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1.
《Polyhedron》1987,6(1):39-44
Copper complexes of two heterocyclic thiosemicarbazones were synthesized and characterized by magnetic-moment measurement, and ESR and IR spectroscopy. Implications of the magnetic and spectral data in relation to the structures of the complexes are discussed. 相似文献
2.
Douglas X. West Cinda S. Carlson Authrine C. Whyte Anthony E. Liberta 《Transition Metal Chemistry》1990,15(1):43-47
Summary Spectral and thermal information, as well as activity againstAspergillus niger, have been obtained for 2-acetylpyridine4
N-ethylthiosemicarbazone and its iron(III), cobalt(II,III), nickel(II) and copper(II) complexes. 相似文献
3.
Summary Metal ion complexes of the thiosemicarbazone,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]hydrazinecarbothioamide (HL4DM) have been prepared and characterized spectrally. HL4DM coordinates primarily as the deprotonated tridentate ligand (i.e., pyrïdylN, azomethineN, and thione sulphur). In contrast to related thiosemicarbazones, oxidation to cobalt(III) does not occur during complex formation with cobalt(II) halides. Oxidation does occur on reflux with ethanolic Co(BF4)2, but we isolated a planar cobalt(II) complex as well. Only with the tetrafluoroborate salts of cobalt(II) and nickel(II) are complexes isolated containing the neutral thiosemicarbazone. Square planar [Ni(L4DM)X]complexes where X=Cl, Br, and OH have been isolated and e.s.r. spectra of a 1% Cu/Ni complex are compared to the results of other workers. 相似文献
4.
Summary Metal ion complexes of the thiosemicarbazone,4
N-cyclohexyl-2-[1-(2-pyridinyl)ethylidene]hydrazinecarbothioamide (HL4CH), have been prepared and spectrally characterised. Both the size of the cyclohexyl-group attached at4N as well as the4N hydrogen affect the stoichiometry and stereochemistry of the isolated complexes. The large cyclohexyl-group evidently causes the isolation of [Fe(HL4CH) (L4CH)H2O](ClO4) instead of the expected [Fe(L4CH)2]ClO4[Co(L4CH)Br] instead of [Co(HL4CH)Br2], and [Ni(L4CH)Br] instead of [Ni(HL4CH)2Br2]. The presence of the hydrogen at4N presumably hinders the deprotonation of HL4CH on complex formation since [Cu(HL4CH)Cl2] was isolated rather than [CuLCl], which occurs when the thiosemicarbazone has4N with two alkyl groups or incorporated in a ring. Further, although we prepared [Ni(L4CH)Br], complexes of this stoichiometry are planar and diamagnetle when4N does not have a hydrogen(s) attached to it rather than tetrahedral and paramagnetic as has been found for the present complex. 相似文献
5.
Summary A series of metal ion complexes of the thiosemicarbazone,N-methyl-2[1-(2-pyridinyl)ethylidene]-hydrazinecarbothioamide (HL4M) has been prepared and spectrally characterized. HL4M coordinates either as a neutral bidentate ligand (i.e., pyridyl N and imine N) or as deprotonated tridentate ligand (i.e., pyridyl N, imine N and thiol sulphur). The cobalt(II) salts yield hexacoordinated cobalt(III) cations, and an isoelectronic species, [Ni(L4M)2], has been formed from Ni(C2H3O2)2. The remaining nickel(II) complexes involve the neutral ligand, as do two of the three copper(II) complexes. HL4M possesses a weaker ligand field and has less covalency in its bonding than related thiosemicarbazones that possess anN-dialkyl-function. 相似文献
6.
Summary Metal ion complexes of the thiosemicarbazone, 3-hexamethyleneimine-3-thiocarboxylic acid-2-[1-(2-pyridyl)-ethylidene]hydrazide (HLhexim) have been prepared and spectrally characterized. HLhexim coordinates primarily as the deprotonated tridentate ligand (i.e., pyridylN, azomethineN, and thione sulphur). The air oxidised cobalt(III) complex, [Co(LHexim)2] (BF4), was isolated from the preparation with cobalt(II) tetrafluoroborate, but other cobalt(II) salts yielded tetrahedral cobalt(II) compounds. Planar nickel(II) and copper(II) complexes were isolated from preparations with halide salts. Significant differences in the spectral properties of the various complexes are observed when compared to other thiosemicarbazones prepared from 2-acetylpyridine. 相似文献
7.
