共查询到20条相似文献,搜索用时 15 毫秒
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Milton J. Kornet 《Journal of heterocyclic chemistry》1992,29(1):103-105
Previously we reported the potent anticonvulsant activity of 3-dimethylamino-3,4-dihydro-2(1H)-quinazolinone. In this report, a series of 3-alkyl-3,4-dihydro-2(1H)-quinazolinones was synthesized in three steps from isatoic anhydrides or an anthranilic acid. Structure/activity investigations revealed optimal activity for the 3-isopropyl and 3-cyciohexyl analogs. These compounds were effective against seizures induced by maximal electroshock. 相似文献
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William J. Houlihan George Cooke Max Denzer Joseph Nicoletti 《Journal of heterocyclic chemistry》1982,19(6):1453-1456
A series of 1-alkyl-4-aryl-3,4-dihydro-2(1H)-quinazolinones and thiones were prepared by a modification of the Pictet-Spengler reaction that involves treatment of an N-alkyl-N-arylurea or thiourea with an aryl aldehyde in the presence of methanesulfonic acid. The 1H-nmr spectra of several of these compounds gave rise to unusual OCH2O and isopropyl signals. 相似文献
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Izgi T Alver O Parlak C Aytekin MT Senyel M 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2007,68(1):55-62
FT-IR and (1)H, (13)C, DEPT, HETCOR, COSY, and NOESY NMR spectra of 2-(1-cyclohexenyl)ethylamine (CyHEA) have been reported for the first time. The vibrational frequencies and (1)H, (13)C NMR chemical shifts of CyHEA (C(8)H(15)N) have been calculated by means of the Hartree-Fock (HF), Becke-Lee-Yang-Parr (BLYP) and Becke-3-Lee-Yang-Parr (B3LYP) density functional methods with 6-31 G(d) and 6-31 G(d,p) basis sets, respectively. The comparison between the experimental and the theoretical results indicates that density functional B3LYP method is superior to the scaled HF and BLYP approach for vibrational frequencies and predicting NMR properties. 相似文献
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Whei Oh Lin Edson de Souza Coutinho 《Monatshefte für Chemie / Chemical Monthly》1983,114(11):1231-1235
The title compounds are obtained directly on reaction of 6-chloroacetamidopiperonal with substituted phenylhydrazines. Piperonal was used as starting material. 相似文献
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D. V. Moiseev V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2006,42(10):1308-1310
A method has been developed for the synthesis of 2′-and 4′-aryl-2,3′-biquinolyls based on the reaction of 1′-alkyl-2′-aryl-1′,2′-dihydro-2,3′-biquinolyls
and 1′-alkyl-4′-aryl-1′,4′-dihydro-2,3′-biquinolyls with sulfur in DMF.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1517–1519, October, 2006. 相似文献
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A. G. Nemazanyi Yu. M. Volovenko T. A. Silaeva M. Yu. Kornilov F. S. Babichev 《Chemistry of Heterocyclic Compounds》1991,27(3):307-308
3-Amino-4-aryl-1(2H)-isoquinolones have been synthesized by treating 2-halobenzamides with arylacetonitriles. The angle of rotation of the 4-phenyl grop has been determined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 378–380, March, 1991. 相似文献
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Khalili B Jajarmi P Eftekhari-Sis B Hashemi MM 《The Journal of organic chemistry》2008,73(6):2090-2095
New 2-alkyl-5-aryl-(1H)-pyrrole-4-ol derivatives were synthesized via three-component reaction of beta-dicarbonyl compounds with arylglyoxals in the presence of ammonium acetate in water at room temperature. 相似文献
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Condensation of propionic (or acetic) aldehyde, cyanothioacetamide, Meldrum's acid, andN-methylmorpholine occursvia the intermediate formation of the corresponding Michael adducts and yields 4-alkyl-5-cyano-6-mercapto-3,4-dihydropyridin-2(1H)-ones. The oxidation of the reaction products with DMSO and their alkylation were studied.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2016–2019, November, 1997. 相似文献
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Several methods for the preparation of 3,4-dihydro-1-benzoxepin-5(2H)-ones are described. In addition to the desired ketones, a variety of novel by-products have been isolated. 相似文献
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Jiu Xi Chen Hua Yue Wu Wei Ke Su 《中国化学快报》2007,18(5):536-538
2,3-Dihydro-2-aryl-4(1H)-quinazolinones were prepared in good yields via condensation of o-aminobenzamide with aldehydes promoted by a catalytic amount of Sc(OTf)_3 under mild conditions. 相似文献
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YU Chen-Xia ZHU Xiao-Tong YAO Chang-Sheng TU Shu-Jiang 《结构化学》2007,26(5):533-536
The title compound (C16H14BrNO) has been synthesized by the reaction of p-tolylamine, Meldrum’s acid and 4-bromo-benzaldehyde, and its structure was characterized by IR, 1H NMR and X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 7.6850(11), b = 8.3004(11), c = 21.301(3) , β = 95.110(2)°, V = 1353.4(3) 3, Mr = 316.19, Z = 4, Dc = 1.552 g/cm3, μ(MoKα) = 3.028 mm-1, F(000) = 640, the final R = 0.0345 and wR = 0.0768. X-ray analysis reveals that the atoms of C(1), C(2), C(3), C(4), C(5) and N(1) form a six-membered ring of boat conformation. 相似文献