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1.
Francisco Yuste Yadira Palls HCtor Barrios Benjamín Ortíz Rubn Snchez-Obregn 《Journal of heterocyclic chemistry》1986,23(1):189-190
The synthesis of praziquantel ( 1 ), a potent anthelmintic agent, is reported. The synthesis requires five steps and proceeds in 16% yield. 相似文献
2.
Sammakia T Johns DM Kim G Berliner MA 《Journal of the American Chemical Society》2005,127(18):6504-6505
The total synthesis of (+)-dihydrocompactin via an intramolecular ionic Diels-Alder reaction that proceeds with remote stereocontrol is described. This reaction proceeds by an intermediate vinyl-oxocarbenium ion (6), the conformational constraints of which lead to the observed asymmetric induction. The sense of asymmetric induction appears contrasteric and is explained by the proposed reactive conformation shown in Figure 1. 相似文献
3.
Metal‐Free Synthesis of Highly Substituted Pyridines by Formal [2+2+2] Cycloaddition under Mild Conditions
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Dr. Lan‐Gui Xie Saad Shaaban Dr. Xiangyu Chen Prof. Dr. Nuno Maulide 《Angewandte Chemie (International ed. in English)》2016,55(41):12864-12867
The synthesis of pyridines through direct intermolecular cycloaddition of alkynes and nitriles is a contemporary challenge in organic synthesis. A Brønsted acid mediated formal [2+2+2] cycloaddition of heteroalkynes and nitriles was developed that proceeds under mild conditions. This constitutes a modular approach to highly substituted pyridine cores. 相似文献
4.
The first total synthesis of (+/-)-actinophyllic acid (1) is reported. Key steps of this synthesis include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-Cope-Mannich rearrangement that assembled the core structure of the natural product's unique ring system. The synthesis was accomplished from di-tert-butyl malonate in 8% overall yield by a concise sequence that proceeds by way of only seven isolated intermediates. 相似文献
5.
Jitendra Gurjar Prof. Dr. Valery V. Fokin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(46):10402-10405
A metal-free and redox-neutral method for Beckmann rearrangement employing inexpensive and readily available SO2F2 gas is described. The reported transformation proceeds at ambient temperature and is compatible with a wide range of sterically and electronically diverse aromatic, heteroaromatic, aliphatic and lignin-like oximes providing amides in good to excellent yields. The reaction proceeds through the formation of an imidoyl fluoride intermediate that can also be used for the synthesis of amidines. 相似文献
6.
Sherry BD Maus L Laforteza BN Toste FD 《Journal of the American Chemical Society》2006,128(25):8132-8133
A trinuclear gold(I)-oxo complex, [(Ph3PAu)3O]BF4, serves as the catalyst for the stereocontrolled synthesis of 2-hydroxy-3,6-dihydropyrans from propargyl vinyl ethers. Importantly, the rearrangement proceeds with excellent diastereoselectivity, and the rearrangement of chiral nonracemic propargyl vinyl ethers proceeds with excellent chirality transfer to furnish enantioenriched pyrans. Additionally, the reaction is amenable to the synthesis of spiroketals from appropriately functionalized precursors. In this case, from a linear precursor, in a single step, the bicyclic spiroketal framework is established with complete stereocontrol over three centers and an alkene functional group in the product. 相似文献
7.
The synthesis of the tetracyclic core of nakadomarin A is described. The core contains all the heterocycles and the required stereocenters found in the natural product and provides a promising route to the target itself. The strategy utilizes a general, diastereoselective pyrrolidine synthesis that proceeds via a homo 3 + 2 dipolar cycloaddition. The scope of this methodology is also described. [structure: see text] 相似文献
8.
A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure-activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the conformation of largazole. 相似文献
9.
John A. Hyatt 《合成通讯》2013,43(1):8-14
The title chroman is useful in synthesis and as a water‐soluble analog of γ‐tocopherol, a member of the vitamin E family. This new synthesis of γ‐trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8‐tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography. 相似文献
10.
N-(phenylthio)-epsilon-caprolactam (1) has been applied as a new promoter for the activation of thioglycosides. This proceeds by the reaction of 1 with trifluoromethansulfonic anhydride, which subsequently activates the thioglycoside for glycosidic bond formation. Notably, the reaction proceeds efficiently at room temperature and is adaptable to our reactivity-based one-pot oligosaccharide synthesis. [reaction: see text] 相似文献
11.
