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Agata Kozioł Ewa Grela Katarzyna Macegoniuk Agnieszka Grabowiecka 《Natural product research》2020,34(8):1074-1079
AbstractIncorporation of the Beckmann rearrangement into the presented research resulted in the formation of nitrogen-containing terpenoid derivatives originating from naturally occurring compounds. Both starting monoterpenes and obtained derivatives were subjected to estimation of their antibacterial potential. In the presented study, Staphylococcus aureus was the most sensitive to examined compounds. The Minimal Inhibitory Concentration (MIC) experiments performed on S. aureus demonstrated that the (?)-menthone oxime (?)-8 and (+)-pulegone oxime (+)-13 had the best antibacterial activity among the tested derivatives and starting compounds. Their MIC90 value was 100?µg/mL. The obtained derivatives were also evaluated for their inhibitory activity against bacterial urease. Among the tested compounds, three active inhibitors were found – oxime 14 and lactams (?)-15 and 16 limited the activity of Sporosarcina pasteurii urease with Ki values of 174.3?µM, 43.0?µM and 4.6?µM, respectively. To our knowledge, derivative 16 is the most active antiureolytic lactam described to date. 相似文献
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以N-(2-溴乙基)邻苯二甲酰亚胺或N-(4-溴丁基)邻苯二甲酰亚胺和硫氢化钠为起始原料,通过取代、肼解、亲核加成等反应合成了10个三芥子酸甘油酯(erucin)类似物,通过核磁共振氢谱、碳谱及质谱对其结构进行了确认。采用比浊法初步测试了其对大肠杆菌、金黄色葡萄球菌、白色葡萄球菌、藤黄八叠球菌、枯草芽孢杆菌、蜡状芽孢杆菌和四联球菌等7种菌的生长抑制活性,测试结果显示,化合物对测试菌种都表现出较好的生长抑制活性,其中苄硫乙基-1-硫代异硫氰酸酯(5e)和苄硫基丁基-1-硫代异硫氰酸酯(5j)活性最高,对大肠杆菌的最低生长抑制浓度仅为7.8μg/m L,对金黄色葡萄球菌的最低生长抑制浓度也仅为15.6μg/m L和31.2μg/m L。 相似文献
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Azebaze AG Ouahouo BM Vardamides JC Valentin A Kuete V Acebey L Beng VP Nkengfack AE Meyer M 《Natural product research》2008,22(4):333-341
The phytochemical study of stem bark of Allanblackia gabonensis has resulted in the isolation and characterisation of one new xanthone derivative, named allanxanthone D, together with 10 known compounds, including 6 xanthones derivatives, allanxanthone A, 1,5-dihydroxyxanthone, 1,7-dihydroxyxanthone and 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone, forbexanthone, 6-deoxyisojacareubin, one polyisoprenylated benzophenone, guttiferone F, one flavanol, epicathechin, two phytosterols, beta-sitosterol and campesterol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and hetero-nuclear evidence. These compounds were evaluated for their activity against Leishmania amazonensis in vitro and antimicrobial activities against a range of Gram negative and Gram positive bacteria. 相似文献
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《Mendeleev Communications》2023,33(1):109-111
Antimycobacterial activity of certain ureas as well as spirocyclic piperidines described in the literature prompted us to synthesize and test a series of hybrids of spirocyclic piperidine with ureas. Surprisingly, no activity was detected against Mycobacterium tuberculosis. However, significant antibacterial activity was identified and confirmed against common gram-positive as well as gram-negative bacteria. 相似文献
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H. Aki Y. Nakashima Y. Kawasaki T. Niiya 《Journal of Thermal Analysis and Calorimetry》2006,85(3):685-688
The antibacterial
action of amoxicillin (AMPC) and the inclusion complexes of AMPC with α-, β-
and γ-cyclodextrins (α-CD, β-CD and γ-CD, respectively)
to Escherichia coli B (E.
