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1.
0引言众所周知,钛及其合金具有优良的机械力学性能,但其生物活性不足。因此,在金属基体上涂敷一层生物活性涂层,结合金属与生物活性材料的各自优势,已成为世界各国学者研究最为活跃的生物复合材料体系之一。该体系可用于临床医学,作为人体硬组织等的修复替换材料。目前,已开发出多种在金属基体上制备生物活性涂层的工艺和方法。如:等离子沉积法[1]、离子束溅射法[2]、激光熔覆法[3]、溶胶鄄凝胶法[4]、电化学沉积与水热处理合成法[5]、电泳沉积[6]、电结晶[7]等多种方法。但现有涂层材料尚存在一些问题:(1)由于替换材料的高硬度而导致其周围硬组织坏死[8];(2)由于疲劳磨损或热膨胀不匹配引起涂层脱落[9];(3)由于异质相导致生物活性降解[10]。因此,研究新的制备工艺,开发新的生物复合材料体系就显得十分重要。考虑到Al2O3具有优异的抗磨损、耐腐蚀等性能,以及较好的生物相容性,常作为临床选用的人造硬组织承载材料[11],故在本研究工作中,我们首次采用阳极氧化与水热处理复合工艺研制酸式磷酸钙/Al2O3鄄Ti生物复合材料体系。该体系不同于由日本Ishizawa等研制的HAp/TiO2鄄Ti复合体系[12]。主要体现在两... 相似文献
2.
Hussein A. Khalaf Gamal A. Mekhemer Ahmed K. Nohman Seham A. A. Mansour 《Monatshefte für Chemie / Chemical Monthly》2007,138(7):641-648
Summary. The influence of the type of precursor, the phosphate content, as well as the source of phosphate ions on the surface texture,
acidity, and catalytic activity of phosphated aluminas has been described. Phosphated alumina catalysts were prepared by impregnating
two different precursors with two different sources of phosphate in different loading levels w = 3, 6, and 10% PO4
3−. The characterisation of the catalyst was performed using X-ray powder diffraction (XRD), thermal analysis (TG), and nitrogen
adsorption–desorption methods at 77 K. The surface acidity of the catalysts has been studied by FT-IR spectroscopy of adsorbed
pyridine at different temperatures. Moreover, the activity in the catalytic decomposition of isopropanol (2-PrOH) has been investigated at 520 K. Investigation of the surface properties shows that the addition of phosphate ions does
not change the crystal phase (γ-phase) and the samples prepared from gel and phosphoric acid have the highest surface area.
An FT-IR study of pyridine adsorption shows both Lewis and Br?nsted acid sites on the surface of the samples prepared from gel, while only Lewis acid sites are detected on the samples prepared from crystalline oxide. The catalytic activity by 2-PrOH conversion shows that the conversion of 2-PrOH as well as the selectivity towards propene formation increases from w = 3 to 6% followed by a decline for w = 10%. Moreover, the strongest activity was detected in case of phosphated alumina gel with w = 6% which gives 97.3% propene and 96.1% conversion of 2-PrOH. 相似文献
3.
F. Moser-Boroumand J. M. Martins P. Füri M. Forrer A. Mermoud H. Van Den Bergh 《International journal of environmental analytical chemistry》2013,93(2):239-256
Abstract An optical method based on fluorescence spectroscopy was developed for in-situ non-destructive, real time, organic pollutant detection and quantification in soil. Optical fiber-based light-induced fluorescence probes allowing in-situ specific chemical detection were constructed. Pyranine was chosen as a model fluorescent Polycyclic Aromatic Hydrocarbon (PAH). The effect of sand particles on fluorescence measurements was established: the fluorescence intensity in water-saturated sand was eight times lower than in aqueous solutions, due to light scattering by the sand particles. To adapt the method to dynamic pollutant concentration measurements in soil, two different designs of light diffusers were constructed and compared. A light distributor with a quartz window was chosen for its higher sensitivity and reproducibility. The probes were introduced into two different columns: short ones used to study the effect of the measurement location in the column and longer ones to study pyranine transport. It was shown that, in columns, the measurement location plays an important role; measurements near the walls, in particular, were different from those performed more towards the center of the column in a given section. As a consequence, one should avoid measurements near the circumference. Preliminary results were successfully compared to a chemical transport model and revealed that the methodology is a powerful tool to measure in-situ concentration changes; on the other hand, fluorescent measurements can be used efficiently to determine transport parameters and give results comparable with those obtained with classical breakthrough curve fittings. 相似文献
4.
