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1.
2.
Three-dimensional quantitative structure–activity relationship (3D-QSAR) models were developed based on comparative molecular
field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), on a series of 43 hydroxyethylamine
derivatives, acting as potent inhibitors of β-site amyloid precursor protein (APP) cleavage enzyme (BACE-1). The crystal structure of the BACE-1 enzyme (PDB ID: 2HM1)
with one of the most active compound 28 was available, and we assumed it to be the bioactive conformation of the studied series, for 3D-QSAR analysis. Statistically
significant 3D-QSAR model was established on a training set of 34 compounds, which were validated by a test set of 9 compounds.
For the best CoMFA model, the statistics are, r
2 = 0.998, r2cv = 0.810{r^{2}_{\rm cv} = 0.810} , n = 34 for the training set and r2pred = 0.934{r^{2}_{\rm pred} = 0.934} , n = 9 for the test set. For the best CoMSIA model (combined steric, electrostatic, hydrophobic, and hydrogen bond donor fields),
the statistics are r
2 = 0.978, r2cv = 0.754{r^{2}_{\rm cv} = 0.754} , n = 34 for the training set and r2pred = 0.750{r^{2}_{\rm pred} = 0.750} , n = 9 for the test set. The resulting contour maps, produced by the best CoMFA and CoMSIA models, were used to identify the
structural features relevant to the biological activity in this series of analogs. The data generated from the present study
will further help to design novel, potent, and selective BACE-1 inhibitors. 相似文献
3.
H. W. Grießhammer M. R. Schindler R. P. Springer 《The European Physical Journal A - Hadrons and Nuclei》2012,48(1):7
We calculate the (parity-violating) spin-rotation angle of a polarized neutron beam through hydrogen and deuterium targets,
using pionless effective field theory up to next-to-leading order. Our result is part of a program to obtain the five leading
independent low-energy parameters that characterize hadronic parity violation from few-body observables in one systematic
and consistent framework. The two spin-rotation angles provide independent constraints on these parameters. Our result for
np spin rotation is $\frac{1}
{\rho }\frac{{d\varphi _{PV}^{np} }}
{{dl}} = \left[ {4.5 \pm 0.5} \right] rad MeV^{ - \frac{1}
{2}} \left( {2g^{\left( {^3 S_1 - ^3 P_1 } \right)} + g^{\left( {^3 S_1 - ^3 P_1 } \right)} } \right) - \left[ {18.5 \pm 1.9} \right] rad MeV^{ - \frac{1}
{2}} \left( {g_{\left( {\Delta {\rm I} = 0} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} - 2g_{\left( {\Delta {\rm I} = 2} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} } \right)$\frac{1}
{\rho }\frac{{d\varphi _{PV}^{np} }}
{{dl}} = \left[ {4.5 \pm 0.5} \right] rad MeV^{ - \frac{1}
{2}} \left( {2g^{\left( {^3 S_1 - ^3 P_1 } \right)} + g^{\left( {^3 S_1 - ^3 P_1 } \right)} } \right) - \left[ {18.5 \pm 1.9} \right] rad MeV^{ - \frac{1}
{2}} \left( {g_{\left( {\Delta {\rm I} = 0} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} - 2g_{\left( {\Delta {\rm I} = 2} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} } \right), while for nd spin rotation we obtain $\frac{1}
{\rho }\frac{{d\varphi _{PV}^{nd} }}
{{dl}} = \left[ {8.0 \pm 0.8} \right] rad MeV^{ - \frac{1}
{2}} g^{\left( {^3 S_1 - ^1 P_1 } \right)} + \left[ {17.0 \pm 1.7} \right] rad MeV^{ - \frac{1}
{2}} g^{\left( {^3 S_1 - ^3 P_1 } \right)} + \left[ {2.3 \pm 0.5} \right] rad MeV^{ - \frac{1}
{2}} \left( {3g_{\left( {\Delta {\rm I} = 0} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} - 2g_{\left( {\Delta {\rm I} = 1} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} } \right)$\frac{1}
{\rho }\frac{{d\varphi _{PV}^{nd} }}
{{dl}} = \left[ {8.0 \pm 0.8} \right] rad MeV^{ - \frac{1}
{2}} g^{\left( {^3 S_1 - ^1 P_1 } \right)} + \left[ {17.0 \pm 1.7} \right] rad MeV^{ - \frac{1}
{2}} g^{\left( {^3 S_1 - ^3 P_1 } \right)} + \left[ {2.3 \pm 0.5} \right] rad MeV^{ - \frac{1}
{2}} \left( {3g_{\left( {\Delta {\rm I} = 0} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} - 2g_{\left( {\Delta {\rm I} = 1} \right)}^{\left( {^1 S_0 - ^3 P_0 } \right)} } \right), where the g
(X-Y), in units of $MeV^{ - \frac{3}
{2}}$MeV^{ - \frac{3}
{2}}, are the presently unknown parameters in the leading-order parity-violating Lagrangian. Using naıve dimensional analysis
