中国南沙群岛卡拉凹顶藻化学成分研究

中国南沙群岛卡拉凹顶藻化学成分研究钟永利，苏镜娱，曾陇梅，阎素君，罗秉浩（中山大学化学系，广州，５１０２７５）关键词红藻，卡拉凹顶藻，木糖甙，β－十六烷基－Ｄ－吡喃木糖甙，胆甾醇凹顶藻（Ｌａｕｒｅｎｃｉａ）含有非常丰富的次生代谢产物，主要包括萜类和含...     

Two Brominated-sesquiteroene from Alga Laurencia Majuscula

Two brominated-sesquiterpenes were isolated from the Alga Laurencia majuscula collected from the Xisha Islands in the South China Sea. Compound 1 was first reported, and determined, on spectral evidence, to be 8-bromo-l-en-chamigrene.     

Two Brominated-sesquiterpene from Alga Laurencia Majuscula

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Tricyclic Sesquiterpene from Laurencia Majuscula

ＴｒｉｃｙｃｌｉｃＳｅｓｑｕｉｔｅｒｐｅｎｅｆｒｏｍＬａｕｒｅｎｃｉａＭａｊｕｓｃｕｌａ＊ＸＵＸｉａｏ－Ｈｕａ,ＺＥＮＧＬｏｎｇ－ＭｅｉａｎｄＳＵＪｉｎｇ－Ｙｕ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ,ＺｈｏｎｇｓｈａｎＵｎｉｖｅｒｓｉｔｙ,...     

New anti-bacterial halogenated tricyclic sesquiterpenes from Bornean Laurencia majuscula (Harvey) Lucas

Three new halogenated tricyclic sesquiterpenes, omphalaurediol (1), rhodolaurenones B (2) and C (3) were isolated together with nine known haloganated sesquiterpenes such as rhodolaurenone A (4), rhodolaureol (5), isorhodolaureol (6), (?)-laurencenone D (7), elatol (8), (+)-deschloroelatol (9), cartilagineol (10), (+)-laurencenone B (11) and 2-chloro-3-hydroxy-α-chamigren-9-one (12) from a population of Bornean red algae Laurencia majuscula. The structures of three new metabolites were determined based on their spectroscopic data (IR, 1D and 2D NMR, and MS). These compounds showed antibacterial activity against three human pathogenic bacteria (Escherichia coli, Salmonella typhi and Vibrio cholera).     

A New Cytotoxic Dihydroxy Sterol from Laurencia Majuscula

NumeroushalogenatedseSquiterpenesasmajormetaboliteshavebeenfrequenhyreportedfromtheredaigaeLaurencia.sp.l"=1WehaverePOrtedtwonewbrondnatedseSquiterpenes['lfromLaurenciamausculaInthispaper.werePOrtthei5olationofacytotokicneu'steroll.Toourknot"ledgethisisthefirstrePOrtofthisnovelcomPoundfromthisgenus.ComPOundI.Colorlessnewhecry'staIs'mp242-243C.gaveapostjhveLiebennanasurchardreachoRindicatedaSteroidskeleton.The-SexhibitedamolecularionatInjz428.3597.correSPOndingtoC=wh8O=.TheIRshowed…     

A new rearranged chamigrane sesquiterpene from Laurencia okamurai

A new rearranged chamigrane sesquiterpene,named laurenokamurin,was isolated from the marine red alga Laurencia okamurai.Its structure was determined on the basis of spectroscopic methods.     

Sesquiterpenes from Red Alga Laurencia tristicha

Three naturally new sesquiterpenes named 10-hydroxyepiaplysin, 10-hydroxyaplysin and 10-hydroxybromoepiaplysin have been isolated from Laurencia tristicha. On the basis of the spectroscopic techniques their structures were elucidated as （3S, 3αR, 8βS）-（-）-2, 3, 3α, 8β3-tetra- hydro-7-bromo-3-hydroxy-3, 3α, 6,8β-tetramethyl-lH-cyclopenta[b]benzofuran, （3R, 3αR, 8βS）- （-）-2,3,3α, 8β-tetrahydro-7-bromo-3-hydroxy-3, 3α,6,8β-tetramethyl-lH-cyclopenta[b]benzofuran and （3S, 3αR, 8βS）-（-）-2, 3,3R, 8β-tetrahydro-3-hydroxy-3,3α,6,8β-tetramethyl-lH-cyclopenta[b]- benzofuran, respectively.     

Sesquiterpenes from the Marine Red Alga Laurencia saitoi

Together with five known sesquiterpenes, EtOH extraction of Laurencia saitoi yielded four new compounds, including three sesquiterpenes and one norsesquiterpene derivative. Their structures and relative configurations were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR (¹H,¹H‐COSY, HMQC, HMBC, and NOESY), as well as low‐ and high‐resolution mass‐spectrometric analyses.     

New C15 Acetogenins from Two Species of Laurencia from the Aegean Sea

The chemical diversity of the approximately 1,200 natural products isolated from red algae of the genus Laurencia, in combination with the wide range of their biological activities, have placed species of Laurencia in the spotlight of marine chemists’ attention for over 60 years. The chemical investigation of the organic (CH₂Cl₂/MeOH) extracts of Laurencia microcladia and Laurencia obtusa, both collected off the coasts of Tinos island in the Aegean Sea, resulted in the isolation of 32 secondary metabolites, including 23 C₁₅ acetogenins (1–23), 7 sesquiterpenes (24–30) and 2 diterpenes (31 and 32). Among them, six new C₁₅ acetogenins, namely 10-acetyl-sagonenyne (2), cis-sagonenyne (3), trans-thuwalenyne C (4), tinosallene A (11), tinosallene B (12) and obtusallene XI (17), were identified and their structures were elucidated by extensive analysis of their spectroscopic data. Compounds 1–3, 5–11, 13 and 15–32 were evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli.     

Two new brominated diterpenes from Laurencia decumbens

Two new brominated diterpenes,namely,laurendecumtriol and 11-deacetylpinnaterpene C,were isolated and identified from the marine red alga Laurencia decumbens.Their structures were established on the basis of various NMR spectroscopic techniques and HR-ESI-MS analyses.