共查询到16条相似文献,搜索用时 93 毫秒
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以冰乙酸为催化剂,将取代吡唑甲醛和巴比妥酸或硫代巴比妥酸在无水乙醇中进行Knoevenagel缩合反应,合成了6个5-(取代吡唑基-4-次甲基)(硫代)巴比妥酸。标题化合物经IR、1^HNMR、元素分析确证结构。 相似文献
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室温离子液体促进的5-亚芳基巴比妥酸衍生物的合成 总被引:1,自引:0,他引:1
在室温离子液体1-丁基-3-甲基咪唑四氟硼酸盐([bmim]BF4)存在下, 采用室温研磨和微波辐射的方法, 由芳香醛和巴比妥酸或硫代巴比妥酸经Knoevenagel缩合反应, 制备了相应的5-亚芳基巴比妥酸或5-亚芳烃基硫代巴比妥酸衍生物. 在室温研磨条件下反应2 h, 产率为78%~96%, 在微波辐射功率为160 W时反应20 s, 产率为82%~98%, 产物结构经1H NMR确证. 相似文献
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5-(吲哚基-3-次甲基)(硫代)巴比妥酸的合成 总被引:1,自引:0,他引:1
以冰乙酸为催化剂,吲哚-3-甲醛与巴比妥酸或硫代巴比妥酸在无水乙醇中进行Knoevenagel缩合,合成了5-(吲哚基-3-次甲基)巴比妥酸或5-(吲哚基-3-次甲基)(硫代)巴比妥酸,其结构经1H NMR和IR表征. 相似文献
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应用量子化学AM1半经验方法分别对巴比妥酸及硫代巴比妥酸的葡萄糖基系列取代衍生物B1-5和T1-5进行几何优化。基于优化后的稳定构型,利用INDO/CI方法计算其电子光谱。同时,根据完全态求和(SOS)公式计算其二阶非线性光学系数。结果显示,当葡萄糖基单元数增加时,无论是巴比妥酸衍生物还是硫代巴比妥酸衍生物,|βμ| 均增大,尤其是硫代巴比妥酸衍生物增大更为显著,表明此种非共轭取代基同样可以改善材料的非线性光学性质。此外,随葡萄糖基链增长时,光谱的变化并不十分显著,且由于所有吸收带均在紫外光区内,因此推测所有体系均有望成为具有高度透明性的非线性光学侯选材料。 相似文献
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I. N. Klochkova A. A. Anis’kov M. P. Shchekina S. V. Chuvaikina K. A. Andreev 《Russian Journal of Organic Chemistry》2013,49(9):1344-1347
Carbocyclization of unsymmetrical 1,5-diarylpenta-1,4-dien-3-ones with thiobarbituric acid afforded previously unknown 7,11-diaryl-3-thioxo-2,4-diazaspiro[5.5]undecane-1,5,9-triones with high regio- and stereoselectivity. The same spiro compounds were also synthesized by three-component condensation of thiobarbituric acid with the corresponding aromatic aldehydes and 4-arylbut-3-en-2-ones. 相似文献
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在哌啶和醋酸催化下,1,8-二甲氧基-4,5-二甲酰基-9,10-二氢蒽和异佛尔酮巴比妥酸衍生物经Knoevenagel缩合合成了具有NLO性质的发色团化合物。在这些发色团中,环锁定的三烯和9,10-二氢蒽用作共轭桥,巴比妥酸和甲氧其分别作为吸电子和给电子基, 组成非共轭的两个D-π-A单位。溶剂变色法和紫外光谱研究证实它们比相应的参考物有较大的NLO活性并能保持与参考化合物相同的透光性。 相似文献
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N. N. Suvorov V. S. Velezheva V. V. Vampilova 《Chemistry of Heterocyclic Compounds》1974,10(5):559-562
5-(3-Indolylmethyl)barbituric and 5-(3-indolylmethyl)thiobarbituric acids were obtained by condensation of 3-indolylmethylmalonic ester with urea and thiourea in monoglyme (1,2-di-methoxyethane) in the presence of lithium methoxide. The first of the two acids was also obtained by catalytic hydrogenation of 5- (3-indolylmethylene)barbituric acid. 相似文献
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V. M. Vvedenskii M. P. Makukha L. Ya. Makarina-Kibak 《Chemistry of Heterocyclic Compounds》1972,5(6):830-831
Aromatic and aliphatic aldehydes readily condense with thiobarbituric acid to form 5-arylidenethiobarbituric acids or 5-arylidenebis(thiobarbituric acid)s. A longer time is required for condensation with ketones. The UV spectra of the arylidene derivatives have two absorption bands, with maxima at 240–275 and 280–405 nm, while the spectra of the alkylidene derivatives only one absorption band, with a maximum at 280–295 nm.For part I, see [1]. 相似文献
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M. Bararjanian S. Balalaie B. Movassag A. M. Amani 《Journal of the Iranian Chemical Society》2009,6(2):436-442
An efficient protocol has been developed for the synthesis of various pyrano[2,3-d]pyrimidinones from condensation of aromatic aldehydes, malononitrile and barbituric-or thiobarbituric acid in aqueous ethanol using L-proline as a neutral bifunctional catalyst. 相似文献
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《Journal of heterocyclic chemistry》2018,55(1):154-160
An efficient P2O5 mediated protocol for the synthesis of pyrido[2,3‐d:6,5‐d]dipyrimidines has been developed through one‐pot three‐component condensation of aromatic aldehydes, barbituric acid/thiobarbituric acid, and 1,3‐dimethyl‐6‐amino‐uracil in ethanol. All the synthesized products were screened for their in vitro antitubercular activity, and results reveal that most of the compounds exhibited moderate to good activity against Mycobacterium tuberculosis H37RV strain. 相似文献