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1.
At 140 °C in acetic anhydride enol acetates of -(3,5-dimethyl-1,2,4-triazol-1-yl)-2,4dichloroacetophenone and -(1,2,4-triazol-1-yl)-2,4-dichloropropiophenone undergo 1,3and 1,5-rearrangement, respectively.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 182–184, January, 1995. 相似文献
2.
Aouine Y Faraj H Alami A El-Hallaoui A Elachqar A Kerbal A 《Molecules (Basel, Switzerland)》2011,16(4):3380-3390
A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected β?aminoalcohol by potassium permanganate. 相似文献
3.
I. M. Shtyrkov G. V. Roitburd V. P. Tashchi M. Z. Krimer 《Russian Chemical Bulletin》1991,40(12):2460-2463
The reaction of 4-amino-1-phenacyl-1,2,4-triazolium bromides with an excess of nitrous acid leads to a mixture of the corresponding -(1,2,4-triazol-1-yl)-acetophenones and -hydroximino--(1,2,4-triazol-1-yl)acetophenones. Products of the latter type are formed during nitrosation at the methylene group of both the intermediate -triazolylacetophenones, and the starting 4-amino-1-phenacyl-1, 2,4-triazolium bromides. The role of Br– as a catalyst is significant for both nitrosation paths. In the reaction of -(1,2,4-triazol-1-yl)acetophenones with HNO2, SCN– is a more active catalyst than Br–. During the nitrosation of para-substituted 4-amino-1-phenacyl-1,2,4-triazolium bromides, the yield of -hydroximino--(1,2,4-triazol-1-y1)acetophenones increases with increase in the acceptor properties of the aryl substituent, which is explained by the increase in the CH-acidity of the nitrosation substrates.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2821–2824, December, 1991. 相似文献
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Krzysztof Walczak Jesper Wengel Erik B. Pedersen 《Monatshefte für Chemie / Chemical Monthly》1992,123(4):349-354
Summary Mercuric catalyzed hydrolysis of acetylatedL-rhamnal1 gave the ,-unsaturated aldehyde2. 1,2,4-Triazole was coupled, in a Michael type addition reaction, to2 at C-3 in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give, after acetylation at the anomeric center, an anomeric mixture of 1,5-di-O-acetyl-3-(1,2,4-triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranose (3). Reaction of3 with silylated 2,4-dihydroxypyrimidines4 in the presence of trimethylsilyl triflate as catalyst followed by deprotection with 33% methylamine in absolute ethanol afforded the corresponding nucleosides7 and8.
Synthese von 1-(3-(1,2,4-Triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranosyl)uracilen über eine ,-ungesättigte Aldohexose
Zusammenfassung Die quecksilberkatalysierte Hydrolyse von acetyliertemL-Rhamnal1 ergab die ,-ungesättigten Aldehyde2. 1,2,3-Triazol wurde in Gegenwart von 1,8-Diazabicyclo[5.4.0]-7-undecen mittels einer Addition vom Michael-Typ an C-3 von2 gekoppelt und ergab dann nach Acetylierung am anomeren Zentrum eine anomere Mischung von 1,5-Di-O-acetyl-3-(1,2,4-triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranose (3). Die Reaktion von3 mit silyliertem 2,4-Di-hydroxypyrimidinen4 in Gegenwart von Trimethylsilyltriflat in absolutem Ethanol ergab die entsprechenden Nucleoside7 und8.相似文献
5.
Triazole derivatives are widely studied, because they represent the largest group of modern fungicides and are widely used both in human and veterinary therapy and in agriculture. We synthesized the title compound in which the thiophene ring was substituted by a 1,2,4-triazole group, a phenacyl group, a phenylaminol group and a benzene ring. 相似文献
6.
Ourstudieswithlsonucleos!desandlsocarbonuc!eosldehavebeencarriedouttosearchforafltl.C3flCCF3fldfifltlV!rsl3CtlV!tICS‘2‘且SOCdfboflUCICOSldCIs3flCWCldSSO贯nUCICOSldCanalogueSInWhiChthefluCleobaSCIsllnkCdtothepOSitionOInbOSeOillerthanCIbycarbon-carbonbond.巨hesynthesisofcarbonucleosldeshasbeencaYFledoutsuccessfullyforseveralyears‘5’.Thesynthesisofderlvatlvesoff.2,4-oxadlazolecarbonucleosldebearingp-D-xylopyranosylmoietyhasbeenreported’·’.Someofthemshowe… 相似文献
7.
Agata Siwek Monika Wujec Joanna Stefańska Piotr Paneth 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):3149-3159
Four 4-aryl-3-(2-methyl-furan-3-yl)-Δ2-1,2,4-triazole-5-thiones were synthesized by intramolecular cyclization of 4-aryl-1-[(2-methyl-furan-3-yl)carbonyl]thiosemicarbazides in alkaline medium. The antimicrobial activity of the synthesized triazoles was evaluated. Semiempirical calculations of geometries, energies, and QSAR parameters have been determined in the hope of gaining insight into different biological activities of closely related isomers. New RM1 parameterization has been shown to perform very well for this class of compounds. 相似文献
8.
