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1.
Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2–4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC50 less than 10 μM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells. 相似文献
2.
A new flavone diglucoside named 7,3′-dihydroxy-4′-methoxyflavone-5-O-β-D-glucopyranosyl (6″ → 1‴)-β-D-glucopyranoside (1), along with four known flavonoids, luteolin (2), isoquercetin (3), catechin (4), and diosmetin (5), has been isolated and characterized from Salix denticulata. The structure of the new flavone diglucoside was characterized by means of high field 1D and 2D NMR and MS spectral analysis. 相似文献
3.
Yi Wu Feng He Qin Pan Yao Shi Zhida Min Jingyu Liang 《Chemistry of Natural Compounds》2011,47(3):369-372
A new C-glucosyl flavone, 6‴-vanilloylspinosin (1), was isolated from the seeds of Ziziphus jujuba var. spinosa, together with three known C-glucosyl flavones, spinosin (2), 6‴-feruloylspinosin (3), and isospinosin (4). The structure of 1 was elucidated by spectral methods (1D NMR, ESI-MS, HR-MS, 2D NMR). 相似文献
4.
Identification of a new flavone glycoside from <Emphasis Type="Italic">Codonopsis nervosa</Emphasis>
Xian-li Zhou Qiang Fan Shuai Huang Cui-juan Wang You-song Wang 《Chemistry of Natural Compounds》2012,47(6):888-890
A new flavone glycoside, luteolin 7-O-[(6″′-caffeoyl)-β-D-glucopyranosyl-(1 → 6)]-β-D-glucopyranoside (1), was isolated from Codonopsis nervosa, along with three other known compounds, luteolin 7-O-β-D-glucopyranoside (2), luteolin 7-O-gentiobioside (3), and tangshenoside VI (4). Their structures were determined on the basis of 1D and 2D NMR, IR, and HR-ESI-MS. 相似文献
5.
Tan Phat Nguyen Thi Thao Vy Tran Dinh Tri Mai Tien Dung Le Nhat Minh Phan Trong Dat Bui 《Natural product research》2015,29(15):1432-1436
From the leaves of Schefflera sessiliflora De P. V., one new C20-gibberellin diterpene 2β,12β-dihydroxygibberellin (12β-hydroxy-GA110 or 2β-hydroxy-GA112) (1), together with three known compounds, trans-tiliroside (2), kaempferol 3-O-β-d-glucuronopyranoside (3), 5-p-trans-coumaroylquinic acid (4), was isolated for the first time from the genus Schefflera by various chromatography methods. Their structures were elucidated by IR, UV, HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolates (2, 3) showed better α-glucosidase inhibitory activity (IC50 = 134.60, 147.10 μM, respectively) than the standard drug acarbose (IC50 = 214.50 μM). 相似文献
6.
Dinh Tri Mai Tien Dung Le Tan Phat Nguyen Nhat Minh Phan Huu An Nguyen Thi Thanh Phuc Nguyen 《Natural product research》2015,29(15):1437-1441
From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new (1) and six known aldehyde compounds (2–7) were isolated by various chromatography methods. Based on their spectroscopic data, these compounds were identified as (Z)-4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl) benzaldehyde (1), p-hydroxybenzaldehyde (2), syringaldehyde (3), (E)-ferulaldehyde (4), (E)-sinapinaldehyde (5), vanillin (6) and 5-hydroxymethylfurfual (7). The α-glucosidase inhibitory activity of all compounds was measured. The isolated compounds (1–6) showed better α-glucosidase inhibitory activity (IC50 values ranging from 36.5 to 192.4 μM) than the standard drug acarbose (IC50 = 214.5 μM). 相似文献
7.
