On a micro-sphere based remodelling formulation for orthotropic soft biological tissue

An essential property of biological tissues in vivo is the ability to adapt according to respective loading conditions--for example by changing its mass, shape, or internal structure, the latter for instance being associated with fibre reorientation and often denoted as remodelling. In this contribution, a three-dimensional micro-sphere-based constitutive model for anisotropic soft biological tissue is presented, which includes these fibre-reorientation-related remodelling effects. As a key aspect, time-dependent remodelling effects are incorporated by introducing evolution equations for the referential orientations of the integration directions, as present in the computational micro-sphere approach. Based on this, a remodelling formulation for the orthotropic case with two mean fibre orientations will be presented. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

A micro-sphere-based remodelling formulation for anisotropic biological tissues

Soft biological tissues possess a pronounced composite-type multi-scale structure together with strongly anisotropic mechanical properties. A fibre-like network structure is characteristic for this kind of materials. If the tissue is exposed to mechanical loading, the initially possibly unstructured collagen fibre network tends to reorient with the local dominant stretch direction – it adapts according to the particular loading conditions. In general, biological tissues exhibit changes in mass, also denoted as growth, and internal structure, which is commonly referred to as remodelling. In this regard, an anisotropic micromechanically motivated model that incorporates such time-dependent remodelling effects will be discussed in this contribution. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Modeling dissipative effects in anisotropic materials by means of evolving generalized structural tensors

In this work, an anisotropic dissipative model is proposed as an extension of a recently presented polyconvex anisotropic strain-energy function for fiber-reinforced materials. This thermodynamically consistent model is able to describe different softening phenomena and includes residual deformations. The so-called preconditioning behavior of a soft biological tissue sample is considered as a numerical example. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Modeling residual stresses in arterial walls based on anisotropic growth

With the aim of obtaining a general local formulation for anisotropic growth in soft biological tissues, a model based on the multiplicative decomposition of the growth tensor is formulated. The two parts of the growth tensor are associated with the main anisotropy directions. Together with an anisotropic driving force, the model enables an effective stress reduction by including growth-induced residual stresses, which is demonstrated in a numerical example of an idealized arterial segment. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Numerical Calculation of Fiber Orientation in Three-Dimensional Arterial Walls

In this contribution an approach for the fiber reorientation in three-dimensional arterial walls is presented. In detail the load-bearing capacity of the tissue is increased by re orienting the fibers with respect to the principal stresses, cf. [1]. The improved fiber reorientation algorithm is combined with the polyconvex nonlinear anisotropic material model presented in [3]. The results of a three-dimensional finite element simulation, where the reorientation approach is applied to a short segment of a patient-specific arterial geometry, are presented. (© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Application of an anisotropic growth formulation to computational structural design

Common structural optimisation problems consist of problem-specific objective functions which have to be minimised mathematically with respect to design and state variables taking into account particular constraints. In contrast to this, we adopt a conceptually different approach for the design of a structure which is not based on a topology-optimisation technique. Instead, we apply a one-dimensional energy-driven constitutive evolution equation for the referential density–originally proposed for the simulation of remodelling effects in bones–and embed this into the micro-sphere-concept to end up with a three-dimensional anisotropic growth formulation. The objective of this contribution is to investigate this approach with emphasis on its application to structural design problems by means of two three-dimensional benchmark-type boundary value problems. (© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

On the Description of Growth in Saturated Living Tissues

A comprehensive model for biological tissues must include the anisotropic tissue structure, the interstitial liquid wich saturated the tissue and the growth mechanism of the tissue. In the present contribution this is done by use of a three phasic model with a solid, liquid and nutrient phase in the framework of the porous media theory (TPM). In order to characterize the transversal isotropic skeleton behavior, an invariant formulation of the Helmholtz free energy function and the permeability tensor is suggested. The growth mechanism is characterizes by a mass transfer between the nutrient and solid phase. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

A Biphasic Approach for the Simulation of Growth Processes in Soft Biological Tissues Incorporating Damage-Induced Stress Softening

