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Dr. Jesse Ling Prof. Clay S. Bennett 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(11):4334-4338
C-Glycosides are both a common motif in many bioactive natural products and important glycoside mimetics. We demonstrate that activating a hemiacetal with a sulfonyl chloride, followed by treating the resultant glycosyl sulfonate with an enolate results in the stereospecific construction of β-linked C-glycosides. This reaction tolerates a range of acceptors and donors, including disaccharides. The resulting products can be readily derivatized into C-glycoside analogues of β-glycoconjugates, including C-disaccharide mimetics. 相似文献
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