共查询到20条相似文献,搜索用时 15 毫秒
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Wen-Jie Mei Na Wang Yun-Jun Liu Yu-Zhuo Ma Ding-Yong Wang Bao-Xia Liang 《Transition Metal Chemistry》2008,33(4):499-503
Two chair ruthenium(II) complexes, Λ- and Δ-[Ru(bpy)2tFMPIP]2 + (bpy = bipyridyl; tFMPIP = (2′-trifluoromethylphenyl)-imidazo-[4,5-f]-[1, 10]-phenanthroline, Λ-1 and Δ-1) have been synthesized and characterized by elemental analysis, ESI-MS and 1H-NMR. The cytotoxicity of these complexes against human hepatocarcinoma cell line Bel-7402, human intestinal adenocarcinoma
cell line HCT-8, and Human lung adenocarcinoma epithelial cell line A-549 have been investigated by colorimetric MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl-1H-tetrazolium
bromide) assay. Both Λ-1 and Δ-1 exhibit excellent inhibitory activity against the growth of Bel-7402 and HCT-8 cells. At dosage of 5 μg/cm3, the inhibition of Λ-1 and Δ-1 against human hepatocarcinoma cell line Bel-7402 is 85 and 85%, respectively. The studies on the DNA-binding properties of
these complexes with Bel-7402 cell DNA by electronic spectra and steady state emission spectra, as well as circular dichlorism
spectra show that there are detectable but subtle differences between Λ-1 and Δ-1, indicating the antitumor activity of these complexes is related to their DNA-binding behaviors. 相似文献
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Trávníček Zdeněk Maloň Michal Popa Igor Doležal Karel Strnad Miroslav 《Transition Metal Chemistry》2002,27(8):918-923
Nickel(II) complexes with 6-benzylaminopurine (BAP) derivatives, namely 6-(3-chlorobenzylamino)purine (HL1), 6-(4-chlorobenzylamino)purine (HL2) and 6-(4-fluorobenzylamino)purine (HL3), have been prepared and characterized by elemental analyses, i.r., u.v.–v.i.s., ES+ and FAB+ mass spectroscopy, magnetic susceptibility and conductivity measurements, and by thermal analysis. The complexes are: [Ni(L1(H2O)2Cl] · H2O, [Ni(L1)(H2O)-(NO3)] · H2O, [Ni(L2)(H2O)2Cl], [Ni(L2)(H2O)2(NO3)] · H2O, [Ni(HL2)(H2O)Cl2] · EtOH and [Ni(L3)(H2O)2Cl]. They have been tested in vitro for their possible cytotoxic activity against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. 相似文献
5.
Grant GJ 《Dalton transactions (Cambridge, England : 2003)》2012,41(29):8745-8761
Platinum(II) and palladium(II) complexes of the trithiacrown [9]aneS(3) containing a range of Group 15 donors are reviewed. These complexes have the general formula [M([9]aneS(3))(L(2))](n+) where L represents at least one Group 15 donor. Complexes involving pnictogens, with the exception of bismuth, are observed. The complexes generally have an elongated square pyramidal geometry with a long distance interaction to the third sulphur of the [9]aneS(3) which forms the apex of the square pyramid. This axial metal-sulphur distance is quite sensitive to the donor properties of L. Poorer donors such as Sb and As ligands show short axial distances whereas the better N donor ligands show longer distances. Pt(II) complexes of the formula [Pt([9]aneS(3))(EPh(3))(2)](2+) (E = P, As, Sb) show a considerable distortion towards a trigonal bipyramidal geometry due to intramolecular π-π interactions. Over seventy of these types of complexes have been crystallographically characterized and are discussed in this article. Other unique features of the complexes, including NMR spectroscopy, redox chemistry, and electronic spectroscopy, are also discussed. 相似文献
6.
