N-N''双吡咯的合成及其邻位基团效应

α,α一联吡咯是某些天然存在的活性吡咯化合物中关键组成, 关于手性联吡咯的研究已有详细的综述报道, 近年发现, 某些含N-取代氨基的空间阻碍吡咯有明显的生理活性和可贵的药理性质, N,N'-联吡咯中N-N键很容易发生均裂反应而生成游离基, 后者很可能与天然吡咯小分子的生理活性有密切关系, 这些都引起了人们的广泛兴趣。     

N′-叔丁基-N-取代酰基(硫)脲类化合物的合成及生物活性测定

将叔丁基引入到酰基 (硫 )脲骨架中 ,设计合成了 8个未见文献报道的N′ 叔丁基 N 取代酰基脲及N′ 叔丁氨基羰基 N 取代酰基硫脲类化合物 ,其结构经元素分析、IR和1 HNMR得到确证 .初步的生物活性测试结果表明部分化合物具有较好的除草活性     

N,N′-二芳基己二酰二肼类化合物的合成及其结构表征

报道了N,N′-二芳基己二酰二肼类化合物的合成方法。以自制的己二酰二氯、取代苯肼为原料,以二氯甲烷为溶剂,用冰浴法合成了9种新型的N,N′-二芳基己二酰二肼类化合物。产品的结构经元素分析、IR、1HNMR等测试技术得到确证,产物的IR谱中,在3 200～3 400 cm-1出现2个N—H吸收峰,1H NMR谱中,在δ7.3～10.5之间有2个N—H吸收峰,产品的元素分析结果与理论值基本相符。收率81%～93%。     

N,N′-二乙酸取代含噻吩环氮杂冠醚配体及其稀土配合物的合成与表征

A new N,N′-diacetic acid substituted azacrown ether containing thiophere ring ligand(H₂L) has been synthesized by using salicylaldehyde, diamine, thiophene and bromoacetic acid as starting materials. With this ligand, its lanthanide complexes [ML(NO₃)]·nH₂O(M=La,Ce,Pr,Nd,Sm,Eu,Dy,Er,Yb;n=2 or 3) are prepared. These compounds are characterized by elemental analysis, IR, ¹H NMR, MS and conductivity measurements. The results show that ether oxygen, carboxy oxygen, nitrogen atoms and nitrate ion are coordinated to the metal ion.     

N,N′-二芳基己二酰双偶氮化合物的合成及其结构表征

N;N′-二芳基己二酰二肼;N;N′-二芳基己二酰双偶氮化合物;合成     

N,N′-亚甲基双丙烯酰胺与4-乙烯基吡啶共聚微凝胶的γ-射线辐照合成

通过γ 射线辐照技术 ,在稀水溶液中实现了N ,N′ 亚甲基双丙烯酰胺 (Bis)与 4 乙烯基吡啶 (4 VP)的无皂乳液共聚 ,得到平均流体力学半径 (Rh)为 5 6～ 15 2nm的一系列微凝胶 ,并通过红外光谱、热分析、透射电镜进行了表征 .通过测定Rh、吸光度、凝胶比 ,研究了与Bis共聚的单体及比例、剂量和剂量率对微凝胶合成的影响 .结果表明 ,微凝胶的大小可以通过吸收剂量、单体相对含量的改变来进行控制 .最后 ,对微凝胶的形成机理进行了初步探讨 .     

N,N′-羰基二咪唑作为活化剂在高分子合成中的研究进展

本文综述N,N′-羰基二咪唑作为活化剂制备脲、酯、碳酸酯、氨酯及酰胺类化合物的反应机理,并对其在高分子领域的应用进行了总结。     

N,N′-二羧甲基-2-甲基苯并咪唑内鎓盐的合成及晶体结构

以2-甲基苯并咪唑为原料,合成了一个新型的苯并咪唑二羧酸衍生物,基结构通过IR,1HNMR,元素分析和X-射线单晶衍射法确定。X射线衍射单晶结构分析表明,固态时标题化合物通过分子间氢键形成一维无限链状结构,这些一维无限链状结构又通过链与链间的苯并咪唑环的π-π堆积作用形成二维结构。标题化合物的晶体属单斜晶系,P21/c空间群;Mr:568.54,a=19.821(3),b=7,.4501(11),c=20.093(3),β=116.479(3),°v=2655.8(3)3,z=4,Dc=1.422 mg.m-3,F(000)=1200,最终偏离因子R=0.0675,wR=0.2187。     

N,N′-二乙(甲)基-N,N′-二苯基脲对铀(VI)和钍(IV)萃取行为的研究

目前国际上一般采用磷酸三丁酯(TBP)作为铀的萃取剂。TBP对铀有较强的萃取能力,但其耐辐照能力较差。酰胺的理化性质类似于TBP,与TBP相比降解产物易除去,“可完全燃烧”等优点而被认为是一种能取代应用于核燃料后处理的有前途的萃取剂。本文以二甲苯或三氯甲烷     

Synthesis of polysubstituted pyrroles via Ag(I)-mediated conjugate addition and cyclization reaction of terminal alkynes with amines

A Ag(I)-mediated conjugate addition and cyclization reaction of terminal alkynes with amines has been developed. Highly substituted pyrrole derivatives were obtained with good yields.     

