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新型吡唑Schiff碱及金属配合物的合成和抑菌活性 总被引:2,自引:0,他引:2
以3-氨基-4-氰基吡唑和芳醛为原料合成了10个新型吡唑Schiff碱及铜(II)、镍(II)、锌(II)、钴(II) 4个金属配合物. 用元素分析, IR, 1H NMR及单晶解析表征了Schiff碱及金属配合物的结构. 测定了Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌、枯草杆菌和绿脓杆菌的抑菌活性. 生物活性研究表明, Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌和绿脓杆菌都有较好的抑菌效果, 其中铜(II)和锌(II)配合物对金黄色葡萄球菌和大肠杆菌的抑菌活性最好. 相似文献
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以1-甲基-2-咪唑醛和甘氨酸缩合的Schiff碱为配体,合成了4种新的过渡金属配合物[M(C7N3H8O2)(H2O)n]Cl O4(M=Co,Ni,Cu,Zn).经元素分析、摩尔电导率测定、红外光谱、电子光谱和热重分析确证配合物的组成和结构.初步抑菌活性实验表明,合成的配合物对多种菌株有明显的抑菌活性. 相似文献
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芳香胺参加的Mannich反应——3-芳氨基-3-苯基-1-(4-溴苯基)丙酮的合成 总被引:2,自引:0,他引:2
文献报道过芳香胺与苯甲醛生成的Schiff碱可在少量相应的芳香胺盐酸盐或浓盐酸催化下制备Mannich碱(Ⅰ),所用的Schiff碱系事先合成,且产率较低(15-68.9%)。本文报导用4-溴苯乙酮、苯甲醛和芳香胺在少量浓盐酸催化下能直接发生Mannich反应, 相似文献
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四氢喹啉及其衍生物是一类在自然界广泛存在并具有重要生物活性的化合物,不仅用作药物、杀虫剂、抗氧化剂、抗腐蚀剂,还用于染料、光学记录材料中.因此其合成多年一直倍受关注[1].在众多的合成方法中,Schiff碱与不饱和化合物的Diels-Alder反应是构筑六元氮杂环最重要的方法之一[1,2].2,4,6-三苯基吡喃四氟化硼(TPT)是一种在光诱导电子转移反应中常用的光敏剂[3],特别是在催化富电子烯烃的光环加成反应方面,显示出独特的性能.我们在最近的研究中发现TPT也可以作为一种有效的Schiff碱与富电子烯烃光诱导Diels-Alder反应的催化剂[3].在进一步研究中,我们发现TPT还可以催化Schiff碱与N-乙烯基吡咯烷酮及N-乙烯基咔唑的Diels-Alder反应并生成高产率(75%~95%)的4-(1-吡咯烷酮基)四氢喹啉(3)和4-(9-咔唑基)四氢喹啉(4).Schiff碱与N-乙烯基吡咯烷酮的反应只生成cis产物,具有很高的立体选择性和区域选择性;而Schiff碱与N-乙烯基咔唑的反应则生成cis和trans混合物. 相似文献
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Ln(Ⅲ)-Cu(Ⅱ)与直链醚-氨基酸新型Schiff碱异核配合物合成和催化 总被引:1,自引:0,他引:1
合成Ln(Ⅲ ) Cu(Ⅱ )与全新型直链醚 氨基酸Schiff碱的异核配合物并提出合成方法 .经元素分析、磁化率、光谱及 2D COSY NMR等表征 ,确定其组成为 [LnCu2(H2 TALY) (NO3 ) 5 ](NO3 ) 2 ·nH2 O (Ln =La ,Nd ,Sm ,Gd ,n =4;Ln =Yb ,Y ,n =3) ,式中H2 TALY为四甘醇醛缩双赖氨酸Schiff碱 .探讨了配位作用 ,特别有意义的是该类新配合物在不加助催化剂时 ,可单独催化聚合甲基丙烯酸甲酯 (MMA) ,转化率可高达1 0 0 % ,分子量约为 1 2万 ,它们可能成为一类具有特点的新催化剂体系 ,同时证明脂肪族Schiff碱配合物对MMA聚合反应也具有优良的催化活性 相似文献
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用5-甲基-4-乙氧羰基呋喃氨基腈与芳醛反应制得Schiff碱,再采用NaBH4还原Schiff碱,得到3个新型5-甲基-4-乙氧羰基呋喃氨基腈衍生物.利用核磁共振谱(1H NMR)、红外光谱(IR),质谱(EI-MS)表征了产物的结构;并初步测定了产物的抗菌活性.结果表明,目标化合物的抗菌活性一般. 相似文献
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A new in-loop solid-phase microextraction (in-loop-SPME) technique, based on an aluminum capillary tube coupled to HPLC, is described for on-line isolation, concentration, and analysis of analytes from aqueous samples. L-Dopa and L-dopamine, in aqueous solutions, were selected as model compounds. The main conditions affecting extraction of the analytes from aqueous samples, desorption, injection, and chromatographic separation were investigated. The method is simple and reproducible. Using the proposed method, reliable determination of L-dopa and L-dopamine at parts-per-billion concentrations was achieved. The calibration plots were linear in the range of 2.5–1500 ng mL−1 with correlation coefficients of 0.999 and 0.998 for L-dopa and L-dopamine, respectively. The detection limits were 0.5–1 ng mL−1 with a relative standard deviation less than 4.1%. Concentration factors more than 100-fold were obtained for these compounds. 相似文献
