A new iridoid glycoside from Veronica sibirica

A new iridoid glycoside,versibirioside（1）,and a known iridoid glycoside,verbaspinoside（2）,were isolated from the whole plant of Veronica sibirica L.Their structures were elucidated by spectroscopic methods,including 2D-NMR spectra.     

A new aryl glycoside from Euphorbia helioscopia L.

A new aryl glycoside,3″-O-galloyl-benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside,was isolated from Euphor- bia helioscopia L.,and its structure was elucidated on the basis of various spectroscopic data analysis.     

A new lathyrane diterpene glycoside from Euphorbia helioscopia L.

<正>A new lathyrane diterpene glycoside,named 3β,7β,15β-trihydroxy-14-oxolathyra-5E,12E-dienyl-16-O-β-D-glucopyranoside, was isolated from Euphorbia helioscopia L.Its structure was established by spectroscopic techniques including 2D NMR.     

New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves of Oricia suaveolens and Oricia renieri (Rutaceae)

Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4′-methoxy-7-O-[α-l-rhamnopyranosyl(1?→5″)-β-d-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3–13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC₅₀ 8.7–15.9 μM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity.     

A new benzophenone glycoside from the leaves of Psidium guajava L.

A new benzophenone glycoside,2,6-dihydroxy-4-O-β-D-glucopyranosylbenzophenone(1),was isolated from the leaves of guajava L.Its structure was elucidated by spectral and chemical methods.1 showed significant activities to secretion of NO in mouse peritoneal macrophages in 10μmol/L.     

A new alkylene dihydrofuran glycoside with antioxidation activity from the root bark of Morus alba L.

<正>A new alkylene dihydrofuran glycoside(1) was isolated from the root bark ofMorus alba L.,along with moracin M-3′-O-β-D-glucopyranoside (2),and moracin M-6,3′-di-O-β-D-glucopyranoside(3).Compound 1 was identified as 2-methylene-3-methoxy-2, 5-dihydrofuran-4-O-β-D-glucopyranoside on the basis of chemical and spectroscopic data including 1D and 2D NMR spectral analysis.In addition,the antioxidant activity of 1 was evaluated using the 1,1-diphenyl-2-picrylhydrazyl(DPPH) and 2,2′-azinobis- 3-ethylbenzothiazoline-6-sulphonic acid(ABTS) assay.The IC_(50) values were 2.49 and 0.45 mg/mL,respectively.     

Lipids from Bud Meristem of Larix sibirica

The total lipids were isolated from meristematic bud tissues of Larix sibirica L. and cell membrane complexes. Their group composition was established. The dynamics of seasonal variation were studied. The principal lipids were found to be polar lipids residing in the membranes. Lipids in membranes were largely (up to 75% of the mass) replaced in winter by proteinaceous material. The principal lipids in the membranes were phospholipids.     

A new flavonoid glycoside from Elsholtzia bodinieri

A new flavonoid glycoside, eriodictyol 7-O-(6″-caffeoyl)-β-D-glucopyranoside (1), along with 14 known compounds, were isolated from the whole plants of Elsholtzia bodinieri. All of the structures were determined by spectroscopic methods and chemical transformation. Compound 1 and luteolin (9) exhibited potent anti-HCV activities with a selective index of 135.85 and 20.84, respectively.     

A new phenolic glycoside from the Idesia polycarpa Maxim. leaves

Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. Leaves led to the isolation of four phenolic glycoside isomers (1–4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds 1 and 3. Moreover, compound 3 presented the highest cytotoxicity against MCF cell lines with IC₅₀ value of 37.17?±?0.26?μg/mL than compounds 1, 2 and 4.     

A new coumarin glycoside from Daphne giraldii

A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-b-D-glucopyranosyl-(1→6)-b-D-glucopyranoside on the basis of spectral evidences.     

A new iridoid glycoside from Gardenia jasminoides

A new iridoid glycoside,6′-O-sinapoylgeniposide,was isolated from Gardenia jasminoides Ellis and its structure was elucidated on the basis of 1D and 2D NMR,HR-ESI-MS techniques.     

A new sesquiterpenoid glycoside from Saussurea involucrata

Abstract

Saussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7R, 8S, 11S)-11, 13-dihydrodehydrocostuslactone-8-O-6'-2''(E)-butenoyl-β-D-glucopyranoside (1), together with seven known compounds (2–8) were isolated from the dried aerial part of S. involucrata. Their structures were elucidated by spectroscopic and physico-chemical analyses. The antioxidant and anti-inflammatory activities of compound 1 were investigated. And compound 1 showed weak radical scavenging activity and low inhibitory activity on nitric oxide (NO) production.     