Nantiya Joycharat Papawarin Issarachote Chonlatid Sontimuang Supayang Piyawan Voravuthikunchai 《Natural product research》2018,32(11):1291-1294
Albizia myriophylla Benth. is a medicinal herb which is used as a traditional remedy for various ailments including diabetes in Thailand. In our continued investigation of the biological activity of A. myriophylla, the ethanol extract, fractions and the isolated compounds from the wood of this plant were evaluated for in vitro α-glucosidase inhibition using spectrophotometric method. The plant ethanol extract and its different fractions possessed α-glucosidase inhibitory activity in a concentration-dependent manner. Dichloromethane fraction of the wood ethanol extract exhibited the highest percent inhibition against α-glucosidase (69.30%) among all fractions. Subsequent α-glucosidase inhibition assay proved that indenoic acid (1), 8-methoxy-7, 3′,4′-trihydroxyflavone (2) and 3,4,7,3′-tetrahydroxyflavan (3) were partially rational for antidiabetic effect of this plant species. Among these compounds, 3 (IC50 98.59 μg/mL) exhibited potent inhibition of α-glucosidase, compared with a positive control acarbose (IC50 125 μg/mL). The inhibitory effect towards α-glucosidase of compounds 1–3 was reported herein for the first time. 相似文献
8.
Liangjin Xu Meihua Yu Lixin Niu Chunyue Huang Yifan Wang Chunzhen Wu 《Natural product research》2020,34(5):605-612
AbstractA novel benzofuranone unprecedentedly with a prenyl group at C-3, nigranol A (1), a new flavonol, nigranol B (2), and three known compounds, sanggenon M (3), nigrasin C (4), and nigrasin A (5) were isolated from the twigs of Morus nigra Linn. Their structures were elucidated on the basis of the analysis of multiple spectroscopic data. All of the compounds, along with eight previously isolated ones (6–13) were investigated for their α-glucosidase inhibitory activities. The result showed that compounds 1–13 except 4 exhibited prominent inhibitory activities against α-glucosidase. Among them, compounds 2 and 7 were the best α-glucosidase inhibitory candidates with IC50 values at 1.63 and 1.43?μM, respectively. Furthermore, the structure-activity relationships of the sanggenon-type flavanones were summarized. 相似文献
9.
Chalermporn Sarakulwattana Wanwimon Mekboonsonglarp Kittisak Likhitwitayawuid Pornchai Rojsitthisak 《Natural product research》2020,34(12):1694-1701
AbstractPhytochemical investigation of the whole plant of Dendrobium scabrilingue resulted in the isolation of two new compounds namely dendroscabrols A (1) and B (2), along with eight known compounds (3–10). The structures of these compounds were determined by NMR and HR-ESI-MS experiments. All of the isolates were evaluated for their α-glucosidase inhibitory effect. Dendroscabrol B (2) and RF-3192C (10) showed the most potent α-glucosidase inhibitory activity. Dendroscabrol A (1), gigantol (5), coelonin (7) and lusianthridin (9) also exhibited strong activity as compared with the positive control acarbose. 相似文献
10.
Poomraphie Nuntawong Virunh Kongkatitham Kittisak Likhitwitayawuid Wanwimon Mekboonsonglarp Suchada Sukrong Somboon Tanasupawat 《Natural product research》2019,33(10):1436-1441
Two new 2-arylbenzofurans, namely 13-O-methyllakoochin B (1) and artogomezianin (2), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3–8). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2) and lakoochin A (3) exhibited strong α-glucosidase inhibitory activity with IC50 values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose. 相似文献
11.
