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1.
为检验定量位点和单个标记位点的等位基因之间的关联性,Schork等[2000]提出了一个odds ratio检验,这个检验是基于抽取不相干“病例”和“对照”个体.但是该检验会因人群混合或分层的影响而失效.受Risch.Zhang[1995]和Schork等[2000]的启发,我们考虑采用非一致同胞数据,并提出一个简单的检验方法.由于该检验是基于家庭的,对人群混合或分层不敏感.该检验很容易推广到多个标记位点的情形,并可以利用所有的含有至少一个“病例”个体和一个“对照”个体的同胞数据.通过数值计算讨论了检验的统计性质,特别研究了高分位点和低分位点(用来定义非一致同胞)的选取对检验功效的影响,讨论的结果对实际应用具有指导作用.进一步的随机模拟表明,利用多个标记位点数据能够明显地提高功效.此外,通过随机模拟比较了文中提出的检验和Allison等[1999]的检验的功效.结果显示,如果适当地选取两个分位点,我们的检验更有效.  相似文献   

2.
基于不可逆热力学,引入运动硬化、等向硬化和损伤内变量,构造了相应的自由能函数和流动势函数,推导出了混凝土材料的粘塑性损伤本构模型.数值模拟的结果表明,该模型能够避开屈服面和破坏准则的基本假设来描述混凝土材料的以下特性:压缩载荷作用下的体积膨胀现象;应变率敏感性;峰值后由损伤和破坏引起的应力软化和刚度退化现象A·D2由于此模型避开了根据各种变形阶段选择与其相应的本构模型的繁琐计算,因此更便于纳入复杂工况下应力分析有限元程序中.  相似文献   

3.
一种改进的遗传k-means聚类算法   总被引:8,自引:0,他引:8  
在经典的k-means聚类算法中,聚类数k必须事先给定,然而在现实中k很难被精确的确定.本文提出了一种改进的遗传k-means聚类算法,并构造了一个用来评价分类程度好坏的适应度函数,该适应度函数考虑的是在提高紧凑度(类内距)和分离度(类间距)的同时使得分类个数尽可能少.最后采用两个人工数据集和三个UCI数据集对k-means聚类算法(KM),遗传聚类算法(GA),遗传k-means聚类算法(GKM)和改进的遗传k-means聚类算法(IGKM)进行比较研究,比较的指标有类间距、类内距和分类正确率.研究证明改进的遗传k-means算法能够自动获取最佳聚类数k并且保持较高的正确率.  相似文献   

4.
考虑气象因素的短期负荷预测模型研究   总被引:1,自引:0,他引:1  
短期负荷预测是针对未来一天到数天各时段的负荷预测的研究,是电力系统负荷预测工作的一项重要内容.针对传统神经网络预测模型应用于短期负荷预测的缺陷,改进了多角度数据分析和组织策略,选择不同年份相近历史日作为相似日,通过最小二乘支持向量机填补确实数据,利用聚类算法预测相似日的短期负荷;同时通过灰度关联算法,考虑气象因素作用下的短期负荷预测模型.实例证明:通过建立与负荷数据相适应的数学模型,对负荷数据进行分析与预测,通过气象因素修正预测模型,可以获得更精确的负荷数据预测.  相似文献   

5.
利用内聚力模型(CZM)模拟弹粘塑性多晶体的裂纹扩展   总被引:2,自引:0,他引:2  
采用内聚力模型(CZM),模拟多晶体中起裂于晶界的二维平面应变裂纹扩展.结果表明,弹粘塑性体中,初始裂纹尖端不会最先开裂.晶体本构的率敏感指数表征了塑性变形和内聚力区耗散两种机制的相互竞争.率敏感指数越大,塑性耗散能越大,内聚力区粘着能越小,使材料的塑性变形越容易,内聚力区诱发的破坏越不易;率敏感指数越小,材料响应越接近弹塑性性质,塑性耗散能减小,粘着能增大,外力功易转化为内聚力区的粘着能,使内聚力单元更易分离.增大内聚力区结合强度或临界张开位移使晶内和晶界的三轴应力度减小,即提高内聚力区韧性也使基体材料抗孔洞损伤能力提高.  相似文献   

6.
函数S-粗集(function singular rough sets)是用R-函数等价类定义的,函数是一个规律,函数S-粗集具有规律特征.函数S-粗集推广了Z.Pawlak粗集.利用函数S-粗集,给出规律生成,规律分离的讨论,提出规律分离定理.给出的结果在投资分险规律估计中得到了应用.  相似文献   

7.
Based on the classical laminated plate theory and the cohesive zone model, a theoretical model for general delamination cracked laminates was established for crack propagation of pure mode Ⅱ ENF specimens. Compared with the conventional beam theory, the proposed model fully considered the softening process of the cohesive zone and introduced the nonlinear behavior of ENF specimens before failure. The predicted failure load is smaller than that under the beam theory and closer to the experimental data in literatures. Compared with the beam theory with only fracture toughness considered, the proposed model can simultaneously analyze the influences of the interface strength, the fracture toughness and the initial interface stiffness on the load-displacement curves in ENF tests. The results show that, the interface strength mainly affects the mechanical behavior of specimens before failure, but has no influence on crack propagation. The fracture toughness is the main parameter affecting crack propagation, and the initial interface stiffness only affects the linear elastic loading stage. The cohesive zone length increases with the fracture toughness and decreases with the interface strength. The effect of the interface strength on the cohesive zone length is more obvious than that of the fracture toughness. When the adhesive zone tip reaches the half length of the specimen, the adhesive zone length will decrease to a certain extent. Copyright ©2022 Applied Mathematics and Mechanics. All rights reserved.  相似文献   