Stieber F Grether U Mazitschek R Soric N Giannis A Waldmann H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(14):3282-3291
The hydrazide group is an oxidatively cleavable traceless linker for solid-phase chemistry. This linker technology was used to develop a multistep solid-phase synthesis of an antibiotic that is active against Mycobacterium tuberculosis. Furthermore, we describe an efficient method for the traceless synthesis of 2-aminothiazoles that display dual inhibitory activity against the receptor tyrosine kinases VEGFR-2 and Tie-2. The synthesis method proceeds through 9 steps on the solid phase and should give access to a much larger library of 2-aminothiazoles, from which a new class of anti-angiogenesis drugs may be developed. 相似文献
12.
Gajanan Rashinkar Santosh Kamble Arjun Kumbhar Rajashri Salunkhe 《Transition Metal Chemistry》2010,35(2):185-190
Microwave-assisted synthesis of secondary and tertiary ferrocenylamines is achieved by using an amine exchange reaction between
ferrocenylmethyltrimethyl ammonium iodide and aryl amines in aqueous hydrotropic solution. The synthesis proceeds in excellent
yields within short reaction times. 相似文献
13.
An eight-step synthesis of cyclic dimeric methyl morpholinoside (c-di-MM), a common synthetic precursor to a number of cyclic dinucleotide analogs is reported. The synthesis of c-di-MM proceeds through a morpholine monomer prepared from readily available inexpensive starting materials and culminates with a key macrolactamization reaction to provide the macrocycle in 15% overall yield. 相似文献
14.
The synthesis of 1-arylsulfonylpyrroles is normally accomplished by the condensation of an arylsulfonyl chloride with pyrrolylpotassium.1 We wish to report a facile synthesis of 1-arylsulfonylpyrroles which is versatile, proceeds in moderate to good yield and eliminates the necessity of using pyrophoric potassium. 相似文献
15.
[reaction: see text] A direct synthesis of pyrroles from imines, acid chlorides, and alkynes mediated by isocyanides is reported. This reaction proceeds with a range of each of these three substrates, providing a method to generate families of pyrroles in high yield. Mechanistic studies suggest this process proceeds via the generation of imino analogues of munchnones, which can undergo in situ coupling with alkynes to liberate isocyanate and form the pyrrole product. 相似文献
16.
Palakuri RameshH.M. Meshram 《Tetrahedron letters》2011,52(19):2443-2445
The total synthesis of (−)-cleistenolide, a novel natural product recently isolated from the annonaceae species cleistochlamys kirkii oliver, is described. The synthesis proceeds starting from easily accessible d-manitol using a selective benzoylation, a selective acetonide deprotection, silylprotection and ring-closing metathesis reaction. 相似文献
17.
18.
《Tetrahedron: Asymmetry》2014,25(15):1150-1152
A modified and improved synthesis of 10-isobornylsultone in three steps and in 81% overall yield starting from (+)-camphor-10-sulfonic acid is described. The synthesis proceeds via methyl sulfonate ester formation, stereoselective reduction and base-catalysed intramolecular cyclisation. 相似文献
19.
Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction
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Dr. Feng Xu Dr. Birgit Kosjek Dr. Fabien L. Cabirol Dr. Haibin Chen Richard Desmond Dr. Jeonghan Park Anupam P. Gohel Dr. Steven J. Collier Dr. Derek J. Smith Dr. Zhuqing Liu Dr. Jacob M. Janey Dr. John Y. L. Chung Dr. Oscar Alvizo 《Angewandte Chemie (International ed. in English)》2018,57(23):6863-6867
Described here is an efficient stereoselective synthesis of vibegron enabled by an enzymatic dynamic kinetic reduction that proceeds in a high‐pH environment. To overcome enzyme performance limitations under these conditions, a ketoreductase was evolved by a computationally and structurally aided strategy to increase cofactor stability through tighter binding. 相似文献
20.
A practical, efficient and diastereoselective synthesis of the cytotoxic and antiprotozoal compound aculeatin D (1) is described, employing a biomimetic oxidative cyclisation cascade reaction to generate the tricyclic system of the natural product. The synthesis proceeds in ten steps from commercially available 1-tetradecanol. 相似文献