Summary Metal ion complexes of the thiosemicarbazone, 3-piperidinyl-3-thiocarboxylic acid-2-[1-(2-pyridyl)ethylidene]hydrazide (HLpip) have been prepared and spectrally characterized. HLpip coordinates both as the deprotonated ligand (i.e., pyridylN, azomethineN, and thione sulphur) and the neutral ligand (i.e., pyridylN and azomethineN) with the sulphur possibly weakly coordinating in [Ni(HLpip)2](BF4)2. All three preparative cobalt(II) salts yielded cobalt(III) cationic complexes. The nickel(II) and copper(II) chloride salts gave [M(Lpip)Cl] solids while complexes involving the neutral ligand were prepared with the corresponding bromide salts. Significant differences in the spectral properties of the various complexes are observed when compared to other thiosemicarbazones prepared from 2-acetylpyridine. 相似文献
8.
A series of Cu(II) complexes of the thiosemicarbazone, 3-azabicyclo[3.2.2]-nonene-3-thiocarboxylic acid 2-[1-(2-pyridinyl)ethylidene]hydrazide(HL) and the corresponding N-oxide (HLO) have been prepared and characterized. Both ligands undergo deprotonation and appear to coordinate via the thione sulfur, the imine nitrogen and the pyridyl nitrogen (or N-oxide oxygen). A single anionic ligand such as Cl?, Br?, NCS? and N?3 completes the bonding to the Cu(II) center of these 4-coordinate complexes. When the complexes are prepared using Cu(II) perchlorate, the solids isolated contain a neutral thiosemicarbazone ligand as well as the deprotonated ligand. The solids are primarily characterized by IR, electronic and electron spin resonance spectroscopy. In addition, electronic and ESR spectra of their chloroform solutions were recorded. Most of the solids (except the nitrates) were unaltered upon dissolution. Simulation of the solution ESR spectra was used to estimate the coupling constants of the various coordinated nuclei. 相似文献
9.
Bhagwan S. Garg M. R. Prathapachandra Kurup Satendra K. Jain Yudhvir K. Bhoon 《Transition Metal Chemistry》1988,13(4):247-249
Summary Iron(III) complexes of four substituted thiosemicarbazones of 2-acetylpyridine of general. formula [FeL2]ClO4 (where L is a deprotonated ligand) have been synthesised and characterised by elemental analyses, magnetic susceptibility measurements in the polycrystalline state at room temperature, i.r. spectra, electronic spectra and e.s.r. spectra recorded in polycrystalline state, in methanol solution at room temperature and at 77 K. All the complexes are 1:1 electrolytes. The ligands coordinate via the pyridine nitrogen, imine nitrogen and thione sulphur. E.s.r. spectra and with magnetic studies suggest a spin-paired configuration for the iron(III) complexes.Author to whom all correspondence should be directed 相似文献
10.
Douglas X. West Cinda S. Carlson Collin P. Galloway Anthony E. Liberta Christina R. Daniel 《Transition Metal Chemistry》1990,15(2):91-95
Summary Complexes of stoichiometry [CuLX] where X=Cl, Br and L=2-acetylpyridine4
N-diethyl- and4
N-dipropylthiosemicarbazone, HL4DE and HL4DP, respectively, have substantially more activity againstAspergillus niger andPaecilomyces variotii than the uncomplexed thiosemicarbazones. Spectral data (i.e., i.r., u.v.vis., and e.s.r) of the complexes are presented along with thermodynamic data for the thiosemicarbazones. 相似文献
11.
Douglas X. West Cinda S. Carlson Anthony E. Liberta Julyan N. Albert Christina R. Daniel 《Transition Metal Chemistry》1990,15(5):341-344
Summary Nickel(II) complexes of 2-acetylpyridine4
N-diethyl- and4
N-dipropylthiosemicarbazone show less activity againstAspercallus niger than the free thiosemicarbazones. However, againstPaecilomyces variotii the nickel(II) complexes possess comparable activity at high concentrations and are more active at lower concentrations. Spectral and thermal information about the nickel(II) complexes, which coordinate the anionic thiosemicarbazone ligands in a tridentate manner, is included. 相似文献
12.
