共查询到20条相似文献,搜索用时 8 毫秒
1.
《Analytical letters》2012,45(6):437-443
Abstract Fluorescamine reacts efficiently with primary amines to form pyrrolinones with long wavelength absorption at 390–410nm. A procedure has been worked out which allows the use of this reaction for the colorimetric assay of primary amines. 相似文献
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《Analytical letters》2012,45(7):657-680
Abstract The effects of substituents on the reactivity of the monosubstituted anilines with fluorescamine (FLA) and the fluorescent properties of the reaction products, FI (Ph), were investigated. Generally, the substituent at o-position markedly inhibited the reactivity of the amino group (ortho-effect). While the electron-donating substituent seemed to be favorable for the formation of FI (Ph), the electron-attracting one seemed to lower reactivity of the amino group. However, the presence of the latter substituent led to the enhanced fluorescence of FI (Ph). The highly significant correlation was observed between the wavelengths (nm) of the emission maxima and the Hammett's substituent constants. 相似文献
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《Analytical letters》2012,45(9):1019-1025
Abstract Fluorescamine reacts with primary amines, it does not react with secondary or tertiary amines, to yield bright acquamarine fluorescent products. This reaction has been developed into a spot test useful for differentiation of amphetamine from methamphetamine; previous spot tests did not have this degree of specificity. The fluorescent products of several primary amines have been demonstrated to have sufficient stability to permit thin-layer chromatography comparisons with authentic materials. The fluorescent derivative of amphetamine has been demonstrated to be capable of differentiation from other fluorescent products formed from fluorescamine based on its unique migration in three different TLC systems. 相似文献
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《Analytical letters》2012,45(5):543-553
Abstract Fluorescamine has been shown to be a promising derivatizing reagent for the room temperature phosphorescence analysis of primary amino acids. The fluorescamine concentration used for derivatization in solution was 600 μg/ml and for direct derivatization, 1160 μg/ml. For derivatized primary amino acids the limits of detection were found to be between 0.8 ng and 2.9 ng with linear dynamic ranges between 2 and 3 orders of magnitude. 相似文献
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《Analytical letters》2012,45(20):1725-1733
Abstract A new simple and fast micro method has been established to determine the optical purity of a small amount of amino acids (0.1–1 μg/ml). The amino acids react readily with fluorescamine to form pyrrolinone-type chromophores, which show strong CD bands at 400–300 nm and much larger optical rotation than the free amino acids in the visible spectral range. 相似文献
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《Analytical letters》2012,45(7):589-602
Abstract Fluorescamine forms stable, fluorescent derivatives with sterically-unhindered primary aromatic amines in both aqueous (borate buffer, pH 9/acetonitrile) and nonaqueous (pyridine/-acetonitrile) media. Aromatic amines with a substituent such as a methyl group or an aromatic ring ortho to the amine functionality either derivatized poorly or not at all because of steric hindrance. 相似文献
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《Analytical letters》2012,45(9):759-769
Abstract Secondary amines are formylated by dimethylformamide dimethylacetal, contradicting recent reports on the ethylation of secondary amines by this reagent. This explains why a single derivative is obtained regardless of the alkyl acetal that is used. These formyl derivatives, also formed by reaction with formic acid, are eluted later than the starting material or the corresponding ethyl derivative. Deuterated imipramine and related antidepressants can be prepared by reducing the formyl derivative of the appropriate desalkyl compound with lithium aluminum deuteride. 相似文献
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《Analytical letters》2012,45(7):625-634
Abstract The product of the reaction of dialkyl acetals of N, N-dimethyl-formamide with desipramine has been found to be N-formyldesipramine, and not the N-ethyl derivative as reported earlier. Evidence for the structure was obtained from NMR, IR and mass spectra of the compound as well as comparison with N-formyl and N-ethyldesipramine prepared by alternate routes. 相似文献
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丹酰氯柱前衍生仲胺的高效液相色谱-电化学检测方法的研究 总被引:2,自引:0,他引:2
立了一种灵敏检测仲胺的新方法。首次以丹酰氯作为仲胺的电化学检测衍生试剂,对分离检测条件、仲胺的衍生条件及电化学定量检测条件作了详细的研究。以甲醇-20mmol/L的邻苯二甲酸氢钾缓冲液(70∶30,pH3.3)为淋洗液,采用安培检测器在E=+1.1V电压条件下,在PERKIN-ELMER/HS-3C18(83mm×4.6mmi.d.,3μm)柱上实现了二甲胺、二乙胺和哌啶的良好反相分离和灵敏检测,线性范围超过两个数量级。二甲胺、二乙胺和哌啶的检出限分别为0.024,0.60,0.090pg。 相似文献
11.
《Analytical letters》2012,45(7-8):575-579
Abstract The chemical ionization mass spectra of fluorescamine and fluorescamine - amino acid derivatives have been studied using methane and ammonia as reagent gases. Major ions in the spectra are protonated molecular ions, adduct ions and ions formed by loss of an oxygen atom. Fluorescamine, 4-phenyl-spiro[furan-2(3H),1′-phthalan]3,3′-dione, is a powerful new fluorogenic reagent for assaying primary amines.1 and EI2 and EI3 mass spectrometric investigations of fluorescamine and its derivatives were carried out. Our present study reports the CI mass spectral analysis of fluorescamine and some of its amino acid derivatives. 相似文献
12.
Zimin Chen Prof. Weiming Yuan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(60):14836-14840
An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules. 相似文献
13.
传统的化学分析方法分析矿石中主次量元素流程长,效率低。受干扰影响大,耗费大量人力物力,采用电感耦合等离子体原子发射光谱法测定技术对锰矿中的主次量元素进行了研究,主要测定了铝、铜、钙、铁、钾、镁、锰、钠、镍、磷、钛、锌等13种元素的含量。仪器采用射频功率1 150W,雾化器流速为0.70L/min,辅助器流速0.50L/min,观测高度12mm的测定条件。采用硝酸、盐酸、氢氟酸、高氯酸四酸溶矿,实验表明,溶液中分别共存200mg/L以下的钾、钠、钙、镁、钒、锰,对各微量元素的测定基本没有干扰。分析方法的检出限0.0002%~0.0065%。相对标准偏差(RSD)3.7%。均符合DZ/T0130—2006地质矿产实验室测试质量管理规范中精密度和准确度的控制指标。 相似文献
14.
Sanjay P. Borikar 《合成通讯》2013,43(5):654-660
A combination of p-toluenesulfonic acid (p-TSA) and sodium nitrite was used as a novel effective nitrosating agent for the N-nitrosation of secondary amines to their corresponding nitroso derivatives under mild and heterogeneous conditions in moderate to excellent yields. 相似文献
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The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup. 相似文献
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A variety of secondary amines were obtained in high isolated yields in the reductive amination of aldehydes and ketones by using lithium amidoborane as reducing agent. Compared to ammonia borane, lithium amidoborane has higher reducibility, and thus, exhibits faster reaction rate. 相似文献
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Alina Marieta Simion Takashi Arimura Akira Miyazawa G. K. Surya Prakash George A. Olah 《合成通讯》2013,43(16):2859-2865
Secondary and tertiary amines can be easily obtained from primary and secondary amines, respectively, in completely aqueous media, in the presence of a bicatalytic system formed of cheap commercial aluminum (Al) powder and 5% rhodium (Rh) or ruthenium (Ru) deposed on charcoal. 相似文献