Efficient Synthesis of Complex Bridged 1,3-Oxazabicycles via Reactions of N-Alkyl-1,10-phenanthrolinium Halides with Cyclic 1,3-Diketones

Complex bridged 1,3-oxazabicycles and 1,4-disubstituted 1,10-phenanthroline derivatives were efficiently prepared by the reactions of N-methyl or N-benzylphenanthrolinium halides with cyclic 1,3-dicarbonyl compounds in a K₂CO₃/CH₃CN system.     

Alkylation of Cyclic 1,3-Diketones

A simple procedure for the C-alkylation of cyclic 1,3-diketones have been reported using Triton B as base in aqueous conditions.     

A Modified Synthesis of Fluorinated 1,3-Diketones

The reinvestigation of acylation reactions of fluorinated aryl methylketones with ethyl esters at 0°C afforded fluorinated 1, 3-diketones in excellent yields.     

Vanillal Esters in Reaction with 2-Naphthylamine and 1,3-Diketones

Analogs of natural alkaloids of acridone series, derivatives of4-(9-alkyl-11-oxo-7,8,9,10,1,12-hexahydrobenzo[a]acridin-12-yl) and 4-(12-oxo-12H-benzo[f]indeno[1,2-b]quinolin-13-yl)2-ethoxyphenyl carboxylates were synthesized by a three-component condensation of vanillal with 2-naphthylamine and 1,3-cyclohexanedione, dimedone, phendione, or 1,3-indanedione.     

Synthesis of 1-Aryl-1,3-Diketones Containing the Dimethyl Malonate Moiety

The synthesis of new 1,3-diketones malonates 3 a-j were prepared in good yield from 1,5-diketones 2 a-j by employing the 1,5 → 1,3 diketone rearrangement.     

Reactions of 1,5-Diketones with Ammonia and Its Derivatives. (Review)

Published data and the authors' own experimental results on the reaction of aliphatic, semicyclic, and oxosemicyclic 1,5-diketones and alkylidene- and arylidene-2,2-dicyclanones with ammonia, ammonium acetate, and XNH₂ derivatives, where X = Alk, Ar, OH, NH₂, PhNH, ArCONH, and CHO, are reviewed. The characteristics and the relationships governing the transformations into azaheterocycles in relation to the nature of the reagents and the reaction conditions are discussed.     

4-二甲氨基吡啶催化的1,3-二酮与3-丁炔-2-酮的苯环化反应

在4-二甲氨基吡啶(DMAP)催化下, 1,3-二酮与3-丁炔-2-酮可以区域选择性地合成四取代的苯, 该方法具有反应条件温和和操作简单等优点, 产物的结构通过IR, 1H NMR, 13C NMR, HRMS确证.     

Reactions of Grignard reagents with 1,3-dicyanoadamantane

Reactions of Grignard reagents RMgX (R = Me, Et, Pr, Bu; X = Br, I) with 1,3-dicyanoadamantane (1) were studied. Optimum conditions for the synthesis of monoaddition products of Grignard reagents to compound 1 were established. The first stage of the reaction of cyanoadamantane 1 with MeMgBr was studied by the MNDO-PM3 method. According to calculations, the more preferable reaction mechanism involves formation of a six-membered cyclic intermediate containing two Mg atoms, two C atoms, and one Br and one N atom.     

Reactions of azidoazolopyridazines with 1,3-dicarbonyl compounds

Azidoazoloazines react with 1,3-dicarbonyl compounds to give cycloaddition products, 1,2,3-triazole derivatives, whose structures have been established by chemical transformations and spectroscopic data.     

Dioximes of 1,3-Diketones in the Trofimov Reaction: New 3-Substituted Pyrroles

Dioximes of 1,3-diketones enter into the Trofimov reaction forming pyrroles containing an acyl or an O-vinyloxime substituent in position 3 of the pyrrole. In the case of sterically hindered dioximes the main reaction products are isoxazoles. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 839–847. June, 2005.     