Ruthenium-tin sol-gel catalysts: effect of the preparation and tin precursor influence 总被引:1,自引:0,他引:1
The influence of the synthesis route and the chemical nature of tin precursors on the catalytic properties of supported sol-gel Ru-Sn/SiO2 catalysts were studied. It was demonstrated that introduction of tin afforded better selectivities than a monometallic sol-gel catalyst in the liquid-phase hydrogenation of cinnamaldehyde; however, the chemical nature of the tin precursor did not influence the catalyst performance. Sol-gel catalyst properties depended significantly upon the preparation method used and on the activation temperature. The selectivity to unsaturated alcohol increased with conversion, which is indicative of the in-situ creation of active sites selective in the carbonyl bond hydrogenation. 相似文献
5.
AbstractBase-mediated [3?+?3] cycloaddition reaction of in-situ formed aza-oxyallyl cations and 1,4-dithiane-2,5-diols has been achieved under mild reaction conditions. This strategy provides direct and efficient access to prepare desired thiomorpholin-3-one derivatives in moderate-to-high yields. The approach features broad substrates scope and short reaction time. Moreover, the resulting products can be readily converted into other useful heterocyclic compounds including 2H-1,4-thiazin-3(4H)-ones and thiomorpholine-3,5-diones. 相似文献
6.
The enzymatic resolution of (R, S)-1-phenylethanol produced by hydrolysis of (R, S)-1-phenylethyl acetate catalyzed by immobilized Candida antarctica lipase B (CALB) was successfully carried out in different solvent systems. A systematic screening and optimization of the
reaction parameters such as enzyme amount, the nature and the content of organic solvent, pressure and temperature in supercritical
carbon dioxide (SC-CO2) and phosphate buffer, with respect to the conversion rate, were performed. CALB exhibits high enantioselectivity in both
tert-butanol with 0.025 mol/l phosphate buffer (pH 7.5) and SC-CO2 with 0.025 mol/l phosphate buffer (pH 7.5) systems. The conversion rate was 41.2% higher in SC-CO2 with 0.025 mol/l phosphate buffer (pH 7.5) then in tert-butanol with 0.025 mol/l phosphate buffer (pH 7.5) and the reaction time decreased from 8 h to 90 min. 相似文献
7.
Y. Greenwald X. Xu M. Fourmigu G. Srdanov C. Koss F. Wudl A. J. Heeger 《Journal of polymer science. Part A, Polymer chemistry》1998,36(17):3115-3120
Thin, homogeneous films of a high electron affinity (n-dopable) polymer, poly(3,4-dicyanothiophene) (PDCTh), were prepared by in-situ thermal polymerization of 2,5-diiodo-3,4-dicyanothiophene on substrates. As a result of the presence of two cyano substituents on the thiophene backbone, PDCTh is an electronegative polymer, with the LUMO at ca. 3.6 eV and the HOMO at ca. 6.7 eV. We demonstrate the fabrication of polymer-polymer rectifying heterojunctions using PDCTh and poly(2-methoxy-5-(2′-ethyl-hexyloxy)-1,4-phenylene vinylene) (MEH-PPV) polymer layers on ITO-glass. Rectification ratios in the current voltage characteristics of these devices exceed 10.3 This device exhibits a photovoltaic effect with a dc sensitivity at -3 V reverse bias of 4 × 10-4 A/W or quantum yield of 0.1% electrons/photon. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 3115–3120, 1998 相似文献
8.
Substrate-Independent Stable and Adherent Reactive Surface Coatings and their Conversion with Amines
Summary: To create stable, adherent and reactive surface coatings, a hybrid polymer composed of poly(methylsilsesquioxane) (PMSSQ) and poly(pentafluorophenyl acrylate) PFPA with a Mn of 32000 g/mol was prepared by a RAFT polymerization procedure. These hybrid polymer has been used for coating experiments. The PFPA part enabled a variable functionalization of the coating afterwards. The stability on various substrates (e.g. glass, PMMA, steel) was tested in an ISO tape test. These reactive surface coatings were modified using different amines, such as amino-terminated PEG, dodecyl amine and N-isopropyl amine. The conversion was analyzed by FT-IR and contact angle measurements. 相似文献
9.
Yaliang Huang Ting Sun Wendi Li Lin Liu Gang Liu Xinyao Yi Jianxiu Wang 《中国化学快报》2022,33(6):3151-3155
We propose a concept for ligase detection by conversion of aggregation-based homogeneous analysis into surface-tethered electrochemical assay through streptavidin(SA)-biotin interaction. Sortase A(Srt A)served as the model analyte and two biotinylated peptides(bio-LPETGG and GGGK-bio) were used as the substrates. Srt A-catalyzed ligation of the peptide substrates led to the generation of bio-LPETGGGKbio. The ligation product(bio-LPETGGGK-bio) induced the aggregation and color change of SA-modifi... 相似文献
10.
