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1.
Kreher UP Rosamilia AE Raston CL Scott JL Strauss CR 《Molecules (Basel, Switzerland)》2004,9(6):387-393
Liquid or low melting association products of carbon dioxide and a secondary amine, both neutral molecules that may be gaseous, are recognised as "distillable" ionic media. 相似文献
2.
Yamaguchi S Watanabe H Mondal SK Kundu A Tahara T 《The Journal of chemical physics》2011,135(19):194705
We unambiguously demonstrate the "up" versus "down" alignment of a pair of prototypical solute molecules adsorbed at the air/water interface for the first time using heterodyne-detected electronic sum frequency generation spectroscopy. This molecular alignment is also reproduced by classical molecular dynamics (MD) simulation theoretically. Furthermore, the MD simulation indicates distinctly different interface-specific hydration structures around the two solute molecules, which dictate the molecular alignment at the interface. It is concluded that the hydrophilicity difference between the terminal functional groups of the solute governs the molecular orientation and surrounding hydration structures at the interface. 相似文献
3.
Paraschiv V Crego-Calama M Ishi-i T Padberg CJ Timmerman P Reinhoudt DN 《Journal of the American Chemical Society》2002,124(26):7638-7639
Chaperones are small molecules that assist in the folding of naturally occurring peptides. There are no examples of small molecules acting as chaperones in the self-assembly of synthetic noncovalent assemblies. In this communication we describe an unprecedented example of the "chaperone effect" in the noncovalent synthesis of organic nanostructures. Tetrarosette assemblies 2(3).(BuCYA)(12) form quantitatively in CHCl(3) at room temperature upon mixing tetramelamine 2 with N-butylcyanurate (BuCYA) in the presence of 5,5-diethylbarbituric acid (DEB). Without the DEB units present, only oligomeric assemblies are formed that cannot rearrange to the tetrarosettes by themselves. The DEB units act as molecular "chaperones" by preorganizing the tetramelamine units for the spontaneous assembly of the tetrarosette structure. 相似文献
4.
Averett LE Geer CB Fuierer RR Akhremitchev BB Gorkun OV Schoenfisch MH 《Langmuir : the ACS journal of surfaces and colloids》2008,24(9):4979-4988
During blood vessel injury, fibrinogen is converted to fibrin, a polymer that serves as the structural scaffold of a blood clot. The primary function of fibrin is to withstand the large shear forces in blood and provide mechanical stability to the clot, protecting the wound. Understanding the biophysical forces involved in maintaining fibrin structure is of great interest to the biomedical community. Previous reports have identified the "A-a" knob-hole interaction as the dominant force responsible for fibrin's structural integrity. Herein, biochemical force spectroscopy is used to study knob-hole interactions between fibrin fragments and variant fibrinogen molecules to identify the forces occurring between individual fibrin molecules. The rupture of the "A-a" knob-hole interaction results in a characteristic profile previously unreported in fibrin force spectroscopy with two distinct populations of specific forces: 110 +/- 34 and 224 +/- 31 pN. In the absence of a functional "A" knob or hole "a", these forces cease to exist. We propose that the characteristic pattern represents the deformation of the D region of fibrinogen prior to the rupture of the "A-a" knob-hole bond. 相似文献
5.
Diaz-Fernandez Y Foti F Mangano C Pallavicini P Patroni S Perez-Gramatges A Rodriguez-Calvo S 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(3):921-930
A micellar approach is proposed to build a series of systems featuring an "off-on-off" fluorescent window response with changes in pH. The solubilizing properties of micelles are used to self-assemble, in water, plain pyrene with lipophilized pyridine and tertiary amine moieties. Since these components are contained in the small volume of the same micelle, pyrene fluorescence is influenced by the basic moieties: protonated pyridines and free tertiary amines behave as quenchers. Accordingly, fluorescence transitions from the "off" to the "on" state, and viceversa, take place when the pH crosses the pK(a) values of the amine and pyridine fragments. To obtain an "off-on-off" fluorescent response in this investigation we use either a set of dibasic lipophilic molecules (containing covalently linked pyridine and tertiary amine groups) or combinations of separate, lipophilic pyridines and tertiary amines. The use of combinations of dibasic and monobasic lipophilic molecules also gives a window-shaped fluorescence response with changes in pH: it is the highest pyridine pK(a) and the lowest tertiary amine pK(a) that determine the window limits. The pK(a) values of all the examined lipophilic molecules were determined in micelles, and compared with the values found for the same molecules in solvent mixtures in which they are molecularly dispersed. The effect of micellization is to significantly lower the observed protonation constants of the lipophilized species. Moreover, the more lipophilic a molecule is, the lower the observed logK value is. Accordingly, changing the substituents on the basic moieties or modifying their structure, tuning the lipophilicity of the mono- or dibases, and choosing among a large set of possible combination of lipophilized mono- and dibases have allowed us to tune, almost at will, both the width and the position along the pH axis of the obtained fluorescent window. 相似文献
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7.