coli) was evaluated by isothermal titration microcalorimetry and
by petri-dish bioassay method. The effects of the compounds on produced heat
during the exponential phase of the E. coli
growing were measured and the growing rate constants of the cells was calculated
from the power-time (p-t) curve before
and after the treatment with AMPC. Results from the both methods showed that
the antibacterial activity became stronger in the following order: AMPC-βCD
> AMPC-γCD ≈ AMPC-αCD > AMPC only. 相似文献
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《Mendeleev Communications》2022,32(5):606-608
Novel para-substituted bis-pyridinium compounds containing 2,7-dioxynaphthalene spacer were synthesized in two simple steps from the corresponding dihydroxy-naphthalene. The microbiological study on five reference (E. coli ATCC 25922, K. pneumoniae ATCC 70060, S. aureus ATCC 43300, P. aeruginosa ATCC27853, and A. baumannii ATCC 15308) and five clinical (E. coli B-3421/19,K. pneumoniae B-2523/18, S. aureus B-8648, P. aeruginosa B-2099/18 and A. baumannii B-2926/18) bacterial strains showed promising range of antibacterial properties for these biocides, compared to modern sanitizers. 相似文献
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Wilawan Mahabusarakam Pattama Mecawun Souwalak Phongpaichit 《Natural product research》2016,30(20):2323-2328
Two new prenylated xanthones, namely dulcisxanthone H and dulcisxanthone I along with garciniaxanthone C, were isolated from the dichloromethane extract of the green branch of Garcinia dulcis. Their structures were elucidated by the analysis of 1-D and 2-D NMR spectral data. Their antibacterial activities were also examined. 相似文献
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Chin‐San Wu 《先进技术聚合物》2012,23(3):463-469
The effects of replacing poly(butylene succinate adipate) (PBSA) with acrylic acid‐grafted PBSA (PBSA‐g‐AA) on the structure and the properties of a PBSA/chitosan composite were investigated. The properties of both PBSA‐g‐AA/chitosan and PBSA/chitosan were compared using Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), X‐ray diffraction (XRD), and an antibacterial activity test. With PBSA‐g‐AA in the composite, the compatibility with chitosan and, consequently, the properties of the composite became greatly improved due to the formation of ester and imide groups that conferred better dispersion and homogeneity of chitosan in the matrix. Composites containing PBSA‐g‐AA/chitosan exhibited superior mechanical properties due to greater compatibility between the two components. Moreover, chitosan enhanced the antibacterial activity of the composites. Composites of PBSA‐g‐AA or PBSA that contain chitosan have better antibacterial activity. The functionalized PBSA‐g‐AA/chitosan composites showed markedly enhanced antibacterial properties due to the carboxyl groups of acrylic acid, which acted as coordination sites for the chitosan phase, allowing the formation of stronger chemical bonds. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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2,5-二(2-氨基乙氧甲基)噻吩合成及抑菌活性 总被引:2,自引:0,他引:2
噻吩烷基胺及其衍生物对疟疾、麻风、真菌、病毒和某些肿瘤均有较强的药理活性[1~ 2 ] ,因此合成和开发这类新物质具有重要的意义。以前 ,由 2 噻吩甲醛合成的噻吩类衍生物药物较多[3] ,但对噻吩双取代衍生物的合成研究还未引起重视。因此 ,为了探索这类化合物的性质和抑菌效果。我们合成了未见文献报道的 2 ,5 二 ( 2 氨基乙氧甲基 )噻吩 ,通过多种测试手段 ,确定了它的组成结构 ,其合成路线如下 :1 实验部分1 1 仪器与试剂Nicolet1 70S红外光谱仪 (KBr压片 ) ,PE 2 4 0C型元素分析仪 ,EM 360 60MHz核磁共振仪。… 相似文献
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Arti Pandey 《Natural product research》2018,32(10):1189-1192
