共查询到20条相似文献,搜索用时 15 毫秒
1.
Ng'ang'a MM Hussain H Chhabra S Langat-Thoruwa C Riaz M Krohn K 《Natural product communications》2011,6(8):1115-1116
A new flavone dimer, drypetdimer A (1), was isolated from Drypetes gerrardii J.Hutch The structure of the new compound was elucidated by detailed spectroscopic analysis such as 1H, 13C NMR, COSY, HMQC, HMBC and HREIMS. 相似文献
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Wen‐Hao Chen Chang‐Ri Han Yang Hui Da‐Shuai Zhang Xin‐Ming Song Guang‐Ying Chen Xiao‐Ping Song 《Helvetica chimica acta》2015,98(5):724-730
Two new eremophilane‐type sesquiterpenoids, 1α‐hydroxyeremophila‐6,9,11‐trien‐8‐one ( 1 ), 4α‐hydroxyeremophila‐1,9‐diene‐3,8‐dione ( 2 ), and a new friedelane‐type triterpenoid, friedelane‐3α,16β‐diol ( 4 ), along with six known terpenoids, 3 and 5 – 9 , have been isolated from the stems of Drypetes congestiflora. Their structures and relative configurations were elucidated on the basis of detailed spectroscopic analyses and by comparison of their NMR data with those reported in the literature. All of the compounds, 1 – 9 , were isolated for the first time from this species. Compound 3 exhibited moderate cytotoxic activities against the A549 and B16F10 cell lines. 相似文献
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Isabelle Sordat-Diserens Andrew Marston Matthias Hamburger Kurt Hostettmann Colin Rogers 《Helvetica chimica acta》1989,72(5):1001-1007
Three novel prenylated xanthones, 1–3 , have been isolated from the root bark of Garcinia gerrardii HARVEY ex T. R. SIM (G. natalensis SCHLECHTER ; G. transvaalensis BURTT DAVY ; Guttiferae). Structure elucidation was achieved by a combination of one- and two-dimensional NMR spectroscopic techniques, including long-range HETCOR, mass spectroscopy, and chemical methods. Garcigerrin A ( 1 ) and B ( 2 ) are pyrano derivatives of 3 . They all show a rare 1,4,5 oxygenation pattern of the xanthone nucleus. Xanthone 3 is fungicidal against Cladosporium cucumerinum. 相似文献
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Antiplasmodial activity of three bisbenzylisoquinoline alkaloids from the tuber of Stephania rotunda
Chea A Bun SS Azas N Gasquet M Bory S Ollivier E Elias R 《Natural product research》2010,24(18):1766-1770
Three bisbenzylisoquinoline alkaloids were isolated for the first time from Stephania rotunda tuber. Their structures were elucidated by spectroscopic methods and their antiplasmodial activity was investigated in vitro on chloroquine resistant Plasmodium falciparum strain W2. These alkaloids were identified as 2-norcepharanthine (1), cepharanoline (2) and fangchinoline (3). In vitro, they displayed significant antiplasmodial activity with inhibitory concentration 50 values of 0.3, 0.2 and 0.3 μM. 相似文献
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Viviane Nadège Nenkep~a Jovita Chi Shirri~a Hanh Trinh Van-Dufat~b Falindor Sipepnou~a Philippe Vérité~d Elisabeth Seguin~c Francois Tillequin~b Jean Wandji~ 《中国化学快报》2008,19(8):943-946
Two new compounds 7-hydroxy-5-O-(β-D-glucopyranoside) flavan (1) and (Z)-4',6'-dihydroxy-2'-O-(β-D-glucopyranoside) chalcone (2), along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia (Euphorbiaceae). Their structures were established on the basis of spectroscopic analysis and chemical evidence. 相似文献
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Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji 《中国化学快报》2011,22(2):171-174
A new friedelane-type triterpene named 3β-hydroxyfriedelane-7,12,22-trione,as well as nine known compounds were isolated from the whole stems of Drypetes laciniata Hutch.(Euphorbiaceae).Their structures were established on the basis of spectroscopic methods.The new triterpene derivative and a known saponin were tested for antimicrobial and antifungal activities and they appeared to be moderate active. 相似文献
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Dongfack MD Van-Dufat HT Lallemand MC Wansi JD Seguin E Tillequin F Wandji J 《Chemical & pharmaceutical bulletin》2008,56(9):1321-1323
The MeOH extract of the stem barks of Drypetes tessmanniana (Euphorbiaceae) afforded two new triterpene derivatives characterized as 3beta-O-(E)-3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene and 3beta,6alpha-dihydroxylup-20(29)-ene together with seven known compounds. Their structures were established on the basis of spectral analysis. 相似文献