A 1D rigid, linear coordination polymer, (4,4'-bipyridine)(2-pyridylsulfonate)copper, has been applied for the controlled-assembly of a new porous host that generates 1D channels by an interdigitated packing through the recognition of hydrogen bonding and pi-pi stacking interactions. The porous structure is architecturally robust when it reversibly uptakes water molecules and exchanges guest small molecules (MeOH, i-PrOH) from solution as determined by single-crystal-to-single-crystal transformation studies. Moreover, the open-channel solid displays irreversible benzene and toluene vapor sorption behaviors attributed to a widening of the channel cross-section that fetters the larger guest molecules, resulting from the dynamic, "soft" supramolecular framework. 相似文献
8.
Iterative copper-catalyzed cycloadditions of azides to alkynes were used to join functionalized triethylene glycol molecules to give "linkers" of defined lengths equipped with several different end-group functionalities. 相似文献
9.
Wang HX Zhou KG Xie YL Zeng J Chai NN Li J Zhang HL 《Chemical communications (Cambridge, England)》2011,47(20):5747-5749
Graphene sheets modified by phenylacetylene moieties provide a facile platform for attaching various photoactive functional molecules via"click" chemistry. The produced photoactive graphene materials are well-dispersed in various solvents and show dramatically improved photo-current responses. 相似文献
10.
Cook AR Sreearunothai P Asaoka S Miller JR 《The journal of physical chemistry. A》2011,115(42):11615-11623
Data showing significant time-resolution-limited "step" capture of electrons following radiolysis by 7 - 10 ps electron pulses in a series of different length and different concentration conjugated polyfluorene polymers in tetrahydrofuran (THF) are presented. At the highest concentration, ~48 mM in repeat units for lengths from 20 to 133 fluorenes, ~30% of the electrons formed during pulse radiolysis were captured in the step, with a constant efficiency per repeat unit. Step capture per repeat unit (q = 6.9 M(-1)) is 60% of the presolvated electron capture efficiency previously reported for biphenyl in THF, giving capture per polymer molecule 12-80 times larger than that for biphenyl at the same concentration. This increase in capture efficiency is large compared to the rate constant per repeat unit for diffusion-limited electron attachment to the same molecules, which is 13% of that of a single unit of fluorene. Plausible mechanisms of this fast capture are explored. It is shown that both capture of quasi-free and localized presolvated electrons can adequately explain the observations. The large yield of radical anions at low concentration of polyfluorene enables observation of subsequent chemistry on the picosecond time scale in these systems, which would otherwise been limited by diffusional attachment to the nanosecond regime. 相似文献
11.
Two-component adlayers consisting of zinc(II) phthalocyanine (ZnPc) and a metalloporphyrin, such as zinc(II) octaethylporphyrin (ZnOEP) or zinc(II) tetraphenylporphyrin (ZnTPP), were prepared by immersing either an Au(111) or Au(100) substrate in a benzene solution containing those molecules. The bimolecular adlayers thus prepared were investigated in 0.1 M HClO4 by cyclic voltammetry (CV) and electrochemical scanning tunneling microscopy (EC-STM). A supramolecularly organized "chessboard" structure was formed for the ZnPc and ZnOEP bimolecular array on Au(111), while characteristic nanohexagons were found in the ZnTPP and ZnOEP bimolecular adlayer. EC-STM revealed that the surface mobility and the molecular re-organization of ZnPc and ZnOEP on Au(111) were tunable by manipulating the electrode potential, whereas the ZnTPP and ZnOEP bimolecular array was independent of the electrode potential. A "bottom-up" hybrid assembly of fullerene molecules was formed successfully on an alternate array of bimolecular ZnPc and ZnOEP molecules. The bimolecular "chessboard" served as a template to form the supramolecular assembly of C60 by selective trapping in the open spaces. A supramolecular organization of ZnPc and ZnOEP was also found on the reconstructed Au(100)-(hex) surface. A highly ordered, compositionally disordered but alternate array of ZnPc and ZnOEP was formed on the reconstructed Au(100)-(hex) surface, indicating that the bimolecular adlayer structure is dependent on the atomic arrangement of underlying Au in the formation of supramolecular nanostructures composed of those molecules. On the bimolecular array consisting of ZnPc and ZnOEP on the Au(100)-(hex), no highly ordered supramolecular assembly of C60 was found, suggesting that the supramolecular assembly of C60 molecules is strongly dependent upon the bimolecular packing arrangement of ZnPc and ZnOEP. 相似文献
12.