Aqueous extracts of Neolamarckia cadamba fruits prepared at different maturity stages were used for the analysis of various phytochemicals, and their antioxidant and antibacterial activities were determined. Ripe fruit extract had highest phenolics (3.14 mM GAE/ g fruit extract) with caffeic acid, tannic acid, syringic acid and quercetin as major phenolic compounds. The ripe fruit extract showed lowest IC50 values in DPPH radical scavenging assay (231.33 μg fruit extract/ mL), and highest ABTS radical scavenging activity (111.18 μM TEAC/g). Immature fruit extract showed lowest minimum inhibitory concentration against tested bacteria, and the antibacterial activity was probably due to membrane permeation, as was evident by leakage of genetic material and reduction in propidium iodide uptake by bacterium; and by inhibition of sugar and amino acid uptake. The appreciable amount of phenolic compounds and biological activities in the aqueous extracts of N. cadamba fruits suggests it's potential application as natural preservative. 相似文献
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Yordan Stremski Desislava Kirkova Plamen Angelov Iliyan Ivanov Danail Georgiev 《合成通讯》2020,50(19):3007-3015
Abstract N-acyliminium reagents formed in situ from benzothiazole and alkyl chloroformates react with hydroxyarenes in a Friedel-Crafts manner, providing access to 2-(hydroxyaryl)-benzothiazolines with antibacterial properties. 相似文献
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肉桂中醛、酸类化合物结构与抗菌活性的关系 总被引:3,自引:0,他引:3
本文对肉桂醛、酸及其衍生物的抑菌效果进行了测定,对其量子化学参数进行了计算,并对这类化合物抗菌活性和分子化学结构之间的关系进行了相关分析。结果表明,该类化合物抑菌率EFPO、ELUMO和EHOMO的相关系数分别为一0.7814(p<0.05)、-0.7328(0.05<ρ<0.1)和0.6318(ρ>0.1)。该类化合物的抗菌活性中心原子可能是羰基氧、α-碳、β-碳,由这些原子组成的不饱和羰基共轭体系可能是抗菌剂的活性功能域. 相似文献
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C. Sacco M. Bellumori F. Santomauro R. Donato R. Capei M. Innocenti 《Natural product research》2015,29(16):1537-1544
In this study, the aim was to evaluate the antimicrobial action of the non-volatile phenols of rosemary leaves against two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis). Three extracts with different phenolic compositions were tested. By the agar disc diffusion method, Gram-positive bacteria were more sensitive to the extracts, and S. epidermidis showed the highest inhibition zones. Overall, all the extracts tested by the broth dilution method showed higher activity than results from the agar disc diffusion method. The minimal bactericidal concentration values indicated that E. coli was the most susceptible strain. This study demonstrated that the flavonoidic fraction of rosemary leaves does not play a crucial role as antimicrobial agents against these microorganisms. The most active extract was characterised by the highest amount of non-volatile terpenoidic compounds. 相似文献
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Chunlian Tian Zehui Zhang Hong Wang Yuru Guo Jihang Zhao Mingchun Liu 《Biomedical chromatography : BMC》2019,33(4)
The current study focused on the extraction technology, components analysis, in vitro antioxidant and antibacterial activities of total flavonoids and fatty acids from Tribulus terrestris L. fruits. The extraction process of total flavonoids and fatty acids was optimized by the response surface method, and the compositions were identified from the two extracts by HPLC–DAD–ESI–MS? and GC–MS, respectively. In addition, the antioxidant and antibacterial activities were evaluated by assay of ABTS, DPPH radical scavenging activity, ferric reducing antioxidant power and minimal inhibitory concentration. The yields of total flavonoids and fatty acids were 0.46 and 9.76% under the optimized conditions. Moreover, nine and eight compositions were identified from the two extracts based on the related references, respectively. In addition, total flavonoids and fatty acids extracts both exhibited certain antioxidant and antibacterial activities. The present findings suggest that total flavonoids extracted from T. terrestris L. fruits comprised a more interesting candidate than fatty acids for the research and development of natural and healthy antioxidants and antibacterial agents for the pharmaceutical and food industries. 相似文献