共查询到20条相似文献,搜索用时 0 毫秒
1.
Incorporation of azo group at axial position of silatranes: synthesis,characterization and antimicrobial activity
下载免费PDF全文
![点击此处可从《应用有机金属化学》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Gurjaspreet Singh Amandeep Saroa Shally Girdhar Sunita Rani Duane Choquesillo‐Lazarte Subash Chandra Sahoo 《应用有机金属化学》2015,29(8):549-555
4‐Aminoazobenzene‐derived silatranes bearing urea and aminosuccinimide as linker groups at the axial position are reported. The urea functionality is introduced in a silane ( 2 ) by the rearrangement reaction between 3‐isocyanatopropyltriethoxysilane and 4‐aminoazobenzene. N‐(3‐silatranylpropyl)‐N′‐[(p‐phenyldiazenyl)phenyl]urea and N‐[3‐(3,7,10‐trimethylsilatranyl)propyl]‐N′‐[(p‐phenyldiazene)phenyl]urea were prepared by transesterification reaction of 2 with triethanolamine and trisisopropanolamine, respectively. An efficient method for C? N bond formation is described for the synthesis of 3‐(silatranylpropyl)amino‐N‐[(p‐phenyldiazene)phenyl]pyrrolidine‐2,5‐dione and 3‐[(3,7,10‐trimethylsilatranyl)propyl]amino‐N‐[(p‐phenyldiazene)phenyl]pyrrolidine‐2,5‐dione via aza‐Michael addition reaction of aminopropylsilatranes with 4‐(N‐maleimido)azobenzene under mild conditions. All the compounds were well characterized using elemental analysis, spectroscopic techniques, thermogravimetric analysis and X‐ray diffraction. UV–visible spectroscopy indicates that the 4‐aminoazobenzene‐derived silatranes are capable acetate receptors. The synthesized compounds were screened for possible antimicrobial properties with the results showing a modest activity. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
2.
本文报道了 4个含异恶唑基团的二铁配合物的制备及其结构表征。以含羟基二铁配合物[Fe2(CO)6(μ-SCH2CH(CH2OH)S)] (1)与 5-甲基异恶唑-4-羧酸为原料,经过酯化反应以高产率制备了配合物[Fe2(CO)6(μ-SCH2CHCH2OOC(5-C3HNOCH3)S)] (2),再分别与三(对甲苯基)膦、三(4-氟苯基)膦或三(2-甲氧基苯基)膦反应,合成了3个含膦配合物[Fe2(CO)5(L)(μ-SCH2CHCH2OOC(5-C3HNOCH3)S)],其中 L=P(4-C6H4CH3)3 (3)、P(4-C6H4F)3 (4)、P(2-C6H4OCH3)3 (5)。使用元素分析、谱学和 X 射线晶体学对新配合物的结构进行了表征。电化学性质研究表明这些配合物可以催化醋酸中的质子还原产生氢气。其中,2拥有最低的过电位而4拥有最高的催化效率。此外,该类配合物还具有一定的抗菌活性。 相似文献
3.
本文报道了4个含异恶唑基团的二铁配合物的制备及其结构表征。以含羟基二铁配合物[Fe2(CO)6(μ-SCH2CH(CH2OH)S)] (1)与5-甲基异恶唑-4-羧酸为原料,经过酯化反应以高产率制备了配合物[Fe2(CO)6(μ-SCH2CHCH2OOC(5-C3HNOCH3)S)] (2),再分别与三(对甲苯基)膦、三(4-氟苯基)膦或三(2-甲氧基苯基)膦反应,合成了3个含膦配合物[Fe2(CO)5(L)(μ-SCH2CHCH2OOC(5-C3HNOCH3)S)],其中L=P(4-C6H4CH3)3 (3)、P(4-C6H4F)3 (4)、P(2-C6H4OCH3)3 (5)。使用元素分析、谱学和X射线晶体学对新配合物的结构进行了表征。电化学性质研究表明这些配合物可以催化醋酸中的质子还原产生氢气。其中,2拥有最低的过电位而4拥有最高的催化效率。此外,该类配合物还具有一定的抗菌活性。 相似文献
4.
Mavallur Varalakshmi Chamarthi Nagaraju Palaa Krishna 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):853-857
AbstractA series of new class of diethyl N-2-hydroxyethyl-N'-substituted phosphoramidimidates 6(a–e) and diethyl P-morpholino-N-substituted phosphonimidates 6(f–j) was synthesized. The precursor intermediates, diethyl substituted phosphoramidites 3(a–b) were prepared initially by a reaction of various amines 1(a–b) and diethyl phosphorochloridite (2) and then they were treated by in situ with aromatic/alkyl azides through Staudinger reaction to accomplish title products. Structures of all the synthesized compounds were characterized by spectroscopic data such as IR, NMR (1H, 13C, 31P), mass, and elemental analyses. The synthesized compounds were screened for their in vitro antimicrobial activity to understand their biological potency. The biological screening results disclosed that compounds 6b, 6c, 6e, 6g, 6h and 6j having potent antimicrobial activity against all the tested pathogens. 相似文献
5.