to estimate the typical size of the couplings, we expect the signal for standard target densities to be $\left| {\frac{{d\varphi _{PV} }}
{{dl}}} \right| \approx \left[ {10^{ - 7} \ldots 10^{ - 6} } \right]\frac{{rad}}
{m}$\left| {\frac{{d\varphi _{PV} }}
{{dl}}} \right| \approx \left[ {10^{ - 7} \ldots 10^{ - 6} } \right]\frac{{rad}}
{m} for both hydrogen and deuterium targets. We find no indication that the nd observable is enhanced compared to the np one. All results are properly renormalized. An estimate of the numerical and systematic uncertainties of our calculations
indicates excellent convergence. An appendix contains the relevant partial-wave projectors of the three-nucleon system. 相似文献
4.
Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with
the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distribution, have been
used to determine parameters which enter into the extraction of |Vcb| from the measurement of the inclusive b-hadron semileptonic decay width. The values obtained in the kinetic scheme are:
and include corrections at order 1/mb3. Using these results, and present measurements of the inclusive semileptonic decay partial width of b-hadrons at LEP, an accurate determination of |Vcb| is obtained:
Received: 26 April 2005, Revised: 16 September 2005, Published online: 16 November 2005 相似文献
5.
E P Bashkin 《Pramana》1987,28(5):601-601
As the temperature is lowered we get an interesting temperature region? d?T?? 2/mr 0 2 (where? d is the quantum degeneracy temperature,m the mass of a gas molecule,r 0 the radius of interparticle interaction) in which the thermal de Broglie wavelength Λ of a particle is considerably greater than its sizer 0 though Λ turns out to be less than the mean interparticle distanceN ?1/3?Λ?r 0. Although the gas molecules obey the classical Boltzmann-Maxwell statistics the system as a whole begins to exhibit a larger number of essentially quantum macroscopic collective features. One of the most interesting and dramatic features is the possibility of propagation of weakly damped spin oscillations in spin-polarized gases (external magnetic field, optical pumping). Such oscillations can propagate both in the low-frequencyθτ?1 regime and the high frequencyθτ?1. The last case is highly non-trivial for a Boltzmann gas with a short range interaction between particles. The weakness of relaxation damping of spin modes implies that the degree of polarization is high enough 1>/|α|?|a|/Λ, whereα=(N +?N ?)N,a is the two-particles-wave scattering length. Under these conditions the spectrum of magnons has the form (Bashkin 1981, 1984; Lhuillier and Laloe 1982) 1 $$\omega = \Omega _H + \left( {{{K^2 \nu _{\rm T}^2 } \mathord{\left/ {\vphantom {{K^2 \nu _{\rm T}^2 } {\Omega _{int} }}} \right. \kern-\nulldelimiterspace} {\Omega _{int} }}} \right)\left( {{{1 - i} \mathord{\left/ {\vphantom {{1 - i} {\Omega _{int} }}} \right. \kern-\nulldelimiterspace} {\Omega _{int} }}\tau } \right), \Omega _{int} = {{ - 4\pi ahN\alpha } \mathord{\left/ {\vphantom {{ - 4\pi ahN\alpha } m}} \right. \kern-\nulldelimiterspace} m}, \nu _{\rm T}^2 = {T \mathord{\left/ {\vphantom {T m}} \right. \kern-\nulldelimiterspace} m}$$ where Ω H is the Larmor precession frequency for spins in the magnetic fieldH. Collisionless Landau damping restricts the region of applicability of (1) with not too large wave vectorsKv T?|Ωint|. The existence of collective spin waves has been experimentally confirmed in NMR-experiments with gaseous atomic hydrogen H↑ (Johnsonet al 1984). The presence of undamped spin oscillations means automatically the existence of long range correlations for transverse magnetization. Such correlations decrease with the distance according to the power law 2 $$\delta _{ik} \left( r \right) = 2\left| a \right|\frac{{\left( {\beta N\alpha } \right)^2 }}{\gamma }\delta _{ik} $$ . Hereβ is the molecule magnetic moment. Spin waves being even damped can nevertheless reveal themselves atT?? 2/mr 0 2 or when |α|?r 0/Λ. The first experimental discovery or damped spin waves in gaseous3He↑ has been done in Nacheret al 1984. Oscillations of magnetization can also propagate in some condensed media such as liquid3He-4He solutions, semimagnetic semiconductors etc. 相似文献
6.
