共查询到19条相似文献,搜索用时 109 毫秒
1.
二醋酸碘苯促进下, 由邻苯二胺或4-甲基邻苯二胺与各种芳醛通过一步反应合成了13种苯并咪唑类化合物, 反应时间3~5 min, 反应产率83%~98%, 用核磁共振、红外光谱、质谱和元素分析对产物的结构进行了表征. 该合成方法具有底物适用范围广、反应条件温和、反应速度快、反应产率高的优点. 根据实验结果对该反应提出了可能的反应机理. 相似文献
2.
3.
碘促进的苯并咪唑及其衍生物的合成 总被引:3,自引:0,他引:3
在碘的氧化作用下,由伯醇和邻苯二胺一步合成了苯并咪唑及其衍生物。考察了碘和碳酸钾用量及温度对反应产率的影响,反应较佳的条件为n(o-ClC6H4CH2OH)∶n(o-phenylenediamine)∶n(I2)∶n(K2CO3)=1.0∶1.1∶5.0∶5.0,反应温度70℃,反应时间5 h。用方法A在较佳的反应条件下2-(2-氯苯基)苯并咪唑的产率可达86%,用方法B其产率达69%。没有选择传统的醛或酸作为反应底物,而是选择了伯醇在碘的氧化作用下直接合成了目标产物,反应为合成苯并咪唑及其衍生物的一个新方法,探讨了可能的反应机理。 相似文献
4.
苯并咪唑类化合物具有广泛的生物活性,其合成和应用研究一直十分活跃.以2-氨甲基苯并眯唑二盐酸盐与α,β-不饱和酮在三乙胺存在下,以正丁醇为溶剂反应,合成了4种8,10-氢-7H-4b,8,10-三氮杂苯并奠类衍生物,产率61%~67%.反应产物结构通过NMR、MS、元素分析和IR表征. 相似文献
5.
6.
7.
以邻苯二胺及2,3-二氨基吡啶为原料,与羰基化合物反应制备苯并吡嗪、吡啶并吡嗪、苯并咪唑和吡啶并咪唑4种氮杂双环化合物,探讨了溶剂、温度、时间和pH值等实验条件对反应的影响。 在合成吡啶并吡嗪时,采用正丙醇为溶剂,用甲醇钠调节pH=9,回流反应1 h,将收率从35.7%提高至89.4%;在合成苯并吡嗪时,用水作溶剂,用亚硫酸钠调节pH=9,60 ℃反应40 min,产物纯化采用低温静置代替减压蒸馏,收率可提高至98.3%;尝试不同方法合成苯并咪唑和吡啶并咪唑,确定最优合成条件分别为:邻苯二胺在88%的甲酸溶液中回流2 h,苯并咪唑收率为92%;2,3-二氨基吡啶在原甲酸三已酯中回流3 h,加浓盐酸继续回流1 h,吡啶并咪唑收率为84.2%。 相似文献
8.
9.
2,5′-双苯并咪唑衍生物的合成 总被引:6,自引:0,他引:6
以二乙酰氧基碘苯为氧化剂,对邻苯二胺衍生物的席夫碱进行分子内脱氢环全反应,生成新化合物5-[5-(4-甲基-1-哌嗪基)-1H-苯并咪唑基]-2-(4-吡啶基)-1H-苯并咪唑,该反应不仅条件温和、反应迅速,产率良好,而且操作简便安全,所得产物及中间体均经1H NMR,FT-IR以及元素分析表征。 相似文献
10.
11.
《合成通讯》2013,43(14):2101-2106
Various 3-haloflavones were prepared by the reaction of the corresponding flavone derivatives with iodobenzene diacetate and trimethylsilyl halide under mild reaction conditions. The iodobenzene diacetate could be replaced by the polymer supported iodobenzene diacetate without the decreasing activity. 相似文献
12.
Luba Ignatovich Olga Starkova Vitalijs Romanovs Ilze Sleiksha Irina Shestakova Jury Popelis Edmunds Lukevics 《Comptes Rendus Chimie》2013,16(6):621-627
The reaction of 1,2-phenylenediamine with a variety of silicon- or germanium-containing 2-furaldehydes or 2-thienylcarbaldehydes in DMFA gave the corresponding benzimidazole derivatives in moderate yields (36–49%) in the presence of sodium hydrogen sulfite. As a result, a new series of silyl, germyl substituted hetarylbenzimidazoles were synthesized and their in vitro cytotoxicity was studied. The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl and propargyl chlorides and bromides leads to the formation of benzimidazolinium salts. Potential cytotoxic activity of synthesized new benzimidazoles and benzimidazolinium salts was tested in vitro on two monolayer tumour cell lines: MG-22A (mouse hepatoma), HT-1080 (human fibrosarcoma) and normal mouse fibroblasts (NIH 3T3) and compared with corresponding benzimidazoles. 相似文献
13.
