共查询到20条相似文献,搜索用时 15 毫秒
1.
Shuang Liang Yun‐Heng Shen Jun‐Mian Tian Yi Feng Zhi Xiong Wei‐Dong Zhang 《Helvetica chimica acta》2011,94(7):1239-1245
Five new biflavonoids, 1 – 5 , were isolated from the stem bark of Daphne aurantiaca. The structures were elucidated as 2,2″‐bisteppogenin ( 1 ), 2,2″‐bisteppogenin 7‐O‐β‐glucopyranoside ( 2 ), 2′′′‐dehydroxy‐2,2″‐bisteppogenin ( 3 ), 2′′′‐dehydroxy‐2,2″‐bisteppogenin 7‐O‐β‐glucopyranoside ( 4 ), and 7‐methoxyneochamaejasmin B ( 5 ) on the basis of spectral analyses. 相似文献
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Wei Xin SUN Qiang ZHANG Jian Qin JIANG 《中国化学快报》2006,17(8):1054-1056
Daphne giraldii Nitsche (Thymelaeaceae) is widely distributed in Shanxi, Gansu, Sichuan and Ningxia provinces of China. According to the modern research, it showed the activity against inflammatory, pain, cancer and so on1. Herein we report the identifica… 相似文献
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传统藏药材高原香薷的矿质元素分析 总被引:2,自引:0,他引:2
对传统藏药材香薷中高原香薷种的17种微量元素进行了分析。结果表明,在高原香薷中人体必需微量元素Cu、Zn、Fe、Mn、Co、Ni、Se等含量较高,尤其以Cu、Fe、Mn元素的含量为高。Na、Ca等宏量元素含量亦较高。 相似文献
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Juan Su Zhi Jun Wu Run Hui Liu Yun Heng Shen Chuan Zhang Hui Liang Li Wei Zhang Wei Dong Zhang 《中国化学快报》2007,18(7):835-836
A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-b-D-glucopyranosyl-(1→6)-b-D-glucopyranoside on the basis of spectral evidences. 相似文献
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Yi-Wen Nie Yuan Li Lan Luo Chun-Yan Zhang Wei Fan Wei-Ying Gu Kou-Rong Shi Xiao-Xiang Zhai Jian-Yong Zhu 《Molecules (Basel, Switzerland)》2021,26(21)
There are abundant natural diterpenoids in the plants of the genus Daphne from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus Daphne, which could be further classified into three main types according to the substitution pattern of ring A and oxygen-containing functions at ring B. A variety of studies have demonstrated that these compounds exert a wide range of bioactivities both in vitro and in vivo including anticancer, anti-inflammatory, anti-HIV, antifertility, neurotrophic, and cholesterol-lowering effects, which is reviewed herein. Meanwhile, the fascinating structure–activity relationship is also concluded in this review in the hope of providing an easy access to available information for the synthesis and optimization of efficient drugs. 相似文献
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Hu QF Mu HX Huang HT Lv HY Li SL Tu PF Li GP 《Chemical & pharmaceutical bulletin》2011,59(11):1421-1424
Two new secolignans and one new neolignan, named feddeiphenols A-C (1-3), together with eight known compounds (4-11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1-11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity. 相似文献
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Muhammad Riaz Asma Saleem Shabana Siddique Bilal Ahmad Khan Mohammad Nur-e-Alam Syed Shahzad-ul-Hussan 《Natural product research》2016,30(8):880-897
Genus Daphne belongs to the Thymelaeaceae family and consists of 70 species. Its various species exist in Europe, Philippine Islands, temperate and subtropical Asia, North Africa, Australia and Pacific. In Pakistan, Daphne is represented by three species. Our focused Daphne oleoides is widely found in diverse climatic conditions from northern cold to central hot regions which creates a rich diversity and novelty in biosynthetic levels of its chemical constituents and hence is a great opportunity. Daphne oeloides is a proven rich source of a variety of unique and interesting nature-made skeletons with a wide range of therapeutic properties. D. oleoides possesses effective therapeutic properties, therefore, has been used in herbal medicines and is still being used to treat various diseases. The modern research by various groups, including ourselves, has resulted in the isolation of a number of natural molecules including some novel tris- and bis- coumarins, daphnane diterpenoids and lignoids. Therefore, due to novelty and richness of the nature-made molecules, and their therapeutic potential combined with our significant work on D. oleoides, this report covers chemical constituents isolated from D. oleoides. The pharmacological activities of the isolated compounds and use of this species in folk medicine have also been reviewed. 相似文献
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The phytochemical investigation of the flower buds of Daphne genkwa yielded eight highly oxygenated daphnane-type diterpene esters, including a new one, genkwanine N 20-palmitate (1) and seven known ones (2–8). The molecular structures of the isolated compounds were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, NMR, and MS, and comparison with literature data. Furthermore, compound 1 showed potential cytotoxic activity in vitro, against A549 and Hep G2 tumour cell lines. 相似文献
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Nguyen Van Minh Baek-Soo Han Ha-Young Choi JeongSu Byun Ji-Su Park 《Natural product research》2018,32(15):1782-1790
