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1.
H. Kažoka A. Krauze M. Vilums L. Černova L. Sīle G. Duburs 《Chemistry of Heterocyclic Compounds》2007,43(6):708-714
The stability of solutions of esters of 6′-carbamoylmethylthio-5′-cyano-2′-methyl-1′,4′-dihydro-4,4′-bipyridine-3′-carboxylic
acids was investigated by HPLC. The corresponding esters of 6′-carbamoylmethylthio-5′-cyano-4,4′-bipyridine-3′-carboxylic
acids,esters of 8-cyano-5-methyl-3-oxo-7-(4-pyridyl)-2,3-dihydro-7H-thiazolo-[3,2-a]pyridine-6-carboxylic acids, methyl 3-amino-2-carbamoyl-6-methyl-4-(4-pyridyl)-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate,
and methyl 3-amino-2-carbamoyl-6-methyl-4-(4-pyridyl)-thieno[2,3-b]pyridine-5-carboxylate were synthesized as standard compounds
(typical impurities). Analysis by HPLC was realized under the conditions of reverse-phase chromatography. It was established
that solutions of the investigated compounds (with mixtures of acetonitrile with phosphate buffer, having pH values of not
less than 3 and not more than 5, as solvents) are stable for one month when the solutions are stored in a place protected
against light. It is also necessary to use chromatographic systems in which the aqueous components have pH 3–5 during determination
of the purity of the esters of 6′-carbamoylmethylthio-5′-cyano-2′-methyl-1′,4′-dihydro-4, 4′-bipyridine-3′-carboxylic acid
by HPLC in order to separate the analyzed sorbates and their typical impurities more completely.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 841–848, June, 2007. 相似文献
2.
New macrocyclic polyethers, 2,3,5,6-bis-[5′(5′)-chlorobenzo]-1,7,10-trioxacyclododeca-2,5-diene (I), 2,3,5,6-bis-[5′(5′)-chlorobenzo]-1,7,10,13-tetra oxacyclo pentadeca-2,5-diene (II), and 2,3,5,6-bis-[5′(5′)-chlorobenzo]-1,7,10,13,16-penta oxa cyclo octadeca-2,5-dien (III), and macrocylic lactones 2,3,5,6-bis-[5′(5′)-chlorobenzo]-1,7,10,13-tetraoxacyclopentadeca-2,5-diene-8,15-dione (IV) and 2,3,5,6-bis[5′(5′)-chlorobenzo]-1,7,10,13,16-pentaoxacyclooctadeca-2,5-diene-8,18-dione (V) were synthesized. Complexes of ligands III and V with metal cations were prepared. Furthermore, their metal-picrate extraction with some metal salts was attempted. Structures
of the ligands and complexes were confirmed using spectroscopic techniques. 相似文献
3.
A. V. Sukhotin V. G. Kartsev Yu. A. Aleksandrov F. M. Dolgushin 《Russian Chemical Bulletin》2005,54(10):2437-2440
Tetrahydrospiropyrrolo[2,1-a]phthalazines were synthesized by the reaction of 5-arylidene-2-spirocyclohexane-1,3-dioxane-4,6-diones with phthalazinium
ylides. One of the reaction products, viz., 3-ethoxycarbonyl-2-(4-methoxyphenyl)-2′,2′-pentamethylene-1,2,3,10b-tetrahydrospiro[pyrrolo[2,1-a]phthalazine-1,5′-[1,3]dioxane]-4′,6′-dione, was studied by X-ray diffraction. The spectroscopic characteristics of the reaction
products are discussed.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2362–2365, October, 2005. 相似文献
4.