Leyla Yurttaş Yusuf Özkay Murat Duran Gülhan Turan-Zitouni Ahmet Özdemir Zerrin Cantürk 《Phosphorus, sulfur, and silicon and the related elements》2016,191(8):1166-1173
The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) derivatives was undertaken starting from the potassium salt of 4-(2-pyrimidinyl)piperazine dithiocarbamate. The structures of the obtained compounds were elucidated by 1H NMR, 13C NMR, MS spectral data, and elemental analysis. The antimicrobial activity of the thirty eight newly synthesized compounds were tested against 12 microorganism strains using the microdilution technique. Compounds 2-(4-ethoxycarbonylthiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B12), 2-(3-fluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A18) and 2-(3,4-difluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A21) were determined to possess high antimicrobial activity. 相似文献
6.
Leyla Yurttaş Aslıhan Kubilay Asaf Evrim Evren İpek Kısacık Hülya Karaca Gençer 《Phosphorus, sulfur, and silicon and the related elements》2020,195(9):767-773
AbstractSome new 3,4,5-trisubstituted 1,2,4-triazole derivatives were synthesized and studied for their antimicrobial activity. The lead compounds were obtained starting from 8-hydroxyquinoline and ethyl 2-chloroacetate. The obtained ester compound (1) first reacted with hydrazine hydrate (2) then with phenyl isothiocyanate (3). Ring closure by KOH led to 3-mercapto-1,2,4-triazole derivative (4). Lastly, it reacted with 2-chloro-N-(substituted (benzo)/thiazole)acetamide derivatives to obtain the final compounds (5a–j). The structural elucidation of the compounds was performed by 1H NMR and 13C NMR spectroscopy and high resolution mass spectrometry techniques and elemental analysis. The synthesized compounds were investigated for their antimicrobial activities against seven bacteria and four fungi. As a result of the activity studies, it was observed that compounds N-(6-nitrobenzothiazol-2-yl)-2-[[4-phenyl-5-((quinolin-8-yloxy)methyl)-4H-1,2,4-triazol-3-yl]thio]acetamide (5a) and N-(6-fluorobenzothiazol-2-yl)-2-[[4-phenyl-5-((quinolin-8-yloxy)methyl)-4H-1,2,4-triazol-3-yl]thio]acetamide (5d) were the most active molecules. Also, the antifungal activity of the compounds was found to be higher than their antibacterial activity although lower than the standard drug’s potential. Additionally, the physicochemical properties of the compounds were calculated which were evaluated to be at a suitable range for oral administration. 相似文献
7.
8.
The structural and spectroscopic characteristics of the synthesized structurally novel compound 4-chloro-6-methylquinoline-2(1H)-one (4C6MQ) and its isomer 4-chloro-8-methylquinoline-2(1H)-one (4C8MQ) have been examined by means of experimental and computational quantum chemical methods like density functional theory (DFT). The crystal structure of the 4C6MQ compound has been brought to light by single-crystal x-ray diffraction (SCXRD) method which consists of two independent molecules (A and B) in the asymmetric unit with similar conformations. Both the isomer compounds are characterized spectroscopically by FTIR, FT-Raman, UV-Vis, and NMR spectrum and compared with DFT results. The geometries of the isomer compounds have been optimized by using DFT/B3LYP method with the 6-311G++(d,p) basis sets. From the optimized geometry of the compounds, geometric parameters (bond lengths, bond angles, and torsion angles); vibrational analysis; chemical shifts; and electronic absorption of the isomer compounds have been computed and compared with the experimental result. The detailed assignments of vibrational wave numbers have been prepared based on potential energy distribution (PED) which was carried out in the VEDA4 program. In addition, natural bonding orbital analysis, frontier molecular orbital, and molecular electrostatic potential have been explained theoretically. The in silico (absorption, distribution, metabolism, excretion and toxicity) studies were analyzed to identify the potential drug likeliness of the isomer compounds. The implications of the inhibitory activity of isomer compounds against DNA gyrase and lanosterol 14 α-demethylase enzyme by molecular docking are discussed. Further, the isomer compounds were screened for their antibacterial and antifungal activities. 相似文献
9.
