共查询到20条相似文献,搜索用时 78 毫秒
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Atul Asati Santimukul Santra Dr. Charalambos Kaittanis Sudip Nath Dr. J. Manuel Perez Prof. 《Angewandte Chemie (International ed. in English)》2009,48(13):2308-2312
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase‐like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
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Horst Kunkely Dr. Arnd Vogler Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(9):1685-1687
Last but not least : A simple molecular redox system is used to split water into hydrogen and oxygen photochemically. Two separate photolyses are combined to a cyclic process (see scheme). Osmocene ([Cp2OsII] with Cp?=C5H5?) serves as photocatalyst.
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Cecilia Anaya de Parrodi Prof. Patrick J. Walsh Prof. 《Angewandte Chemie (International ed. in English)》2009,48(26):4679-4682
Alkynes of reactions : Recent breakthroughs in metal‐catalyzed alkyne reactions, which expand the synthetic utility of alkynes, have been achieved. These approaches broaden the range of alkynes that are accessible by C? N and C? C bond‐forming reactions and demonstrate that the use of bifunctional heterobimetallic catalysts can lead to new reactivity and excellent enantioselectivity (see scheme).
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Natsumi Tanaka Takahiro Suzuki Dr. Takehiko Matsumura Yosuke Hosoya Masahisa Nakada Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(14):2580-2583
Intelligent design : The total synthesis of the cytotoxic (?)‐FR182877 relies on 1) tandem Diels–Alder reactions to close rings A–D (see scheme), 2) a palladium‐mediated 7‐exo‐trig reaction, and 3) an iridium‐mediated isomerization followed by epimerization and stereoselective reduction.
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Ming‐Dong Zhou Yang Yu Alejandro Capap KavitaR. Jain Eberhardt Herdtweck Xiao‐Rong Li Jun Li Shu‐Liang Zang FritzE. Kühn 《化学:亚洲杂志》2009,4(3):411-418
It′s a fine line : Methyltrioxorhenium(VII) (MTO) readily forms 1:1 adducts with several N‐(salicylidene)aniline derived Schiff bases. Steric and electronic effects of the ligands play a major role when it comes to stability and catalytic activity. Good donors on the Schiff base ligands, in general, lead to shorter Re? O(Schiff base) bridges and lower catalytic activity, while it is the opposite for acceptor ligands on the Schiff bases.
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Sylvia Kirchberg Roland Fröhlich Dr. Armido Studer Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(23):4235-4238
Indoles are not indolent : Various indoles react with arylboronic acids chemodivergently. C? H arylation of free indole and N‐methylindole gives the corresponding C(2)‐arylated indoles A whereas N‐acylated, N‐benzoylated, and N‐Boc‐protected indoles provide the corresponding arylcarboaminoxylated products B with excellent diastereoselectivity in good to excellent yields.
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Peter W. Roesky Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(27):4892-4894
Excellent couplings : Recent developments in the metal‐catalyzed C? H activation of sp3 centers in an α position relative to an amine nitrogen atom are presented. Their reaction with alkenes to give alkylamines (hydroaminoalkylation) is also summarized (see general scheme).
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Akira Tai Fukuji Higashi Soichiro Yokomizo 《Journal of polymer science. Part A, Polymer chemistry》1971,9(9):2481-2491
The structural changes of the polymers having the following structures: at high temperatures were studied by the spectroscopic and thermal analysis. When the polymers were heated in air, they were oxidized predominantly to polymers having the structure: The rate of oxidation was fast and the reaction was almost completed within 2 hr at 180°C. In the case of polymer 3, an intramolecular cyclization to form acridone was detected as a minor reaction. 相似文献
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《Angewandte Chemie (International ed. in English)》2009,48(14):2449-2449
“The biggest challenge facing chemists is being creative. When I was eighteen I wanted to be an astrophysicist…︁.” This and more about Sandro Gambarotta can be found on page 2449.
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As simple as it gets! Potassium tert‐butoxide alone catalyzes the direct dehydrogenative Si? O coupling of several synthetically important silanes with 1°, 2°, and even 3° alcohols without the need for stoichiometric hydrochloric acid scavengers. The stereoretentive mechanism is probed with a silicon‐stereogenic silane.
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Sebastian Bartsch Dipl.‐Biochem. Uwe T. Bornscheuer Prof. 《Angewandte Chemie (International ed. in English)》2009,48(18):3362-3365
All ways lead to Rome? Computer modeling and kinetic measurements identified a distinct residue in Phe/Tyr ammonia lyases (PAL/TAL) which controls whether the Friedel–Crafts or an E1cB reaction mechanism takes place. Hence, Glu484 in pcPAL favors the Friedel–Crafts reaction (see picture, MIO=4‐methylidene imidazol‐5‐one) whereas an Asn in TAL gives an elimination reaction. These mechanistic investigations also reveal activity of a PAL mutant and a TAL towards an amino alcohol.
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《Angewandte Chemie (International ed. in English)》2009,48(15):2635-2635
“My first experiment was preparation of proline‐derived chiral ligands for asymmetric alkylation. My favorite subjects at school were history and English…?.” This and more about Keisuke Suzuki can be found on page 2635.
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Suribabu Jammi Md Ashif Ali Sekarpandi Sakthivel Laxmidhar Rout Tharmalingam Punniyamurthy 《化学:亚洲杂志》2009,4(2):314-320
Simple addition : Copper(II) aqua complex 1 can be prepared in a one‐pot synthesis and is self‐assembled by H‐bond interactions. Complex 1 is shown to accelerate the nitroaldol reaction on water, which is a heterogeneous process, requiring no additive or base, and 1 can be recycled without loss of activity.
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Akinari Hamajima Minoru Isobe 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2009,121(16):2985-2989
Eines der Haupttoxine bei Fischvergiftungen, das Ciguatoxin (siehe Struktur), war Ziel einer Totalsynthese. Der Syntheseweg beruht auf der Kupplung dreier Segmente, und die Schlüsselumwandlungen umfassen eine Komplexbildung zwischen Acetylen und Dicobalthexacarbonyl.