A. V. Timshina S. A. Rubtsova I. N. Alekseev P. A. Slepukhin A. V. Kuchin 《Russian Journal of Organic Chemistry》2010,46(3):363-367
(1R,1′R,2S,4R)-1,7,7-Trimethylspiro[bicyclo[2.2.1]heptane-2,2′-[1,3]dithiolane] 1′-oxide, (1R,2S,3′R,4R)-1,7,7-trimethylspiro[bicyclo[2.2.1]heptane-2,2′-[1,3]dithiolane] 1′,1′,3′-trioxide, and (1R,4R)-1,7,7-trimethylspiro[bicyclo[2.2.1]heptane-2,2′-[1,3]dithiolane] 1′,1′,3′,3′-tetraoxide were synthesized by oxidation of
camphor ethylene dithioacetal with m-chloroperoxybenzoic acid at different substrate-tooxidant ratios. The structure of the products was proved by IR and NMR
spectroscopy and X-ray analysis. 相似文献
5.
New series of 4,4-dimethylbenzopyrano[4,3-d]-1,2,3-selenadiazoles and 4,4-dimethylbenzopyrano-[4,3-d]-1,2,3-thiadiazoles have
been synthesized from semicarbazones of chroman-4-one precursors. Some 4-acetyl-2′-acetylamino-2,2-dimethylspiro[chroman-4,5′-2-1,3,4-thiadiazolines]
have been synthesized by cyclization of thiosemicarbazones of 2,2-dimethylchroman-4-ones using acetic anhydride. The selected
compounds were tested for Phosphotyrosine phosphatase 1B inhibition.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 775–779, May, 2006. 相似文献
6.
The isotopomers of L-tryptophan (L-Trp) labeled with hydrogen isotopes in the indole ring were obtained by isotope exchange
method. Heavy and tritiated water were used as the sources of stable and radioactive label. Three isotopomers, i.e., [4′-2H]-L-Trp, [4′-3H]-L-Trp, and doubly labeled [4′-2H/3H]-L-Trp were synthesized by isotope exchange enhanced by irradiation with a mercury discharge lamp. The indole whole ring
labeled isotopomers, i.e., [2′,4′,5′,6′,7′-2H5]-L-, [2′,4′,5′,6′,7′-3H5]-L-, and doubly labeled [2′,4′,5′,6′,7′-2H/3H]-L-Trp were synthesized by isotope exchange between L-Trp and D2O or DTO in the presence of deuteriated trifluoroacetic acid. 相似文献
7.
I. Strakova A. Strakovs M. Petrova S. Belyakov 《Chemistry of Heterocyclic Compounds》2007,43(12):1512-1518
The [3+2] cycloaddition reactions of a series of 1,3-substituted 5-diazo-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazoles with
maleic anhydride and dimethyl acetylenedicarboxylate gave 1′,3′-substituted 3-spiro[4,6-dioxo-4,6,3a,6a-tetrahydro-3H-furo[3,4-c]pyrazole]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles]
and 1′,3′-substituted 3-spiro[4,5-di(methoxycarbonyl)-3H-pyrazole]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles]
respectively. When heated the former eliminate nitrogen and are transformed into 1′,3′-substituted 6-spiro[2,4-dioxo-3-oxabicyclo[3.1.0]hexane]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1784–1791, December, 2007. 相似文献
8.
A. V. Velikorodov O. Yu. Poddubnyi A. K. Kuanchalieva O. O. Krivosheev 《Russian Journal of Organic Chemistry》2010,46(12):1826-1829
1,3-Dipolar cycloaddition to methyl 4-[2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-1-oxoethyl]-phenylcarbamate of diazomethane in chloroform-diethyl ether and of 3,4-dimethoxybenzonitrile
oxide generated from the corresponding aldehyde oxime by the action of N-chlorobenzenesulfonamide sodium salt (Chloramine B) in boiling ethanol gave, respectively, methyl 4-(2-oxo-1′,5′-dihydro-1H-spiro[indole-3,4′-pyrazol]-3′-ylcarbonyl)phenylcarbamate and methyl 4-[3′-(3,4-dimethoxyphenyl)-2-oxo-1H,4′H-spiro[indole-3,5′-isoxazol]-4′-ylcarbonyl]phenylcarbamate. The condensation of methyl 4-[2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)-1-oxoethyl]phenylcarbamate with hydrazine hydrate in ethanol afforded methyl 4-(2-oxo-1,2,2′,4′-tetrahydrospiro[indole-3,3′-pyrazol]-5′-yl)phenylcarbamate. 相似文献
9.