Mikhailov I. E. Popov L. D. Vikrischuk N. I. Beldovskaya A. D. Dushenko G. A. Revinskii Yu. V. Minkin V. I. 《Russian Journal of General Chemistry》2017,87(1):156-158
Russian Journal of General Chemistry - The interaction of 4-oxo-1,3-benzoxazinium perchlorate with 2-pyridylhydrazine has given 5-(2-hydroxyphenyl)-3-ethyl-1-(pyridin-2-yl)-1Н-1,2,4-triazole... 相似文献
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Wen PEI* Kobe JOZE College of Chemical Engineering Zhejiang University of Technology Hangzhou National Institute of Chemistry Hajdrihova SI- Ljubljana Slovenia 《中国化学快报》2001,(6)
Much attention is currently focused on the design of new generations of platinum anti-cancer complexes to prevent resistance of cisplatin. We have developed a new platinum-based antitumor agent with broad-spectrum antiviral activity. The cis-[Pt(DMSO)2Cl2] and K[Pt (DMSO) Cl3] reacted with 1-??-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and its deoxy-analogue (deoxyribavirin) to give the coordinated complexes which exhibited activity against both DNA and RNA viruses1. The… 相似文献
12.
《Tetrahedron》1987,43(10):2223-2228
13.
COOEtCOCH3(CH3)2NNHNH2NNCH3OOEtNH2NH2NNCH3ONHNH2PhNCSNNCH3ONHNHCNHSOH-NNCH3NNHNPhS12345 1 INTRODUCTION A large number of 1,2,4-triazole derivatives have been synthesized in recent years[1~4]. Many of them are reported to exhibit broad spectrum biologi-… 相似文献
14.
《高等学校化学研究》2007,(1)
Introduction1,2,4-Triazole derivatives represent an interesting class of heterocyclic compounds[1]and have become the most rapidly expanding group of antifungal compounds with the advantages of toxicity, high oral bioavailabi-lity, and broad spectrum of a… 相似文献
15.
A simple approach involving refluxing appropriately disubstituted thiosemicarbazide 8 in presence of formic acid for the synthesis of 1, a potent azole antifungal agent, has been described. 相似文献
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Alan R. Katritzky Saad El-Zemity Hengyuan Lang Ezzat A. Kadous Abdallah M. El-Shazly 《合成通讯》2013,43(2):357-365
1-(α-Aminomethyl)-1,2,4-triazoles readily add to enol ethers or enamides to give novel classes of compounds, 1-(γ-amino-α-alkoxy)propyl- (8) and 1-(γ-amino-α-amido)propyl- (10) substituted 1,2,4-triazoles, in excellent yields. 相似文献
18.
Synthesis and Crystal Structure of N′-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide
LI Wei-hua ZHANG Shu-fang + HOU Bao-rong YU Zhi-gang *. Institute of Oceanology Chinese Academy of Sciences Qingdao P. R. China. College of Chemistry Chemical Engineering Ocean University of China Qingdao P. R. China 《高等学校化学研究》2006,(5)
IntroductionBoth triazole derivatives and Schiff base have beenreported to possess significant antifungal[1—3]and plantgrowth regulatory activities[4—6].Triazole drugs are alsovery common in the medical field,which has given animmense impetus to the res… 相似文献
19.
1INTRODUCTIONTheCIDT(N-cyanoimido-S,S-dimethylthiocarbo-nate)hasbeenwidelyutilizedinorganicsynthesisduringthelasttwodecadesandhasbecomeveryusefulforconstructingfunctionalizedheterocyliccom-poundsbecauseoftheirversatility.MuchattentionhasrecentlybeenfocusedonthedevelopmentofCIDTaswellastheirsyntheticapplications[1~4].Meanwhile,manypyrazoleandtriazolederivativesarereportedtoshowvariousbiologicalactivities,suchasantifungal[5],herbicidal[6~8],insectcidal[9]andotheractivities[10~12].Thu… 相似文献
20.
成功地合成了化合物rac-3-[(1H-1,2,4-三唑-1-基)甲基]-1,1′-联萘酚,利用X射线单晶衍射确定了其空间结构;与此同时,利用1H NMR1、3C NMR和元素分析确认了所合成的中间体及目标产物的化学结构.结果表明,目标化合物晶体属于单斜晶系,P21/C空间群,晶胞参数a=1.141 39(10)nm,b=0.955 53(8)nm,c=1.688 16(14)nm,β=97.305(4)°,V=1.826 2(3)nm3,Z=4,Dc=1.336 g/cm3,F(000)=768,wR=0.105 9.目标分子通过分子间氢键作用相互堆积,形成空间三维结构. 相似文献