Structure and synthesis of gastrolactone

The novel cyclopentenoid monoterpene, gastrolactone ($\text{4}$), was synthesized from carvenolide ($\text{5}$), and the synthetic material was found to be identical to the natural product by direct comparison. This synthesis confirmed structure $\text{4}$ which had been suggested earlier on the basis of spectral data.     

Structure and synthesis of leucettidine

The structure of leucettidine ($\text{1}$$\text{2}$) has been revised according to its UV-data to 6-(1-hydroxypropyl)-1-methyllumazine and has been proven by an unambiguous synthesis of this natural product.     

Structure and synthesis of bicalamenene

The structure of an unsymmetrical dimeric sesquiterpene named bicalamenene has been established based on the spectral study and synthesis.     

Structure and synthesis of furanosesquiterpenes from eumorphia prostata

A reinvestigation ofEumorphia prostata afforded two new furanosesquiterpenes. The structure of eumorphistonol has been determined by synthesis. Two further furans were prepared and the absolute configuration of the main compound was deduced by a chiral synthesis.     

Total synthesis of (+)-amphidinolide A. Structure elucidation and completion of the synthesis

The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis and total synthesis. The 20-membered ring of amphidinolide A was formed by a ruthenium-catalyzed alkene-alkyne coupling to forge the C15-C16 bond. Using the reported structure 1 as a starting point, a number of diastereomers of amphidinolide A were prepared. Deviations of the chemical shift of key protons in each isomer relative to the natural material were used as a guide to determine the locations of the errors in the relative stereochemistry. The spectroscopic data for the synthetic and natural material are in excellent agreement.     

Structure, activity, synthesis and biosynthesis of aryl-C-glycosides

The focus of this review is to highlight the structure, bioactivity and biosynthesis of naturally occurring aryl-C-glycosides. General synthetic methods and their relevance to proposed biochemical mechanisms for the aryl-C-glycoside bond formation are also presented.     

Structure and synthesis of hypophyllanthin,nirtetralin, phyltetralin and lintetralin

Structures propounded for the four aryltetralin lignan constituents isolated from $\text{Phyllanthus niruri}$ Linn. are confirmed by syntheses of their (±)-forms.     

Structure determination of mycolactone C via total synthesis

[structure: see text] By total synthesis, mycolactone C has been established as an approximately 1:1 mixture of Z-Delta4'5'- and E-Delta4'5'-geometric isomers of C12'-deoxymycolactones A and B.     

Structure and total synthesis of deplancheine,a novel indoloquinolizidine alkaloid

The structure of deplancheine $\text{5}$, an indoloquinolizidine alkaloid of a novel type, has been established from its spectral properties and also by an orginal synthesis.     

Structure and synthesis of chlorophenol derivatives from helichrysum species

The isolation of a further chlorophenol acetylene from Helichrysum coriaceum as well as the synthesis of three naturally occurring chlorophenols are described.     

Structure and total synthesis of chryscandin,a new antifungal antibiotic

The structure elucidation and total synthesis of chryscandin (1), a new antifungal antibiotic produced by $\text{Chrysosporium pannorum}$ No.4629, is reported.