With diabetes mellitus becoming an important public health concern, insulin‐delivery systems are attracting increasing interest from both scientific and technological researchers. This feature article covers the present state‐of‐the‐art glucose‐responsive insulin‐delivery system (denoted as GRIDS), based on responsive polymer materials, a promising system for self‐regulated insulin delivery. Three types of GRIDS are discussed, based on different fundamental mechanisms of glucose‐recognition, with: a) glucose enzyme, b) glucose binding protein, and c) synthetic boronic acid as the glucose‐sensitive component. At the end, a personal perspective on the major issues yet to be worked out in future research is provided. 相似文献
Multicompartmental microcylinders can be produced by a combination of electrohydrodynamic co‐spinning and microsectioning, as described by J. Lahann et al. in their Communication on page 4589 ff. The number of individual compartments, relative compartment orientation, chemical composition and functionality, and aspect ratio can be precisely tuned. Each color in the longitudinal and cross‐sectional micrograph images depicts an individual compartment.
Perfluoroaryl boranes are an important class of organometallic Lewis acids. The synthesis of perfluorinated compounds brings special challenges to tried‐and‐true synthetic methodologies. In their Communication on page 2955 ff., W. E. Piers and co‐workers present the synthesis of a new, fully fluorinated heterocyclic borane that is also a member of the rare antiaromatic borole class of compounds. The route relies on normally facile transmetallation reactions made more difficult by the electron‐withdrawing C6F5 groups of the target product.
