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1.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1988,44(8):819-822
The enflurane and ethoxyflurane 1H, 13C and 19F NMR spectra are examined—including sign determination of FF and FH couplings—and considered in the light of previously reported results for methoxyflurane. Conformational differences between methoxyflurane and the former two molecules are indicated by through space FH coupling constants and by the nonequivalence of geminal fluorine nuclei. Populations of conformers about the CC bond are estimated. 相似文献
2.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1991,47(8):1071-1074
The conformations of 3-(substituted benzo[b]furan-2-yl)-GABA (1–4) in solution (D2O) are estimated from high-resolution (400 MHz) 1H NMR coupling data. Conformations and populations of conformers are calculated by means of a modified Karplus-like relationship for the vicinal coupling constants and are compared with X-ray crystallographic investigations. 1H NMR spectral analysis evidences how 1–4 keep also in solution the preferred g− conformation around the C3C4 bond as found in the solid state while a partial rotation is set up around the C2C3 bond. 相似文献
3.
5JHH Couplings proceeding through a HCCCCH - fragment rather than a HCOCCH - path in certain L-idofuranose derivatives are described. The probable mechanism is discussed. 相似文献
4.
2-Oxo-1,3,2-dioxathiane and all methyl- and several alkyl-substituted 2-oxo-1,3,2-dioxathianes were prepared for a 1H NMR conformational study. The conformational energy of the axial SO group in CCl4, - ΔGθSO = 14.8±0.3kJ mol?1, was determined by chemical equilibration of the epimeric cis-4,6-dimethyl derivatives and it was found to decrease with the increasing solvent polarity. The conformational equilibria of alkyl-substituted derivatives were solved and the proportions of the conformers estimated using 1H NMR chemical shifts, vicinal coupling constants and in three cases also dipole moments. The configurational interactions in the C4C5C6 moiety are close to the corresponding values of 1,3-dioxanes. 相似文献
5.
The structures and energies of the four planar conformers of glyoxylic acid and the glyoxylate ion have been studied ab initio using the unscaled 4—31G basis set with full geometry optimization. Changes in the CO, OH and CO bond lengths in the conversion of the cc conformer into the ct and tt conformers, and into the tc conformer, are consistent with the formation of four-membered and five-membered hydrogen-bonded ring structures, respectively. Changes in the distances between the nearest non-bonded atoms around each C atom reveal that the internal geometry of the CHO and COOH groups is significantly affected by cis—trans isomerization with respect to the OCCO backbone, and that the geometry of the CHO group is affected by proton dissociation from the COOH group. Furthermore, the movement of the component atoms in each functional group, characterized as clockwise or anticlockwise about the C atom, results in some cases in a rotation of the functional group as a whole. Whereas experiment shows the tc conformer to be more stable than the tt by 1.2 ± 0.5 kcal mol?1, the calculations find the tt conformer to be the most stable, separated in energy from the ct, tc and cc conformers by 0.4, 1.4 and 10.7 kcal mol?1, respectively. Augmentation of the 4—31G basis set in several forms, and use of (9,5/4) and (9,5/4,1) basis sets, only served to decrease slightly the tt/tc energy difference, not change the sign. The calculated proton affinity of the glyoxylate ion with respect to the tt conformer is 342.7 kcal mol?1, compared to 357.7 kcal mol?1 for the formate ion. The expectation energy differences Δ Vnn, Δ Vee and Δ Ven for the cis—trans isomerization of the ct and cc conformers are opposite in sign to those for the glyoxal reaction, and in magnitude they all far exceed the ΔET values, which shows that hydroxyl group substitution has a much greater influence than a comparison of only the ΔET values would suggest. 相似文献
6.
《Journal of Molecular Structure》1987,157(4):385-398
The microwave spectrum of N-methylethylenediamine and several deuterated species has been investigated in the frequency range 26.5–40 GHz. The rotational spectra of two different conformers with a NH ⋯ N internal hydrogen bond have been assigned. Both conformers have the methyl group trans to the CC bond. The N atom connected to the methyl group acts as proton donor for a conformer (T1), and as acceptor for the second one (T2g). The former is more stable in energy by 0.65(15) kcal mol−1. Rotational lines of several vibrational satellites have been assigned in order to investigate their large amplitude motions and interactions. 相似文献
7.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1991,47(3-4):431-438
Raman and infrared spectra of tiapride were recorded from 4000 to 200 cm−1. Assignments of the fundamental vibrations involved in intra or intermolecular H-bonds as NH⋯O, N+H⋯O and N+H⋯Cl− are discussed. Analysis of some characteristic vibrations leads to the conclusion that the conformations are quite independent of the solvent effects. The change from tiapride base to chlorhydrate that occurs during the crystallization involves a new order of the aliphatic chain which changes the planarity of the chelated form. 相似文献
8.