Summary Metal ion complexes of 2-acetylpyridineS-methyldithiocarbazate, HNNS, have been prepared and spectrally characterised. Preparations in EtOH yield complexes in which the deprotonated ligand, NNS, is complexedvia its pyridyl nitrogen, azomethine nitrogen, and thione sulphur. The stoichiometries are: [M(NNS)2]X (M=Fe3+, Co3+ and X=ClO
4
–
, [FeCl4]–, BF
4
–
, 1/2 [CoCl4]2– and 1/2 [CoBr4]2–), [M(NNS)X] (M=Ni2+, Cu2+ and X=Cl–, Br–), [Cu(NNS)H2O]BF4 and Ni(HNNS)(NNS)F(EtOH)]BF4. The spectral (i.e., i.r., u.v.-vis.-n.i.r. and e.s.r.) and physical properties of these complexes are compared to those of theS-methyldithiocarbazates of 2-formylpyridine and 2-acetylpyridineN-oxide, as well as the related thiosemicarbazones prepared from 2-acetylpyridine. Thermal studies of the nickel(II) complexes indicate that the nature of thermal decomposition of coordinated NNS is different from that of HNNS. 相似文献
13.
Douglas X. West Imporn Thientanavanich Anthony E. Liberta 《Transition Metal Chemistry》1995,20(3):303-308
Summary Copper(II) complexes of 6-methyl-2-acetylpyridine N(4)-substituted thiosemicarbazones, coordinated either as a neutral or a monoanionic ligand, have been prepared and characterized. I.r., electronic and e.p.r. spectra of the complexes, as well as1H- and13C-n.m.r. spectra of the thiosemicarbazones, have been recorded. Both the thiosemicarbazones and their copper(II) complexes show either modest or no growth inhibitory activity againstAspergillus niger, but theN(4)-dialkyl- and 3-azacyclo-derivatives, and particularly their copper(II) complexes, have considerable activity againstPaecilomyces variotii. 相似文献
14.
Avinash S. Kumbhar Subhash B. Padhye Douglas X. West Anthony E. Liberta 《Transition Metal Chemistry》1992,17(3):247-249
The electrochemical behaviour of a series of copper(II) complexes of 2-acetylpyridine 3-azacyclothiosemicarbazones is reported.
The complexes undergo a quasireversible one electron reduction in the range −0.400 to −0.450 Vversus Ag/AgCl, attributable to the copper(II)/-copper(I) redox couple. The electrochemical, as well as spectral characteristics
of these complexes, can be correlated with their antifungal activity againstAspergillus niger, Paecilomyces variotti, Penicillum rubrum andAspergillus terreus. 相似文献
15.
Summary
4
N-diethyl- and4
N-dipropylthiosemicarbazones of 2-acetylpyridine coordinate to FeIII, CoIII and CoII centres as tridentate NNS ligands. Spectral and physical data indicates that the size of the4
N-substituents can influence the stereochemistry and stoichiometry of the complexes, which show minimal ability to inhibit fungal growth and are considerably less active than the related copper(II) and nickel(II) complexes. 相似文献
16.
R. W. Mason K. McGrouther P. R. R. Ranatunge‐Bandarage B. H. Robinson J. Simpson 《应用有机金属化学》1999,13(3):163-174
Toxicity, antitumour, platinum distribution, hepatotoxicity and histology data are presented for a series of ferrocenylamines: [(η‐C5H4(CH2)nNH2)FeCp] (n = 0,1) ( 1 , 2 ); [(η‐C5H4CH2NHPh)FeCp] ( 3 ); [(η‐C5H4CH2NMe2)FeCp] ( 4 ); {[η‐C5H4CH(Me)NMe2]FeCp} ( 5 ); [η‐C5H4CH2NMe2)2Fe] ( 6 ); {[1,2η‐C5H3(CHMeNMe2)(PPh2)]FeCp} ( 7 ); {[1,2η‐C5H3(CHMeNMe2)(PPh2)]Fe[η‐C5H4PPh2]} ( 8 ); and their complexes cis‐PtCl2L2 ( 9 ); trans ‐ Pt(L)(dmso)X2 ( 10 ); [σ ‐ (L)Pt(dmso)X] ( 11 , 12 ) {σ‐(L)[Pt(dmso)X]2} ( 13 ); [σ‐(L)PtP(OPh)3Cl] ( 14 ) (L = ferrocenylamine). The toxicity order is 1 – 3 ≫ 4 – 8 for the ferrocenylamines; the lower toxicity of tertiary amines may be due to protonation in vivo. Pt(II) complexes all show increased toxicity over the ligand. Liver, not kidney, damage is the norm from i.p. injection of 1 – 14 and detailed platinum distribution, blood serum and histology studies with 9 and 11 show that the platinum distribution does not correlate with liver dysfunction. Complexes 9 – 14 , but not 1 – 8 , were active against P‐388 mouse leukaemia tumour and cisplatin‐resistant sarcoma, but inactive against L‐1210 mouse leukaemia and B‐16 melanoma. Copyright © 1999 John Wiley & Sons, Ltd. 相似文献
17.