İbrahim Erden Ali Erdoğmuş Nebahat Demirhan Ulvi Avcıata 《Transition Metal Chemistry》2008,33(4):439-442
A new fluorene ligand, benzo[15-crown-5]-5H-pyrido[3′,2′:4,5]cylopenta[1,2-b]pyridin-5-ylidenehydrazone (bph), has been synthesized from the reaction of 4,5-diazafluoren-9-one
with 4′-formylbenzo-15-crown-5. The Co(II), Cu(II), and Ru(II) complexes of the ligand were prepared and characterized. The
metal-to-ligand ratio of the Co(II) and Cu(II) complexes was found to be 2:1 and that of the Ru(II) complex was found to be
1:1. The ligand and complexes have been characterized by FTIR, UV–visible, 1H NMR and fluorescence spectra, as well as elemental analyses and mass spectra. 相似文献
10.
V. A. Glushkov E. V. Rotermel’ T. F. Odegova Yu. V. Shklyaev 《Russian Journal of Organic Chemistry》2011,47(9):1318-1322
Hydrolytic cleavage of 1-substituted 2-azaspiro[4.5]undeca-1,6,9-trienes in acid medium is accompanied by dienone-phenole
rearrangement with formation of substituted N-[2-(p-hydroxyphenyl)ethyl] carboxylic acid amides. 1,2-Dimethoxy-3-oxo-15-phenyl-14-azadispiro[5.1.5.2]pentadeca-1,4,14-triene
and 2′-R-7a′-methyl-3a′,4′,5′,6′,7′,7a′-hexahydrospiro[cyclohexa[2,5]diene-1,3′-indol]-4-ones undergo analogous cleavage. 相似文献
11.
Benzo[b]-1,4-diazabicyclo[2.2.2]octene and 4′-methylbenzo[1′,2′-b]-1,4-diazabicyclo[2.2.2]octene were synthesized by the reaction
of N-acetyl-6-H- and 6-methyl-1,2,3,4-tetrahydroquinoxalines with ethylene oxide and subsequent cyclization of the N-(β-hydroxyethyl)-N'-acetyl
derivatives in refluxing HBr. The errors of the published data on the benzo[b]-1,4-diazabicyclo[2.2.2]octene system are demonstrated.
See [1] for communication 2.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 827–830. 相似文献
12.
F. A. Amer M. Hammouda A.-A. S. El-Ahl B. F. Abdel-Wahab 《Chemistry of Heterocyclic Compounds》2007,43(12):1559-1566
New pyrrolo[3,4-c]isoxazole derivatives were synthesized from the key intermediates 4-cyanopyrrolidin-3-ones in two steps.
Pyrrolo[2,3-d][1,2,3]triazoles and triazolo[4,5-c]pyridazine were obtained from 2-arylhydrazono-4-cyano-1-(4′-methoxyphenyl)-3-oxopyrrolidines
by refluxing with phenylhydrazine in either ethanol or glacial acetic acid. Aldol self-condensation of 1-aryl-4-cyanopyrrolidin-3-ones
afforded dipyrrolo-[3,2-b:3′, 4′-d]pyran derivatives.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1841–1848, December, 2007. 相似文献
13.
H. Kažoka A. Krauze M. Viļums L. Černova L. Sīle G. Duburs 《Chemistry of Heterocyclic Compounds》2007,43(1):50-57
Esters of 6′-carbamoylmethylthio-5′-cyano-1′,4′-dihydro-3,4′-bipyridine-3′-carboxylic acids are obtained by the alkylation
of piperidinium 3′-alkoxycarbonyl-5′-cyano-1′,4′-dihydro-3,4′-bipyridine-6′-thiolates with iodoacetamide. For an HPLC study
of the stability of solutions of the abovementioned 1,4-dihydrobipyridines (solution pH 2.3–9.0) the appropriate esters of
6′-carbamoylmethylthio-5′-cyano-3,4′-bipyridine-3′-carboxylic acids and esters of 8-cyano-5-methyl(or phenyl)-3-oxo-7-pyridin-3-yl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6-carboxylic
acids were synthesized as reference compounds. Analysis by HPLC was carried out under conditions of reverse-phase chromatography.