Second derivative analysis of Raman spectra of H2O, D2O and HOD in liquid phase at room temperature for parallel and perpendicular polarized modes in the OH and OD stretching regions is reported. Five components obtained at approximately 3215, 3375, 3455, 3535 and 3640 cm−1 for the second derivative plots of Raman spectra of liquid water are explained as due to the presence of three types of associated water species with (i) both OH bonds involved in moderately strong hydrogen bonds (SS), (ii) both OH bonds involved in weak hydrogen bonds (WW), and (iii) one OH bond involved in strong and one in weak hydrogen bonds (SW) respectively. The derivative plots obtained for Raman spectra of D2O and HOD also contain features expected to be present on the basis of this model. 相似文献
9.
Janet E. Del Bene 《Chemical physics letters》1979,64(2):227-229
Ab initio SCF calculations have been performed to investigate the structural and electronic features of the interactions of H+ and Li+ with the oxygen bases H2CO and OH?. The data indicate that the OH interactions are primarily covalent while the LiO interactions are primarily electrostatic, although the LiO interaction in LiOH has considerable covalent character. 相似文献
10.
E. Taskinen 《Tetrahedron》1976,32(19):2327-2329
The relative thermodynamic stability of the monoalkoxy- and 1,2-dialkoxyethylene systems [OCCH(C) and OCCO, respectively] has been studied by chemical equilibration of suitable isomeric compounds. Although a single alkoxy substituent stabilizes the CC bond by about 25 kJ mol?1, the 1,2-dialkoxyethylene system is no more stable than the monoalkoxyethylene (“ordinary” vinyl ether) system. On the contrary, the MeOCCOMe system was found to be about 4 kJ mol?1 (on an enthalpy basis) less stable than the system MeOCCH. 相似文献
11.
5 - Acetyl - 10 - cyano - 10,11 - dihydro - 5H - dibenz[b,f]azepine, 3, has been synthesized and its conformations in solution have been studied by variable temperature NMR. At ?55° in CDCl3 solution, 3 shows the signals due to four different conformational isomers. At 55°, signals due to only two conformers can be seen. The ABX pattern of each of the four conformers was analyzed using double resonance experiments and the LAOCN3 computer program. The relative abundances of the isomers in the mixtures were estimated by computer additions of different proportions of the spectra calculated for the separate isomers. These spectral observations are discussed in detail and interpreted in terms of slow inversion of the seven-membered ring by torsion of the 4a55a bonds and restricted twisting of the C10C11 ethylene bridge. 相似文献
12.
The influence of small monovalent metal ions on hydrogen bonds of the OH…N type is studied with the example Li+/H2ONH3. The net stabilization effect is discussed and compared with the OH…O system. The applicability of the semi-empirical CNDO/2 method and ab initio calculations with extended and minimal basis sets is investigated. 相似文献
13.
Yu.A. Strelenko Yu.G. Bundel F.H. Kasumov V.I. Rozenberg O.A. Reutov Yu.A. Ustynyuk 《Journal of organometallic chemistry》1978,159(2):131-135
The 199Hg chemical shifts in a number of benzylmercuric chlorides containing methyl substituents in various positions of the benzene nucleus are studied by the heteronuclear 1H-{199Hg} double resonance technique. Meta- and para-methyl substituents are shown to have no pronounced action on the shielding whereas ortho-methyl groups each shift the signal by 30 ppm downfield. The observed effect is due to an increase in the population of conformers with the CHg bond lying out of the aromatic cycle plane. The departure from planarity favours conjugation between the electrons of the CHg bond and the π-electronic system of the ring. The J(1H199Hg) and J(13C199Hg) coupling constant values obtained in this work confirm the latter conclusion. 相似文献
14.
The improved Seth-Paul-Van Duyse equation (SPVDE) has been used to determine transmissive factors of polar effects for the furan ring. The SPVDE was applied to the CO stretching frequencies of OO-trans and OO-cis conformers of a series of substituted 5-phenyl-2-furancarbonyl compounds measured in carbon tetrachloride. The transmissive factors for furan ring in both conformation OO-trans and OO-cis have been calculated with a higher accuracy than found by using the methods described earlier. The applicability of the improved SPVDE to the 96 CO stretching frequencies of various 5-phenyl-2-furancarbonyl compounds has been proved. 相似文献
15.
