Preliminary research on dual-energy X-ray phase-contrast imaging

Dual-energy X-ray absorptiometry(DEXA) has been widely applied to measure the bone mineral density(BMD) and soft-tissue composition of the human body. However, the use of DEXA is greatly limited for lowZ materials such as soft tissues due to their weak absorption, while X-ray phase-contrast imaging(XPCI) shows significantly improved contrast in comparison with the conventional standard absorption-based X-ray imaging for soft tissues. In this paper, we propose a novel X-ray phase-contrast method to measure the area density of low-Z materials, including a single-energy method and a dual-energy method. The single-energy method is for the area density calculation of one low-Z material, while the dual-energy method aims to calculate the area densities of two low-Z materials simultaneously. Comparing the experimental and simulation results with the theoretical ones, the new method proves to have the potential to replace DEXA in area density measurement. The new method sets the prerequisites for a future precise and low-dose area density calculation method for low-Z materials.     

X射线相衬成像光子筛

基于 Zernike相衬成像原理和光瞳切趾原理,提出一种将相位板和切趾光子筛集成为一个相衬显微物镜的 X射线相衬成像光子筛的设计方法.这种 X射线相衬成像物镜可以实现生物体组织或者其他弱吸收材料的高分辨率和高衬度成像.通过优化光子筛透镜的衍射结构,可以抑制成像系统的点扩展函数的旁瓣和消除高阶衍射焦点,从而提高成像分辨率;另外,将光子筛透镜和变相板合为一体,克服了成像透镜和变相板难以对准的缺陷.以高斯切趾光子筛为例,实验验证了设计方法的可行性. 关键词： X射线显微技术 相衬成像 光瞳切趾 光子筛     

用于软X射线图像诊断的CMOS探测系统

通过将闪烁体光纤面板与CMOS图像传感器耦合,研制了在线诊断X射线图像的CMOS探测系统。通过XOP软件计算,确定了响应能区为1~10 keV的CsI闪烁体厚度为30 m。在微点X射线源平台上,基于标准的Typ 18-d型分辨率板对CMOS探测系统的空间分辨能力进行了实验测试,结果为60 m。在神光Ⅲ原型激光装置上,利用该套CMOS探测系统在流体力学不稳定性与混合实验中对钛背光源的光谱进行了诊断,获得了清晰的类氢和类氦光谱图像。数据分析显示,实测的谱分辨为442,与理论分析符合较好。CMOS探测系统小巧轻便,性价比高,适合各大高校与科研院所用于在线诊断软X射线图像。     

软X射线激光背光阴影成像技术的空间分辨研究

软X射线激光阴影成像技术是一种诊断高温稠密等离子体临界面附近阴影轮廓的诊断技术,具有测量视场大、空间分辨能力高的特点,具有重要的应用前景.对该技术的空间分辨具体能够达到什么程度则没有进行过系统研究.本文分别从光路几何、衍射极限、成像像差三个方面进行了仔细分析,结果表明目前采用该技术的诊断系统能够达到约2μm的空间分辨.主要受限是光路几何因素,通过增加放大倍数、选择单元尺寸更小的接收元器件等方式,有希望达到优于1μm的空间分辨.     

同步辐射相位衬度成像医学应用初探

近年来,相位衬度成像技术医学领域应用的发展引人瞩目.同步辐射相位衬度成像无须使用对比剂就能显示传统X射线无法显示的肌腱、软骨、韧带、脂肪、血管及神经等软组织.文章作者应用包括类同轴相衬成像和衍射增强成像在内的相位衬度成像技术进行了肝胆、肺脏、肾脏、胃肠道、心脏、血管、骨关节组织与肿瘤成像,证实了同步辐射相位衬度成像较传统X射线成像图像清晰,分辩率明显提高,特别适用于软组织、血管等的成像.     

基于X光微点源的半影成像技术

基于X光微点源装置,从实验角度验证了半影成像的原理。利用针孔成像,直接测量了微点源源区图像;给出了半影孔成像、半影锥成像和环孔成像原理,以及在微点源的半影成像结果和维纳滤波重建结果。从实验结果可知：半影锥成像具有与半影孔成像相同的诊断能力,两种方法的重建图像尺寸与源尺寸一致;环孔成像的诊断能力更好,重建图像的尺寸和形状更接近源图像。     

Propagation of stochastic electromagnetic vortex beams through the turbulent biological tissues

The general analytical expression of the stochastic electromagnetic vortex beams through turbulent biological tissues is derived based on the fractal model. The statistical properties, including the spectral density, the spectral degree of coherence and the spectral degree of polarization are investigated in detail. It can be found that the normalized spectral density of the stochastic electromagnetic vortex beams with higher topological charge is less influenced by turbulence than that with lower topological charge. In addition, the change of the degree of polarization versus propagation distance of the anisotropic vortex beams in biological tissues differs from that of the isotropic vortex beams. The findings might be useful in the investigation of the structures of biological tissues and operation of communication and sensing systems involving biological tissues turbulence channels.     

