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Olga S. Ovchinnikova Vilmos Kertesz Gary J. Van Berkel 《Rapid communications in mass spectrometry : RCM》2011,25(24):3735-3740
This paper describes the coupling of ambient pressure transmission geometry laser ablation with a liquid‐phase sample collection into a continuous flow surface sampling probe/electrospray emitter for mass spectrometry based chemical imaging. The flow probe/emitter device was placed in close proximity to the surface to collect the sample plume produced by laser ablation. The sample collected was immediately aspirated into the probe and onto the electrospray emitter, ionized and detected with the mass spectrometer. Freehand drawn ink lines and letters and an inked fingerprint on microscope slides were analyzed. The circular laser ablation area was about 210 µm in diameter and under the conditions used in these experiments the spatial resolution, as determined by the size of the surface features distinguished in the chemical images, was about 100 µm. Published in 2011 by John Wiley & Sons, Ltd. 相似文献
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We have demonstrated an on‐line laser ablation sampling system and coupling of the system to liquid chromatography (LC) using an infrared (IR) laser to ablate and transfer materials into a flowing solvent stream. With this approach, samples are deposited on a microscope slide mounted on a translation stage and ablated in transmission geometry using a pulsed mid‐IR laser. The ablated material is captured in an exposed flowing solvent stream that carries the ablated material to the electrospray source. Post‐ablation separation is accomplished using a capillary column downstream of the capture zone. The performance of the system was assessed using peptide and protein mixtures ablated from the target and analyzed with and without LC separation. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Remilekun O. Lawal Fabrizio Donnarumma Kermit K. Murray 《Journal of mass spectrometry : JMS》2019,54(3):281-287
A 193‐nm wavelength deep ultraviolet laser was used for ambient laser ablation electrospray ionization mass spectrometry of biological samples. A pulsed ArF excimer laser was used to ablate solid samples, and the resulting plume of the desorbed material merged with charged electrospray droplets to form ions that were detected with a quadrupole time‐of‐flight mass spectrometer. Solutions containing peptide and protein standards up to 66‐kDa molecular weight were deposited on a metal target, dried, and analyzed. No fragmentation was observed from peptides and proteins as well as from the more easily fragmented vitamin B12 molecule. The mass spectra contained peaks from multiply charged ions that were identical to conventional electrospray. Deep UV laser ablation of tissue allowed detection of lipids from untreated tissue. The mechanism of ionization is postulated to involve absorption of laser energy by a fraction of the analyte molecules that act as a sacrificial matrix or by residual water in the sample. 相似文献
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Analysis of non‐derivatised bacteriohopanepolyols by ultrahigh‐performance liquid chromatography/tandem mass spectrometry
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Helen M. Talbot Frances R. Sidgwick Juliane Bischoff Kate A. Osborne Darci Rush Angela Sherry Charlotte L. Spencer‐Jones 《Rapid communications in mass spectrometry : RCM》2016,30(19):2087-2098
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Trong-Mui Do Hui-Fang Hsieh Wei-Ciang Chang E.-E. Chang Chu-Fang Wang 《Spectrochimica Acta Part B: Atomic Spectroscopy》2011,66(8):610-618
In this study we developed a dried-droplet method for laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The proposed method provides accurate and precise results when building calibration curves and determining elements of interest in real liquid samples. After placing just 1 μL of a liquid standard solution or a real sample onto the filter surface and then converting the solution into a very small, thin dry spot, the sample could be applied as an analytical subject for LA. To demonstrate the feasibility of this proposed method, we used LA-ICP-MS and conventional ICP-MS to determine the levels of 13 elements (Li, V, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, Tl, and Pb) in five water samples. The correlation coefficients obtained from the various calibration curves ranged from 0.9920 (205Tl) to 0.9998 (51V), sufficient to allow the determination of a wide range of elements in the samples. We also investigated the effects of Methylene Blue (MB) and the NaCl concentration on the elemental analyses. MB could be used as an indicator during the ablation process; its presence in the samples only negligibly influenced the intensities of the signals of most of the tested elements. Notably, high NaCl contents led to signal suppression for some of the elements. In comparison with the established sample introduction by nebulization, our developed technique abrogates the need for time-consuming sample preparation and reduces the possibility of sample contamination. 相似文献
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Electrospun superhydrophobic polystyrene hollow fiber as a probe for liquid–liquid microextraction with gas chromatography‐mass spectrometry
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Habib Bagheri Mohammad Yahya Baktash Kimia Jahandar 《Journal of separation science》2016,39(19):3782-3788
A superhydrophobic polystyrene hollow fiber was electrospun around a copper spring collector. This approach led to the construction of a hollow fiber membrane, and the copper spring acted as a scaffold. The characteristic properties of the hollow fiber were studied by scanning electron microscopy. The membrane was used as a probe to transfer the extracting solvent from aquatic media to a gas chromatograph. After performing the liquid–liquid microextraction procedure on 10 mL of water sample by octanol, the whole solution was passed through the prepared polystyrene hollow fiber. Propanol, containing 2 mg/L lindane as the internal standard, was used for desorption and an aliquot of 2 μL of the desorbing solvent was subsequently injected into gas chromatography with mass spectrometry. Effects of different parameters influencing the extraction efficiency were optimized. The limits of detection and quantification were 2 and 6 ng/L, respectively. The relative standard deviations at a concentration level of 100 ng/L were between 2 and 6% (n = 3) while the method linearity ranged from 6 to 200 ng/L. Some real water samples were analyzed by the developed method and relative recoveries were in the range of 76–107%. 相似文献
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A non‐instrument‐based method for the analysis of formalin‐fixed paraffin‐embedded human spinal cord via matrix‐assisted laser desorption/ionisation imaging mass spectrometry
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Matthew B. O'Rourke Steven P. Djordjevic Matthew P. Padula 《Rapid communications in mass spectrometry : RCM》2015,29(19):1836-1840
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Koshi Nagai Baasanjav Uranbileg Zhen Chen Amane Fujioka Takahiro Yamazaki Yotaro Matsumoto Hiroki Tsukamoto Hitoshi Ikeda Yutaka Yatomi Hitoshi Chiba Shu‐Ping Hui Toru Nakazawa Ritsumi Saito Seizo Koshiba Junken Aoki Daisuke Saigusa Yoshihisa Tomioka 《Rapid communications in mass spectrometry : RCM》2020,34(Z1)
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《Rapid communications in mass spectrometry : RCM》2018,32(2):159-166