Synthesis of some 2-(heteroarylamino)benzimidazoles and their cyclization with phosgene

2-(Benzimidazol-2-ylamino)pyridine (4a) , 2-(benzimidazol-2-ylamino)pyrazine (4b) , and 2-(benzimidazol-2-ylamino)thiazole (4c) underwent a ring-closure reaction on treatment with phosgene affording 6H-pyrimido-[1′,2′:5,4][1,3,5]triazino[1,2-a]benzimidazol-6-one (1a) , 6H-pyrazino[1′,2′:5,4][1,3,5]triazino[1,2-a]benzimidazol-6-one (1b) , and 5H-thiazolo[2′,3′:4,5][1,3,5]triazino[1,2-a]benzimidazol-5-one (1c) respectively. The structure of these hitherto unknown heterocyclic systems was confirmed by their ir and mass spectra.     

Synthesis of some substituted benzimidazoles with potential antimicrobial activity

Summary The synthesis andin vitro antimicrobial evaluation of several benzimidazole derivatives with different heterocyclic nuclei at position-2 are described.

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Synthese einiger substituierter Benzimidazole mit potentieller antimikrobieller Aktivität

Zusammenfassung Die Synthese und antimikrobielle Prüfung einiger Benzimidazole mit verschiedenen heterozyklischen Substituenten in 2-Stellung wird beschrieben.

     

Synthesis of some substituted 1-(2-propynyl)-4-piperidones

Summary Some 1-(1,2-dimethyl-2-propynyl)-4-piperidones were synthesized, and the effect of substitution in the piperidine ring on the reversible cyclization of unsaturated-alkylamino ketones into 4-piperidones was investigated.     

Synthesis of some benzimidazoles containing 2-perfluoro substituents

A new method is described for the preparation of 2-perfluoroalkylether- benzimidazoles through the N-monoacyl derivatives of o-phenylenediamine. 2-pentafluorophenylbenzimidazole has been obtained by the reaction of o-phenylenediamine and pentafluorobenzoic acid in the presence of polyphosphoric acid. 2-Perfluoroalkylbenzimidazoles have been prepared in excellent yields by direct condensation of o-phenylenediamine with perfluoroalkane- carboxylic acids in the absence of any solvent or added reagent. Some derivatives of these compounds are also described.     

Synthesis of some substituted difluoronitroacetanilides and their reduction to substituted N-difluoronitroethylanilines

The synthesis of difluoronitroacetanilide and its p-methyl and m-methoxyl derivatives and their reduction by diborane in tetrahydrofuran to the corresponding N-difluoronitroethylanilines is described. Yields on the acetanilides ranged from 13 to 43% and on the anilines from 50 to 64%.     

Synthesis of some novel 2-thioxoimidazolidin-4-one substituted glycosyl hydrazone derivatives

Russian Journal of General Chemistry - A series of novel 2-thioxoimidazolidine glycosides were prepared via reaction of the key intermediate...     

Synthesis and reactivity of substituted alkoxymethylphosphonites and their derivatives

Alkoxy‐substituted methylphosphonites and their derivatives are prepared using an organomagnesium method of synthesizing the organophosphorus compounds and alkoxymethylation of various PH acids and their derivatives. Also, certain properties of these promising compounds as important precursors of new functionalized organophosphorue compounds with alkoxymethyl fragments are presented. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:281–289, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.21015     

Synthesis of substituted imidazo[5, 1-b]benzimidazoles

By heating 2-acetylamino-1-methyl- and 1-benzyl-2-formylaminomethylbenzimidazoles with phosphorus oxychloride in toluene, 1,4-dimethyl- and 4-benzylimidazo[5, 1-b]benzimidazoles have been obtained.For part II, see [2].     

Synthesis and reactions of some 5(6)-(1-adamantyl)benzimidazoles

4-(1-Adamantyl)-1,2-diaminobenzene, previously unreported in the literature, has been prepared and a novel series of 5(6)-(1-adamantyl)benzimidazole derivatives synthesized. Nitration, hydrogenation, and side chain reactions have been carried out. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1172–1182, August, 2008.     

Synthesis of some substituted 1,2,4-triazole and 1,3,4-thiadiazole derivatives

New S-substituted 1,2,4-triazole and 1,3,4-thiadiazole derivatives have been prepared. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1712–1715, November, 2008.     

2,2’─呋喃联吡咯型联体杂环化合物的合成

在强极性的醇酸体系中，利用Knorr－Paal反应制得了呋喃联吡咯系的13个新化合物，并进行了红外光谱、质谱、核磁共振谱及元素分析测定。     

5-(2,3-二羟丙基)嘧啶的合成及其高碘酸盐氧化

近十年来,呋喃和嘧啶的并合体系之一的呋喃并[2,3-d]嘧啶的合成受到了一定的注意.对其衍生物的肌肉松弛、利尿、抗敏、镇静等作用及抗癌作用曾进行了研究.两个主要的合成途径是由取代4-羟基嘧啶与a-卤代羰基化合物缩合,或从2-氨基呋喃-3-甲腈或酮与胺或甲酰胺环化.     

Synthesis of polynitroazaalkanols and some of their derivatives

Conclusions Polynitroazaalkanols and their chloro derivatives, nitrates, and acetates have been obtained for the first time.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 445–447, February, 1970.     

New chromogens of the ferroin type-VI: some derivatives of 1- and 3-cyanoisoquinoline and substituted 2-cyanopyridines

The chromogenic reactions with iron(II), copper(I) and cobalt(II) of 32 recently synthesized pyridazines, triazines, tetrazines and certain other compounds containing the ferroin grouping have been examined spectrophotometrically. Some interesting examples were found of steric and donor-atom selectivities in chelation of iron by ligands containing several ferroin groups. Of the various chromogens studied, the pyridyl and isoquinolyl derivatives of phenyl or pyridyl substituted 1,2,4-triazine show the most promising analytical utility.     

Synthesis of substituted 1-(2-arylvinyl)-2-azolyl-1-pyridylethanols-1

A series of new 1-(2-arylvinyl)-2-azolyl-1-pyridylethanols-1 has been obtained with various positions of the nitrogen atom in the pyridine fragment and with substituents in the benzene ring, by the reaction of (2-arylvinyloxiran-2-yl)pyridines with triazole and imidazole, for agrochemical screening. The compounds mentioned displayed high fungicidal activity. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1167–1174, August, 2007.     

Heteroadamantanes and their derivatives. 13. Synthesis of 1-azaadamantane and some derivatives of it

3,5,7-Tribromo-1-azaadamantane is made by the action of sodium nitrite on 3,5,7-triamino-1-azaadamantane in concentrated hydrobromic acid. The reduction of this compound with hydrazine hydrate in the presence of a nickel catalyst gives 1-azaadamantane.For Communication 12, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1083–1085, August, 1990.