Zeba N. Siddiqui Farheen Farooq T.N. Mohammed Musthafa Anis Ahmad Asad U. Khan 《Journal of Saudi Chemical Society》2013,17(2):237-243
Two novel halopyrazole derivatives (3, 5) were synthesized from 5-chloro-3-methyl-1-phenylpyrazole-4-carboxaldehyde (1) using appropriate synthetic routes. Newly synthesized compounds were characterized using elemental analysis, spectral data (IR, 1H NMR, 13C NMR and mass spectrometry) and were evaluated for their in vitro antimicrobial activity. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined for the test compounds as well as for reference standards. The investigation of antimicrobial screening revealed that compounds (3, 5) showed good antibacterial and antifungal activities, respectively. 相似文献
10.
In this study, new benzoylthiourea derivatives, (E)-N-[(2-benzamidomethyleneamino)ethylcarbamothioyl]benzamide H3L′, N-(1-(3-benzoylthioureido)propan-2-ylcarbamothioyl)-benzamide H4L″, (E)-N-[4-(benzamidomethyleneamino)phenylcarbamothioyl]benzamide H3L‴, were synthesized. Structures of the compounds were identified by spectroscopic techniques. In addition, all synthesized
compounds were evaluated for in vitro antibacterial and antifungal activity. Compound H3L‴ exhibited antibacterial activity. 相似文献
11.
Firuze Diyar Altındağ Begüm Nurpelin Sağlık Ulviye Acar Çevik İlhan Işıkdağ Hülya Karaca Gençer 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):887-894
AbstractA series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and HRMS spectra and elemental analyses. Antifungal activity tests were performed against four different fungal strains. Molecular docking studies were performed to investigate the mode of action towards the fungal lanosterol 14α-demethylase, a cytochrome P450-dependent enzyme. ADME studies were carried out and a connection between activities and physicochemical properties of the target compounds was determined. Most of the final compounds exhibited significant activity against Candida albicans and Candida krusei with MIC50 value 12.5?μg/mL. The results of in vitro anti-Candida activity, a docking study and ADME prediction revealed that the newly synthesized compounds have potential anti-Candida activity and evidenced the most active derivative, 5b (2-Pyrrolidinthiocarbonylthio-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide), which can be further optimized as a lead compound. 相似文献
12.
Rodica
Olar Mihaela Badea Veronica Lazar Carmen Balotescu Elena Cristurean Dana Marinescu 《Journal of Thermal Analysis and Calorimetry》2007,88(2):323-327
N,N-Dimethylbiguanide derivatives (HDMBG)X, where X=CH3COO
(1), Cl (2)
and NO3 (3) respectively,
exhibit in vitro antimicrobial activity
on representative bacterial and fungal strains. The presence of N,N-dimethylbiguanidium
ion for all derivatives was evidenced by IR and 1H
NMR spectra. Thermal analysis gave information on their decomposition steps
and also on the accompanying thermodynamic effects. According to TG and DTG
curves processes as melting, oxidative degradation as well as oxidative condensation
of –C=N– units occur. The different nature of the anions results
different melting points. Paracyanide formation at various condensation degrees
was observed. 相似文献
13.
《Journal of Saudi Chemical Society》2014,18(6):1015-1021
A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehydes 4a–l have been synthesized and tested for their biological activities. Formation of the pyrazole derivatives was achieved by treating with Vilsmeier-Haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to Diclofenac sodium as standard drug. Compounds 4g, 4i and 4k exhibited the maximum anti-inflammatory and analgesic activities. The detailed synthesis, spectroscopic and toxicity data are reported. 相似文献
14.
Subharthi Banerjee Madhulika Ghose Shiv Shankar Paul Swarup Patra 《Journal of Coordination Chemistry》2016,69(4):604-617
The synthesis and structural characterization of a gadolinium(III) complex with phenanthroline and thiocyanate ligands have been accomplished. The X-ray crystal structure reveals that Gd(III) in a slightly distorted square anti-prism coordinated with four thiocyanate ions and two phenanthroline molecules; one phenanthroline is protonated which compensates the charge of Gd(III) center. The crystal structure shows chemically significant non-covalent interactions like hydrogen bonding involving the thiocyanate ligand and π–π interactions between uncoordinated phenanthrolinium and coordinated phen. Investigation on the intermolecular interactions and crystal packing via Hirshfeld surface analysis reveals that close contacts are mainly associated with weak interactions. The fingerprint plots demonstrate that these weak interactions are important for crystal packing. The Gd(III) complex shows photophysical activity. The compound is capable of degrading toxic pollutants like nitroaromatics and may have far reaching consequences for cleaning these toxic pollutants from industrial effluents. 相似文献
15.