There have been synthesized Pt(II) stereoisomeric complexes with hydroxy-α-amino acid serine (SerH = NH2CH(CH2OH)COOH is α-amino-β-hydroxypropionic acid): trans-[Pt(S-SerH)2Cl2], trans-[Pt(R-SerH)(S-SerH)Cl2] with monodentately (through NH2 group ) bound SerH and cis-, trans-[Pt(R-Ser)(S-Ser)], trans-[Pt(S-Ser)2] with bidentately bound (through groups NH2 and COO) ligands (R, S is the absolute configuration of asymmetric carbon atom). The successive phases in the synthesis of Pt(II) stereoisomeric complexes with serine were studied by 195Pt NMR spectroscopy. To identificate the compounds synthesized the method of elemental analysis, IR and NMR (195Pt, 13C, 1H) spectroscopy were used. For trans-[Pt(R-Ser)(S-Ser)] the X-ray diffraction data were obtained. 相似文献
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《Journal of Coordination Chemistry》2012,65(3):473-483
The complexes K[PtCl3(Meug)] (1; Meug = methyleugenol), K[PtCl3(Meteug)] (2; Meteug = methyl eugenoxyacetate), and K[PtCl3(Eteug)] (3; Eteug = ethyl eugenoxyacetate) reacted with AgNO3, SnCl2, KOH, or ethanol–water solutions to lose one aryl proton and form dinuclear metallacyclic complexes Pt2Cl2(Meug-1H)2 (4), Pt2Cl2(Meteug-1H)2 (5), and Pt2Cl2(Eteug-1H)2 (6), respectively. Complexes 4–6 reacted with aliphatic, aromatic, and heterocyclic amines to give various mononuclear metallacyclic platinum complexes 7–15. 1H NMR spectra showed that in 4–15 Meug, Meteug, and Eteug are bound with Pt(II) both at the benzene carbon and at the ethylenic double bond of the side chain. NOESY spectra and single-crystal X-ray diffraction indicated that in 7–15 the amines are in cis-position with respect to the ethylenic double bond. 相似文献
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Nanoscale molecular capsules have been prepared by self-assembly of resorcin[4]-arene derivatives and Pd(II) or Pt(II) complexes; the positively charged N-alkylpyridinium derivatives are encapsulated inside capsules due to strong cation-pi interactions. 相似文献
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Hori A Kataoka H Okano T Sakamoto S Yamaguchi K Fujita M 《Chemical communications (Cambridge, England)》2003,(2):182-183
The reversible cross-catenation of two different coordination rings (Pd(II)- and Pt(II)-linked rings) has been achieved by using the labile nature of the Pd-N interaction and efficient hydrophobic contact between the rings. 相似文献
11.
Vicente J Chicote MT Guerrero R Vicente-Hernandez I Jones PG Bautista D 《Inorganic chemistry》2006,45(13):5201-5209
The reactions of [Ag(NH=CMe2)2]ClO4 with cis-[PtCl2L2] in a 1:1 molar ratio give cis-[PtCl(NH=CMe2)(PPh3)2]ClO4 (1cis) or cis-[PtCl(NH=CMe2)2(dmso)]ClO4 (2), and in 2:1 molar ratio, they produce [Pt(NH=CMe2)2L2](ClO4)2 [L = PPh3 (3), L2= tbbpy = 4,4'-di-tert-butyl-2,2'-dipyridyl (4)]. Complex 2 reacts with PPh3 (1:2) to give trans-[PtCl(NH=CMe2)(PPh3)2]ClO(4) (1trans). The two-step reaction of cis-[PtCl2(dmso)2], [Au(NH=CMe2)(PPh3)]ClO4, and PPh3 (1:1:1) gives [SP-4-3]-[PtCl(NH=CMe2)(dmso)(PPh3)]ClO4 (5). The reactions of complexes 2 and 4 with PhICl2 give the Pt(IV) derivatives [OC-6-13]-[PtCl3(NH=CMe2)(2)(dmso)]ClO4 (6) and [OC-6-13]-[PtCl2(NH=CMe2)2(dtbbpy)](ClO4)2 (7), respectively. Complexes 1cis and 1trans react with NaH and [AuCl(PPh3)] (1:10:1.2) to give cis- and trans-[PtCl{mu-N(AuPPh3)=CMe2}(PPh3)2]ClO4 (8cis and 8trans), respectively. The crystal structures of 4.0.5Et2O.0.5Me2CO and 6 have been determined; both exhibit pseudosymmetry. 相似文献
12.
M. Kabešová J. Pirskij M. Dunaj-Jurčo 《Journal of Thermal Analysis and Calorimetry》1988,34(5-6):1349-1358
The paper deals with the thermal properties of complex compounds of the general formula CuL2(NCX)2 (whereL=bipy or phen,X=S or Se). The phenanthroline complexes exhibit a higher thermal stability than those with bipyridine. For the latter complexes thermal decomposition begins with the release of bipyridine molecules, while for the phenanthroline complexes redox reactions of pseudohalogenide ligands with Cu(II) take place. The redox reactions start at a lower temperature for the selenocyanate complexes than for the thiocyanate complexes.