In this contribution a coupled material framework is presented, which considers the effects of damage and growth in soft biological tissues. The tissue is described as a porous medium by taking into account a solid and a fluid phase. The fluid phase is assumed to carry nutrients supplying growth of the solid phase. The latter one is described as a fiber-reinforced material, where a damage variable is introduced for the fiber part of the associated free energy function. The performance of the proposed model is demonstrated in a finite element analysis of a simplified human heart model. (© 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Numerical analysis of micro-stress evolution in dual phase polycrystals

Diffraction methods gain much attention in nondestructive residual stress analysis. While the determination of macroscopic residual stresses is of main interest, the presence of microscopic residual stresses arising from microstructural characteristics of the material can influence the analysis of the acquired data. The residual stress measurements by neutron diffraction on IN718 pancake forgings are analyzed in this work. We present a simple mechanical model supporting the hypothesis that the phase average of the microscopic residual stress accumulated during the forging process is anisotropic causing anisotropy of the macro stress free reference lattice parameter. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

A microstructurally motivated anisotropic viscoelastic model for soft tissues

In this paper, a microstructurally motivated approach to take into account the anisotropic viscoelastic behaviour of soft biological tissues is proposed. The constitutive model is based on the assumption that this behaviour results from an interaction between collagen fibres and surrounding matrix constituents. Accordingly, a non–linear viscoelastic one–dimensional model for fibres and the nearby ground substance is developed. This model is then generalised to the anisotropic three–dimensional case. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

玻壳成型过程诱导残余应力的数值预测

建立了玻壳压制成型固化过程中残余应力预测的数值模拟模型,采用平行平板间玻璃熔体的固化问题来描述成型过程中残余应力形成的机理,并假定材料为热流变简单粘弹性材料．基于板壳理论,将产品视为平板单元的组合,并采用有限元法来求解,这种方法可以象全三维计算一样一层层地计算残余应力,非常适合复杂形状的薄压制成型产品．最后通过实验比较验证了所提出的模型和方法．     

A generalized polyconvex hyperelastic model for anisotropic solids

A generalized polyconvex hyperelastic model for anisotropic solids is presented. The strain energy function is formulated in terms of convex functions of generalized invariants and is given by a series with an arbitrary number of terms. The model addresses solids with orthotropic or transversely isotropic material symmetry as well as fiber-reinforced materials. Special cases of the strain energy function suitable for anisotropic elastomers and soft biological tissues are proposed. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

An anisotropic viscoelastic soft tissue model at large strains

Soft biological tissues represent complex inhomogeneous, and as a rule multiphase materials subjected to large strains under in vivo mechanical conditions. Apart from a number of other structural-related features they are characterized by a ratedependent material behavior which is attributed to fluid-solid interactions as well as intrinsic viscoelastic properties of the solid matrix. The authors propose to model rate-dependent phenomena of the solid phase of soft biological tissues within the context of a thermodynamically consistent phenomenological material approach resulting from an overstress concept. Due to the presence of directed fibrous constituents soft tissues should be considered as anisotropic materials. Therefore, the viscous overstress model has been completed by a transversely isotropic approach. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Modelling of growth inhomogeneities in timber structures for realistic computations

This contribution discusses the numerical analysis of timber structures by means of the Finite Elements Method. As a naturally grown and fibrous material, wood shows distinctive material directions, which are captured by a cylindrically anisotropic model. Due to the growth conditions of a tree, the fiber course in wooden structural parts can differ. Especially branches, leading to knots, affect the mechanical properties. Therefore, an approach for the modelling of these growth inhomogeneities is presented. For the three-dimensional determination of the fiber course in the area of the inhomogeneities, an optimization procedure, using the idea of minimization of shear stresses in tree growth, has been developed. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Modelling and remodelling of biological tissue in the framework of continuum biomechanics