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The present study describes the simple and fast preparation of Cerium (III) hexacyanoferrate (II) (CeHCF) solid nanoparticles at three different water/formamide (%) ratios used as solvent (v/v) (100:0, 80:20, 0:100). CeHCF nanoparticles (Nps) were characterized by fourier transform infrared pectroscopy (FTIR), x-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potential and cyclic voltammetry (CV). Electrodes modified with CeHCF presented a well-defined redox pair with formal potential (Eo′) of approximately 0.29 V (vs. Ag/AgCl(sat) attributed to the Fe2 +/Fe3+ redox pair in the presence of cerium (III)). The Nps in the three systems investigates, presents a random size distribution to different surface, where most were distributed between 20 and 160 nm. Considering the three investigated systems, only CeHCF-1 (100:0) was sensitive to L-dopamine, presenting a linear signal region as a function of L-dopamine concentrations, with a limit of detection (LD) of 0.125 mmol L−1, limit of quantification (LQ) of 0.419 mmol L−1 and amperometric sensitivity (S) of 148.16 μA mmol L−1. 相似文献
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本文旨在引入咪唑环,对溴代甲氧基二苯甲酮类化合物进行结构衍生,以发现对血管内皮细胞具有更高保护活性的化合物。通过以2-甲基-5-溴-苯甲酸为起始原料,经过酰氯化、傅克酰化、溴代、与N-溴代丁二酰亚胺(NBS)自由基取代及与取代咪唑的亲核取代等多步反应,合成了8个新型溴代甲氧基二苯甲酮咪唑类化合物。目标化合物的结构均经质谱(MS)、核磁共振波谱仪(NMR)和高分辨质谱(HRMS)进行确证。并采用噻唑蓝(MTT)法考察了目标化合物对过氧化氢损伤的EA.hy 926细胞的保护活性,结果表明,目标化合物6a、6g、6h具有显著的细胞保护活性,其半抑制浓度(EC50)分别为1.9、4.0和3.2μmol/L,优于阳性对照槲皮素(EC_(50)为18μmol/L),表明该类化合物在心血管疾病的治疗方面有潜在的应用前景。 相似文献
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新型卟啉-席夫碱铜(Ⅱ)/锌(Ⅱ)配合物的合成与光热性能 总被引:1,自引:0,他引:1
以吡咯、取代苯甲醛等为原料合成了5-(对-亚苄基亚氨基)苯基-10,15,20-三苯基卟啉的铜(Ⅱ)/锌(Ⅱ)配合物和5-[对-(4-硝基亚苄基亚氨基)]苯基-10,15,20-三苯基卟啉的铜(Ⅱ)/锌(Ⅱ)配合物. 通过FTIR, UV-Vis, 1H NMR, FAB-MS及X射线单晶衍射等手段对产物进行了表征, 并研究了其发光性能及热稳定性. 实验结果表明, 合成配合物的最大发光波长为600 nm, 位于可见光中的红光区; 化合物在空气中的初始分解温度为70 ℃. 相似文献
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利用计算机辅助药物设计软件Catalyst构建了哌啶酮类法尼基转移酶抑制剂的药效团模型, 结合所构建的药效团模型, 设计并合成出17个哌啶酮类化合物, 其中16个目标化合物未见文献报道, 其结构均经IR, MS及1H NMR等确证. 利用MTT法得到其对于肿瘤细胞抑制的IC50值. 初步生物活性测试表明, 目标化合物均具有抑瘤活性, 其中11个化合物的IC50值低于阳性对照5-Fu, 并且实测值与所构建的药效团模型的预测值相关性较好. 相似文献
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Gerhard Full Peter Winterhalter Gertraut Schmidt Peter Herion Peter Schreier 《Journal of separation science》1993,16(11):642-644
This paper reports the differentiation between the enantiomers of theaspiranes and theaspirones, potent flavor compounds widely used in the flavor industry. Optically pure reference compounds of isomeric theaspiranes were obtained by enantioselective synthesis. Enantiomerically pure reference theaspirones were isolated from quince fruit; their absolute stereochemistry was assigned by CD spectroscopy. For both types of compounds the order of elution was elucidated by using authentic reference compounds. These data enabled the determination of the enantiomeric distribution of both types of compounds in a variety of plant tissues. Because of the complexity of the natural flavor isolates, compounds were identified by mass spectrometry after multidimensional gas chromatography employing a Sichromat 2 double oven chromatograph. After separation of the target compounds on the first, achiral, column (DB-5), they were transferred to a chiral column (C-Dex B) for determination of the enantiomeric distribution. Multiple ion detection (MID) enabled the determination of the enantiomeric distribution even for complex mixtures containing the target compounds at extremely low levels. 相似文献
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