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1.
Simultaneous ejection of six electrons at a constant potential by hexakis(4-ferrocenylphenyl)benzene
A simple synthesis of a dendritic hexaferrocenyl electron donor (5) is described in which six ferrocene moieties are connected at the vertices of the propeller of the hexaphenylbenzene core. The molecular structure of 5 is confirmed by X-ray crystallography. An electrochemical analysis along with redox titrations (which are tantamount to coulometry) confirmed that it ejects six electrons at a single potential. [structure: see text] 相似文献
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A novel triterpenoid, schinarisanlactone A (1), was isolated from the fruits of Schisandra arisanensis. Compound 1 possesses an unprecedented skeleton having a 5/7/7/5/7/5/6/5-fused octacyclic ring system. The structure of 1 was determined by 2D NMR techniques (COSY, HMQC, HMBC, and NOESY) and was confirmed by X-ray crystallographic analysis. Schinarisanlactone A (1) exhibited significant anti-HIV activity. 相似文献
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以5-溴异喹啉为起始原料,经过9步反应合成了AMPA受体拮抗剂——NS1209,总产率37.3%,其结构经1H NMR和MS确证. 相似文献
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Wen-Li Zhou Hai-Bo Tan Sheng-Xiang Qiu Guang-Ying Chen Hong-Xin Liu Chao Zheng 《Tetrahedron letters》2017,58(19):1817-1821
A confirmed structure of meroterpenoid myrtucommulone K, which is vastly different from the originally reported one, is conducted. The first biomimetic total synthesis towards the assignment of its absolute configuration has been efficiently accessed in 5 steps, and key to the success was a heteroatom Diels-Alder cycloaddition. The structure of myrtucommulone K was re-elucidated and confirmed by extensive spectroscopic interpretation of 1D and 2D NMR. 相似文献
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A. Hrabalek L. Pus V. Baranek J. Kunes K. Palat 《Chemistry of Heterocyclic Compounds》2002,38(2):183-189
A series of unsymmetrical sulfides derived from 1-substituted tetrazole-5-thiols was prepared by fusion of the corresponding 1-R-tetrazole-5-thiol sodium salt with 1-R'-5-halotetrazole. The structure was confirmed by 1H NMR and 13C NMR spectra. The target compounds were prepared in 50-80% yields. 相似文献
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We describe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins. A regio- and stereoselective glycosylation of protected ribose with silylated 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides predominantly in the alpha-configuration (60-75%) without any 4-substituted imidazole ribonucleoside. The structure of the 5-fluoroimidazole ribonucleoside was confirmed by X-ray crystallography and 2D NMR spectroscopy. 相似文献
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A new series of N^1-acetylamino-(5-alkyl/aryl- 1,3,4-thiadiazole-2-yl)-5-fluorouracil derivatives were designed and synthesized. These compounds have not been reported in literature, and their structure chemical were confirmed by IR, ^1H NMR and MS (HRMS). The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil. 相似文献
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GAO Fei-fei LI Yao-xian ZHANG Suo-qin ZHANG Guang-liang 《高等学校化学研究》2006,22(5):593-597
IntroductionAcetohydroxyacid synthase(AHAS)serves as thefirst common enzyme in the pathway for the biosynthesisof the branch-chained amino acids,isoleucine,valine,and leucine[1].This pathway is found in bacteria,fun-gi,algae,and higher plants,butnotin ani… 相似文献
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A new series of N1-acetylamino-(5-alkyl/aryl- 1,3,4-thiadiazole-2-y1)-5-fluorouracil derivatives were designed and synthesized.These compounds have not been reported in literature,and their structure chemical were confirmed by IR,1H NMR and MS (HRMS).The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil. 相似文献
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Synthesis and Characterization of Novel Aliphatic Polycarbonates Bearing Pendant Allyl Ether Groups 总被引:1,自引:0,他引:1
