共查询到19条相似文献,搜索用时 234 毫秒
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本文报道了以(E)-1-(2-对甲苯磺酰胺基)-3-芳基丙-2-烯-1-酮(1)为底物与N-硫代丁二酰亚胺(2)通过亲电环化反应合成2-芳基-3-硫代-2,3-二氢喹啉-4(1H)-酮类化合物。以三氟化硼乙醚为催化剂(20 mol %),1,2-二氯乙烷为溶剂,反应温度为60 oC,可以60-92%的收率得到一系列2-芳基-3-硫代-4(1H)-喹啉酮衍生物,化合物3a-k均未见文献报道,其结构均经过1H NMR, 13C NMR以及高分辨质谱进行确定。 相似文献
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以取代的芳香醛和乙酰丙酸乙酯为原料,通过克诺维纳盖尔(Knoevenagel)缩合、亲核加成、环合、脱水等过程,快速高效地合成了8种未见文献报道的2-芳基-4-丙酸乙酯基-1,5-苯并二氮杂卓化合物.通过1H NMR、13C NMR、IR、MS和单晶衍射确定了其目标产物结构,对合成目标化合物的反应条件进行了较详细的研究,并提出了可能的反应机理。 相似文献
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蒽酮1和氯甲基吡啶盐酸盐2在甲苯中回流反应生成10,10-二吡啶甲基-9(10H)蒽酮(3),收率63%~68%;3用硼氢化钠还原生成10,10-二吡啶甲基-9,l0-二氢蒽-9-醇(4),收率87%~90%;蒽醇4在酸催化下发生歧化反应,得到还原产物10,10-二吡啶甲基-9,10-二氢蒽(5)和氧化产物蒽酮3.该歧化反应受催化剂、溶剂和反应温度等影响.当蒽醇4用三氟化硼为催化剂、甲苯为溶剂、回流反应,5的收率达到74%.所合成的新化合物都经1H NMR,13C NMR,MS和元素分析表征确认. 相似文献
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以取代苯甲醛、溴乙腈和6-苄基-3-硫代-3,4-二氢-1,2,4-三嗪-5(2H)-酮为起始原料,在超声辅助下,一锅合成了9个新型6-苄基-2-亚苄基-2H-噻唑[3,2-b][1,2,4]三嗪-3,7-二酮类化合物,结构经1H NMR,13C NMR和MS(ESI)表征并对其合成机理进行了初步研究。测试了目标化合物(4a~4i)的体外乙酰胆碱酯酶的抑制活性,其中4a和4d抑制活性最好,有进一步研究的价值。 相似文献
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用对甲苯磺酸-2,3-丙酮缩甘油酯(2)与乙酰乙酸乙酯盐、碳酸二乙酯反应, 制备β-酮酯类衍生物1. 以(±)-1,2-丙酮缩甘油为起始物, 经对甲苯磺酰化、亲核取代、脱羧等反应, 方便、高产率地合成了6,7-丙酮缩二醇-3-酮-庚酸乙酯(1). 试图通过对甲苯磺酸-2,3-丙酮缩甘油酯(2)和乙酰乙酸乙酯双阴离子反应制备6,7-丙酮缩二醇-3-酮-庚酸乙酯(1)未获成功. 所合成的化合物经元素分析, IR, 1H NMR, 13C NMR和MS光谱表征. 相似文献
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Nano MnO2 was found to be an efficient oxidant agent for the synthesis of 2-substituted benzoxazoles through one-pot reaction of o-aminophenol and different aromatic aldehydes in acetonitrile under ultrasonic irradiation. This method was performed under mild conditions with high yields, inexpensive and readily available oxidant agent, facile and easy experimental procedure, simple purification of final products, and short reaction times. The prepared nano MnO2 has been characterized by FTIR, XRD, and SEM techniques. The pure products were identified and characterized by physical and spectroscopic data such as; melting point, IR, 1H NMR, and 13C NMR. 相似文献
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An efficient and very simple method for synthesis of 4,4′-diaminotriphenylmethane and its derivatives has been achieved via reaction of various substituted aromatic aldehydes containing both electron-donating and electron-withdrawing groups with various anilines having electron-withdrawing and electron-donating groups in the presence of catalytic amounts of HZSM5 zeolite and H3PW12O40 under solvent-free conditions. The reaction proceed with shorter reaction time and higher yield compared to the results obtained in different solvents. Anilines having electron-donating groups in comparison with those having electrondonating group performed this transformation in better yields. Also the results show that the steric hindrance plays an important role in this transformation. Reusability is an advantage of the HZSM5 zeolite, while it showed lesser activity than H3PW12O40. The one-pot reaction, simple work up, high yields, use of efficient catalytic amount and eco-friendly reagents are the advantages of the proposed method. All products were characterized using 1H NMR, 13C NMR and IR. 相似文献
