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本文使用组合化学方法以聚苯乙烯亚磺酸钠树脂为载体合成了2,5-取代-1,3,4-恶二唑化合物库。树脂1首先与溴代乙酸乙酯反应聚合物支载的乙酸酯。肼解后所得的肼树脂进一步与取代的苄氯反应得双酰肼树脂。树脂4与三氯氧磷回流得聚合物支载的2,5-取代-1,3,4-恶二唑。 相似文献
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3-丙酰基-2;5-二芳基-1;3;4-噁唑啉类化合物的合成;噁唑啉;衍生物;合成;结构表征 相似文献
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以3-( 4-氟苯基) -1H-吡唑-5-甲酸乙酯为原料,与H2NNH2?H2O发生肼解生成3-( 4-氟苯基) -1H-吡唑-5-甲酰肼,再与CS2环化生成2-巯基噁二唑中间体,最后在巯基上进行烷基化反应合成了一系列新型的2-硫醚-5-吡唑基-1,3,4-噁二唑类化合物,并利用IR、1H NMR、HRMS等波谱技术对目标化合物结构进行了表征。该合成方法具有原料易得,后处理简便,收率较高的优点。 相似文献
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3-N-乙酰基-2-取代芳基-5-[5'-甲基-异噁唑-3']-Δ3-1,3,4-噁唑啉类化合物的合成 总被引:31,自引:0,他引:31
甲基-异噁唑甲酰肼;3-N-乙酰基-2-取代芳基-5-[5'-甲基-异噁唑-3']-Δ3-1;3;4-噁唑啉类化合物的合成 相似文献
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3-(3-乙酰基-5-芳氧亚甲基-2;3-二氢-1;3;4-噁二唑-2-基)色酮类化合物的合成;噁二唑啉;色酮;合成 相似文献
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1,3,4-二唑类化合物具有广泛的生物生理活性,如杀菌[1]、除草[2]、杀虫[3]和消炎[4]等,而2,5-二芳基-1,3,4-二唑类化合物一般具有昆虫生长调节活性,1980年美国Dow公司报道了2,5-双(2,4-二氯苯基)-1,3,4-二... 相似文献
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以2-甲基-4-氨基-5-氰基嘧啶为原料,通过水解、酯化、肼解、环化和醚化等步骤,合成了12个含1,3,4-噁二唑(噻二唑)取代嘧啶化合物。通过1H NMR,13C NMR,MS 和元素分析进行确证其结构。初步抑菌活性测试标明,化合物浓度在50 μg/mL时,化合物6f和6f′对油菜菌核病菌(S. sclerotiorum)、马铃薯晚疫病菌(P. infestans)、水稻纹枯病(T. cucumeris)、小麦赤霉病菌(G. zeae)具有中等抑制率,其活性与对照药剂醚菌酯相当。 相似文献
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2-苯基-5-芳基-1,3,4-噁二唑的合成与表征 总被引:2,自引:5,他引:2
苯甲酸乙酯与水合肼反应制得苯甲酰肼(1),1再分别与芳酰氯反应制得N、N′-二酰基肼(3a~3i),3a~3i在POCl3作用下脱水环化生成2-苯基-5-芳基-1,3,4-噁二唑(4a~4i)。其结构经元素分析,IR,^1H NMR和MS表征,并对其裂解途径进行了探讨。 相似文献
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De Jiang LI He Qing FU 《中国化学快报》2006,17(5):625-627
1, 3, 4-Oxadiazoline derivatives are found to possess significant biological activities such as antifungal1, insecticidal2, CNS depressant3-5, anticonvulsant effects and plant growth accelerator. They are highly important heterocycles, and have been used … 相似文献
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E. Karthikeyan S. Perumal s. Selvaraj 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2379-2386
Diastereoselective synthesis of a series of (Z)-1-[3-aryl-2-(phenylsulfanyl)-2-oxiranyl]-1-ethanones was effected from the reaction of (Z)-4-aryl-3-(phenylsulfanyl)-3-buten-2-ones with alkaline hydrogen peroxide in tetrahydrofuran. The stereochemistry of the oxiranes has been deduced from two-dimensional NOESY spectrum. 相似文献
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Malose J. Mphahlele Omankutty Gheevarghese Nkosinathi F. H. Makhubela 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):303-314
Abstract O-Mesyloximes derived from 2-aryl-1,2,3,4-tetrahydro-1-methylsulfonyl-4-quinolones react with sodium ethoxide in ethanol to afford the 4-amino-2-arylquinolines in high yield. No traces of the 3-amino-2-aryl-4-quinolones expected from the Neber rearrangement of the substrates were detected or isolated from the reaction mixture. The structures of the products were determined using a combination of 1H NMR, 13C NMR, IR and mass spectroscopic techniques. 相似文献
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M.-G. A. Shvekhgeimer O. A. Ushakova V. V. Nesterov M. Yu. Antipin 《Chemistry of Heterocyclic Compounds》2005,41(2):181-186
2-Cyanoaryldiazonium bisulfates, obtained by the action of nitrosyl sulfuric acid on isatin 3-hydrazone and its 5-bromo and 5-nitro derivatives, couple with 1-aryl-3-methylpyrazol-5-ones and form 4-arylhydrazones of 1-aryl-3-methylpyrazole-4,5-diones. It was established on the basis of data of IR, UV, and 1H NMR spectra and of X-ray structural analysis that the coupling products exist in the hydrazone form stabilized by an intramolecular hydrogen bond.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 210–215, February, 2005. 相似文献
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3-Aryl-4-(5-aryl-Δ2-1,2,4-oxadiazolin-3-yl)sydnones (5) were synthesized in high yields by the reaction of 3-arylsydnone-4-carboxamide oximes (prepared from the corresponding 3-arylsydnone-4-carbonitriles) with aromatic aldehydes in the presence of acid catalysts. No reaction occurred when aliphatic aldehydes were used. The oxadiazolin-3-ylsydnones (5) were easily converted into the corresponding 3-aryl-4-(5-aryl-1,2,4-oxadiazol-3-yl)sydnones by N-bromosuccinimide oxidation. The 3-arylsydnone-4-carbonitrile oxides were synthesized in good yields by N-bromosuccinimide oxidation of the corresponding 3-arylsydnone-4-carboxaldehyde oximes. 相似文献
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The reactions of 1-aryl-4-hydrazinocarbonyl-2-pyrrolidinones with 2,4-pentanedione and 2,5-hexanedione have been studied.
It was found that heating the hydrazinocarbonyl compounds with 2,4-pentanedione gave 3,5-dimethylpyrazole compounds and with
2,5-hexanedione gave 1-substituted 2,5-dimethylpyrroles.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 229–232, February, 2008. 相似文献