It was shown that solutions of the investigated compounds in a mixture of acetonitrile and phosphate buffer (pH 3.0–5.0) were
stable for 1 month on storage protected from light. Under the action of light in all the solutions investigated irrespective
of pH the formation occurs of the corresponding esters of 6′-carbamoylmethylthio-5′-cyano-3,4′-bipyridine-3′-carboxylic acids.
The presence of esters of 8-cyano-5-methyl(or phenyl)-3-oxo-7-pyridin-3-yl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6-carboxylic
acids (no more than 4%) was detected only in 0.1% solutions of phosphoric acid (pH 2.3) under conditions of storage of the
latter protected from light. A series of as yet unidentified products was detected in solutions of pH 7.0–9.0.
Dedicated to E. Lukevics on his 70th birthday
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 59–68, January, 2007. 相似文献
14.
I. S. Levina L. E. Kulikova E. V. Shulishov I. P. Klimenko A. V. Kamernitskii Yu. V. Tomilov 《Russian Chemical Bulletin》2006,55(11):2119-2121
4′,4′-Dimethyl[16α,17α]spiropentanopregn-4-ene-3,20-dione was synthesized. The addition of diazo-2,2-dimethylcyclopropane
generated from N-(2,2-dimethylcyclopropyl)-N-nitrosourea to 16,17-didehydropregnenolone acetate occurs regio-and stereospecifically to give 3β-acetoxy-1′,1′-dimethyl-20-oxopregn-5-ene-[16α,17α;7′,6′]-4′,
5′-diazaspiro[2.4]-hept-4′-ene in high yield. Its thermolysis affords a spiropentane-containing steroid, which is transformed
into the target diketone. The anti position of the gem-dimethyl group in the fused spiropentane fragment is evident from the X-ray diffraction study of the final product.
Dedicated to Academician O. M. Nefedov on the occasion of his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2040–2042, November, 2006. 相似文献
15.
Wael A. El-Sayed Mohamed I. Hegab Hala E. M. Tolan Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2008,139(9):1055-1060
A series of new N- and S-substituted 1,3,4-oxadiazole derivatives were synthesized. 5-Pyridin-3-yl-3-[2-(5-thioxo-4,5-dihydro-l,3,4-thiadiazol-2-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione and 5-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)methyl]-N-phenyl-1,3,4-thiadiazol-2-amine were formed by cyclization of 3-(5-pyridin-3-yl-2-thioxo-1,3,4-oxadiazol-3(2H)-ylpropanimidohydrazide and 2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)thio]thiosemicarbazide with CS2 and H2SO4. On the other hand, a number of new bicyclic 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were synthesized. 6-Pyridin-3-ylbis[1,2,4]‐triazolo[3,4-b:4′,3′-d][1,3,4]thiadiazole-3(2H)-thione was synthesized by reaction of 6-(hydrazino)-3-pyridine-3-yl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole with CS2/KOH/EtOH. The structures of the newly synthesized compounds were elucidated by the spectral and analytical data IR, Mass, and 1H NMR spectra.
Correspondence: Adel A.-H. Abdel-Rahman, Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam,
Egypt; Wael A. El-Sayed, National Research Centre, Department of Photochemistry, Cairo, Egypt. 相似文献
16.
V. M. Kysil L. M. Potikha R. M. Gutsul V. A. Kovtunenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2006,42(1):100-108
During acylation of 7-isonicotinoyl-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one or its alkylation followed by treatment
with organic bases, spirocyclization occurs with formation of derivatives of a novel heterocyclic system: 1′-acyl-and 1′-alkylspiro[7H,12H-6a,11b-diazabenz[e]aceanthrylene-6(5H),4′(1′
H)-pyridine]-5,7-diones. We have studied the spectral properties of the synthesized spirans. We have shown that 7-nicotinoyl-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one
does not undergo an analogous reaction of repeated acylation, while treatment of its quaternary salt with bases leads to a
complex mixture of unidentified products.
For Communication 18, see [1].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 113–122, January, 2006. 相似文献
17.
