共查询到19条相似文献,搜索用时 373 毫秒
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对于多螺环化合物特别是第二代稠杂螺环树枝状化合物来说,按照IUPAC有关系统命名原则,从螺结构的角度来命名由于太复杂而几乎不可能.本文通过亚基取代途径对第一代螺环结构的简化,方便地系统命名了一种第二代稠杂螺环树枝状化合物.这些六螺化合物可以系统地命名为:1,2,3,4,5,6,7,8,9,10,11,12-十二氢化-2,2:6,6:10,10-三[3,3-二(烷氧羰基)亚环丁-1,1-二甲氧基]苯并[l]菲.通过这一途径,更高代螺环树枝状化合物及其它类型多螺化合物有望可以简单地系统命名. 相似文献
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为了合成新结构类型查尔酮衍生物,发现具有抗氧化活性的查尔酮类化合物,设计合成了查尔酮A和螺杂环B两种类型,共21个查尔酮类似物,结构经ESI-MS,ESI-HRMS和1H NMR确认.培养出螺杂环B1的单晶,通过X衍射确证了其为单斜晶系.其中螺杂环B为新结构类型化合物,通过1,3-偶极环加成反应,用不需加催化剂的"一锅煮"方法合成,该反应具有很好的立体选择性和区域选择性、且环境友好.用DPPH法测试了所有化合物的抗氧化活性,筛选出了多个对1,1-二苯基-2-三硝基苯肼(DPPH)自由基具有良好清除率的化合物,a环3,4-OH取代的两类化合物都具有良好的抗氧化活性,苯环邻位二羟基取代的查尔酮类化合物可能具有很好的抗氧化活性. 相似文献
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自1900年首次发现螺环化合物以来,由于它在药物分子、手性配体、激光染料等领域的重要作用,越来越多的螺环化合物被发现和研究.目前已研发出了几种典型的反应来合成螺环化合物,如分子间的环加成或偶联反应及双官能团化合物分子内的偶联反应.但这些方法仍存在选择性难以控制、螺环中官能团耐受性差、条件苛刻等不足.因此,有必要发展合成含各类官能团的螺环的方法.近年来,芳基化合物的分子内去芳构化已经成为合成螺环骨架的有效策略,尤其是通过光催化去芳构化合成螺环.CO2作为C1合成子具有丰富、低成本、可持续及无毒等优势,若将CO2作为羧酸源键联在螺环骨架上,将有可能构建具有潜在生物活性的螺环羧酸衍生物.基于本课题组对光催化CO2转化利用反应的持续研究,本文设计开发了一种合成螺环羧酸化合物的便捷方法,即光催化苄基邻卤芳醚与CO2的连续去芳构化/羧化反应.根据条件筛选实验结果,最终选择1,2,3,5-四(咔唑-9-基)-4,6-二氰基苯(4Cz IPN)作为光敏剂, N,N-二异丙基乙基胺(DIPEA)为还原剂,叔丁醇钠作为... 相似文献
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手性螺环配体的合成及其在不对称催化反应中的应用研究进展 总被引:2,自引:0,他引:2
手性螺环配体的合成及其在不对称催化反应中的应用是不对称合成和催化研究中重要的研究领域之一, 一些手性螺环配体被合成出来并成功地应用于不对称催化反应中. 综述了近十年来手性螺环配体的合成及在不对称催化反应中的应用研究进展. 相似文献
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High nucleophilicity of cyclic amidocarbene toward aryl isocyanates, new approach to spiro[azetidinone-4,3'-indolinone] derivatives 总被引:1,自引:0,他引:1
The nucleophilic addition of beta-lactam-4-ylidenes 2, a type of ambiphilic cyclic amidocarbene, to aryl isocyanates has been studied and their application in organic synthesis has been demonstrated. Thermolysis of spiro[beta-lactam-4,2'-oxadiazolines] 1 in the presence of aryl isocyanates afforded both N-lactam and O-lactam substituted spiro[azetidine-2-one-4,3'-indole-2'-one] derivatives 5 and 6 in the total yield of 65-86%. Upon hydrolysis, products 5 and 6 were converted into spiro[azetidine-2-one-4,3'-indole-2'-one] 9 that was analogous to known biologically active compounds. 相似文献
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螺杂环化合物独特的立体结构和丰富的理化特性,激发了研究工作者对其高效合成方法的持续关注.炔醇在过渡金属作用下经exo-dig式分子内环化可原位形成环外烯醇醚.其作为一类高活性的C2合成子,能够与同时具有亲电和亲核特性的“双亲性底物”发生串联反应,实现螺杂环骨架的快速构建.综述了近年来炔醇分子内环化促发的串联反应在螺杂环化合物合成中的应用进展,以期激发更多相关研究工作的设计与报道.按照参与螺环构建的“双亲性底物”原子数目的不同进行分类,重点阐述了反应采用的催化体系和反应机制,分析了目前该领域存在的挑战,并对未来的发展进行了展望. 相似文献
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An efficient in situ reduction and cyclization reaction for the synthesis of nitrogen‐containing spiro compounds directly form 5‐nitro‐1H‐indazole, 6‐nitro‐1H‐indazole and 5‐nitroindole in Fe–H2O–AcOH medium is reported. 5‐Nitro‐1H‐indazole, 6‐nitro‐1H‐indazole and 5‐nitroindole were first used to synthesize spiro compounds, and this is a novel method for the synthesis of spiro compounds from nitro compounds. The advantages of this reaction are stable reagents, easily available raw materials, wide range of substrates and high yields. 相似文献
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The synthesis of the tetracyclic spiro compounds 11, 12, 13, 14, 17, 18, 19 and 20 with homoproaporphine skeleton is described. Crucial intermediates are the secondary alcohols 10 and 16 . The structure of the spiro compounds is proved by transformation of 11 into the dihydronaphthalene derivative 24 and NMR.-spectroscopic studies of the latter. 相似文献
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Dr. Martin Kamlar Dr. Michal Urban Prof. Dr. Jan Veselý 《Chemical record (New York, N.Y.)》2023,23(7):e202200284
Over the last ten years, the combination of organocatalysis with transition metal (TM) catalysis has become one of the most important toolboxes used for synthesizing optically pure compounds containing chiral quaternary centers, including spiro heterocyclic molecules. The dominant method in the enantioselective synthesis of spiro heterocyclic compounds based on synergistic catalysis includes chiral aminocatalysis and NHC catalysis, as already established covalent organocatalytic strategies. Another area of organocatalysis widely combined with TM catalysis producing enantiomerically enriched spiro heterocyclic compounds is non-covalent catalysis, dominated by chiral phosphoric acids, thiourea, and squaramide derivatives. This review article aims to summarize enantioselective methods used for constructing spirocyclic heterocycles based on a combination of organocatalysis and transition metal catalysis. 相似文献
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Ruixian Deng Shuming Zhan Chunyu Li Zhenhua Gu 《Angewandte Chemie (International ed. in English)》2020,59(8):3093-3098
A transition‐metal‐free synthesis of spiro compounds from 9H‐fluoren‐9‐ols mediated by hypervalent iodine is reported. In this reaction, an unprecedented β‐carbon elimination of tertiary alkoxyliodine(III) to form new diaryliodonium salts is proposed. The obtained phenol intermediates undergo oxidative dearomatization to furnish a class of oxo‐spiro compounds. This domino reaction significantly increases the complexity of these molecules and shows excellent regio‐ and stereoselectivity. 相似文献