Synthesis of 2,3-Dihydroimidazo[1,2-a]pyridines from 1,3-Diketones

A series of 2-hydroxy-, 2-chloro-, and 2-(2-hydroxyethylamino)-6-aryl-4-polyfluoroalkyl-3-cyanopyridines has been synthesized. The latter react with phosphorus oxychloride to give fluorine containing 2,3-dihydroimidazo[1,2-a]pyridines.     

Facile Synthesis of Selectively Monoprotected Unsymmetrical 1,3-Diketones from 2,2-Dimethoxyethyl Esters

Selectively monoprotected unsymmetrical 1,3-diketones were obtained by the reaction of 2,2-dimethoxyethyl esters with enamines in the presence of dichlorobis(trifiuoro-methanesulfonato)titanium.     

Reactions of 1,3-dehydroadamantane with inorganic oxygen-free acids

A convenient and efficient procedure has been developed for the synthesis of 1-azidoadamantane, 1-adamantyl isocyanate, and 1-adamantyl isothiocyanate by reaction of 1,3-dehydroadamantane with hydrazoic, isocyanic, and isothiocyanic acids, respectively, under mild conditions. The reaction of 1,3-dehydroadamantane with hydrogen cyanide under analogous conditions gives adamantane-1-carbonitrile in a poor yield which may be improved using hexane as solvent.     

Reactions of substituted 7-aminoindoles with 1,3-diketones

The condensation of 2,3-dimethyl and 1,2,3-trimethyl-7-aminoindoles with-dicarbonyl compounds leads to enaminoketones, which undergo cyclization by the action of trifluoroacetic acid giving substituted pyrrolo[3,2-h]quinolines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 58–62, January, 1995.     

Reactions of the 1-ferrocenyl-1,3-diphenylallyl cation with nucleophiles

Conclusion The reactions of 1-ferrocenyl-1,3-diphenylallyl cation with nucleophiles have been studied. In most cases they take place at the secondary carbon cation center; products of reaction at the tertiary center are found only in the case of small nucleophiles (MeO^–, OH^–). The data are evidence for the importance of steric factors, and also show that the ratio of reaction products at the -and -positions does not directly reflect charge distribution in the 1-ferrocenylallyl system.Deceased.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2769–2776, December, 1986.     

低价钛诱导的芳香邻二酮及α-羟基酮的还原偶联反应

Treatment of aromatic 1 , 2-diketones or aromatic a-hydroxy ketones with an activated low-valent titanium reagent, prepared by reduction of TiCl3·1/3AlCl3 with a Zn-Cu reagent, gave an intermolecular coupling reaction leading to the (Z)-1, 2.3.4-tetraaryl-2-butenes. Apossible coupling reaction process was proposed for the aromatic a-hydroxy ketones.     

Reactions of 4-hydrazinoquinazoline with derivatives of 1,3-cyclanediones

In reactions of 4-hydrazinoquinazoline with 2 formyl- and 2-acetyldimedones, 2 formyl-1,3-indandione, dehydroacetic acid, and 2, 2-dimethyl-5-ethoxymethylene-1, 3-dioxane-4, 6-dione, the corresponding hydrazinomethylene and 1-hydrazinoethylidene derivatives have been obtained. Attempts to convert the 2-hydrazinomethylene- and 2-(1-hydrazinoethylidene)dimedones to indazole derivatives were unsuccessful. In reactions of 4-hydrazinoquinazoline with 2-cyano-3-ethoxy-5,5-dimethylcyclohex-2-en-1-one, 3-hydrazino derivatives were obtained; with 2-amino-5-oxo-7, 7-dimethyl-5, 6, 7, 8-tetrahydroquinazoline and 1 phenyl-4,5-dioxo-6, 6-dimethyl-4, 5, 6, 7-tetrahydroindazole, the corresponding 5(4-quinazolylhydrazino) derivatives were obtained.