苗药双肾草中一个新的联苄类化合物

从苗药双肾草[Herminium bulleyi(Rolfe) Tang et Wang]块茎的甲醇提取物中分离鉴定了6个化合物, 其中化合物6是新化合物, 命名为双肾草素, 经NMR等波谱解析, 确定其结构为2,2-dimethyl-5-methoxy-7-[2-(3″-hydroxyphenyl)ethyl]chromene, 其余化合物均为首次从该植物中分离得到.     

2-芳基-5-苄氧苯基-1,3,4-噁二唑类化合物的合成

由苄氧基苯甲酰肼与各种芳酰氯反应制得N-取代苯甲酰基-4-苄氧苯酰肼(2),2在三氯氧磷存在下发生脱水闭环反应,合成了一系列2-芳基-5-苄氧苯基-1,3,4-噁二唑类化合物,其结构经1H NMR,IR,MS和元素分析表征。     

吡啶联异噁唑类化合物的设计、合成及抗肿瘤活性

根据已知的激酶变构抑制剂与其靶点激酶的X射线共晶结构,设计了一系列以吡啶联异噁唑为中心结构的潜在激酶变构抑制剂.以2-甲基-5-硝基-3-吡啶甲酸甲酯为原料,通过形成酰胺、磺酰胺和连接嘧啶片段等衍生化手段合成了21个新的吡啶联异噁唑类化合物,其结构经1H NMR,13C NMR和MS确证.采用噻唑蓝(MTT)法测试了所合成化合物的体外抗肿瘤活性,初步测试结果表明该类化合物对肿瘤细胞的增长具有显著的抑制作用.     

NMR对苯并噁嗪类化合物结构的研究

利用'H、'13CNMR谱及HMBC、HMQC二维谱对10种苯并噁嗪类化合物的结构进行了研究,初步得出了它们的NMR谱特征,分析了化学位移的影响因素。     

4-烷氧/苄氧基苯基四唑和1,3,4-噁二唑类化合物的合成及除草活性

以4-氰基苯酚为起始原料, 在4-烷氧基/苄氧基苯甲脒结构基础上, 设计合成了5个4-烷氧基/苄氧基苯基四唑及17个新型2-取代-5-(4-烷氧基/苄氧基)苯基噁二唑类化合物, 通过元素分析、1H NMR和MS对所合成的新化合物进行了结构表征. 初步除草活性测试结果表明, 部分化合物对双子叶油菜和单子叶稗草表现出较好的生长抑制活性.     

4-烷氧/苄氧基苯基四唑和1,3,4-噁二唑类化合物的合成及除草活性

以4-氰基苯酚为起始原料,在4-烷氧基/苄氧基苯甲脒结构基础上,设计合成了5个4-烷氧基/苄氧基苯基四唑及17个新型2-取代-5-(4-烷氧基/苄氧基)苯基噁二唑类化合物,通过元素分析、1H NMR和MS对所合成的新化合物进行了结构表征.初步除草活性测试结果表明,部分化合物对双子叶油菜和单子叶稗草表现出较好的生长抑制活性.     

含氟1,3,4-噁唑啉和1,3,4-噁二唑类化合物的合成及其抗癌活性

对氟苯甲酰腙与乙酸酐或丙酸酐反应后再脱水环化制得2-苯基-3-乙酰基-5-对氟苯基-1,3,4-噁唑啉(3)或2-苯基-3-丙酰基-5-对氟苯基-1,3,4-噁唑啉(4).N-对氟苯甲酰基-N′-苯甲酰肼在POCl3存在下脱水环化制得2-苯基-5-对氟苯基-1,3,4-噁二唑(6).新化合物3,4和6的结构经1H NMR,IR,MS和元素分析表征.用MTT方法评价了其对HepG-2,A549-1和231-2癌细胞株的体外生长抑制活性.结果表明,3,4和6均具有潜在的体外抑制癌细胞生长活性,其中3的活性最强.     

Cu(Ⅰ)催化下2,3-二氢-1,4-苯并二噁烷类化合物的合成

以CuBr为催化剂,1,4,7-三氮杂环壬烷衍生物为配体,K₂CO₃为碱,110 ℃下通过取代的邻碘代酚和取代的环氧化物的串联反应制备了2,3-二氢-1,4-苯并二噁烷类化合物。各种芳香取代的环氧化物和脂肪取代的环氧化物均能顺利的与邻碘代酚反应,产物收率64%~83%。讨论了底物取代基与产物收率的关系,推测了反应机理。并用NMR和元素分析确定了产物结构。     

HMCM-22分子筛催化1,3-苯并二噁茂烷类化合物合成的研究

研究了HMCM-22分子筛催化邻苯二酚与环己酮、丁酮、丙酮、丙醛、丁醛、异丁醛、戊醛、异戊醛、正己醛、正辛醛、苯甲醛、二苯甲酮等十余种醛(酮)的缩合反应.考察了反应时间、酚与醛(酮)的配比、HMCM-22分子筛用量等因素对酚与醛(酮)反应的影响.结果表明,当酚与醛(酮)摩尔比为1∶1.4,催化剂用量为3.5 g/1mol醛(酮),反应5 h,选择性一般在97%以上,转化率也一般在70%以上,表明HMCM-22分子筛对邻苯二酚与醛(酮)的反应有较好的催化性能.     