A new phenolic glycoside from Saprosma merrillii

A new phenolic glycoside derivative, saproglucoside (1), along with five known phenolic glycoside derivatives (2–6) were isolated from the stems of Saprosma merrillii. The structure of the new compound 1 was determined by 1D and 2D NMR as well as by HRESIMS and hydrolysis. The inhibitory activities of all compounds against seven pathogenic bacteria and two cancer cell lines were evaluated.     

A new neolignan glycoside from Dolomiaea souliei

Abstract

One new neolignan glycoside, dolomiside A (1), together with 11 known phenylpropanoid glycosides were isolated from Dolomiaea souliei (Franch.) Shih. The structures of these isolates were determined by UV, CD, HR-ESI-TOFMS, 1D and 2D NMR analysis.     

A new antifungal eudesmanolide glycoside isolated from Sphaeranthus indicus Linn. (Family Compositae)

A new antifungal eudesmanolide glycoside 11,13-dihydro-3-O-(β-digitoxopyranose)-7α-hydroxy eudasman-6,12-olide (2) in addition to known compounds 1 and 3, has been isolated from Sphaeranthus indicus Linn. Its structure was determined by spectral analysis (UV, IR, 1D and 2D NMR and mass spectrum).     

A new flavone glycoside from Selaginella moellendorffii Hieron.

From the ethanol extract of Selaginella moellendorffii Hieron., a new flavone O-glycoside and three known flavone C-glycosides have been isolated and identified as 5-carboxymethyl-4'-hydroxyflavone-7-O-β-D-glucopyranoside 1, 6,8-di-C-β-D-glucopyrano-sylapigenin 2, 6-C-β-D-glucopyranosyl-8-C-β-D-xylopyranosyl apigenin 3, 6-C-β-D-xylopyranosyl-8-C-β-D-glucopyranosylapi-genin 4, respectively. Their structures were elucidated by spectroscopic methods.     

A new C27-steroidal glycoside from Ophiopogon japonicus

A new C27-steroidal glycoside with three known compounds were isolated from the tuber of Ophiopogonjaponicus （Thunb.） Ker-Gawl. Based on the spectral analysis, including HRMS, 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HMQC and HMBC, their chemical structures were determined as pennogenin-3-O-α-L-rhamnopyranosyl-（1→ 2）-β-D-xylopyranosyl-（1→ 4）-13-D-gluco- pyranoside （1）, pennogenin-3-O-α-L-rhamnopyranosyl-（1→ 2）-β-D-glucopyranoside （2）, ophiopojaponin C （3） and ophiopogonin D （4）. 2007 Jian Zhong Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.     

A new anthraquinone glycoside from seeds of Cassia obtusifolia

A new anthraquinone glycoside 1, along with a known anthraquinone glycoside aurantio-obmsin-6-O-β-D-glucopyranoside 2, were isolated from the seeds of Cassia obtusifolia. On the basis of spectral and chemical evidences, the structure of 1 was established as 1-demethylaurantio-obtusin-2-O-β-D-glucopyranoside. Moreover, the 13C NMR of 2 was assigned totally and correctly for the first time based on the two-dimensional NMR.     

A new C21-steroidal glycoside from Cynanchum stauntonii

A new C21-steroidal glycoside with two known compounds were isolated from the root of Cynanchum Stauntonii.Based on thespectral analysis,including MS,1H NMR,13C NMR,DEPT,1H-1H COSY,13C-1H COSY,HMQC and HMBC,their chemicalstructures were determinated as glaucogenin-C 3-O-a-L-cymaropyranosyl-(1→4)-b-D-digitoxopyranosyl-(1→4)-β-D-canaropyranoside(1),stigmasterol(2)and ursolic acid(3).     

A new phenylethanoid glycoside from Orobanche cernua Loefling

A novel phenylethanoid glycoside, 3′-O-methyl isocrenatoside (1), along with two known compounds, methyl caffeate (2) and protocatechuic aldehyde (3), were isolated from the fresh whole plant of Orobanche cernua Loefling. All the isolated compounds (1–3) were elucidated on the basis of spectroscopic analysis including IR, MS and NMR data. The cytotoxic activities of these compounds were evaluated. Results showed that 3′-O-methyl isocrenatoside (1) and methyl caffeate (2) exhibited significant cytotoxicity, with IC₅₀ values of 71.89, 36.97 μg/mL and 32.32, 34.58 μg/mL against the B16F10 murine melanoma and Lewis lung carcinoma cell lines, respectively.