阿拉善马先蒿中新木脂素甙成分研究

阿拉善马先蒿中新木脂素甙成分研究高建军，刘自民，王继和，贾忠建（兰州大学有机化学研究所应用有机化学国家重点实验室，兰州，７３００００）关键词阿拉善马先蒿，玄参科，新木脂素甙前文［１］报道了从阿拉善马先蒿（ＰｅｄｉｃｕｌａｒｉｓａｌａｓｃｈａｎｉｃａＭ...     

三对节中两个新环烯醚萜甙的研究

从三对节的叶子中分离得到４个化合物,经化学和光谱方法鉴定其为７－Ｏ－ｐ－Ｃｏｕｍａｒｏｙｌｏｘｙｕｇａｎｄｏｓｉｄｅ（１）,７－Ｏ－ｃｉｎｎａｍｏｙｌｏｘｙｕｇａｎｄｏｓｉｄｅ（２）,ａｃｔｅｏｓｉｄｅ（３）和ｍａｒｔｙｎｏｓｉｄｅ（４）,其中前两者是新环烯醚萜甙化合物,后两者为首次从该植物中获得的苯丙素甙类化合物。     

光萼台中荚蒾叶中新二氧杂三环癸烷骨架环烯醚萜类化学成分的研究

对光萼台中荚蒾(Viburnum formosanum Hayata subsp.leiogynum Hsu)的化学成分进行了研究,从其叶子的Et OAc/Me OH(V∶V=1∶1)提取物中分离得到2个新的二氧杂三环癸烷结构骨架的环烯醚萜类化合物.新化合物的化学结构及其相对立体构型通过综合波谱解析得到了确定.     

山茱萸炮制过程中环烯醚萜苷类成分的质谱研究

利用高效液相色谱-电喷雾多级串联质谱(HPLC-ESI-MSn)联用技术, 对传统中药山茱萸炮制过程中环烯醚萜苷类成分的变化进行了研究. 采用反相C18色谱柱, 二元线性梯度洗脱, 分离并获得了山茱萸中7个环烯醚萜苷类化合物. 并通过电喷雾一级质谱获得了上述7种化合物的分子量信息, 利用电喷雾质谱的源内碰撞诱导解离技术, 获得了该类化合物在负离子模式下的碎裂特征, 在此基础上, 对其进行了结构鉴定和含量分析. 首次发现了差向异构体7α-乙氧基莫诺苷和7β-乙氧基莫诺苷化合物. 研究结果表明, 当采用HPLC-ESI-MS法分析山茱萸环烯醚萜苷类化合物时, 通过色谱保留时间色谱峰面积和质谱特征两方面信息能够提供更加准确可靠的定性定量结果.     

8,9-环氧苧烯的合成

以异戊二烯、甲基乙烯基酮为原料,氯化铝为催化剂,经Diels-Alder反应,合成得到1-甲基-4-乙酰基-1-环己烯,再用锍叶立德对羰基环氧化,专一地得到消旋体8,9-环氧烯,两步反应总得率为56%。从8,9-环氧烯出发,进一步合成得到萜类香料1,8-对二烯-10-醇和4-(4-甲基-3-环己烯-1-基)-4-戊烯醛。所有产物的结构经IR、NMR和MS证实。     

利用活性炭色谱柱一步分离纯化独一味中总环烯醚萜苷类成分的方法

<正>公开号:CN103432195A公开日:2013.12.11申请人:张泉龙摘要本发明涉及一种利用活性炭色谱柱分离纯化独一味中总环烯醚萜苷的方法,其特征是将独一味地上部分用乙醇提取,提取液浓缩成浸膏,浸膏溶解后上活性炭色谱柱,先用蒸馏水冲洗至无色,再用70%~90%乙醇洗脱,收集流份,即得。采用活性炭(0.42~0.5 mm)为色谱柱固定相,用70%~90%乙醇为流动相洗脱,所得总环烯醚萜苷类成分的     

大环二萜类化合物的研究(Ⅳ)——Isosarcophytol—A前体化合物的合成

Isosarcophytol-A(1)是1982年首次从澳大利亚软珊瑚(Nephthea brassica)中分离鉴定的西松烷型(Cembrane)大环二萜类化合物,其结构为6,10,14-三甲基-3-异丙基-3E,5E,9E,13E-环十四碳四烯-1-醇,是Sarcophytol—A(2)的异构体,但有关1的生物活性试验和全合成研究尚未见报道.我们在前文报道了以低价钛诱导的分子内二羰基偶联为环化方法,完成了天然大环二萜类化合物Cembrene—C的全合成和Sarcophytol—A(2)苄醚衍生物(3)的合成.本文报道以天然法呢醇4为起始原料,经区域选择性氧化、羟醛缩合等六步反应,合成了1的前体化合物11.合成路线如下:     

Iridoid Glycosides from Lamiophlomis rotata

The seven new iridoid diglycosides 1 – 7 , together with eleven known iridoid and phenylpropanoid glycosides, were isolated from the 50% EtOH extract of the roots of Lamiophlomis rotata. Their structures were elucidated by chemical and spectroscopic methods.     