Zusammenfassung Vorliegende Arbeit behandelt die thermischen Eigenschaften von Komplexverbindungen der allgemeinen Formel CuL2(NCX)2 (mitL=Bipyridin oder Phenanthrolin undX=S oder Se). Die Phenanthrolinkomplexe zeigen eine grössere thermische Stabilität als die Bipyridinkomplexe. Die thermiscne Zersetzung letzterer beginnt mit der Abgabe von Bipyridinmolekülen, während bei den Phenanthrolinkomplexen Redoxreaktionen von Pseudohalogenidliganden·mit Cu(II) stattfinden. Diese Redoxreaktionen beginnen bei den Selenozyanatkomplexen bei niedrigeren Temperaturen als bei den Thiozyanatkomplexen.
CuL2(NCX)2, L= , X= . . , — . - , .相似文献
13.
The reactions of the two complexes BBR3464 [{trans-PtCl(NH3)2}2{mu-trans-Pt(NH3)2(NH2(CH2)6NH2)2}](4+) and BBR3610 [{trans-PtCl(NH3)2}2{mu-C2H4(NH2(CH2)6NH2)2}](4+) and the corresponding diaqua complexes with the nucleophiles thiourea (tu) and l-methionine (l-Met), were investigated under pseudo-first-order conditions as a function of concentration and temperature, using UV-vis spectrophotometric and stopped-flow techniques. 1H NMR spectroscopy was used to follow the stepwise substitution of the chloro ligands by guanosine-5'-monophosphate under second-order conditions. For the sulfur donor containing nucleophiles (tu and l-Met), a second reaction step, the displacement of the labilized amine chain linker, as a result of the strong trans-effect of tu and l-Met, was found. The activation parameters for all reactions studied suggest an associative substitution mechanism. The displacement of the chain linker by S-donor nucleophiles illustrates the limit of application of polynuclear complexes with monodentate aliphatic amine bridges and primary ammines, in agreement with previous studies reported in the literature. 相似文献
14.
The rate constants of deuterium exchange for cyclohexane in CH3COOD/D2O have been measured in the presence of 12 complexes of Pt(II) with various ligands (Cl, H2O, NH3, Br, NO2, py, DMSO, PPh3, etc.). The change in the rate constant is shown to follow the reverse series of the trans-effect of Pt(II) ligands. The rate constant of the interaction of PtCl2Sn (S is H2O, CH3COOH, n=1, 2) with cyclohexane in CH3COOD/D2O (11), k, equals 2.5×108 exp (–18200/RT) 1 mol–1 sec–1 (at 354–385 K). The ratio of rate constants for PtCl2S2, PtCl3S– and PtCl
4
2–
is 10060.5 at 100°C.
CH3COOD–D2O 12- Pt(II) (Cl, H2O, NH3, Br, NO2, , DMCO, PPh3 .). , Pt(II). PtCl2Sn (S–H2O, CH3COOH, n=1,2) 11 CH3COOD–D2O k=2,5·108 exp(–18200/RT). –1 –1 (354–385°). 100°C PtCl2S2, PtCl3S– PtCl 4 2– 10060,5.相似文献
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Sarju J Arbour J Sayer J Rohrmoser B Scherer W Wagner G 《Dalton transactions (Cambridge, England : 2003)》2008,(39):5302-5312
The nitrile ligands in trans-[PtX2(PhCN)2] (X = Cl, Br, I) undergo sequential 1,3 dipolar cycloadditions with nitrones R1R2C=N+(Me)-O(-) (R1 = H, R2 = Ph; R1 = CO2Et, R2 = CH2CO2Et) to selectively form the Delta4-1,2,4-oxadiazoline complexes trans-[PtX2(PhCN) (N=C(Ph)-O-N(Me)-CR1R2)] or trans-[PtX2(N=C(Ph)-O-N(Me)-CR1R2)2] in high yields. The reactivity of the mixed ligand complexes trans-[PtX2(PhCN)(N=C(Ph)-O-N(Me)-CR1R2)] towards oxidation and ligand substitution was studied in more detail. Oxidation with Cl2 or Br2 provides the Pt(IV) species trans-[PtX2Y2(PhCN)(N=C(Ph)-O-N(Me)-CH(Ph))] (X, Y = Cl, Br). The mixed halide complex (X = Cl, Y = Br) undergoes halide scrambling in solution to form trans-[PtX(4-n)Yn(PhCN)(N=C(Ph)-O-N(Me)-CH(Ph))] as a statistical mixture. Ligand substitution in trans-[PtCl2(PhCN)(N=C(Ph)-O-N(Me)-CR1R2)] allows for selective replacement of the coordinated nitrile by nitrogen heterocycles such as pyridine, DMAP or 1-benzyl-2-methylimidazole to produce mixed ligand Pt(II) complexes of the type trans- [PtX2(heterocycle)(N=C(Ph)-O-N(Me)-CR1R2)]. All compounds were characterised by elemental analysis, mass spectrometry, IR and 1H, 13C and 195Pt NMR spectroscopy. Single-crystal X-ray structural analysis of (R,S)-trans-[PtBr2(N=C(Ph)-O-N(Me)-CH(Ph))2] and trans-[PtCl2(C5H5N)(N=C(Ph)-O-N(Me)-CH(Ph))] confirms the molecular structure and the trans configuration of the heterocycles relative to each other. 相似文献
16.