Gajendra Singh Anoop K. Sharma Neeraj Kumar L. Prakash 《Research on Chemical Intermediates》2000,26(5):445-453
(±)cis-2-(4-methoxyphenyl)-3-hydroxy/methoxy-6-methoxy/8-methoxy-2,3-dihydro-1,5-benzothiazepin-4-[5H/5-chloroacetyl/5-(4′-methylpiperazino-1′)acetyl]-ones
and nucleosides viz; (±)cis-2-(4-methoxyphenyl)-3,6-dimethoxy-2,3-dihydro-1,5-benzothiazepin-4-[5-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)]-one and (±)cis-2-(4-methoxyphenyl)-3,8-dimethoxy-2,3-dihydro-1,5-benzothiazepin-4-[5-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)]-one have been
synthesized by the condensation of substituted-2-aminobenzenethiols with methyl (±)trans-3-(4-methoxyphenyl)glycidate in xylene and by stirring the 3-methoxy derivative of 1,5-benzothiazepin-4(5H)-ones with sugar
namely β-D-ribofuranosyl-1-acetate-2,3,5-tribenzoate at 155–160 °C in vacuo for 10 hours, respectively.
The synthesized compounds have been characterized by the elemental analyses and spectral data and screened for their antimicrobial
activity. 相似文献
18.
G. M. Mamardashvili N. Zh. Mamardashvili O. I. Koifman 《Russian Journal of Coordination Chemistry》2011,37(11):872-877
The complexation properties of zinc 10,20-bis[5-(2,3,7,8,12,13,17,18-octaethylporphyrinate)ethynylphenyl]-5,5′,10′,15,15′,20′-hexamethylcalix[4]pyrrole
toward halide ions, triethylenediamine, and 4,4′-bipyridyl were studied by spectrophotometric titration and 1H NMR spectroscopy. The influence of binding of anions (F− and Cl−) by the calix[4]pyrrole fragment of zinc calixpyrrole-bisporphyrinate on the complexation properties of its interporphyrin
cavity toward the bidentate organic ligand triethylenediamine. 相似文献
19.
Synthesis, structures, and properties of spiro[6-azaperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one derivatives 总被引:1,自引:0,他引:1
V. N. Komissarov E. N. Gruzdeva L. P. Olekhnovich G. S. Borodkin V. N. Khrustalev S. V. Lindeman Yu. T. Struchkov V. A. Kogan V. I. Minkin 《Russian Chemical Bulletin》1997,46(11):1924-1930
The reaction of 5-amino-4-chloroquinolines with 4-amino-2,6-di-tert-butylphenol yielded derivatives of spiro[6-azaperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one, which exhibit photo-and thermochromic
properties in solutions. The structure of 2′,6′-di-tert-butyl-5,7,9-trimethylspiro[6-aza,-2,3-dihydroperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-one was established by X-ray diffraction
study. The ring-chain isomerization of 2′,6′-di-tert-butyl-5,7-dimethyl-and 2′,6′-di-tert-butyl-5,7,8-trimethylspiro[6-aza-2,3-dihydroperimidine-2,4′-cyclohexa-2′,5′-dien]-1′-ones was studied by dynamic NMR spectroscopy.
Deceased.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2028–2034, November, 1997. 相似文献
20.
A synthesis of novel derivatives of 6-methyluracil, 6-methyl-2-thioxo-, and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one
containing a 2-(phenoxy)ethyl substituent at position 5 of the pyrimidine ring has been carried out. It was found that 5-[2-(phenoxy)ethyl]
derivatives of 6-methyl-2-thioxo- and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one are obtained by the condensation of
the corresponding ethyl 3-oxo-2-(2-phenoxyethyl)butanoates with thiourea or guanidine. 6-Methyl-5-[2-(phenoxy)ethyl]uracils
can be prepared by treating 6-methyl-5-[2-(phenoxy)ethyl]-2-thioxo-2,3-dihydro-1H-pyrimidin-4-ones with an excess of aqueous
monochloroacetic acid solution.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1213–1217, August, 2005. 相似文献