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1.
三唑农药的手性拆分及对映体的转化 总被引:5,自引:0,他引:5
利用Chiralcel OJ-H和Chiralcel OD-H手性柱对烯唑醇、三唑酮和三唑醇的手性拆分进行了研究,进一步测定了烯唑醇和三唑酮对映体的旋光性质,据此确定了两种农药对映体的绝对构型,在此基础上结合三唑酮转化为三唑醇的还原实验确定了三唑醇4个对映异构体的绝对构型。考察了几种三唑农药在有机溶剂和缓冲溶液中的手性稳定性,其中三唑酮在甲醇、乙醇和水中存在明显的对映体转化行为,而烯唑醇和三唑醇则是手性稳定的,升高温度及碱性环境会加快三唑酮的对映体转化。 相似文献
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对有机化学研究中的手性化合物, 尤其是天然产物分子的立体构型的鉴定, 日益受到研究人员的重视. 然而, 在化合物不能结晶或其它条件影响到不能用实验来直接解析其立体构型的情况下, 计算化学是一个比较有效的手段. 目前可供利用的计算方法有旋光计算, 如利用量子力学方法或矩阵模型及13C NMR计算等. 本文对这些不同的计算方法进行介绍. 相似文献
3.
对于手性化合物立体化学理论与实验相结合的研究中容易出现的相关共性科学问题进行了讨论, 包括计算化学中软件、 简化模型的使用及计算过程中相关方法的应用范围和前提条件. 针对性地提出了在能量分析、 旋光光谱(OR)、 电子圆二色光谱(ECD)、 振动圆二色光谱(VCD)和核磁共振碳谱(13C NMR)等计算中可能出现的陷阱以及规避方法, 并考察了相关的计算实例. 相似文献
4.
手性化合物的结构确定,尤其是新型手性化合物的绝对构型测定一直是不对称研究的重要工作.除单晶测试外,光谱学方法近年来被广泛应用于手性分子结构鉴定,主要包括电子和振动圆二色谱、旋光光谱、旋光拉曼谱等.本文对上述测试方法的原理、应用范围和相关理论计算方法做了介绍.把谱学测试与理论计算相结合,将成为手性分子结构鉴定的重要发展方向. 相似文献
5.
Cirilli R Ferretti R Gallinella B La Torre F La Regina G Silvestri R 《Journal of separation science》2005,28(7):627-634
The enantiomeric separation of a series of imidazole analogues of Fluoxetine and Miconazole endowed with potent antifungal activity was performed using cellulose tris(4-methylbenzoate) (Chiralcel OJ) and cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD) as chiral stationary phases. Binary mixtures of n-hexane and alcohol as well as pure alcohols (ethanol or 2-propanol) were used as eluents. The enantiomer elution order was monitored by chiroptical detectors based on on-line optical rotation and circular dichroism measurements. For some of the compounds studied very high enantioseparation factor values (alpha > 7) on Chiralcel OJ CSP were observed. In order to study the chiroptical characteristics of the two most biologically active compounds, chromatographic resolutions were carried out on a semipreparative scale. Assignment of the absolute configuration was empirically established by comparing the CD spectra of the separated enantiomers with those obtained from the enantiomers of Miconazole. 相似文献
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Nitr0alkenesareversatilesyntheticintermediatesaspowerfulelectron-deficientreactantsincycloadditionandconjugatadditionreacti0ntoproducealargevarietyfunctionalizedcarbocyclicrings'.Purthermore,thenitrogrouPcanbeconvertedintoawiderangeoffiinctionalities2-Al0ughDiels-Alderreaction3andcyclopropanationoffunctionalizedcarbonnucleophiles4toY-chiralnitr0alkenehavebeenreportedrecently.Sofarthedetailedresearch0ftheconjugateadditionsoffimctionalizedalcoholst0chira1nitf0keneshasn0tbeenreported.Herewewish… 相似文献
8.
Carmen Pons 《Analytica chimica acta》2005,528(2):197-203
A novel optical fibre reflectance sensor coupled to a multisyringe flow injection system (MSFIA) for the determination and speciation analysis of iron at trace level using chelating disks (iminodiacetic groups) is proposed. Once iron(III) has been retained onto a chelating disk, an ammonium thiocyanate stream is injected in order to form the iron(III)-thiocyanate complex which is spectrophotometrically detected at 480 nm. Iron(III) is eluted with 2 M hydrochloric acid so that the chelating disk is regenerated for subsequent experiments. The determination of total iron is achieved by the on-line oxidation of iron(II) to iron(III) with a suitable hydrogen peroxide stream.A mass calibration was feasible in the range from 0.001 to 0.25 μg. The detection limit (3sb/S) was 0.001 μg. The repeatability (RSD), calculated from nine replicates using 1 ml injections of a 0.1 mg/l concentration, was 2.2%. The repeatability between five chelating disks was 3.6%. The applicability of the proposed methodology in fresh and seawater samples has been proved.The proposed technique has been validated by replicate analysis (n = 4) of certified reference materials of water with satisfactory results. 相似文献