic conditions at pH 2 and respectively dried by the CO2 supercritical method and by solvent evaporation. The Al precursor was also chelated with ethylacetoacetate, which made it possible to study the structure and texture of such gels in conditions favorable to the formation of mixed Al–O–Si bonds. Nitrogen adsorption isotherms according to the Brunauer, Emmett and Teller method (BET), 27Al magic angle spinning nuclear magnetic resonance (27Al MAS-NMR), Fourier Transformed Infrared Spectroscopy (FTIR) and Infrared absorbance spectra after Temperature Programmed Desorption (TPD) of pyridine, showed that the Si–O infrared asymmetric stretching vibration and the Bronsted acidity relative to the Lewis acidity, depended on the ratio of AlIV to Si atoms.  相似文献   

15.
Regioselectivity of nucleophilic aromatic photosubstitution has been shown experimentally to depend upon activation energies of the competing transition states. Computational means of determining relative activation energies were sought, therefore, in order to predict regioselectivity. Optimization of the three triplet transition states of 2-chloro-4-nitroanisole with hydroxide ion gave energies of insufficient accuracy to predict regioselectivity. Computed enthalpy changes from the first triplet transition state to the triplet σ-complexes correlated precisely with the experimental activation energies. This exemplifies the Bell–Evans–Polanyi Principle, and it provides an accurate means of assessing regioselectivity.  相似文献   

16.
A new synthetic strategy towards the C27–C35 subunit of Eribulin (1) has been devised to include a protected 1,2-amino alcohol at C34–C35. Early introduction of the C35 amino group in the synthesis of 1 increases the efficiency of the route. This new approach can be accomplished on a multi-gram scale and allows for the successful synthesis of Eribulin.  相似文献   

17.
In the framework of developing analyses for exogenous contaminants in food matrices such as honey, we have compared data obtained by high-performance liquid chromatography coupled with mass spectrometry (LC–MS) to those provided by high-performance liquid chromatography and tandem mass spectrometry (LC–MS–MS). Initial results obtained with LC–MS showed that the technique lacked selectivity, which is why the method was validated by LC–MS–MS. This method involves a solid-phase extraction (SPE) of nitrofuran metabolites and nitrofuran parent drugs, a derivatization by 2-nitrobenzaldehyde for 17 h, and finally a clean-up by SPE. The data obtained show that the limits of detection varied between 0.2 and 0.6 μg kg−1 for the metabolites and between 1 and 2 μg kg−1 for nitrofuran parent drugs. The method was applied to different flower honeys. The results showed that nitrofurans (used as antibiotics) are consistently present in this matrix, the predominant compound being furazolidone. Figure Working bees  相似文献   

18.
The current success of Density Functional Theory applications hinges upon the availability of explicitly density-dependent functionals to self-consistently solve a set of one-electron equations, the Kohn–Sham (KS) equations, which determine the occupied orbitals and its associated electronic density. In KS theory, a local exchange potential is proposed as part of an effective potential. This potential is compared to the exchange operator of the Hartree–Fock theory, which is of a non-local nature. The present paper discusses the variational framework of the KS equations, and the equivalence between both exchange potentials within a correlation-free theory. The common difficulties of current local exchange functionals to correctly simulate the non-locality of the exchange energy density in chemical systems are also analyzed and explained through an exactly solvable model. We give then numerical arguments and conclude by analyzing the performance of various commonly used approximations to exchange functionals.  相似文献   

19.
Impedance spectroscopy is a rapidly developing technique for the transduction of biosensing events at the surface of an electrode. The immobilization of biomaterial as DNA strands on the electrode surface alters the capacitance and the interfacial electron transfer resistance of the conductive electrodes. The impedimetric technique is an effective method of probing modifications to these interfacial properties, thus allowing the differentiation of hybridization events. In this work, an avidin bulk-modified graphite–epoxy biocomposite (Av-GEB) was employed to immobilize biotinylated oligonucleotides as well as double-stranded DNA onto the electrode surface. Impedance spectra were recorded to detect the change in the interfacial electron transfer resistance (R et) of the redox marker ferrocyanide/ferricyanide at a polarization potential of +0.17 V. The sensitivity of the technique and the good reproducibility of the results obtained with it confirm the validity of this method based on a universal affinity biocomposite platform coupled with the impedimetric technique.  相似文献   

20.
To evaluate the thermal stability of materials, various criteria have been used. Not only the simple parameters, as characteristic temperatures, but also the combined criteria E/RT p , k f (T) and criterion based on the length of induction period of crystallization have been taken into account. Four gels with the composition Li2O–2SiO2nTiO2 (n = 0.00, 0.03, 0.062, and 0.1) were prepared and the validity of the criteria was tested by applying them to these gels. The results indicate that thermal stability of the studied gels decrease with amount of TiO2.  相似文献   

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