Palaa Krishna 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):685-690
AbstractA series of new 5-amino-7-bromoquinolin-8-ol sulfonate derivatives 5(a–j) were synthesized from 8-hydroxyquinoline through multi-step process with high yields using mild, efficient and conventional methods. Chemoselectivity was observed during the transformation of 5-amino-7-bromoquinolin-8-ol to 5-amino-7-bromoquinolin-8-ol sulfonate with various sulfonylchlorides exclusively to afford sulfonate derivatives. Also, the products were investigated for their in vitro antimicrobial activities and compared with the standard drugs. Among all the synthesized compounds 5-amino-7-bromoquinolin-8-yl biphenyl-4-sulfonate (5b) and 5-amino-7-bromoquinolin-8-yl 2-hydroxy-5-nitrobenzenesulfonate (5g) have showed potent antibacterial activity, whereas 5-amino-7-bromoquinolin-8-yl biphenyl-4-sulfonate (5b) and 5-amino-7-bromoquinolin-8-yl 2-hydroxy-5-nitrobenzenesulfonate (5g) possessed potent antifungal activities among all the tested pathogens. 相似文献
16.
Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin. 相似文献
17.
《Journal of Coordination Chemistry》2012,65(6):1071-1079
Monooxovanadium(V) complexes of the composition VOCl3? n (L) n (where L = 2-phenylphenoxide ion; n = 1–3) (1–3) have been synthesized in quantitative yields by the reaction of VOCl3 with 2-phenylphenol in toluene. The characterization of the complexes has been accomplished by elemental analysis, molar conductance measurements, IR, 1H-NMR, electronic, mass spectral, and thermal studies. The ligands as well as the complexes have been screened for their in vitro antimicrobial activity against the pathogenic bacteria Escherichia coli and Staphylococcus aureus and fungi Candida albicans, Aspergillus niger, and Fusarium oxysporum by a twofold serial dilution. An increase in the biocidal activity was observed for the vanadium complexes. The minimum inhibitory concentration (MIC) values were 6.25–25 µg mL?1 for complexes, relative to that of the free ligand of 25–50 µg mL?1. 相似文献
18.
《Arabian Journal of Chemistry》2014,7(3):287-291
In the present study novel derivatives of 4-thiazolidinone were prepared from biphenyl-4-carboxylic acid and evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger. The newly synthesized compounds were characterized by IR, 1H NMR and C, H, N analyses. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Among the synthesized derivatives 4g (biphenyl-4-carboxylic acid [2-(3-bromophenyl)-5-(3-nitrobenzylidene)-4-oxo-thiazolidin-3-yl]-amide) and 4i (biphenyl-4-carboxylic acid [5-(3-bromobenzylidene)-2-(3-bromophenyl)-4-oxo-thiazolidin-3-yl]-amide) were found to be most effective antimicrobial compounds. 相似文献
19.
《Comptes Rendus Chimie》2017,20(2):125-131
Particles of the copper(I) thiosemicarbazone complex [Cu(Brcatsc)(PPh3)2Cl]·CH3CN (1), Brcatsc = 2-bromo-3-phenylpropenalthiosemicarbazone, were synthesized by an ultrasonic-bath-assisted method and characterized by elemental analyses, NMR (1H, 13C, and 31P) and FT-IR spectroscopies, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The thermal stability of 1 was studied by thermal gravimetry analysis and its structure was determined by single crystal X-ray diffraction. The compound 1 is a mononuclear complex with the copper(I) ion coordinated in a distorted tetrahedral geometry by one S atom of Brcatsc, two P atoms of two PPh3, and one Cl atom. The complex involves the Brcatsc thiosemicarbazone ligand in an S monodentate bonding mode. The antibacterial activity of the ligand and its copper(I) complex was studied against two gram-positive (Staphylococcus aureus and Enterococcus faecalis) and two gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. 相似文献
20.
In the present study, 20 new tetracyclic 1,4-benzothiazines (4a–4 t) were conveniently synthesized in good yields and characterized by different spectral and physical techniques. The in vitro antimicrobial evaluation of the synthesized benzothiazine derivatives was performed by serial dilution against two Gram-positive bacteria [Bacillus subtilis (MTCC 441) and Staphylococcus epidermidis (MTCC 6880)], two Gram-negative bacteria [Escherichia coli (MTCC 1652) and Pseudomonas aeruginosa (MTCC 424)], and two fungal strains [Candida albicans (MTCC 227) and Aspergillus niger (MTCC 8189)]. The derivatives 4 l and 4 t were found to be more potent than standard drug, i.e., fluconazole, against A. niger and C. albicans, respectively. 相似文献