基于激光驱动等离子体X光源的X射线相衬成像

为了诊断惯性约束聚变(ICF)内爆靶丸球壳的多层信息,在神光Ⅱ激光器上对激光驱动等离子体X光源的相衬成像进行了研究。利用神光Ⅱ第9路激光驱动平面Ti靶获得X光源,在10μm的针孔约束下作为次级点光源对样品成像,用X光胶片记录。成功地将相衬成像技术应用于ICF实验,综合考虑成像放大倍数、分辨力、成像衬度和抑制烧蚀碎片等因素,选择合适的实验条件,成功获得了清晰的双层内爆靶丸球壳结构,空间分辨力优于10μm。     

Ray tracing method for the grazing incidence flat-field imaging soft X-ray spectrometer

A ray tracing method is introduced for helping adjustment and spectra analysis of the grazing incidence flat-field imaging soft X-ray spectrometer. For a single point source, the spectra images obtained by separate components, the toroidal mirror, and the grazing incidence flat-field concave grating with varied line spaces are given respectively. The calculated spectral images of the single point source by the spectrometer are also given for comparison with measurements with different experimental alignments.     

基于光子筛的软X光谱仪

 介绍了采用新型软X光谱学光子筛作为分光元件的软X光谱仪的原理和结构参数设计。新谱仪理论测量范围为100 eV~2 keV,光谱分辨力达0.35 nm。应用该谱仪在SILEX-Ⅰ装置上测量了飞秒激光与固体铜靶相互作用产生的X射线发射谱。实验结果表明,该谱仪主要性能指标达到设计要求,适合于激光与等离子体相互作用产生的软X射线研究。     

无吸收光栅的X射线相位衬度成像实验研究

通过对基于空间相干源和具有分析光栅功能的X射线转换屏的微分干涉X射线相位衬度成像 系统的理论分析, 利用线发射体阵列结构阳极X射线管和光助电化学刻蚀技术 研制的相位光栅和具有分析光栅功能的X射线转换屏, 组建了一种无吸收光栅的X射线微分干涉相衬成像系统. 在此系统上开展了生物样品的实验研究, 获得了较传统吸收成像更为清晰和更多样品结构信息的相位衬度图像. 从而试验验证了该系统方案设计的可行性, 为X射线相衬成像技术从实验室走向临床应用提供了有效途径.     

Microspectroscopic soft X-ray analysis of keratin based biofibers

Scanning soft X-ray transmission microspectroscopy (STXM) and transmission electron microscopy (TEM) have been employed for a high-resolution morphological and chemical analysis of hair fibers from human, sheep and alpaca. STXM allows optimum contrast imaging of the main hair building blocks due to tuneable photon energy. Chemical similarities and deviations for the human hair building blocks as well as for the three investigated species are discussed on the basis of the local near-edge X-ray absorption fine structure (NEXAFS). The spectra of melanosomes corroborate the state-of-the-art model for the chemical structure of eumelanin. Complementary TEM micrographs reveal the occurrence of cortex sectioning in alpaca hair to some extent. A spectroscopic analysis for human hair cortex indicates low mass loss upon soft X-ray irradiation, but transformation of chemical species with decreasing amount of peptide bonds and increasing NEXAFS signal for unsaturated carbon–carbon bonds.     

Optimization of the in-line X-ray phase-contrast imaging setup considering edge-contrast enhancement and spatial resolution

Employing the approximation theory based on refraction and the definition of the total point-spread-function of the imaging system, the variation in the edge contrast of simple model samples is discussed with different source-to-sample and sample-to-detector distances, which actually means different spatial resolutions of the imaging system. The experiments were carried out with the Beamline 4W1A imaging setup at the Beijing Synchrotron Radiation Facility for simple model and insect samples. The results show that to obtain clear phase-contrast images of biologic tissues for the X-ray in-line imaging setup, with determined parameters such as the size of the X-ray source, the pixel size of the detector and the fixed source-to-sample distance, there is a range of optimized sample-to-detector distances. The analysis method discussed in this article can be helpful in optimizing the setup of X-ray in-line phase-contrast imaging.     