14.
A series of novel 1‐phenylthieno[1,2,4]triazolo[4,3‐a]pyrimidin‐5(4H)‐one derivatives 5 and 6 were synthesized by oxidative cyclization of thienopyrimidinonyl hydrazones using iodobenzene diacetate. J. Heterocyclic Chem., (2011). 相似文献
15.
Myung Hee Jung Jewn-Giew Park Bok-Sim Ryu Kui-Woong Cho 《Journal of heterocyclic chemistry》1999,36(2):429-434
2-Pyridin-3-ylbenzoxazoles were synthesized by the reaction between 3-pyridinecarboxaldehyde and substituted o-aminophenols in the presence of iodobenzene diacetate. The resulting benzoxazoles 3 were treated with methyl iodide to give the corresponding pyridinium salts 4 which underwent the hydride reduction with sodium borohydride or sodium cyanoborohydride to produce 2-(1-methyl-1,2,5,6-tetrahy-dropyridin-3-yl)benzoxazole borane complex derivatives. 相似文献
16.
Stable 3-acetyl derivatives of imidazo[1,2-a]benzimidazole were synthesized by the action of acetic anhydride on 2,9-disubstituted imidazo[1,2-a]benzimidazole. The former were also obtained by cyclization of 1-alkyl (aralkyl) -3-acylmethyl-2-iminobenzimidazoline hydrobromides in acetic anhydride in the presence of anhydrous sodium acetate. 3-Benzoyl-substituted imidazo[1,2-a]benzimidazoles, which are unstable in acidic media, were synthesized by the action of benzoyl chloride in the presence of pyridine or excess starting imidazo [1,2-a] benzimidazole.See [1] for communication XI.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 121– 125, January, 1976. 相似文献
17.
《Journal of heterocyclic chemistry》2017,54(2):1590-1597
A new series of 2‐aryl‐5‐((2‐arylthiazol‐4‐yl)methyl)‐1,3,4‐oxadiazole derivatives was synthesized by condensation of 2‐(2‐substituted thiazol‐4‐yl)acetohydrazide with aryl aldehydes followed by oxidative cyclocondensation using iodobenzene diacetate. The structure of synthesized compounds was characterized by IR, NMR, and mass analysis. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity. Some of the compounds showed moderate antimicrobial activity. 相似文献
18.
Myung Hee Jung Jung Mee Park Ihl‐Young Choi Lee Mija Ahn 《Journal of heterocyclic chemistry》2003,40(1):37-44
A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2‐Pyridin‐3‐ylbenzimidazoles 3a‐d have been synthesized by condensation of 3‐pyridinecarbox‐aldehyde 1 with substituted 1,2‐phenylenediamines 2a‐d following oxidative cyclization with iodobenzene diacetate. Methylation of 3a‐d with iodomethane and potassium hydroxide, subsequent formation of methylpyridinium salts 4a‐d and 7a‐d and reduction thereafter afforded tetrahydropyridinylbenzimidazoles 5a‐d and 8a‐d . 相似文献
19.
John W. Barton Michele C. Goodland Ken J. Gould John Hadley John F.W. McOmie 《Tetrahedron》1978,34(4):495-498
Condensation of benzocyclobutene-1,2-dione with 10 derivatives of o-phenylenediamine gave the corresponding benzo-substituted derivatives of 5,10-diazabenzo[b]biphenylene. Attempted oxidative demethylation of 2,3-dimethoxy-5,10-diaza benzo[b]biphenylene gave 2-methoxy-5-phthalimido benzo-1,4-quinone. Other attempts to demethylate methoxy diazabenzobiphenylenes are described. 5,10-Diazabenzo[b]biphenylene was not oxidised by air, lead tetra-acetate, or phenyliodoso diacetate, but with peracetic acid it gave dibenzodiazocine-5,12-dione and o-nitroaniline. Reduction of the diazabiphenylene with Raney nickel gave 2-phenylquinoxaline. The diazabiphenylene is readily hydrolysed by nitric and hydrochloric acid to regenerate benzocyclobutene-1,2-dione and o-phenylenediamine which then recondense to give a mixture of products. A similar hydrolysis occurs with sodium hydroxide 相似文献