The hydrophobic effect is important for many biological and technological processes. Despite progress in theory, experimental data clarifying water structure and the interaction between hydrophobic solutes at the nanometer scale are scarce due to the very low solubility of hydrophobic species. This article describes an AFM single molecule force spectroscopy method to probe the interaction between molecules with low solubility and reports measurements of the strength and the length scale of the "hydrophobic bond" between hexadecane molecules. Hexadecane molecules are tethered by flexible poly(ethylene glycol) linkers to AFM probes and substrates, removing the aggregation state uncertainty of solution-based approaches as well as spurious surface effects. A shorter hydrophilic polymer layer is added to increase the accessibility of hydrophobic molecules for the force spectroscopy measurements. Statistical analysis of the rupture forces yields a barrier width of 0.24 nm, and a dissociation rate of 1.1 s(-1). The results of single molecule measurements are related to the theoretical predictions of the free energy of cavitation in water and to the empirical model of micellization of nonionic surfactants. It is estimated that approximately one-quarter of each molecule's surface is hydrated during forced dissociation, consistent with an extended (nonglobular) conformation of the hexadecane molecules in the dimer. 相似文献
13.
A unique "non-evaporation" phenomenon, i.e., the unusually slow evaporation process of sessile microdroplets on self-assembled monolayer (SAM) surfaces, is reported. It has been observed that only droplets containing a certain proportion of a volatile and a less-volatile component undergo non-evaporation, which is characterized by hours-long existence of the droplets maintaining constant contact angle, contact area, and volume. We propose that for alcohol-water binary mixtures on SAM surfaces, the highly orientated and closely packed hydrophobic 1-decanethiol molecules induce a concentration gradient of alcohol in water, with a higher concentration of alcohol near the SAM surface. Initial evaporation of the alcohol (more volatile) increased the contact angle until the establishment of a new composition, which contains a strong hydrogen-bonding network among the water molecules in the presence of the alcohol alkyl chains. There is a lessened tendency for the alcohol to evaporate in the presence of a concentration gradient due to such interactions, which results in the observed "non-evaporating" phenomenon. This type of unusual evaporating profile was not observed on conventional substrates, such as polycarbonate sheets and microscope glass slides modified with alkyltrichlorosilanes. 相似文献
14.
Biologically active compounds which are light-responsive offer experimental possibilities which are otherwise very difficult to achieve. Since light can be manipulated very precisely, for example, with lasers and microscopes rapid jumps in concentration of the active form of molecules are possible with exact control of the area, time, and dosage. The development of such strategies started in the 1970s. This review summarizes new developments of the last five years and deals with "small molecules", proteins, and nucleic acids which can either be irreversibly activated with light (these compounds are referred to as "caged compounds") or reversibly switched between an active and an inactive state. 相似文献
15.
"Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step 总被引:1,自引:0,他引:1
Mindt TL Struthers H Brans L Anguelov T Schweinsberg C Maes V Tourwé D Schibli R 《Journal of the American Chemical Society》2006,128(47):15096-15097
Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The "click-to-chelate" approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications. 相似文献
16.