Dr. Joerg H. Schrittwieser Dr. Bas Groenendaal Dr. Verena Resch Dr. Diego Ghislieri Dr. Silvia Wallner Eva‐Maria Fischereder Elisabeth Fuchs Barbara Grischek Dr. Johann H. Sattler Prof. Dr. Peter Macheroux Prof. Dr. Nicholas J. Turner Prof. Dr. Wolfgang Kroutil 《Angewandte Chemie (International ed. in English)》2014,53(14):3731-3734
Deracemization, that is, the transformation of a racemate into a single product enantiomer with theoretically 100 % conversion and 100 % ee, is an appealing but also challenging option for asymmetric synthesis. Herein a novel chemo‐enzymatic deracemization concept by a cascade is described: the pathway involves two enantioselective oxidation steps and one non‐stereoselective reduction step, enabling stereoinversion and a simultaneous kinetic resolution. The concept was exemplified for the transformation of rac‐benzylisoquinolines to optically pure (S)‐berbines. The racemic substrates were transformed to optically pure products (ee>97 %) with up to 98 % conversion and up to 88 % yield of isolated product. 相似文献
11.
12.
Mònica Campàs Pablo de la Iglesia Margarita Fernández-Tejedor Jorge Diogène 《Analytical and bioanalytical chemistry》2010,396(6):2321-2330
This work describes the development and applicability of two functional assays for the detection of yessotoxin (YTX), a polycyclic
ether marine toxin produced by dinoflagellates. The assays are based on the interaction between this toxin and the phosphodiesterase
(PDE) enzyme and the subsequent measurement of the enzyme activity by colorimetric and electrochemical methods. Firstly, several
enzyme substrates were tested in order to select those able to be detected by colorimetry or electrochemistry after enzymatic
hydrolysis. The substrates that provided the highest absorbance values and density currents were p-nitrophenyl phenylphosphonate and α-naphthyl phosphate, respectively. After optimisation of the experimental parameters, limits of detection of 0.8 and 0.6 μM
were attained by colorimetry and electrochemistry, respectively. An inhibitory effect of YTX on the PDE activity was observed.
The assays have been applied to the analysis of YTX production by Protoceratium reticulatum cultures, and results were compared with liquid chromatography–tandem mass spectrometry analysis. 相似文献
13.
14.
G. K?llensperger G. Friedbacher R. Kotzick R. Niessner M. Grasserbauer 《Fresenius' Journal of Analytical Chemistry》1999,364(4):296-304
In-situ atomic force microscopy (AFM) studies were performed on aerosol samples showing the potential of a topochemical approach
for gaining information on chemical and physical aerosol properties. The behavior of single sub-micron particles has been
investigated with respect to changing humidity in the surrounding atmosphere. Volume calculations allowed monitoring of these
changes on a quantitative basis. As expected these in-situ experiments showed the restructuring of particles with highly agglomerated chain-like structures induced by condensation
and evaporation on a nanometer scale. The particle volumes decreased as the branched chain-like structure changed into a more
regular clump-like structure. The degree of restructuring was clearly depending on the chemical surface properties as could
be proven for soot-like test aerosol particles. The collapse of the chain-like structure on a nanometer scale was found to
be significantly more pronounced for soot particles previously exposed to ozone. Furthermore, in-situ studies were performed on ammonium sulfate test aerosol. Though a distinct deliquescence point typical for salts could not
be detected, neither in the topography nor in the phase image, ammonium sulfate test aerosol particles seemed to partially
dissolve in humid atmosphere and hence to decrease in volume. Thus, the volume decrease induced by purging with humid nitrogen
and subsequent drying which was also observed for a considerable fraction of urban aerosol, could be interpreted in terms
of composition and surface properties considering the geometrical structure (i.e. state of agglomeration) of the particles.
Received: 14 January 1999 / Revised: 1 March 1999 / Accepted: 4 March 1999 相似文献
15.
Mohamed Hasyeoui Dr. Peter M. Chapple Frédéric Lassagne Dr. Thierry Roisnel Marie Cordier Prof. Ali Samarat Dr. Yann Sarazin Prof. Florence Mongin 《European journal of organic chemistry》2023,26(35):e202300555
The functionalization of methylated azines and diazines has aroused the interest of chemists given the structural diversity that it affords. Hindered lithium dialkylamides have been used to deprotometallate these substrates chemoselectively. In contrast, it can be observed that, despite some promising work, lithium diethylamide has been used very little for this purpose. Our objective here is on the one hand to make an inventory of what reagents have been used to deprotometallate methylpyridines, -quinolines and -quinoxalines, and on the other hand to describe the results obtained by seeking to functionalize a series of substrates with lithium diethylamide (picolines, 2,4-lutidine, methylquinolines and 2-methylquinoxaline). Our efforts to take advantage of the use of an in-situ trap (a zinc chloride chelate) in these reactions are also described. 相似文献
16.
