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1.
《中国化学》2017,35(11):1661-1664
((2S ,4R )‐4‐Hydroxy‐N ‐(2‐methylnaphthalen‐1‐yl)pyrrolidine‐2‐carboxamide (HMNPC), an amide derived from 4‐hydroxy‐L ‐proline and 2‐methyl naphthalen‐1‐amine, is a powerful ligand for Cu‐catalyzed coupling of (hetero)aryl halides with sulfinic acid salts, allowing for first time the metal‐catalyzed coupling of (hetero)aryl chlorides and NaSO2Me. A considerable number of (hetero)aryl chlorides worked well, providing the pharmaceutically important (hetero)aryl methylsulfones in good to excellent yields. 相似文献
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Ryan T. McGuire Connor M. Simon Arun A. Yadav Michael J. Ferguson Mark Stradiotto 《Angewandte Chemie (International ed. in English)》2020,59(23):8952-8956
The development of Ni‐catalyzed C?N cross‐couplings of sulfonamides with (hetero)aryl chlorides is reported. These transformations, which were previously achievable only with Pd catalysis, are enabled by use of air‐stable ( L )NiCl(o‐tol) pre‐catalysts (L= PhPAd‐DalPhos and PAd2‐DalPhos ), without photocatalysis. The collective scope of (pseudo)halide electrophiles (X=Cl, Br, I, OTs, and OC(O)NEt2) demonstrated herein is unprecedented for any reported catalyst system for sulfonamide C?N cross‐coupling (Pd, Cu, Ni, or other). Preliminary competition experiments and relevant coordination chemistry studies are also presented. 相似文献
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Ryan T. McGuire Connor M. Simon Dr. Arun A. Yadav Dr. Michael J. Ferguson Prof. Dr. Mark Stradiotto 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(23):9037-9041
The development of Ni-catalyzed C−N cross-couplings of sulfonamides with (hetero)aryl chlorides is reported. These transformations, which were previously achievable only with Pd catalysis, are enabled by use of air-stable ( L )NiCl(o-tol) pre-catalysts (L= PhPAd-DalPhos and PAd2-DalPhos ), without photocatalysis. The collective scope of (pseudo)halide electrophiles (X=Cl, Br, I, OTs, and OC(O)NEt2) demonstrated herein is unprecedented for any reported catalyst system for sulfonamide C−N cross-coupling (Pd, Cu, Ni, or other). Preliminary competition experiments and relevant coordination chemistry studies are also presented. 相似文献
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Dr. On Ying Yuen Dr. Chau Ming So Ho Wing Man Prof. Fuk Yee Kwong 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(19):6471-6476
A general palladium‐catalyzed Hiyama cross‐coupling reaction of aryl and heteroaryl chlorides with aryl and heteroaryl trialkoxysilanes by a Pd(OAc)2/ L2 catalytic system is presented. A newly developed water addition protocol can dramatically improve the product yields. The conjugation of the Pd/ L2 system and the water addition protocol can efficiently catalyze a broad range of electron‐rich, ‐neutral, ‐deficient, and sterically hindered aryl chlorides and heteroaryl chlorides with excellent yields within three hours and the catalyst loading can be down to 0.05 mol % Pd for the first time. Hiyama coupling of heteroaryl chlorides with heteroaryl silanes is also reported for the first time. The reaction can be easily scaled up 200 times (100 mmol) without any degasification and purification of reactants; this facilitates the practical application in routine synthesis. 相似文献
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Mild Cobalt‐Catalyzed Negishi Cross‐Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides 下载免费PDF全文
M. Sc. Diana Haas M. Sc. Jeffrey M. Hammann B. Sc. Ferdinand H. Lutter Prof. Dr. Paul Knochel 《Angewandte Chemie (International ed. in English)》2016,55(11):3809-3812
A catalytic system consisting of CoCl2 ? 2 LiCl (5 mol %) and HCO2Na (50 mol %) enables the cross‐coupling of various N‐heterocyclic chlorides and bromides as well as aromatic halogenated ketones with various electron‐rich and ‐poor arylzinc reagents. The reactions reached full conversion within a few hours at 25 °C. 相似文献