A New Iridoid Glycoside and a New Iridoid from Pedicularis kansuensis f. aibiflora

A new iridoid glycoside 1 and a new iridoid 2 were isolated from the whole plant ofPedicularis kansuensis f. albiflora. Their structures were elucidated by spectroscopic methods.     

Iridoid Glycosides from Gardenia jasminoides Ellis

Three new iridoid glycosides, 4″‐O‐[(E)‐p‐coumaroyl]gentiobiosylgenipin ( 1 ), 6′‐O‐[(E)‐caffeoyl]deacetylasperulosidic acid methyl ester ( 2 ), and 6′‐O‐[(E)‐sinapoyl]gardoside ( 3 ), together with seven analogues, 4 – 10 , were isolated from the BuOH extract of the fruits of Gardenia jasminoides Ellis . Their structures were determined by means of spectroscopic analyses, including HR‐ESI‐MS, IR, and ¹H‐ and ¹³C‐NMR, and 2D experiments (COSY, HSQC, and HMBC), and comparison with known related compounds.     

A New Iridoid Glycoside and a New Iridoid from Pedicularis kansuensis f. albiflora

A new iridoid glycoside 1 and a new iridoid 2 were isolated from the whole plant of Pedicularis kansuensis f. albiflora. Their structures were elucidated by spectroscopie methods.     

Triterpenoids and Iridoid Glycosides from Gentiana dahurica

One new and six known pentacyclic triterpenoids, 1 and 4 – 9 , resp., along with two new and three known iridoid glycosides, 2 and 3 , and 10 – 12 , resp., were isolated from the roots of Gentiana dahurica (‘Qin‐Jiao’). The new structures were elucidated by means of spectroscopic and chemical methods as 1β,2α,3α,24‐tetrahydroxyursa‐12,20(30)‐dien‐28‐oic acid ( 1 ), 6′‐O‐acetylgentiopicroside ( 2 ), and 3′‐acetylgentiopicroside ( 3 ). Isolated compounds were tested for their cytotoxicity against the MCF‐7 human breast cancer cell line using the MTT assay. Among them, triterpenoids 2α,3β,24‐trihydroxyurs‐12‐en‐28‐oic acid ( 6 ) and 3β,24‐dihydroxyurs‐12‐en‐28‐oic acid ( 9 ) were found to have moderate cytotoxic effects with IC₅₀ values of 20.9 and 21.7 μg/ml, respectively. Additionally, the chemotaxonomic significance of the identified secondary metabolites is briefly discussed.     

Iridoid Glycosides from Hedyotis corymbosa

Three new iridoid glycosides, hedycorysides A–C ( 1 – 3 , resp.), were isolated from the whole plant of Hedyotis corymbosa (Linn .) Lam ., along with four known compounds. Their structures were elucidated by extensive 1D‐ and 2D‐NMR analysis, as well as by HR‐ESI‐MS experiments. The three new compounds are the first benzoylated geniposide derivatives from Hedyotis.     

Two New Megastigmane Glycosides and a New Iridoid Glycoside from Gelsemium elegans

Two new megastigmane glycosides, eleganosides A and B ( 1 and 3 , resp.), and one new iridoid glycoside, gouwenoside A ( 4 ), together with two known compounds, foliasalacioside B₁ ( 2 ) and loganin ( 5 ), were isolated from the aerial parts of Gelsemium elegans (Gardn. et Champ.) Benth. (Loganiaceae). Their structures were elucidated by spectroscopic methods including 1D‐ and 2D‐NMR techniques. The absolute configuration of 1 was determined by CD spectroscopy.     

Secologanin,a Biogenetic Key Compound—Synthesis and Biogenesis of the Iridoid and Secoiridoid Glycosides

The monoterpene glycoside secologanin is a key intermediate in the biosynthesis of most indole, cinchona, ipecacuanha, and pyrroloquinoline alkaloids, as well as of simple monoterpene alkaloids. More than a thousand alkaloids are formed from secologanin in vivo; this represents almost a quarter of this large group of natural products. It is also the parent compound of the secoiridoids. Many of the compounds derived from secologanin display a high degree of biological activity and are employed as pharmaceuticals, e.g., the dimeric indole alkaloid leurocristine (vincristine) which is used very successfully in the treatment of acute leukemia. A knowledge of the biosynthesis and biological reactions of secologanin provides a sound basis for the biosynthesis-orientated classification of numerous natural products and the taxonomy of many plants. Secologanin and structurally related substances can be synthesized in a few steps by stereocontrolled photochemical and thermal cycloadditions. Its biomimetic reaction with amines and amino acids yields other natural products and compounds of pharmacological interest.     

A New Neolignan Glycoside from Pedicularis armata

A new neolignan glycoside named armaoside (1) was isolated from the whole plant of Pedicularis armata Maxim. Its structure was elucidated by spectroscopic and chemical methods. Antibacterial assay showed that it has moderately antibacterial activities against Eschecichia coli, Bacillus subtilis and Staphylococcus aureus.