Nadir Kiraz Ömer Kesmez Esin Burunkaya Leyla Budama Burçin Acar Meltem Asiltürk H. Erdem Çamurlu Ertuğrul Arpaç 《Journal of Sol-Gel Science and Technology》2010,56(3):227-235
This paper describes the preparation and characterization of glass films consisting of SiO2, Li2O, Na2O, K2O or MgO in varying compositions on stainless steel and aluminum substrates by sol–gel method. Silver phosphate or silver
incorporated zeolite was also introduced into the sols for obtaining antibacterial effect. The SiO2/Li2O/Na2O system having the composition of 85:5:10 wt% was found as the optimum for obtaining a stable sol and film formation. The
films were investigated by scanning electron microscopy (SEM) and electron dispersive analysis by X-ray (EDX), Fourier transformed
infrared (FTIR) spectroscopy, thermo-gravimetric analysis (TGA) and differential thermal analysis (DTA). Homogenous films
having 300 ± 20 nm thicknesses were formed by spin coating and then by curing at 500 °C for 1 h. Obtained films had high adherence
to the metal substrates and they were also durable in acidic, basic or NaCl environments. They also presented a powerful antibacterial
effect against E. coli. 相似文献
17.
In an earlier binding study conducted in our laboratory using Thermobifida fusca cellulases Cel6B, Cel9A, and Cel5A (formally Thermomonospora fusca E3, E4, and E5), it was observed that binding capacities for these three cellulases were 18–30 times higher on BMCC than on Avicel. These
results stimulated an interest in how the difference in accessibility between the two cellulosic substrates would affect synergism
observed with cellulase mixtures. To explore the impact of substrate, accessibility on the extent of conversion and synergism,
three binary T. fusca cellulase mixtures were tested over a range of cellulase ratios and total molar cellulase concentrations on Avicel and BMCC.
Higher extents of conversion were observed for BMCC due to the higher enzyme to substrate ratio resulting from the higher
binding The processive endoglucanase, Cel9A, had four times the extent of conversion of the end endocellulase Cel5A, while
the exocellulase Cel6B had three times the extent of conversion of Cel5A. Approximately 500 nmol/g of the cel9A+Cel6B mixture
was needed to obtain 80% conversion, while the Cel6B+Cel5A and Cel9A+Cel5A mixtures required 1500 and 1250 nmol/g, respectively,
to obtain 80% conversion. Thus, it appears that the more accessible structure of BMCC, as reflected by its binding capacity,
results in relative higher processive activity. 相似文献
18.
Yasuji Ihara Yoshiharu Kimura Mamoru Nango Nobuhiko Kuroki 《Journal of polymer science. Part A, Polymer chemistry》1983,21(5):1535-1542
Catalytic hydrolysis of enantiomeric substrates by N-decanoyl-L -histidine was studied at pH 7.30, 0.02M phosphate buffer, and 25°C in the presence of quaternized polymers. The rate of reaction is remarkably accelerated in the presence of polyethylenimine derivatives, but the observed stereoselectivity depends on the structure of the substrates. 相似文献
19.
《Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy》1993,49(5-6):837-843
The different spectral behaviour of silver surface-enhanced Raman spectroscopy (SERS) substrates roughened electrochemically in and without the presence of an analyte has been shown clearly. These differences are associated with anomalous local pH conditions within the cavities in surfaces of high microporosity in the in-situ roughened silver substrates. In-situ roughened silver electrodes appeared to have a much higher porosity compared with ex-situ roughened surfaces. 相似文献
20.
Masaya Kakimoto Hideki Ueno Hiroyuki Kojima Yoichi Yamaguchi Akira Nishimura 《Journal of polymer science. Part A, Polymer chemistry》1996,34(13):2753-2758
The doping effects on optical and electrical properties of polysilanes were investigated by in-situ measurement. When polysilanes bearing a p-N,N-dialkylaminophenyl substituent were doped with iodine vapor, drastic spectral changes were observed. The evolved visible absorption up to 700 nm was found to be strong and stable compared to that of iodine-doped polysilanes such as poly(methylphenylsilane). On the basis of the studies concerning iodine doping of the related p-N,N-dimethylaminophenyl-substituted silane and disilane, and also theoretical calculations, this new absorption can be best interpreted by the result of charge transfer consisting of the strong interaction between iodine and dialkylamino substituents in the polysilanes. © 1996 John Wiley & Sons, Inc. 相似文献