Huilin Li Fengrui Song Junpeng Xing Rong Tsao Zhiqiang Liu Shuying Liu 《Journal of the American Society for Mass Spectrometry》2009,20(8):1496-1503
In vitro α-glucosidase inhibition assays and ultrafiltration liquid chromatography with photodiode array detection coupled to electrospray
ionization tandem mass spectrometry (ultrafiltration LC-DAD-ESI-MS
n
) were combined to screen α-glucosidase inhibitors from hawthorn leaf flavonoids extract (HLFE). As a result, four compounds
were identified as α-glucosidase inhibitors in the HLFE, and their structures were confirmed to be quercetin-3-O-rha- (1-4)-glc-rha
and C-glycosylflavones (vitexin-2″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin) by high-resolution sustained off resonance
irradiation collision-induced dissociation (SORI-CID) data obtained by Fourier transform ion cyclotron resonance mass spectrometry
(FTICR MS). Several other C-glycosylflavones (vitexin, isovitexin, orientin, isooriention) and their aglycones apigenin and
luteolin were evaluated by in vitro assays, and were found to possess strong α-glucosidase inhibitory activities as well. Moreover, the substituent groups on the flavones had a great impact on the enzyme
inhibition activity. C-3′-OH of the B-ring of flavones in particular increased the α-glucosidase inhibition activity, whereas C-glycosylations at C-6 or C-8 of the A ring weakened the inhibition activity. 相似文献
12.
A new phenanthrene, bobulretin A (1), and a new 9,10-dihydrophenanthrene, bobulretin B (2) along with four known bibenzyls (3–6) were isolated from the whole plants of Bulbophyllum retusiusculum. Their structures were elucidated by means of extensive spectroscopic analysis. Bobulretin B (2), isolated as enantiomer mixture with unequal proportions, was verified by analysis on a chiral OD-H HPLC column. Compounds 1, 3 and 4 were evaluated for their α-glucosidase inhibitory activity. Neither of them showed obvious activity. 相似文献
13.
Jian Zhang Zhi-Qi Yin Peng Cao You-Bin Li Jin-Ao Duan 《Chemistry of Natural Compounds》2008,44(6):701-703
A new flavonol derivative 3, 8-dihydroxy-10-methoxy-5-H-isochromeno[4, 3-b]chromen-7-one (1) together with four known compounds, glutinone (2), luteolin (3), acacetin 7-O-α-L-rhamnopyranosyl- (1→6)-β-D-glucopyranoside (4), and rutin (5) were isolated from the dried roots of Fagopyrum dibotrys. Their structures were determined by UV, IR, MS, 1H, and 13C NMR spectroscopic analysis, including 2D NMR.
Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 567–568, November–December, 2008. 相似文献
14.
Two new alkyl glycosides, heptyl vicianoside (1) and methyl 2-O-β-d-fucopyranosyl-α-l-arabinofuranoside (methyl caramboside, 4), were isolated from the sour fruit of Averrhoa carambola L. (Oxalidaceae), along with octyl vicianoside (2), cis-3-hexenyl rutinoside (3), and methyl α-d-fructofuranoside (5). Their structures were determined by spectroscopic and chemical methods. Compounds 2, 3, and 5 were obtained from the genus Averrhoa for the first time. All the compounds were evaluated for in vitro α-glucosidase, pancreatic lipase, and acetylcholinesterase inhibitory activities, but none of them were potent. 相似文献
15.
Two new coumarins, euonidiol (1) and euoniside (2), and a known flavone, luteolin 7-methyl ether, were isolated from the aerial parts of the plant Euonymus hamiltanianus Wall. All the compounds were characterized on the basis of spectral analysis viz. 1H NMR, 13C NMR, DEPT, IR, UV, ESI-MS, and elemental analysis.
Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 10–11, January–February, 2008. 相似文献
16.
Ming-Jen Cheng Ming-Der Wu Sung-Yuan Hsieh Yung-Shun Su Ih-Sheng Chen Gwo-Fang Yuan 《Chemistry of Natural Compounds》2011,47(4):536-540
A chemical study on the n-BuOH-soluble fraction of the 95% EtOH extract of long-grain rice (Oryza sativa) fermented with the endophytic fungus Annulohypoxylon boveri var. microspora (BCRC 34012) has resulted in the isolation of one new natural azaphilone derivative, designated as annulohypoxyboverin (1) together with 12 known compounds, (3R,6R,7E)-3-hydroxy-4,7-megstigma-dien-9-one (2), α-tocopheryl quinone (3), isofraxidin (4), coumarin (5), cinnamic acid (6), a mixture of palmitic acid (7) and stearic acid (8), N-cis-feruloyltyramine (9), luteolin (10), kaempferol (11), kaempferitrin (12), and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl (13). Annulohypoxyboverin (1) contains a dihydrobenzofuran-2,4-dione backbone, 1-hydroxyhexyl side chain, and one γ-lactone ring. Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR experiments, and by HR-ESI-MS.