六通道掠入射软X射线针孔照相技术

在对平面反射镜高能X射线截止原理分析研究的基础上,为传统的针孔照相系统配置了光学滤片加平面反射镜组成的滤波系统,消除了大部分的高能尾部的影响。介绍了六通道掠入射软X射线针孔相机的结构设计、工作原理及性能。将光源按光子能量切割成6个能段分别进行记录,滤波后各通道的出射光为窄带软X射线。在阳加速器上对六通道掠入射软X射线针孔相机系统进行考核,加速器输出电流为779 kA,电流上升时间为75 ns,使用的负载为16根环形W丝阵,成功获取了6个通道的针孔照相图像,并结合Dante谱仪相应通道测得的功率时间谱进行了对比分析,确定了部分Z箍缩辐射热点的图像与功率发射谱的对应关系。     

X射线光栅微分相衬成像视场分析

X射线光栅微分相衬成像对由轻元素构成的物质的内部探测具有传统吸收成像无法比拟的优势, 尤其在癌症的早期诊断和轻元素材料及器件的无损检测等领域应用潜力巨大. 大视场成像是影响该技术从实验室走向实际应用的重要因素. 针对大视场成像的客观需求, 基于菲涅耳衍射原理和光栅结构特征, 建立了量化物理模型用于分析影响成像视场的因素, 提出了实现大成像视场的有效途径, 为未来大视场光栅微分相衬成像方法的设计和应用提供理论依据.     

X-ray diffraction enhanced imaging study of intraocular tumors in human beings

Diffraction enhanced imaging(DEI) with edge enhancement is suitable for the observation of weakly absorbing objects.The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work.The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility(BSRF).The obtained radiographic images were analyzed in correlation with those of pathology.The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time,with good visualization of the microscopic details of eyeball ring such as sclera,choroids and other details of intraocular organelles.And the best resolution of DEI images reaches up to the magnitude of several tens of μm.The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.     

离子束刻蚀软X射线透射光栅实验研究

利用全息-离子束刻蚀方法研制出了聚酰亚胺薄膜为衬底的金软X射线透射光栅.研究了光栅制作中曝光量、显影条件和离子束刻蚀工艺等因素对光栅参数的影响,并给出了在惯性约束激光核聚变实验研究中的应用结果,     

X-ray diffraction enhanced imaging study of intraocular tumors in human beings

Diffraction enhanced imaging （DEI） with edge enhancement is suitable for the observation of weakly absorbing objects. The potential ability of the DEI was explored for displaying the microanatomy and pathology of human eyeball in this work. The images of surgical specimens from malignant intraocular tumor of hospitalized patients were taken using the hard X-rays from the topography station of Beamline 4W1A at Beijing Synchrotron Radiation Facility （BSRF）. The obtained radiographic images were analyzed in correlation with those of pathology. The results show that the anatomic and pathologic details of intraocular tumors in human beings can be observed clearly by DEI for the first time, with good visualization of the microscopic details of eyeball ring such as sclera, choroids and other details of intraocular organelles. And the best resolution of DEI images reaches up to the magnitude of several tens of μm. The results suggest that it is capable of exhibiting clearly the details of intraocular tumor using DEI method.     

Non-contact acoustic method for the simultaneous measurement of thickness and acoustic properties of biological tissues

The frequency dependence of the magnitude and phase shift of reflected waves from a thin tissue specimen has been found to yield characteristics patterns as a function of the specimen thickness. By analysis of those characteristic patterns, the specimen thickness can be determined so that the attenuation constant and the sound speed can be obtained by a non-contact procedure. The method is demonstrated in the frequency range 100 MHz to 200 MHz, using a scanning acoustic microscope and approximately 10 μm thick myocardial tissue samples of human origin, one paraffin embedded.     

X射线光场成像技术研究

X射线三维成像技术是目前国内外X射线成像研究领域的一个研究热点.但针对一些特殊成像目标,传统X射线计算层析(CT)成像模式易出现投影信息缺失等问题,影响CT重建的图像质量,使得CT成像的应用受到一定的限制.本文主要研究了基于光场成像理论的X射线三维立体成像技术.首先从同步辐射光源模型出发,对X射线光场成像进行建模;然后,基于光场成像数字重聚焦理论,对成像目标场在深度方向上进行切片重建.结果表明:该方法可以实现对成像目标任一视角下任一深度的内部切片重建,但是由于光学聚焦过程中的离焦现象,会引入较为严重的背景噪声.当对其原始数据进行滤波后,再进行X射线光场重聚焦,可以有效消除重建伪影,提高图像的重建质量.本研究既有算法理论意义,又可应用于工业、医疗等较复杂目标的快速检测,具有较大的应用价值.