Gang LIU Feng HE Yah Ping WANG Jun FENG Ren Xi ZHUO 《中国化学快报》2006,17(1):137-139
To fulfill the diverse requirements in surgery and medicine, biomedical polymers have been drawing interests and attentions increasingly since the last decade1. In these fields, aliphatic carbonates have been proved to be a kind of material with excellent… 相似文献
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5-Fluorouracil (5-Fu,1)1 is an important antitumor drug. Some derivatives2,3 have shown better therapeutic efficacy than 5-Fu. In order to find much more better antitumor drugs of its derivatives, several attempts have been made and many different types of its derivatives have been prepared at N1, N3 position4~7. Moreover, several different ways have been used for alkylation of 5-Fu7~10. However, up to now, the arylation of 5-Fu at N1 or N3 position hasn't been reported, and the compound o… 相似文献
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R. G. Melik-Ogandzhanyan A. S. Gapoyan V. É. Khachatryan V. S. Mirzoyan 《Chemistry of Heterocyclic Compounds》1985,21(5):572-575
A number of aldimines of 7-aminopyrrolo[2,3-d]pyrimidine have been synthesized by the action of bromine on hydrazones of 5-allyl-4-hydrazinopyridine. The structures of the compounds obtained were confirmed by IR spectroscopy and mass spectrometry.For Communication 57, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 678–681, May, 1985. 相似文献
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以丹皮酚和对氯苯甲醛为起始原料,通过Claisen-Schmidt反应得到2-羟基-4-甲氧基-4′-氯查尔酮(3),再经过Mannich反应得到10个查尔酮曼尼希碱衍生物(4a~4e, 5a~5e)。目标化合物结构均经高分辨质谱、核磁共振氢谱、碳谱进行确证。采用MTT法测试了所合成化合物对人肺癌细胞A549、人肝癌细胞HepG2的体外抗增殖活性。结果表明,目标化合物对肿瘤细胞A549、HepG2均具有较强的细胞增值抑制作用,且明显优于阳性对照药5-氟尿嘧啶。 相似文献
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Yuan Yuan Zhang Xing Yan Zeng Kui Nie Zhi Cheng Zhong Yu Liang Wang Yu Zhong Wang 《中国化学快报》2010,21(4):426-428
<正>A series of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates were designed and synthesized.Their structures were confirmed by ~1H NMR,~(13)C NMR,IR and HRMS.The biological activities were primarily evaluated against Eimeria tenella according to Anticoccidial Index(ACI) method in vivo.The results showed that compounds 5e,5f and 5i exhibited anticoccidial activities against E.tenella at 27 mg kg~(-1). 相似文献
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Wen Zhao Zhong-Hua Shen Jia-Hua Xing Guo Yang Tian-Ming Xu Wei-Li Peng Xing-Hai Liu 《Chemical Papers》2017,71(5):921-928
A series of novel fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR, MS and elemental analysis. The primary nematicidal activity results indicated that some of them (compound 5b, 5e, 5r and 5s) exhibited 100% efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5r interacts with amino acid residue Tyr 121 of AchE via hydrogen bond and Phe288 of AchE via CH–π interaction, respectively. 相似文献
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A new phthalocyanine-subphthalocyanine heterodyad ( 5 ) was prepared by Pd(0)-catalyzed Sonogashira coupling reaction between an asymmetrical phthalocyanine ( 3 ) bearing monoiodo and multiple triazolide moieties on its backbone and a subphthalocyanine ( 4 ) bearing axially propargyl group. The structure of this heterodyad ( 5 ) was subsequently confirmed by the conventional spectroscopic techniques. The photophysical and photochemical properties including; fluorescence and singlet oxygen generation of ( 5 ) along with its building chromophores ( 3 ) and ( 4 ) were also investigated. Interestingly, a purple colored solution was observed by this novel dyad which was significantly different from those colors (green or blue) obtained by phthalocyanine-subphthalocyanine conjugates. Based on steady state absorption spectroscopic data and transient absorption results, the synthesized dyad 5 was free of aggregation and there is good energy transfer occurs between Pc and subPc moieties. This result was confirmed using density functional theory (DFT) and time-dependent DFT (TDDFT) analyses: B3LYP exchange-correlation functional and the 6–31 + G(d) basis set. 相似文献