The relative configuration of 1 was confirmed by NOESY experiment. Other known compounds were identified by comparing their spectral data with those of literature
data. 相似文献
17.
Guang-Ying Chen Bin Zhang Ting Zhao Najat Nidhal Wang Jia-Li Xue-Ming Zhou 《Natural product research》2020,34(13):1874-1878
AbstractA new triterpenoid glucoside, leuctriterpencoside (1), along with two known compounds (2–3) were isolated from Leucas zeylanica. The structure of the new compound was elucidated using comprehensive spectroscopic methods. Compound 1 showed significant inhibitory activity against α-glucosidase (IC50 value of 0.85?±?0.12?μM). 相似文献
18.
Anjana Adhikari-Devkota Sara Mustafa Idris Elbashir Takashi Watanabe 《Natural product research》2019,33(11):1670-1673
Flowers of Citrus plants are used as mild sedatives and for the treatment of insomnia in traditional medicines. In Japan, tea made from the flowers of Satsuma mandarin is consumed as healthy drink. Hesperidin (1), hesperetin (2), rutin (3), quercetin (4), nicotiflorin (5), eriocitrin (6), narirutin (7), phenylethyl glucoside (8) and unshuoside A (9) were isolated from the MeOH extract of fresh flowers. Structure elucidation of these compounds was performed on the basis of NMR spectroscopic data. Among them, rutin (3), quercetin (4) and eriocitrin (6) showed potent free radical scavenging activity, whereas hesperetin (2) and quercetin (4) showed potent α-glucosidase inhibitory activity. 相似文献
19.
Chengcheng Zhao Zheming Ying Xiaojun Tao Mingyue Jiang 《Natural product research》2018,32(13):1548-1553
A new lactam alkaloid named oleraciamide D (1), indentified as (5R)-4-(3-methoxy-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-5,6-dihydropyridin-2(1H)-one, together with five known compounds, indole-3-aldehyde (2), portulacatone (3), N-trans-feruloyloctopamine (4), N-trans-feruloyl-3′-O-methyldopamine (5) and N-trans-feruloyltyramine (6) were isolated from Potulaca oleracea L. Among them, indole-3-aldehyde (2) was isolated from the medicine for the first time. The structure of the new alkaloid was elucidated via UHPLC-ESI-Q-TOF/MS, 1D NMR and 2D NMR. The five known compounds were established by comparing the 1H-NMR and 13C NMR with the reported literature. Oleraciamide D (1) showed cytotoxicity against SH-SY5Y cells when concentration at 50 uM by CCK-8 method. 相似文献
20.
Tan Phat Nguyen Tien Dung Le Phan Nhat Minh Bui Trong Dat Nguyen Kim Tuyen Pham Thi My Lien Do 《Natural product research》2016,30(21):2389-2395
From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new dihydrofurocoumarin, named pandanusin A (1) and 15 known compounds, including one furanocoumarin (2), two coumarins (3, 4), four lignans (5–8), one neolignan (9), two flavonoids (10, 11), three phenolics (12–14), one monoglyceride (15) and one monosaccharide (16) were isolated by various chromatography methods. Among them, compounds (3–5) were obtained from the Pandanus genus for the first time and compounds (9–14, 16) were reported from this species for the first time. Their structures were elucidated by HR–ESI–MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolated compounds (1–12, 14) showed better α-glucosidase inhibitory activity (IC50 = 42.2, 36.5, 84.7, 73.2, 40.8, 26.7, 76.5, 33.8, 68.1, 14.4, 22.1, 81.5, 43.8 μM, respectively) than the standard drug acarbose (IC50 = 214.5 μM). 相似文献