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Nickel‐Catalyzed N‐Arylation of Primary Amides and Lactams with Activated (Hetero)aryl Electrophiles 下载免费PDF全文
Christopher M. Lavoie Preston M. MacQueen Prof. Dr. Mark Stradiotto 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(52):18752-18755
The first nickel‐catalyzed N‐arylation of amides with (hetero)aryl (pseudo)halides is reported, enabled by use of the air‐stable pre‐catalyst (PAd‐DalPhos)Ni(o‐tolyl)Cl ( C1 ). A range of structurally diverse primary amides and lactams were cross‐coupled successfully with activated (hetero)aryl chloride, bromide, triflate, tosylate, mesylate, and sulfamate electrophiles. 相似文献
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Dorus Heijnen Dr. Jean‐Baptiste Gualtierotti Dr. Valentín Hornillos Prof. Dr. Ben L. Feringa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(12):3991-3995
Nickel‐catalyzed selective cross‐coupling of aromatic electrophiles (bromides, chlorides, fluorides and methyl ethers) with organolithium reagents is presented. The use of a commercially available nickel N‐heterocyclic carbene (NHC) complex allows the reaction with a variety of (hetero)aryllithium compounds, including those prepared via metal‐halogen exchange or direct metallation, whereas a commercially available electron‐rich nickel‐bisphosphine complex smoothly converts alkyllithium species into the corresponding coupled product. These reactions proceed rapidly (1 h) under mild conditions (room temperature) while avoiding the undesired formation of reduced or homocoupled products. 相似文献
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Joseph P. Tassone Emma V. England Preston M. MacQueen Michael J. Ferguson Mark Stradiotto 《Angewandte Chemie (International ed. in English)》2019,58(8):2485-2489
The base metal‐catalyzed C?N cross‐coupling of bulky α,α,α‐trisubstituted primary alkylamines with (hetero)aryl electrophiles represents a challenging and under‐developed class of transformations that is of significant potential utility, including in the synthesis of lipophilic active pharmaceutical ingredients. Herein, we report that a new, air‐stable Ni(II) pre‐catalyst incorporating the optimized ancillary ligand PhPAd‐DalPhos enables such transformations of (hetero)aryl chloride, bromide, and tosylate electrophiles to be carried out for the first time with substrate scope rivalling that achieved using state‐of‐the‐art Pd catalysts, including room temperature cross‐couplings of (hetero)aryl chlorides that are unprecedented for any catalyst (Pd, Ni, or other). 相似文献
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Highly selective acylation of the alcoholic hydroxy group can be achieved with (hydroxyalkyl)phenols carrying both alcoholic and phenolic hydroxyls by the use of the most common acylating agents, acid chlorides, under microwave irradiation. 相似文献
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The copper‐catalyzed Ullmann C‐O coupling reactions between phenols and aryl/vinyl halides have been efficiently performed by employing (E)‐3‐(dimethylamino)‐1‐(2‐hydroxyphenyl)prop‐2‐en‐1‐one, an easily available enaminone, as ligand. This new ligand is advantageous for its easy availability, broad applicability and good efficiency. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Novel heteroleptic Ni (II) complexes bearing a highly hindered yet flexible IPr* ligand, Ni (IPr*)(PPh3)Br2 ( 1 ) and Ni (IPr*)(PCy3)Br2 ( 2 ) (IPr* = 1,3-bis(2,6-bis (diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene), were easily prepared in 78% and 89% yield, respectively. Both were characterized by elemental analysis and NMR spectroscopy, and 1 was subjected to X-ray crystallography. Compared with 2 and its analogue bearing a less sterically demanding IPr ligand (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), complex 1 exhibited superior catalytic activity in the magnesium-mediated reductive coupling of benzyl chlorides with aryl chlorides, featuring outstanding tolerance of both coupling partners with steric demand. This study discloses a ligand-facilitated reductive coupling of benzyl chlorides with aryl chlorides, which provides a new and practical synthetic tool for the synthesis of diarylmethanes. 相似文献