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A simple and efficient procedure for the synthesis of substituted benzothiazoles through condensation of 2-aminothiophenol with aromatic aldehydes in the presence of H2O2/HCl system in ethanol at room temperature is described. The target compounds have been characterized by 1H NMR, 13C NMR, IR and MS. Short reaction time, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure. 相似文献
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Ian S. Blagbrough Manal S. Elmasry Timothy J. Woodman Afaf Aboul Kheir 《Tetrahedron》2009,65(25):4930-12310
Quantitative 1H NMR spectroscopic methods are not frequently reported, but current NMR instrumentation allows ready access to such data. Mebeverine HCl is an attractive molecule for NMR spectroscopy teaching purposes as it possesses a variety of simple but significant functional groups; we fully assign its 1H and 13C NMR spectra. Using mebeverine HCl, we show that concentration changes, in water as a solvent, can lead to significant changes in the 1H chemical shifts of non-exchangeable aromatic protons and to a lesser extent to aromatic methoxy protons. An important observation is that different protons migrate to different extents as the concentration of the solute is varied, and thus the 1H NMR spectra are concentration-dependent across a useful range. This chemical shift variation of selected protons was therefore analyzed and applied in the quantitative determination of mebeverine HCl in a medicine (Colofac IBS) formulated as a tablet. Self-association phenomena in water could account for these observed chemical shift migration effects as shown by determining the hydrodynamic radius from the modified form of the Stokes-Einstein equation, and thence the apparent hydrodynamic volume, VH, for mebeverine HCl in D2O solution which is 10-fold greater than that seen in either CDCl3 or CD3OD. 相似文献
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A highly efficient and simple protocol for the preparation of 2-arylbenzothiazoles through condensation of 2-aminothiophenol and different aldehydes in the presence of H3PO4/TiO2-ZrO2(1/1)-cetyl pyridinium bromide (CPB) is described. The reaction proceeded under mild and solvent-free conditions to afford 2-arylbenzothiazole derivatives. In this method, the title compounds were obtained in good to excellent yields and short reaction times. The structures of synthesized products were identified by infrared, 1H NMR, 13C NMR, and mass spectroscopy. 相似文献
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Nader Ghaffari Khaligh 《催化学报》2014,35(4):474-480
7‐Aryl‐8H‐benzo[f]indeno[2,1‐b]quinoline‐8‐one derivatives were synthesized by means of a one‐pot condensation of 2‐naphthylamine, aromatic aldehydes, and indane‐1,3‐dione in ethanol under refluxing conditions in the presence of poly(4‐vinylpyridinium) hydrogen sulfate, a solid acid catalyst. This method has the advantages of high yield, clean reaction, simple methodology, and short reaction time. The catalyst could be recycled and reused four times without significant loss of activity. The structure of the novel compounds was confirmed by IR, 1H NMR, and 13C NMR spec-troscopy and elemental analysis. 相似文献
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Some new spirocarbocyclic compounds with highly diastereoselectivity were synthesized using a simple, green and high efficiency method. The IR, 1H NMR and 13C NMR spectroscopy and C.H.N analyses were applied for identification of these compounds. This novel synthetic approach was performed from acid catalytic pathway using CuFe2O4 MNPs as a nanocatalyst in aqueous moiety. 相似文献