Convenient synthesis of polysubstituted pyrroles and symmetrical and unsymmetrical bis-pyrroles catalyzed by H3PW12O40

A mild and environmentally-benign protocol for the efficient synthesis of polysubstituted pyrroles via a one-pot three-component reaction of amines, α-bromo ketones and dialkyl acetylenedicarboxylate using H₃PW₁₂O₄₀ as a recyclable heterogeneous catalyst under solvent-free conditions at room temperature is reported. Importantly, the synthesis of symmetrical and unsymmetrical polysubstituted bis-pyrroles has been performed in good yields for the first time, which can be considered as a salient feature of this protocol.     

Facile synthesis of polysubstituted 2,3-dihydropyrroles and pyrroles from Mn(OAc)3-promoted oxidative cyclization of alkenes with amines/alkyne esters or enaminone esters

A novel oxidative cyclization of alkenes with amines/alkyne esters or enaminone esters can be efficiently promoted by Mn(OAc)₃, furnishing a series of polysubstituted 2,3-dihydropyrroles in moderate to excellent isolated yields (75–91%). Afterward addition of a suitable oxidant such as K₂S₂O₈ can furnish efficient synthesis of the corresponding polysubstituted pyrroles in a one-pot pathway.     

A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides

The dienamine products formed by the reaction between polysubstituted succinimides and the Petasis reagent were subjected to isomerization under mild acidic conditions to give polysubstituted pyrroles in excellent yields (85–95%). The scope and limitations of this methodology are explored.     

N,N-二异丙基乙二胺盐酸盐的合成

N;N-二异丙基乙二胺盐酸盐的合成;二异丙胺;环氧乙烷;N;N-二异丙基乙醇胺;N;N-二异丙基氯乙胺;N;N-二异丙基乙二胺     

A Vicinal Acyloxy Group Participation SN2 Reaction of Thiol Nucleophiles in the Formation of Thioacetals

Thioacetalization of acyl protected furanosides led to products with an ethanethiol group at C‐2 and 3‐O‐acetyl‐ 1,2‐di‐O‐isopropylidene‐D‐furanoses were converted into corresponding thioacetals with two ethanethiol groups at both C‐2 and C‐3 positions under the standard thioacetalization conditions. All products were characterized by ¹H NMR, ¹³C NMR and HRMS data. X‐ray structure analysis indicates that the vicinal acyloxy group is stereoselectively substituted by ethanethiols. The supposed mechanisms for these two kinds of transformations were presented.     

The solvent‐free synthesis of polysubstituted pyrroles by a reusable copper Schiff base complex immobilized on silica coated Fe3O4, and DNA binding study of one resulting derivative as a potential anticancer drug

We demonstrate herein the synthesis of a new copper Schiff base complex immobilized on silica‐coated Fe₃O₄ nanoparticles. The structure and composition of this magnetic nanocatalyst were analyzed using Fourier transform infrared (FT‐IR), X‐ray powder diffraction (XRD), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), energy dispersive X‐ray (EDX) and inductively coupled plasma atomic emission spectroscopy (ICP‐AES). This nanocomposite was found to be an efficient nanocatalyst for the synthesis of polysubstituted pyrrole derivatives and the products were isolated with high turnover number (TON) and high to excellent yields. Among the new synthesized polysubstituted pyrrole derivatives, we explored the first computational and experimental binding study of methyl 1‐benzyl‐4‐(furan‐2‐yl)‐2‐methyl‐1H‐pyrrole‐3‐carboxylate (SP‐10) with calf thymus deoxyribonucleic acid (ct‐DNA), suggesting their application as potential anticancer activity. In addition, the binding modes of SP‐10 with DNA and human serum albumin (HSA) were verified by molecular docking technique.     

N，N-二乙基一对二甲氨基苯甲酰胺的合成

以对二甲氨基苯甲酸为原料合成了增感剂N，N-二乙基-对二甲氨基苯甲酰胺，其结构经IR，UV和MS确认。     

N,N-二甲氨基丙烯酸乙酯的制备

报道了一种以二甲氨基乙醇（DEAE）与丙烯酸丁酯（BA）为原料,钛酯四丁酯（TBT）为催化剂,在负压下反应及蒸馏,生产N,N－二甲氨基丙烯酸乙酯（OMAEA）的方法,并讨论了原料配比、催化剂用量、压力与温度及反应气氛对产物收率的影响,提出了优化的反应条件。     

A Convenient One-Pot Synthesis of Symmetric Secondary and Tertiary Vicinal Diamines

A convenient one-pot synthesis of symmetric vicinal diamines utilizing sodium borohydride/trifluoroacetic acid reduction methodology is described .