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Wansi JD Wandji J Kamdem WA Ndom JC Ngeufa HE Chiozem DD Chi Shirri J Choudhary MI Tsabang N Tillequin F Fomum ZT 《Natural product research》2006,20(6):586-592
The CH2Cl2/CH3OH (1/1) extract of the dried stem of Drypetes chevalieri Beille afforded two new triterpeno?ds named drypechevalin A (11-oxo-beta-amyrin-3beta-ylcaffeate) and drypechevalin B (3,7-dioxo-D:A-friedooleanan-24-al) along with five known compounds: lupeol, lupeone, erythrodiol, putranjivadione, friedelin. Their structures were established on the basis of spectroscopic analysis and chemical evidence. 相似文献
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Lois M. Muiva-Mutisya Yoseph Atilaw Matthias Heydenreich Andreas Koch Hoseah M. Akala Agnes C. Cheruiyot 《Natural product research》2018,32(12):1407-1414
The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodium falciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4–4.6 μM without significant cytotoxicity against Vero and HEp2 cell lines (IC50 > 100 μM). The new compound (1) showed weak antiplasmodial activity, IC50 12.5–24.2 μM, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9 μM). 相似文献
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Grace MH Lategan C Mbeunkui F Graziose R Smith PJ Raskin I Lila MA 《Natural product communications》2010,5(12):1869-1872
The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 microg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-beta-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 microg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 microg/mL, respectively. A structure-activity relationship is discussed. 相似文献
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Gustav Komlaga Grégory Genta-Jouve Sandrine Cojean Rita A. Dickson Merlin L.K. Mensah Philippe M. Loiseau Pierre Champy Mehdi A. Beniddir 《Tetrahedron letters》2017,58(38):3754-3756
The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration of the new compound were elucidated on the basis of extensive spectroscopic analysis, optical rotation, and GIAO NMR shift calculation followed by CP3 analysis. The antiplasmodial activity of these compounds was evaluated against chloroquine-resistant (W2) and -sensitive (3D7) strains of Plasmodium falciparum. Among them, ent-norsecurinine (2) and (+)-allonorsecurinine (1) showed the strongest activity (IC50: 1.14 ± 0.32 and 2.57 ± 0.53 µM) respectively, against W2 but one of the weakest against 3D7. 相似文献
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Indole alkaloids from the African Strychnos species, their antiplasmodial and cytotoxic action, and structure -activity relationships are discussed in the review 相似文献
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Duc Hong Lande Abed Nasereddin Arne Alder Tim W. Gilberger Ron Dzikowski Johann Grünefeld Conrad Kunick 《Molecules (Basel, Switzerland)》2021,26(16)
Malaria is one of the most dangerous infectious diseases. Because the causative Plasmodium parasites have developed resistances against virtually all established antimalarial drugs, novel antiplasmodial agents are required. In order to target plasmodial kinases, novel N-unsubstituted bisindolylcyclobutenediones were designed as analogs to the kinase inhibitory bisindolylmaleimides. Molecular docking experiments produced favorable poses of the unsubstituted bisindolylcyclobutenedione in the ATP binding pocket of various plasmodial protein kinases. The synthesis of the title compounds was accomplished by sequential Friedel-Crafts acylation procedures. In vitro screening of the new compounds against transgenic NF54-luc P. falciparum parasites revealed a set of derivatives with submicromolar activity, of which some displayed a reasonable selectivity profile against a human cell line. Although the molecular docking studies suggested the plasmodial protein kinase PfGSK-3 as the putative biological target, the title compounds failed to inhibit the isolated enzyme in vitro. As selective submicromolar antiplasmodial agents, the N-unsubstituted bisindolylcyclobutenediones are promising starting structures in the search for antimalarial drugs, albeit for a rational development, the biological target addressed by these compounds has yet to be identified. 相似文献
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Neurotropic activity of several classes of organogermanium compounds (namely germatranes, germanols, germsesquioxanes, germyladamantanes, germylamides, germylimides and germylsubstituted amines, imines and hydroxamic acids) and their synthesis are reviewed. 相似文献