This paper utilizes multireference configuration interaction theory to calculate the lifetime of A2Πu state for nitrogen molecular ion N+2.It obtains the transition moment function for A2Πu→X2Σ+ g,Franck-Condon factors between vibrational levels of the two states.The calculated lifetimes are 16.81,14.62,13.10,12.18,11.40,and 11.64 μs forv'= 0,1,2,3,4,5 vibrational levels of A2Πu state,respectively,which are in excellent agreement with available experimental values. 相似文献
7.
S. Stave M. O. Distler I. Nakagawa N. Sparveris P. Achenbach C. Ayerbe Gayoso D. Baumann J. Bernauer A. M. Bernstein R. Böhm D. Bosnar T. Botto A. Christopoulou D. Dale M. Ding L. Doria J. Friedrich A. Karabarbounis M. Makek H. Merkel U. Müller R. Neuhausen L. Nungesser C. N. Papanicolas A. Piegsa J. Pochodzalla M. Potokar M. Seimetz S. Širca S. Stiliaris Th. Walcher M. Weis 《The European Physical Journal A - Hadrons and Nuclei》2006,30(3):471-476
To determine nonspherical angular-momentum amplitudes in hadrons at long ranges (low Q2), data were taken for the p(ˉe, e'p)π0 reaction in the Δ region at Q
2 = 0.060 (GeV/c)2 utilizing the magnetic spectrometers of the A1 Collaboration at MAMI. The results for the dominant transition magnetic dipole
amplitude and the quadrupole to dipole ratios at W = 1232 MeV are
, Re(
)%, and Re(
)%. These disagree with predictions of constituent quark models but are in reasonable agreement with lattice calculations
with nonlinear (chiral) pion mass extrapolations, with chiral effective field theory, and with dynamical models with pion
cloud effects. These results confirm the dominance, and general Q2 variation, of the pionic contribution at large distances. 相似文献
8.
We present the results of elliptic flow for the collision of nearly symmetric nuclei (10Ne20+ 13Al27_{10}{\rm Ne}^{20}+\,_{13}{\rm Al}^{27}, 18Ar40+ 21Sc45_{18}{\rm Ar}^{40}+\,_{21}{\rm Sc}^{45}, 30Zn64+ 28Ni58_{30}{\rm Zn}^{64}+\,_{28}{\rm Ni}^{58}, 36Kr86+ 41Nb93_{36}{\rm Kr}^{86}+\,_{41}{\rm Nb}^{93}) using the quantum molecular dynamics (QMD) model. General features of elliptic flow are investigated with the help of theoretical
simulations. The simulations are performed at beam energies between 45 and 105 MeV /nucleon. A significant change can be seen
from in-plane to out-of-plane elliptic flow of different fragments with incident energy. A comparison with experimental data
is also made. Further, we show that elliptic flow for different fragments follows power-law dependence as given by the function
C(Atot)tC{(A_{\rm tot})^\tau}. 相似文献
9.