Roberto Cao Ariana Garcia Ernestina Castell 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):487-491
Summary A QSAR based on a multiple regression analysis for 15 copper(II) semi- and thiosemicarbazone complexes with cytotoxic properties is presented. In vitro cytotoxicity was selected as the dependent variable and Van der Waals volumes (Vm), octanol- water partition coefficients (logP), specific rate constants of the copper(II) complexes towards superoxide radicals (k
s
) and variation in C=N vibration bands (CN) in IR spectra of the complexes with respect to the free ligands were selected as the independent variables. The stepwise regression procedure and the all possible regressions were practiced in the analysis of the data. The orthogonality analysis proved noncollinearity among the variables. According to the obtained equation the two best copper(II) complexes were submitted to a broad in vivo screening study and resulted to be active against La, P-388 and L-1210 leukemias.
QSAR von Kupfer(II)-Komplexen mit cytotoxischen Eigenschaften
Zusammenfassung Es wird eine quantitative Struktur-Aktivitäts-Beziehung basierend auf einer multiplen Regressionsanalyse für 18 Kupfer(II)-Semi- und Thiosemicarbazon-Komplexe präsentiert. Die in vitro-Cytotoxizität wurde als die abhängige Variable und Van-der-Waals-Volumina (Vm), Octanol-Wasser-Verteilungskoeffizienten (logP), spezifische Geschwindigkeitskonstanten der Kupfer(II)-Komplexe gegenüber Superoxid-Radikalen (k s ) und die Variationen der C=N-Vibrationsbanden (CN) in den IR-Spektren der Komplexe gegenüber den freien Liganden als unabhängige Variablen eingeführt. Es wurde stufenweise Regression und die alle möglichen Regressionen-Prozedur in der Analyse der Daten verwendet. Die Orthogonalitätsanalyse zeigte Nichtkolinearität der Variablen an. Entsprechend den erhaltenen Gleichungen wurden die beiden besten Kupfer(II)-Komplexe einem breiten in vivo-Screening unterworfen. Sie waren gegenüber La, P-388 und L-1210 Leukemie aktiv.相似文献
17.
M. P. Sánchez Sánchez J. M. Salas Peregrin M. A. Romero Molina 《Monatshefte für Chemie / Chemical Monthly》1987,118(8-9):883-891
Some news thiopyrimidine derivatives and complexes [4-amino-5-nitroso-6-oxo-1,2,3,6-tetrahydro-2-thio-pyrimidine (TANH), its 2-methylthio derivative (MTH), the ammonium salt ofTANH (sTANH) and six new complexes of formulas: Rh(MT)2Cl · 2H2O, Pd(MTH)2Cl2, Pt(MTH)2Cl4, Au(MTH)Cl3 Pd(TANH)2Cl2 and Au(TAN
–)Cl] have been synthesized and characterized by elemental analysis, IR and1H-NMR spectroscopy techniques. The thermal behaviour of all compounds has also been studied.
Rh(III), Pd(II), Pt(IV) und Au(III) Komplexe von 2-Thiopyrimidin Derivaten
Zusammenfassung Es wurden einige neue Thiopyrimidinderivate und deren Komplexe synthetisiert und mittels Elementaranalyse, IR und1H-NMR charakterisiert: 4-Amino-5-nitroso-6-oxo-1,2,3,6-tetrahydro-2-thio-pyrimidin (TANH), dessen 2-Methylthio-Derivat (MTH), das Ammoniumsalz vonTANH (sTANH) und sechs neue Komplexe der Formeln Rh(MT)2Cl · 2H2O, Pd(MTH)2Cl2, Pt(MTH)2Cl4, Au(MTH)Cl3, Pd(TANH)2Cl2 und Au(TAN –)Cl. Das thermische Verhalten der Verbindungen wurde ebenfalls untersucht.相似文献
18.