Douglas X. West Patricia M. Ahrweiler Gözen Ertem John P. Scovill Daniel L. Klayman Judith L. Flippen-Anderson Richard Gilardi Clifford George Lewis K. Pannell 《Transition Metal Chemistry》1985,10(7):264-270
Summary A series of iron(III) complexes of thiosemicarbazones derived from 2-acetylpyridine, 6-methyl-2-acetylpyridine and 2-acetylpyridineN-oxide have been prepared from Fe(ClO4)3 and FeCl3. All of the isolated solids have cations involving two monobasic tridentate ligands, and either perchlorate or tetrachloroferrate(III) anions and are 11 electrolytes. Coordinationvia the pyridine nitrogen (or theN-oxide oxygen), the imine nitrogen and the sulphur atom are confirmed by infrared spectra and x-ray diffraction. The presence of two different iron(III) species is indicated by the electron spin resonance spectra of the tetrachloroferrate(III) solids. E.s.r. along with electronic spectra prove the spin-paired configuration of these cationic iron(III) complexes.NATO Fellow, on leave from Istanbul Medical Faculty, Istanbul University. 相似文献
18.
Coordination compounds of some transition metal ions with 2-acetylpyridene-o-hydroxybenzoylhydrazone (APo-OHBH) were synthesized. Their structures have been characterised by elemental analyses, electrical conductance, magnetic moments (at 25 degrees C) and spectral (IR, UV, NMR) studies. The fast atom bombardment (FAB) method was used for obtaining mass spectra of the positive ion FAB studies of the ligand and some metal complexes. The thermal behaviour of selected complexes was investigated by thermal gravimetrical analysis (TGA) and differential thermal analysis (DTA) techniques. The IR spectra show that the ligand acts in a neutral bidentate, neutral tridentate and/or mononegative tridentate fashion depending on the metal salt used and the medium of the reaction. Preliminary pharmacological tests on the ligand and its complexes showed some antimicrobial activity. 相似文献
19.
Douglas X. West Gözen Ertem Robert M. Makeever John P. Scovill Daniel L. Klayman 《Transition Metal Chemistry》1985,10(2):41-45
Summary A series of metal ion complexes of the thiosemicarbazone, 3-azabicyclo[3.2.2]nonane-3-thiocarboxylic acid 2-[1-(6-methyl-2-pyridinyl)ethylidene]hydrazide (6 MLH) have been prepared and spectrally characterized. The ligand undergoes deprotonation to coordinatevia the thione sulphur, the imine nitrogen and the pyridyl nitrogen. A single anionic ligand such as Cl–, Br– and NO3
– completes the bonding to the CuII and NiII centre. The compound derived from CoCl2 contains two 6 MLH ligands bound to a CoII centre and a CoCl
4
2–
counter ion. Complexes derived from perchlorate salts may feature 6 MLH, 6 ML, or both with the CoII being oxidized to CoIII. The solids were characterized by i.r., electronic and e.s.r. spectroscopy. In addition, electronic and e.s.r. spectra of their chloroform solutions were recorded.NATO Fellow, on leave from Istanbul Medical Faculty, Istanbul University. 相似文献
20.
Gwaram NS Ali HM Khaledi H Abdulla MA Hadi AH Lin TK Ching CL Ooi CL 《Molecules (Basel, Switzerland)》2012,17(5):5952-5971
A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa. 相似文献