Screening for new natural anti-neuroinflammatory compounds was performed with the traditional folk medicine Genkwa Flos, which potently inhibited nitric oxide (NO) production by LPS-activated microglial BV-2 cells. Two new lathyrane-type diterpenes, genkwalathins A (1) and B (2), and 14 known daphnane-type diterpenes (3–16) were isolated. The lathyrane-type diterpenes were isolated for the first time from the Thymelaeaceae family in this study. Compounds 1 and 2 moderately inhibited LPS-induced NO production in BV-2 cells without affecting cell viability, while six daphnane-type diterpenes (3, 4, 6, 7, 9 and 10) potently reduced NO production with IC50 values less than 1 μM, although they did display weak cytotoxicity. A structure–activity relationship study on the daphnane-type diterpenes indicated that the stereochemistry at C-19, the benzoate group at C-20, and the epoxide moiety could be important for their anti-neuroinflammatory effects. 相似文献
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Five daphnane type diterpenes have been isolated from the chloroform soluble fraction of Daphne genkwa. The structure of the new compound (1) was assigned as 5beta-hydroxyresiniferonol-6alpha,7alpha-epoxy-12beta-acetoxy-9,13,14-ortho-2E-decenoate by extensive NMR studies. 相似文献
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Three new monoterpene glucosides, lamiuamplexosides A–C ( 1 – 3 ), along with thirteen known glucosides, were isolated from the whole plant of Lamium amplexicaule L. The structures of 1 – 3 were elucidated on the basis of spectroscopic, chemical, and physicochemical evidence. 相似文献
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Two new bis‐coumarins, namely daphnogitin ( 1 ), daphnogirin ( 2 ), and a flavan‐3‐ol derivative, 5‐O‐methylafzelechin ( 3 ), together with eleven known compounds, daphnetoxin, 1,2‐dihydrodaphnetoxin, daphnetin, daphnoretin, daphneticin, isodaphneticin, trans‐2,3‐dihydro‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐2‐(hydroxymethyl)‐9H‐pyrano[2,3‐f]‐1,4‐benzodioxin‐9‐one (= demethoxyisodaphneticin; 4b ), (+)‐pinoresinol, acuminatin, (−)‐dihydrosesamin, and isosalicifoline, were isolated from the leaves and stems of Daphne giraldii. Compound 4b was isolated for the first time as a natural product, and 1,2‐dihydrodaphnetoxin, daphneticin, isodaphneticin, (+)‐pinoresinol, acuminatin, (−)‐dihydrosesamin, and isosalicifoline were isolated for the first time from Daphne giraldii. The structures of the three new compounds were elucidated by spectroscopic analysis. 相似文献
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芫花 (DaphnegenkwaSieb.etZucc.)属于瑞香科植物[1] ,芫花的浸取液对棉蛉虫、稻螟虫、菜青虫、班蝥等害虫具有较好的杀虫效果 ,且对人畜无害 ,是一种理想的无公害农药[2 ] 。为了提高药效 ,更好地开发这种无公害农药 ,本文对芫花中杀虫有效成分的提取工艺与杀虫效果进行了初步研究。1 实验部分1 1 试剂和仪器苯 ,氯仿和 95 %的乙醇均为分析纯 ;岛津UV -2 40型紫外可见分光光度仪 ;FT -80ANMR仪。1 2 实验方法芫花枝条干粉 1 5 0 0g,加水 1 0 .0 0L煮沸 1 2小时 ,煮沸过程中陆续补加少量水分。将煮沸… 相似文献
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Ai‐Xue Zuo Yong Shen Zhi‐Yong Jiang Xue‐Mei Zhang Jun Zhou Jun Lü Ji‐Jun Chen 《Helvetica chimica acta》2010,93(3):504-510
Three new phenolic glucosides named orcinosides A, B, and C ( 1, 2 , and 3 , resp.) were isolated in low yields (4.0×10−6, 11.5×10−6, 4.5×10−6%, resp.) from the rhizomes of Curculigo orchioides. Their structures were elucidated by comprehensive spectroscopic analyses including FAB‐MS, HR‐ESI‐MS, IR, and 1D‐ and 2D‐NMR (HSQC, HMBC) data. Compounds 1 – 3 contained two orcinol‐glucoside moieties linked through a CH2 group. 相似文献
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Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim 总被引:1,自引:0,他引:1 下载免费PDF全文
Xinzhou Yang Mi Huang Sijian Zheng Xinhua Ma Dingrong Wan Yunjiang Feng 《Journal of separation science》2016,39(11):2179-2187
An ethyl acetate extract from the barks of the ethnic Chinese medicine Daphne tangutica Maxim. exhibited antihepatocellular carcinoma activity against HepG2 and Hep3B cell lines. By using high‐performance liquid chromatography based activity profiling in combination with offline liquid chromatography with mass spectrometry and NMR analysis, we rapidly identified ten major components of the extract, including seven active principles, coumarins ( 1–4 ) and biscoumarins ( 7, 8, 10 ), along with three inactive flavonoids ( 5, 6, 9 ). This study demonstrated that our combined protocol can be used as an important strategy for chemical profiling, dereplication as well as the identification of bioactive compounds from herbal medicines. 相似文献
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Li PAN Xiao Feng ZHANG Hai Feng WU Li Sheng DING 《中国化学快报》2006,17(1):38-40
Daphne tangutica Maxim., a shrub of Thymelaeaceae family, meanly grows in northwest area of China at altitude of 1500-4000 m. The root barks of this plant are utilized as a traditional Tibetan medicine for releasing pain, curing rheumatism and as an abort… 相似文献
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Ling‐Zhi Li Pin‐Yi Gao Ying Peng Li‐Hui Wang Jing‐Yu Yang Chun‐Fu Wu Yan Zhang Shao‐Jiang Song 《Helvetica chimica acta》2010,93(6):1172-1179
Three new daphnane‐type diterpenoids, genkwanines M–O ( 1 – 3 , resp.), together with seven known daphnane‐type diterpenoids, genkwanines D and H, genkwaine F, genkwadaphnine, yuanhuatine, yuanhuafine, and yuanhuapine ( 4 – 10 , resp.), were isolated from the flower buds of Daphne genkwa during a phytochemical investigation. The structures of the new compounds were elucidated on the basis of spectroscopic analyses, especially 2D‐NMR spectra (HSQC, HMBC, and NOESY). 相似文献