由酮合成对称二烃基二硒醚的新方法

在正丁胺的催化下, 酮与硒氢化钠, 二硒化钠乙醇溶液通过"一锅"法反应得到了中等产率的二硒醚.     

A new reagent for the efficient synthesis of disulfides from alkyl halides

Benzyltriethylammonium tetracosathioheptamolybdate [(C₆H₅CH₂N(Et)₃)₆Mo₇S₂₄] has been found to be a superior sulfur transfer reagent for the conversion of alkyl halides to the corresponding disulfides in excellent yields under very mild reaction conditions.     

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new tools was demonstrated by their application to a flow Staudinger aza-Wittig reaction sequence. Finally, a multistep aza-Wittig, reduction and purification flow process was designed, allowing access to amine products in an automated fashion.     

CuO nanoparticles-catalyzed a novel method to the synthesis of symmetrical diselenides from aryl halides: selenoamide as an organic Se-donor reagent

A new method is reported for the synthesis of symmetrical diaryldiselenides from aryl halides using selenoamide as an organic Se-donor reagent in the presence of copper (II) oxide nanoparticles. CuO nanoparticles were found to be an efficient and inexpensive catalyst for ligand-free C-Se bond formation with a series of symmetrical diaryldiselenides obtained in good to excellent yield.     

Tetraethylammonium tetraselenotungstate: a new and efficient selenium transfer reagent for the chemoselective synthesis of functionalised diselenides

A variety of functionalised organodiselenides were prepared in excellent yields from the corresponding halides and activated alcohols on treatment with tetraethylammonium tetraselenotungstate 1 under very mild conditions.     

A high yielding one-pot, novel synthesis of carbamate esters from alcohols using Mitsunobu's reagent

A novel process for the one-step conversion of primary alcohols into carbamates as protected amines has been developed using Mitsunobu's reagent in the presence of gaseous carbon dioxide. Thus, carbamate esters of the different amines were prepared in very good to excellent yields.     

Simple synthesis of fresh alkyl iodides using alcohols and hydriodic acid

A simple synthesis of fresh alkyl iodides using alcohols and hydriodic acid (HI) is reported. The alkyl iodides were obtained in quick and easy work-up with good to excellent yields (66-94%) and very high purities (97-99%). Freshly prepared iodomethane and 1-iodobutane were applied to synthesize biologically relevant 3,7-dimethyladenine and 9-butyladenine, which were characterized thoroughly using 1D and 2D NMR, individually.     

A high yielding, one-pot synthesis of dialkyl carbonates from alcohols using Mitsunobu’s reagent

A Mitsunobu-based protocol has been developed for the synthesis of symmetrical and unsymmetrical dialkylcarbonates from a variety of primary, secondary and tertiary alcohols using gaseous carbon dioxide, in good to excellent yields. This protocol is mild and efficient compared to other reported methods.     

Preparative synthesis of primary and secondary alkyl chlorides from alcohols

Conclusions We have developed a preparative single-stage tosylate method for obtaining chlorides from secondary and primary alcohols which isomerize when chlorinated by other methods.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2506–2508, November, 1987.     

Facile and chemo-selective synthesis of tertiary alkyl isothiocyanates from alcohols

When tert-alcohols were treated with (COOH)₂ and NaSCN in the presence of iodine, tertiary alkyl isothiocyanates were obtained in good yield, whereas the corresponding thiocyanates were obtained in low yield in the absence of iodine.     

A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides

Here, we have reported a novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticle notably enhances the miscibility, providing a faster, high yielding and cost-effective process in ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as by-product leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl symmetrical disulfides are obtained in good to excellent yields up to exceeding 98%.     

A simple one-pot synthesis of β-alkoxy alcohols from alkenes

β-Methoxy alcohols are easily obtained from the one-pot reaction of alkenes with oxone^® in methanol, in the absence of any additive or catalyst. The use of other alcohols as solvents has shown that the efficiency of the process decreases with the steric hindrance of the alcohol.     

A simple synthesis of choline alkyl phosphates

Alkyl (2-dimethylamino)ethyl methyl phosphates are prepared and isomerize smoothly to the corresponding alkyl choline phosphates.     

A new synthesis of sultams from amino alcohols

The base-mediated cyclization of N,O-dimesylate derivatives of cyclic and acyclic amino alcohols provides a simple access to five- and six-member sultams: isothiazolidine-1,1-dioxides and thiazinane-1,1-dioxides respectively.     

A simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm

A convenient and efficient one-pot preparation of nitriles from alcohols using N-(p-toluenesulfonyl)imidazole (TsIm) is described. In this method, treatment of alcohols with a mixture of NaCN, TsIm and triethylamine in the presence of catalytic amounts of tetra-n-butylammonium iodide (TBAI) in refluxing DMF furnishes the corresponding alkyl nitriles in good yields. This methodology is highly efficient for various structurally diverse alcohols with selectivity for ROH: 1° > 2° > 3°.     

Triselenium dicyanide from malononitrile and selenium dioxide. One-pot synthesis of selenocyanates

Triselenium dicyanide is formed by the interaction of malononitrile and selenium dioxide in dimethylsulfoxide or dimethylformamide. Addition of aromatic amines, indoles and some active methylene compounds to this reaction mixture gives the corresponding selenocyanates in one-pot.     

Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent

An efficient mixed reagent for direct synthesis of symmetrical carboxylic anhydrides from carboxylic acids has been prepared. Carboxylic acids are converted to anhydrides using triphenylphosphine/trichloroisocyanuric acid under mild reaction conditions at room temperature. Short reaction time, excellent yields of products, low cost, availability of reagents, simple experimental procedure, and easy work-up of the products are the main advantages of the presented method.