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Dr. Sebastian Barata-Vallejo Sergio M. Bonesi Dr. Al Postigo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(58):e202201776
Direct fluoroalkoxylation reactions of (hetero)arenes, carbon-carbon multiple bonds, and substitution reactions at Csp3 carbon centers by CF3O, CHF2O, and (CF3)2CFO groups are discussed. Emphasis on thermal radical, electron transfer, photocatalytic, electrochemical and redox-neutral radical methods are placed to accomplish fluoroalkoxylation reactions. All these methods employ either radical fluoroalkoxylating reagents or some nucleophilic trifluoromethoxylating sources of CF3O. A summary of all these methods is provided in Table 2. 相似文献
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Nickel‐Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1‐Bromo‐1,1‐difluoroalkanes 下载免费PDF全文
Yu‐Lan Xiao Qiao‐Qiao Min Chang Xu Dr. Ruo‐Wen Wang Prof. Dr. Xingang Zhang 《Angewandte Chemie (International ed. in English)》2016,55(19):5837-5841
A nickel‐catalyzed cross‐coupling between (hetero)arylborons and unactivated 1‐bromo‐1,1‐difluoroalkanes has been developed. The use of two ligands (a bidentate bipyridine‐based ligand, 4,4′‐ditBu‐bpy, and a monodentate pyridine‐based ligand, DMAP) offers a highly efficient nickel‐based catalytic system to prepare difluoroalkylated arenes which have important applications in medicinal chemistry. 相似文献
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A catalytic method for the decarboxylative coupling of 2-(azaaryl)carboxylates with aryl halides is described. The decarboxylative cross-coupling presented is mediated by a system catalytic in both palladium and copper without requiring stoichiometric amounts of organometallic reagents or organoboronic acids. This method circumvents additional synthetic steps required to prepare 2-azaaryl organometallics and organoborates as nucleophilic coupling partners, which are prone to protodemetallation and protodeborylation and produce potentially toxic byproducts. 相似文献
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二氧化硅负载胂钯(0)配合物催化酰氯和芳基碘与四苯硼化钠的苯基化反应 总被引:1,自引:0,他引:1
氯丙基三乙氧基硅烷依次与气相法二氧化硅、二苯胂钾、氯化钯作用, 再用水合肼还原, 合成了二氧化硅负载的胂钯(0)配合物. 该配合物是酰氯及芳基碘化物与四苯硼化钠苯基化反应的有效催化剂, 为苯基酮及不对称联苯的合成提供了简便且实用的新方法. 相似文献
19.
Nurtalya Alandini Luca Buzzetti Gianfranco Favi Tim Schulte Lisa Candish Karl D. Collins Paolo Melchiorre 《Angewandte Chemie (International ed. in English)》2020,59(13):5248-5253
Herein, we report a one‐electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross‐coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive‐functional‐group‐containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron‐poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods. 相似文献
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A benign initiating system for cationic polymerization of isobutyl vinyl ether: Silver salt/aryl(alkyl) halide/lewis base 下载免费PDF全文
Li Lin Guangyou Zhang Koichi Kodama Mikio Yasutake Takuji Hirose 《Journal of polymer science. Part A, Polymer chemistry》2015,53(17):2050-2058
Aryl(alkyl) halides and silver salts were studied as environmentally benign initiating systems for cationic polymerization of isobutyl vinyl ether (IBVE). The reactivity of the benzyl cations could be effectively controlled by using dimethyl sulfide (Me2S) as an additive, which was shown to be an effective Lewis base (LB), and diethyl ether as a reaction solvent. Detailed study of various benzyl cations and the order of addition of the reagents revealed that the reaction was controlled by the electronic and steric features of aryl(alkyl) halides, LBs, and IBVE, and a plausible reaction mechanism was presented. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 2050–2058 相似文献