Jacques Amaudrut Jean-Claude Leblanc Claude Moïse Jean Sala-Pala 《Journal of organometallic chemistry》1985,295(2):167-174
Reactions of [Cp2M(CO)H] (M = Nb, Ta; Cp = η5-C5H5) with various acetylenes RCCR having electron-withdrawing groups were investigated. They give the σ-al- kenyl complexes [Cp2M(CO)(CRCHR)] via insertion of the alkyne into the MH bond. On the basis of 1H and 19F NMR data the reactions were shown to be: (i) regioselective, monosubstituted alkynes giving only the α-R metallated complex; (ii) stereoselective, exclusive formation of the Z-isomer being observed with hexafluorobut-2-yne. The Z isomer has been shown to exist as two conformers, the steric requirements of the ligands creating a barrier to rotation of the alkenyl group around the MC σ bond. 相似文献
16.
《Journal of organometallic chemistry》1987,321(3):339-352
By means of the addition of the PH-functional methylenebisphosphanes R1R2-PCH2PR3H (PCP) to the MoMo triple bond in (η5-C5H5)2Mo2(CO)4(MoMo) the complexes (η5-C5H5)2Mo2(CO)4(PCP) containing a five-membered ring system Mo2P2C are obtained. Starting with unsymmetrically substituted methylenebisphosphanes R′2PCH2PRH only one isomer is formed, while the disecondary derivatives RHPCH2PHR (as the diastereomeric mixture) gave two isomers of (η5-C5H5)2Mo2(CO)4(PCP) (A2 and AB) as indicated by the 31P{1H} and 13C{1H} NMR spectra.X-ray structural analysis of the derivative of the racemate of t-BuHPCH2PH(t-Bu) space group C2/c, monoclinic, a 18.034(2), b 14.909(1), c 11.106(1) Å, α 90, β 99.788(8), γ 90°) reveals a puckered Mo2P2C five-membered ring system (dihedral angle PMoMo′P′ 54.4(2)°) with square-pyramidal coordination geometry at the Mo atoms. Two of the CO ligands (C(6)O(1) and C(6′)O(1′)) are almost coplanar with the molybdenum atoms, while the terminal CO groups (C(7)O(2) and C(7′)O(2′)) are about orthogonal (dihedral angle C(7)MoMo′C(7′) 88.4(3), MoMo′ 3.2109(4), MoP 2.4567(8), PC(8) 1.834(3), PH(P) 1.37(3) Å). 相似文献
17.
Rigid harmonic asymetric top contour simulation is applied to assign the OH stretch transitions observed in the vapour phase infrared spectra of ethanol and isopropanol to gauche and trans conformers. For hetanol, the high frequency ν(OH) absorption must be assigned to the trans, for isopropanol the high frequency absorption is found to be due to the gauche conformer. 相似文献
18.
The methoxyflurane NMR spectrum was reexamined looking for a through-space transmitted four-bond FH coupling. This coupling was measured and its sign determined relative to the corresponding vicinal FH coupling. This sign determination required a triple irradiation technique, which is also described. A Karplus-like equation for the vicinal FH couplings yields the relative populations of both preferential conformers, and determines the positive sign of both three- and four-bond FH couplings. 相似文献
19.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1990,46(6):957-965
1H NMR data are reported for a series of 2-aryl-1-halopropanes. Vicinal coupling constants in the CH2CH—fragment show that the rotamer populations about the CC bond are sensitive to para substituents. The ratio of anti:gauche aryl/halide conformers is greatest when the para substituent is the electron-donating ethyl group and least when it is the strongly electron-withdrawing nitro group. This points to a non-steric conformational interaction involving the ring and the sidechain heteroatom. Comparison of the empirical results with conformational preferences predicted from molecular mechanics calculations using the COSMIC force field suggests that the interaction serves to enhance the population of the anti arrangement. 相似文献
20.
A. Kunicki W. Kosińska M. BolesŁawski S. Pasynkiewicz 《Journal of organometallic chemistry》1977,141(3):283-288
It has been shown by means of 1H NMR, IR and cryometrical measurements that, with oxygen bridges, Me(OMe)AlCl and Me(OMe)AII are trimers in solutions.Two isomers, cis and trans, are present, which are responsible for the multiple 1H NMR spectra. The proton signals of MeAl and OMe groups are assigned in each isomer. 相似文献