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Wee Han Ang Dr. Lorien J. Parker Anastasia De Luca Lucienne Juillerat‐Jeanneret Dr. Craig J. Morton Dr. Mario Lo Bello Prof. Michael W. Parker Prof. Paul J. Dyson Prof. 《Angewandte Chemie (International ed. in English)》2009,48(21):3854-3857
Double trouble : A hybrid organic–inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active‐site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
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Dominique Bélanger Xia Tong Sadia Soumaré Yves L. Dory Prof. Yue Zhao Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(17):4428-4436
Pepped up polymers : The synthesis and properties of novel chiral cyclic peptides designed to complex with suitable polymers through hydrogen bonding are described. A substituted cyclic peptide self‐assembles into supramolecular nanotubes and develops noncovalent interactions with poly(vinyl alcohol) (PVA) by means of its carboxyl side chains.
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Ramon Kranaster Dipl.‐Chem. Andreas Marx Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(25):4625-4628
A novel screening approach based on an oligonucleotide‐addressing enzyme assay enables multiplexed simultaneous profiling of DNA polymerases in nanoliter volumes in terms of their different properties. This approach was used to identify enzymes with altered properties out of a library of protein mutants.
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Xiaogang Liu Prof. 《Angewandte Chemie (International ed. in English)》2009,48(17):3018-3021
Hex nut : An emerging synthetic approach based on metal–organic coordination‐polymer templates has been used to fabricate micro‐ and nanoscale crystals. By using a diverse range of molecular building blocks coupled with conventional synthetic techniques, it is possible to synthesize ZnO crystals with tailored sizes, shapes (such as hexagonal rings; see figure), and surface properties.
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Fruity electrodes : A simple bottom‐up self‐assembly method was used to fabricate rambutan‐like tin–carbon (Sn@C) nanoarchitecture (see scheme, green Sn) to improve the reversible storage of lithium in tin. The mechanism of the growth of the pear‐like hairs is explored.
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Gangavaram V. M. Sharma Dr. Bommagani Shoban Babu Kallaganti V. S. Ramakrishna Pendem Nagendar Dr. Ajit C. Kunwar Dr. Peter Schramm Carsten Baldauf Dr. Hans‐Jörg Hofmann Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(22):5552-5566
Origami peptides : A novel class of foldamers consisting of α/δ‐hybrid peptides has been investigated theoretically and experimentally by exploiting the rigidity of the side chain of a new δ‐amino acid prepared from D ‐glucose and D ‐xylose with a furanose side chain (see figure).
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Christian M. Stegmann Daniel Seeliger Dr. George M. Sheldrick Prof. Dr. Bert L. de Groot Dr. Markus C. Wahl Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(28):5207-5210
Water molecules doing time : Atomic‐resolution crystal structures of the PPIase domain of cyclophilin G, alone and in complex with cyclosporin A, and together with MD simulations and calorimetry, reveal how trapped water molecules influence the thermodynamic profile of a protein–ligand interaction.
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Malek Taher Maghsoodlou Sayyed Mostafa Habibi Khorassani Lotfali Saghatforoush Farhad Maghfuri Ghasem Marandi Roya Kabiri 《Journal of heterocyclic chemistry》2008,45(1):289-293
High hindrance Hexa tert‐butoxy carbonyl dipyrrolophenanthroline and helical dihydropyrrolophen‐anthroline compounds were prepared from reactions between di tert‐butyl acetylenedicarboxylate and 1,10‐phenanthroline in polar solvents media. 相似文献
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Luis M. Fidalgo Graeme Whyte Dr. Brandon T. Ruotolo Dr. Justin L. P. Benesch Dr. Florian Stengel Chris Abell Prof. Carol V. Robinson Prof. Wilhelm T. S. Huck Prof. 《Angewandte Chemie (International ed. in English)》2009,48(20):3665-3668
Fully integrated : Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 μm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on‐chip protein evolution and chemical synthesis.