A biological tissue in general is formed by cells, extracellular matrix (ECM) and fluids. Consequently, its overall material behaviour results from its components and their interaction among each other. Furthermore, in case of living tissues, the material properties do not remain constant but naturally change due to adaptation processes or diseases. In the context of the Theory of Porous Media (TPM), a continuum-mechanical model is introduced to describe the complex fluid-structure interaction in biological tissue on a macroscopic scale. The tissue is treated as an aggregate of two immiscible constituents, where the cells and the ECM are summarised to a solid phase, whereas the fluid phase represents the extracellular and interstitial liquids as well as necrotic debris and cell or matrix precursors in solution. The growth and remodelling processes are described by a distinct mass exchange between the fluid and solid phase, which also results in a change of the constituent material behaviour. To furthermore guarantee the compliance with the entropy principle, the growth energy is introduced as an additional quantity. It measures the average of chemical energy available for cell metabolism, and thus, controls the growth and remodelling processes. To set an example, the presented model is applied for the simulation of the early stages of avascular tumour growth in the framework of the finite element method (FEM). (© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Microsopic Simulation of Thermally-Induced 2nd Order Eigenstresses in AlSi-Alloys

Due to the different coefficients of thermal expansion of aluminium and silicon, high residual stresses of second order occur in Al-Si alloys depending on the cooling rate during the molding process. In products as for example crank cases made of Al-Si alloys these residual stresses may cause microcracks. In the work at hand measurements of the eigenstresses in the single phases (i.e. residual stresses of second kind) performed via neutron diffractometry are compared to numerical simulations for a specific cooling rate. To this end a three-phase model is presented, which considers the α aluminium, the eutectic aluminium, and the silicon particles. The presented model is able to predict the residual stresses in the single phases within an elastoplastic framework. The simulation of tensile loadings of these structures are compared to experiments. The numerical computations are carried on stochastic geometry models by using a fast solver [1] for the Lippmann-Schwinger integral equation, which is based on the fast Fourier transformation. (© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Theoretical and numerical aspects in the multiphasic modelling of human brain tissue

A surgical intervention is often required if the functionality of the sensitive human brain tissue is seriously compromised, e. g., due to the occurrence of malignant brain tumours. A promising method for an effective tumour-treatment procedure is given by the so-called convection-enhanced drug delivery (CED), cf. [1]. In this regard, the aim of this contribution is to simulate the expected effects as well as coupled impacts of a (scheduled) CED-procedure with the help of numerical computations, which base on a sophisticated multiphasic and multi-physical modelling strategy applied to human brain tissue. In particular, a quaternary porous-media model, cf. [3–5], is used for the discussion of selected numerical examples and demonstrates the applicability of the model. In detail, the optimal catheter placement and the application of multiple infusion catheters are studied in terms of the occurring anisotropic therapeutic spreading of the infused drug. (© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Deformation of dispersely failing unidirectional composites

An anisotropic medium is considered in which, upon loading, scattered microdamages accumulate giving rise to nonlinear and residual strains. The damage at a point of the medium is characterized by a scalar function on a unit sphere, referred to as the damage function. This function is approximated by a fourth-rank tensor used for specifying the relation between the increments of strains and stresses. The calculation dependences are presented in detail for a unidirectional composite, which is taken to be a homogeneous transversely isotropic medium. Determination of the unknown constants is illustrated by the example of an actual fiberglass plastic. Institute of Polymer Mechanics, University of Latvia, Riga, LV-1006, Latvia. Translated from Mekhanika Kompozitnykh Materialov, Vol. 35, No. 5, pp. 561–574, September–October, 1999.     

Wave Propagation in an Elastic Medium Intersected by Systems of Parallel Fractures

An elastic anisotropic medium intersected by systems of parallel fractures is investigated. Every fracture is considered as a plane boundary with jumps of displacements and stresses, and these jumps are linear functions of displacements and stresses averaged on the boundary. For this medium, an effective model is constructed by the method of matrix averaging. The equations of this model describe wave propagation in the given medium and are more complicated than the equations of elasticity theory. In particular cases, the equations obtained are converted to the equations of elastic media. On the basis of the equations of the effective model, expressions for the densities of the kinetic and potential energies are derived, and conditions of absoption in the medium are established. Bibliography: 15 titles.