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1.
2-氨基-2-(2-甲氧基-5-吡啶)乙醇是一种重要的药物中间体。本论文提供一种以2-甲氧基吡啶-5-甲酸为原料,经过7步反应制备2-氨基-2-(2-甲氧基-5-吡啶)乙醇的方法,每步反应产率均高于78%,总收率约为23%,最终产品纯度大于98.5%。 相似文献
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二氨基-3-硝基吡啶和2_氨基-5-硝基吡啶的EI—MS质谱图接近,单纯通过Ⅱ-MS质谱图较难区分这两种异构体,作者以甲烷为反应气对2-氨基-3-硝基吡啶和2-氨基-5-硝基吡啶进行化学电离,并利用离子阱质谱的串联质谱技术在离子阱内以He作碰撞气进行碰撞诱导裂解,所得的CI—MS—MS质谱图表明,两者之间存在明显的差别,可用于2-氨基-3-硝基吡啶和2-氨基一5一硝基吡啶的鉴别。 相似文献
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以2-氯-3-硝基-5-溴吡啶为起始原料,经取代反应、水解反应、Suzuki偶联反应得到6-甲基-5-硝基-3-吡啶硼酸频哪酯。反应总收率为51%,中间体及目标产物结构由IR和1H-NMR表征。 相似文献
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以3-甲基-2-氰基吡啶为原料,经水解、酯化、硝化、甲氧基取代、溴代反应制得中间体3-溴甲基-5-甲氧基吡啶-2-甲酸甲酯(7),然后中间体与不同的有机胺经环合反应得到一系列新的沙利度胺衍生物3-甲氧基-6-取代-5,6-二氢吡咯[3,4-b]吡啶-7-酮1a~1l.其结构经1H NMR,13C NMR及HRMS确证.采用MTT(噻唑蓝)法测试了目标化合物抑制HCT-116,MG-63,MCF-7,HUVEC及HMVEC细胞的活性,结果表明,几乎所有化合物对人体正常细胞无明显抑制作用,化合物1h~1l只对MG-63细胞株有明显的抑制活性,化合物1c~1g对这三种肿瘤细胞都有较强的抑制活性,其中化合物1d和1e活性最强. 相似文献
11.
G. P. Sagitullina M. A. Vorontsova A. K. Garkushenko N. V. Poendaev R. S. Sagitullin 《Russian Journal of Organic Chemistry》2010,46(12):1830-1834
Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal
acetylenes. Desilylation, oxidative decarbonylation, and the retro-Favorskii reaction of the cross-coupling products of 2-bromo-5-nitropyridine
with trimethylsilylacetylene, prop-2-ynyl alcohol, and 2-methylbut-3-yn-2-ol, respectively, gave 2-ethynyl-5-nitropyridine.
The hydration of 2-ethynyl-5-nitropyridine and 5-nitro-2-(phenylethynyl)pyridine according to Kucherov afforded 2-acetyl-5-nitropyridine
and 5-nitro-2-phenacylpyridine, respectively. 相似文献
12.
Sołtysiak Paulina Dziuk Błażej Zarychta Bartosz Ejsmont Krzysztof Spaleniak Grzegorz 《Structural chemistry》2020,31(3):1185-1196
Structural Chemistry - The crystal and molecular structures of 3-(N-methylamino)-2-nitropyridine, 5-(N-methylamino)-2-nitropyridine and 2-(N-methylamino)-5-nitropyridine have been characterized by... 相似文献
13.
2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶的一级质谱图接近,单纯通过一级质谱图较难区分这两种异构体,利用离子阱质谱的串联质谱技术对2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶在离子阱内以He作碰撞气进行碰撞诱导裂解,所得的二级质谱图表明,两者之间存在明显的差别,可用于2 氨基 3 硝基吡啶和2 氨基 5 硝基吡啶的鉴别。 相似文献
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The reactions of 2-amino-3-nitropyridine and 2-amino-5-nitropyridine with hydrazine hydrate resulted in elimination of the amino group and reduction of the nitro group with formation of 3-aminopyridine. A probable reaction mechanism involves addition of hydrazine hydrate at the N-C2 bond, followed by elimination of ammonia and reduction of the nitro group to amino. 2-Amino-4-methyl-3-nitropyridine and 2-amino-5-methyl-3-nitropyridine reacted with hydrazine hydrate in a similar way. 相似文献
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The reactions of the anions of isonicotinamide and 2-amino-5-nitropyridine with 2-chloro-5-nitropyridine and 3-nitropyridine were observed to give rise to unexpected substitution products presumably via a radical anion mechanism. 相似文献
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Lucjan Achremowicz 《Tetrahedron letters》1980,21(25):2433-2434
3-Nitropyridine 1-oxide and 5-methyl-3-nitropyridine 1-oxide are produced readily by oxidative demethylation using SeO2 of 2-methyl- and 2,5-dimethyl-3-nitropyridine 1-oxides. 相似文献
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J. B. Campbell J. M. Greene E. R. Lavagnino D. N. Gardner A. J. Pike J. Snoddy E. C. Taylor 《Journal of heterocyclic chemistry》1986,23(3):669-672
New methods of preparing 2,3-diaminopyridine ( 13 ) from 2-chloro-3-nitropyridine ( 11 ) and 3,4-diaminopy-ridine ( 8 ) from 4-ethoxy-3-nitropyridine hydrochloride ( 5 ) have been explored and evaluated. 相似文献
18.
We have investigated reactions of 5-nitropyridine-2-sulfonic acid and its potassium salt in which substitution of the sulfonate group by oxygen, nitrogen and halogen nucleophiles has been attempted. By this approach, 2-methoxy- (95% yield), 2-ethoxy- (97%), 2-isopropoxy- (65%), 2-amino- (92%), 2-butylamino- (76%), 2-diethylamino- (62%), 2-ethylamino- (32%), 2-benzylamino- (77%), 2-(R-1-phenylethylamino)- (71%) and 2-chloro-5-nitropyridine (87%) have been obtained. No reactions were observed with phenols or anilines. With t-BuOH, 2-hydroxy-5-nitropyridine was formed together with 2-methylpropene. 相似文献
19.
The reaction of 2-chloro-3-nitropyridine with two equivalents of hydroxide ion was studied by NMR and X-ray crystallography. On the basis of NMR coupling constants, the originally formed ring-opened intermediate is the pseudo-cis form, as predicted by the SN(ANRORC) mechanism. However, the first intermediate is unstable and isomerizes to a second intermediate, which was isolated. The pseudo-trans geometry of the second intermediate [3-pentenenitrile, 2-nitro-5-oxo, ion(-1), sodium] explains why additional base does not lead to the ring-closing reaction as observed with 2-chloro-5-nitropyridine. 相似文献
20.
The condensation reaction of 2-cyanomethyl-5-nitropyridine with aromatic aldehydes has been carried out with the aim of preparing 2-azastilbene derivatives having intramolecular charge transfer. The yield of the condensation products can be increased if the reaction is carried out in the medium used for obtaining the starting 2-cyanomethyl-5-nitropyridine without separating or purifying it. The electronic absorption spectra of the compounds show a charge-transfer band, the energy of which increases and the intensity falls with lowering of the electron-donor properties of the substituent in the 4-position. Introduction of the heteroatom into the acceptor part when changing from the stilbene to the 2-azastilbene system is accompanied by a decrease in the energy and increase in the intensity of the charge-transfer electronic transition. 相似文献