HY分子筛催化1,3-苯并二噁茂烷类化合物合成的研究

研究了HY分子筛催化邻苯二酚与环己酮、丁酮、丙酮、丙醛、丁醛、异丁醛、戊醛、异戊醛、正己醛、正辛醛、苯甲醛、二苯甲酮等十余种醛(酮)的缩合反应。考察了反应时间、酚与醛(酮)的配比、HY分子筛用量等因素对酚与醛(酮)反应的影响。实验发现,当邻苯二酚与醛(酮)摩尔比为1∶1.0、催化剂用量为每mol邻苯二酚2.5g、反应4h,选择性一般在97%以上,醛(酮)的转化率一般在57%以上,表明HY分子筛对邻苯二酚与醛(酮)的反应有较好的催化性能。     

New stress metabolite from Bulbophyllum kwangtungense

A new dibenz[b,f]oxepin (1) was found to be produced as a stress metabolite from the leaves and stems of Bulbophyllum kwangtungense Schlecht, in response to abiotic stress elicitation by CuCl2. The structure of 1 was established by spectroscopic and spectrometric means.     

A new phenanthrene and a new 9,10-dihydrophenanthren from Bulbophyllum retusiusculum

A new phenanthrene, bobulretin A (1), and a new 9,10-dihydrophenanthrene, bobulretin B (2) along with four known bibenzyls (3–6) were isolated from the whole plants of Bulbophyllum retusiusculum. Their structures were elucidated by means of extensive spectroscopic analysis. Bobulretin B (2), isolated as enantiomer mixture with unequal proportions, was verified by analysis on a chiral OD-H HPLC column. Compounds 1, 3 and 4 were evaluated for their α-glucosidase inhibitory activity. Neither of them showed obvious activity.     

Three New Bibenzyl Derivatives from the Chinese Liverwort Marchantia polymorpha L.

From the Et₂O extract of the Chinese liverwort Marchantia polymorpha L., three new bibenzyl (=1,1′‐(ethane‐1,2‐diyl)bisbenzene) derivatives, compounds 1 – 3 , were obtained, together with the two known compounds marchantin J and perrottetin E. Their structures were established by NMR and HR‐EI‐MS analyses. Polymorphatin A ( 1 ) represents a new type of bis[bibenzyl] skeleton, and compound 3 is the first example of a bibenzyl oxidatively coupled to a phenylmethanol.     

Novel Bibenzyl Derivatives from the Tubers of Bletilla striata

Three novel bibenzyl derivatives, blestritins A–C ( 1 – 3 ), along with 18 known constituents, were isolated from the tubers of Bletilla striata (Orchidaceae), a traditional Chinese medicine used for the treatment of tuberculosis and haemorrhage of the stomach and lungs. Their structures were identified on the basis of spectroscopic analyses.     

A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum

A new flavone C-glycoside, apigenin 6-C-α-arabinofuranosyl 8-C-α-arabinopyranoside (1) and a new bibenzyl, bulbotetusine (2), were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. The absolute configuration of 2 was determined by the comparison of experimental and calculated electronic circular dichroism. Compounds 1 and 2 showed no obvious cytotoxic activity against any five human tumour cell lines with IC₅₀ values >40 μM.     

New Bibenzyl and Phenanthrenedione from Dendrobium densiflorum

Several species of Dendrobium plants (Orchidaceae) are used in traditional Chinesemedicine as a Yin tonic to nourish the stomach, promote the production of body fluid,and reduce feverl. Chemical components of several Dendrobium plants have been widelyinvestigated" 3. D. densytorum Lindl. ex Wall. is one species of Dendrobium plants,several components of this species have been reported before" 5. We herein reportstructural elucidation of a new bibenzyl named densiflorol A 1 and a newphenant…     

A New Bibenzyl Derivative from Dendrobium moniliforme

A new bibenzyl derivative,3,4-dihydroxy-4′,5-dimethoxy bibenzyl,was isolated from a orchid Dendrobium moniliforme. The structure elucidation and ^1H,^13C NMR assignments were achieved by spectroscopic method.     

A New Bibenzyl Derivative from Bletilla striata

Bletilla striata (Thunb.) Reichb. f. is a perennial herb growing abundantly in Henan, Hunan, Hubei and Sichuan provinces of China. Many compounds have been found previously in this plant1. We report here the isolation and structural elucidation of a new bibenzyl derivative, compound 1 from the EtOAc extraction of roots of B. striata. The MeOH extract of the crushed herb was partitioned with petroleum ether, EtOAc and n-BuOH successively. The EtOAc fraction was fractionated by sili…     

A New Bibenzyl Glycoside from Dendrobium moniliforme

A new bibenzyl glycoside has been isolated from the stems of Dendrobium moniliforme (L.) Sw.(Orchidaceas).Its structure has been identified on the basis of spectroscopic and chemical methods.