8.
The problem on the stress–strain state near a mode I crack in an infinite plate is solved in the frame of a cohesive zone model. The complex variable method of Muskhelishvili is used to obtain the crack opening displacements caused by the cohesive traction, which models the failure zone at the crack tip, as well as by the external load. The finite stress condition and logarithmic singularity of the derivative of the separation with respect to the coordinate at the tip of a physical crack are taken into account.The cohesive traction distribution is sought in a piecewise linear form, nodal values of which are being numerically chosen to satisfy the traction-separation law. According to this law, the cohesive traction is coupled with the corresponding separation and fracture toughness. The tips of the physical crack and cohesive zone (geometric variables) along with the discrete cohesive traction are used as the problem parameters determining the stress-strain state. If the crack length is included in the set, then the critical crack size can be found for the given loading intensity.The obtained determining system of equations is solved numerically. To find the initial point for a standard numerical algorithm, the asymptotic determining system is derived. In this system, the geometric variables can be easily eliminated, which make it possible to linearize the system.In the numerical examples, the one-parameter traction-separation laws are used. Influence of the shape parameters of the law on the critical crack size and the corresponding cohesive length is studied. The possibility of using asymptotic solutions for determining the critical parameters is analysed. It is established that the critical crack length slightly depends on the shape parameter, while the cohesive length shows a strong dependence on the shape of cohesive laws.  相似文献   

9.
半无穷大裂纹端部粘聚力分析   总被引:2,自引:0,他引:2  
准脆性材料裂纹端部断裂过程区粘聚力是导致非线性断裂特性的重要原因,根据准脆性材料的断裂特性,对存在粘聚力分布的半无穷大裂纹力学分析模型,由变形叠加原理得到以该粘聚应力分布为未知函数的积分方程,通过对积分方程的分析推证,得到了该分布函数解的数学结构和级数型表达式;提出了由实际裂纹张开位移,确定裂纹端部粘聚力分布函数的两种方法:其一由连续的裂纹张开位移通过积分变换求解未知函数级数展开项的系数,其二是由离散的裂纹张开位移数据通过最小二乘法确定该函数;推导出了相应方法求解未知量的代数方程,并且给出了适当的算例和讨论。  相似文献   

10.
The paper addresses the analysis of a model for a thin shallow linear elastic shell with a smooth vertical through crack that is based on the Kirchhoff–Love shell theory and accounts for cohesive forces acting between the crack faces. We follow the basic idea behind the Barenblatt theory assuming that the density of the total energy spent by the cohesive forces is the sum of longitudinal and transverse contributions, each of which in general is nonconvex. In order to eliminate nonphysical interpenetration of the crack faces, an inequality constraint that involves both the normal component of the longitudinal displacements and the normal derivative of the transverse deflection of the crack faces is imposed. We first prove the existence of minimizers for the total energy and study in detail the Euler–Lagrange system for them. Then we derive the left and right Eulerian shape derivatives of the minimal value of the total energy by developing a fully variational technique. Finally we apply the developed technique coupled with a difference quotient argument to obtain higher differentiability results in Besov and Sobolev spaces for the minimizers.  相似文献   

11.
The presented procedure for cohesive crack propagation is based on an adaptive finite element (FE) implementation, which enables the introduction of cohesive surfaces in dependence on the current crack state. In contrast to already existing formulations, the focus of the present model lies on failure processes that can be described at quasi-static conditions within an implicit framework. Furthermore, an extension for mesh independent crack propagation in terms of an additional mesh adaptive formulation is presented. By the evaluation of the failure criterion considering the preferred crack direction, a new crack tip coordinate is computed and the discretization is accordingly adjusted. The remaining mesh is modified for the new boundary representation. The application of the proposed method is shown by the numerical investigation of a concrete fracture specimen from an experimental research project. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)  相似文献   

12.
知识规律与规律的属性扰动   总被引:1,自引:0,他引:1  
By employing the knowledge(R-element equivalence class)in one direction Srough sets and dual of one direction S-rough sets,the concept of knowledge law is given;the generation theorem of knowledge law,the excursion theorem of knowledge law,and the attribute disturbance discernible theorem of knowledge law are proposed.Knowledge law is a new characteristic of S-rough sets.  相似文献   

13.
在水槽中测量了中等雷诺数下平板湍流边界层中的瞬时流向速度的时间序列,验证了Benzi提出的推广的自相似标度律,用子波变换将壁湍流脉动速度分解为多尺度湍涡结构的速度,研究了每一个尺度的湍涡速度结构函数的推广的自相似标度律。主要结论如下:湍流的统计性质是自相似的,这不仅适用于充分发展湍流,而且适用于中等雷诺数和低雷诺数湍流,而且具有相同的标度指数;推广的自相似标度律的适用的尺度范围远远大于惯性子区的范围,可以一直延伸至耗散区的尺度范围;推广的自相似标度律不仅适用于均匀各向同性湍流,也适用于剪切湍流如边界层湍流。  相似文献   

14.
在反平面剪切载荷及侧压力共同作用下引起的裂纹及裂纹扩展导致的层间界面失效,是岩土工程层间界面及砌体结构中界面层上典型的失效方式.运用弹性力学和断裂力学的理论原理,提出了能够反映上述层间界面断裂失效问题力学特性的剪切梁模型.文中采用具有应力软化特性的“粘性裂纹”(内聚力裂纹)模型来表述层间裂纹前方损伤过程区的本构行为.对通过粘性层结合在一起的两个弹性板,在反平面剪切载荷及侧压力共同作用下的力学行为作了解析分析计算,研究了层间界面裂纹扩展规律.  相似文献   

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