The solvation structure of the hydrated excess proton in concentrated aqueous HCl solution is studied using the self-consistent iterative multi-state empirical valence bond method. At 0.43-0.85 M concentrations, hydronium cations are found to form unusual cation pairs. This behavior is consistent with our earlier finding that hydronium cations can have an "amphiphilic" character due in part to the asymmetric nature of their hydrogen bonding to nearby water molecules. The existence of these hydronium amphiphilic pairs is further supported by a Car-Parrinello ab initio molecular dynamics simulation at 1.0 M HCl concentration. It is also found that the hydronium cation pairs are stabilized by a delocalization of the hydrated excess proton charge defects involving additional water molecules. At the higher concentrations of 1.68 and 3.26 M, the abundance of such hydronium pairs decreases, and the analysis of the radial distribution functions indicates the possible formation of an aggregate structure with longer-ranged order. 相似文献
17.
Hayashi K Shimanouchi T Kato K Miyazaki T Nakamura A Umakoshi H 《Colloids and surfaces. B, Biointerfaces》2011,87(1):28-35
The surface properties of Span 80 vesicles at various cholesterol contents, together with those of various liposomes, were characterized by using fluorescence probes. The membrane fluidity of the Span 80 vesicles was measured by 1,6-diphenyl-1.3.5-hexatriene (DPH) and trimethlyammonium-DPH (TMA-DPH), and the results suggested that the surface of the Span 80 vesicles was fluid due to the lateral diffusion of Span 80 molecules. The depolarization measured by TMA-DPH and the headgroup mobility measured by dielectric dispersion analysis indicated the high mobility of the head group of Span 80 vesicles. This suggested that the surface of Span 80 vesicles was flexible due to the head group structure of Span 80, sorbitol. In addition, spectrophotometric analysis with 6-dodecanoyl-N, N-dimethyl-2-naphthylamine and 8-anilino-1-naphthalenesulfonic acid indicated that the water molecules could easily invade into the interior of the Span 80 vesicle membrane, suggesting that the membrane surface was more wet than the liposome surface. These surface properties indicated that the protein could interact with the interior of vesicle membranes, which was similar to the case of cholesterol. Thus the present results confirmed that the Span 80 vesicle surfaces showed the unique characteristics of fluidity, flexibility, and "wetness", whereas the liposome surfaces did not. 相似文献
18.
A programmable "build-couple" approach to the synthesis of heterofunctionalized polyvalent molecules
A maximally divergent "build-couple" synthesis of heterofunctionalized polyvalent molecules is described. This strategic approach enables the synthesis of highly diverse polyvalent structures from a pre-programmed combinatorial set of modules. 相似文献
19.
Horton DA Severinsen R Kofod-Hansen M Bourne GT Smythe ML 《Journal of combinatorial chemistry》2005,7(3):421-435
Peptidyl privileged structures have been widely used by many groups to discover biologically active molecules. In this context, privileged substructures are used as "hydrophobic anchors", to which peptide functionality is appended to gain specificity. Utilization of this concept has led to the discovery of many different active compounds at a wide range of biological receptors. A synthetic approach to these compounds has been developed on a "safety-catch" linker that allows rapid preparation of large libraries of these molecules. Importantly, amide bond formation/cleavage through treatment with amines is the final step; it is a linker strategy that allows significant diversification to be easily incorporated, and it only requires the inclusion of an amide bond. In addition, chemistry has been developed that permits the urea moiety to be inserted at the N-terminus of the peptide, allowing the same set of amines (either privileged substructures or amino acid analogues) to be used at both the N- and C-termini of the molecule. To show the robustness of this approach, a small library of peptidyl privileged structures were synthesized, illustrating that large combinatorial libraries can be synthesized using these technologies. 相似文献
20.
Kollmar C 《The Journal of chemical physics》2004,121(23):11581-11586
Various energy functionals applying the "JK-only" approximation which leads to two-index two-electron integrals instead of four-index two-electron integrals in the electron-electron interaction term of the electronic energy are presented. Numerical results of multiconfiguration self-consistent field calculations for the best possible "JK-only" wave function are compared to those obtained from the pair excitation multiconfiguration self-consistent (PEMCSCF) method and two versions of density matrix functional theory. One of these is derived making explicit use of some necessary conditions for N representability of the second-order density matrix. It is shown that this method models the energy functional based on the best possible "JK-only" wave function with good accuracy. The calculations also indicate that only a minor fraction of the total correlation energy is incorporated by "JK-only" approaches for larger molecules. 相似文献