Budzisz E Małecka M Lorenz IP Mayer P Kwiecień RA Paneth P Krajewska U Rózalski M 《Inorganic chemistry》2006,45(24):9688-9695
We report the influence of the substituent at the N atom of the ligands on the synthesis, biological activity, and stability of Pd(II) complexes of the general formula PdL(2). The compounds adopt a cis or trans configuration with respect to the substituent at the nitrogen atom. Sterically hindered substituents promote the formation of trans isomers, whereas when the nitrogen atom is unsubstituted, cis isomers are formed. The compounds were characterized by elemental analysis, infrared and 1H NMR spectroscopies, and electrospray mass spectrometry. The complexes were also studied using X-ray diffraction and computational DFT methods. Both complexes cis-3a and trans-3c exhibit square-planar geometries around the Pd(II) atom. The cytotoxic effects of these complexes were examined on two human leukemia cell lines, HL-60 and NALM-6. Pd complex cis-3a showed significant cytotoxic activity. The effects exhibited by this complex were comparable to those reported for carboplatin. Loigand 2a was not cytotoxic. Computational analysis carried out at the PB/B3LYP/LACVP**//mPW1PW91/LanL2DZ level showed excellent correlation between the energy difference of the cis and trans isomers and the cytotoxic activity, rendering computations a useful predictive tool for the design of new drugs. 相似文献
19.
The oxidation of complexes of manganese(II) with 1,10-phenanthroline by bromate was studied. It was shown that the curve for the dependence of the induction period of the autocatalytic process on the 1,10-phenanthroline concentration passes through a maximum. During the induction period, both the manganese(II) complexes and 1,10-phenanthroline react with bromide ions. The formation of these ionic associates leads to a decrease in the concentration of free bromide, and correspondingly to a decrease in the duration of the induction period. A supposition was advanced that complexes of manganese(II) formed with phenanthroline also catalyze the redox transformations of bromine oxide compounds; complexes with a coordinately unsaturated sphere have the highest catalytic activity.L. V. Pisarzhevskii Institute of Physical Chemistry, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Teoreticheskaya i Éksperimental'naya Khimiya, No. 1, pp. 45–51, January–February, 1991. Original article submitted May 25, 1990. 相似文献
20.
Janzen DE Vanderveer DG Mehne LF da Silva Filho DA Brédas JL Grant GJ 《Dalton transactions (Cambridge, England : 2003)》2008,(14):1872-1882
We report the synthesis and full characterization for a series of cyclometallated complexes of Pt(II) and Pd(II) incorporating the fluxional trithiacrown ligand 1,4,7-trithiacyclononane ([9]aneS3). Reaction of [M(C insertion mark N)(micro-Cl)]2 (M = Pt(II), Pd(II); C insertion mark N = 2-phenylpyridinate (ppy) or 7,8-benzoquinolinate (bzq)) with [9]aneS3 followed by metathesis with NH4PF6 yields [M(C insertion mark N)([9]aneS3)](PF6). The complexes [M(C insertion mark P)([9]aneS3)](PF6) (M = Pt(II), Pd(II); Cinsertion markP = [CH2C6H4P(o-tolyl)2-C,P]-) were synthesized from their respective [Pt(C insertion mark P)(micro-Cl)]2 or [Pd(C insertion mark P)(micro-O2CCH3)]2 (C insertion mark P) starting materials. All five new complexes have been fully characterized by multinuclear NMR, IR and UV-Vis spectroscopies in addition to elemental analysis, cyclic voltammetry, and single-crystal structural determinations. As expected, the coordinated [9]aneS3 ligand shows fluxional behavior in its NMR spectra, resulting in a single 13C NMR resonance despite the asymmetric coordination environment of the cyclometallating ligand. Electrochemical studies reveal irreversible one-electron metal-centered oxidations for all Pt(II) complexes, but unusual two-electron reversible oxidations for the Pd(II) complexes of ppy and bzq. The X-ray crystal structures of each complex indicate an axial M-S interaction formed by the endodentate conformation of the [9]aneS3 ligand. The structure of [Pd(bzq)([9]aneS3)](PF6) exhibits disorder in the [9]aneS3 conformation indicating a rare exodentate conformation as the major contributor in the solid-state structure. DFT calculations on [Pt([9]aneS3)(ppy)](PF6) and [Pd([9]aneS3)(ppy)](PF6) indicate the HOMO for both complexes is primarily dz2 in character with a significant contribution from the phenyl ring of the ppy ligand and p orbital of the axial sulfur donor. In contrast, the calculated LUMO is primarily ppy pi* in character for [Pt([9]aneS3)(ppy)](PF6), but dx2-y2 in character for [Pd([9]aneS3)(ppy)](PF6). 相似文献