Bernard Helffer 《Communications in Mathematical Physics》1994,161(3):631-643
The aim of this paper is to prove that ifV is a strictly convex potential with quadratic behavior at ∞, then the quotient μ2/μ1 between the largest eigenvalue and the second eigenvalue of the Kac operator defined on L2(? m ) by exp ?V(x)/2 · exp Δx · exp ?V(x)/2 where Δx is the Laplacian on ? m satisfies the condition: $${{\mu _2 } \mathord{\left/ {\vphantom {{\mu _2 } {\mu _1 {{ \leqslant \exp - \cosh ^{ - 1} (\sigma + 1)} \mathord{\left/ {\vphantom {{ \leqslant \exp - \cosh ^{ - 1} (\sigma + 1)} {2,}}} \right. \kern-\nulldelimiterspace} {2,}}}}} \right. \kern-\nulldelimiterspace} {\mu _1 {{ \leqslant \exp - \cosh ^{ - 1} (\sigma + 1)} \mathord{\left/ {\vphantom {{ \leqslant \exp - \cosh ^{ - 1} (\sigma + 1)} {2,}}} \right. \kern-\nulldelimiterspace} {2,}}}}$$ where σ is such that HessV(x)≥σ>0. 相似文献
10.
Y. A. Gauduel Y. Glinec J.-P. Rousseau F. Burgy V. Malka 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2010,60(1):121-135
The damages triggered by ionizing radiation on chemical and biological targets depend on the survival probability of radicals
produced in clusters of ionization-excitation events. In this paper, we report on femtolysis (FEMTOsecond radioLYSIS) of pure
liquid water using an innovative laser produced high-energy, ultra-short electron bunches in the 2.5-15 MeV range and high
energy radiation femtochemistry (HERF) measurements. The short-time monitoring of a primary reducing radical, hydrated electron
e-aq^{-}_{aq}, has been performed in confined ionization spaces (nascent spurs). The calculated yield of hydrated electrons at early time,
G(e-aq)ETG({\rm e}^{-}_{aq})_{ET}, is estimated to be 6.5 ± 0.5 (number/100 eV) at t ~ 5 ps after the ultrafast energy deposition. This estimated value is high compare to (i) the available data of previous
works that used scavenging techniques; (ii) the predictions of stochastic water radiolysis modelling for which the initial
behaviour of hydrated electron is investigated in the framework of a classical diffusion regime of independent pairs. The
HERF developments give new insights into the early ubiquitous radical escape probability in nascent aqueous spurs and emphasize
the importance of short-lived solvent bridged electron-radical complexes
[H3O+...{\rm H}_{3}{\rm O}^{+...}
eaq-{\rm e}_{aq}^{-} ..OH]nH2O{\rm OH}]_{n{\rm H}_2{\rm O}}
(non-independent pairs). A complete understanding of the
G(e-aq)ET{\rm e}^{-}_{aq})_{ET} value needs to account for quantum aspects of 1s-like trapped electron ground state and neoformed
prototropic radicals that govern ultra-fast recombination processes within these non-independent pair configurations. Femtolysis
data
emphasize that within a time-dependent non-diffusion regime, spatio-temporal correlations between hydrated electron and nearest
neighbours OH radical or hydrated proton (H3O+{\rm H}_{3}{\rm O}^{+}) would assist ultrafast anisotropic 1D recombination within solvent bridged electron-radical complexes. The emerging HERF
domain would provide guidance for understanding of ultrashort-lived sub-structure of tracks and stimulate future semi-quantum
simulations on prethermal radical reactions. 相似文献
11.
L. Pereira A. Morozov M. M. Fraga T. Heindl R. Krücken J. Wieser A. Ulrich 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2010,56(3):325-334
The temperature dependences of the quenching rate constants of the states
N2 (${\rm C} \ {^{3}{
\rm \Pi }_{u}}${\rm C} \ {^{3}{
\rm \Pi }_{u}} v′=0,1) by N2 (X) and of the state
N2 (${\rm C} \ {^{3}{
\rm \Pi }_{u}} \ v^{\prime}=0${\rm C} \ {^{3}{
\rm \Pi }_{u}} \ v^{\prime}=0) by O2 (X) are studied.
Time-resolved light emission from the gas was analyzed in the temperature
range from 300 K to 210 K keeping the gas at constant density. In case of
quenching by N2 (X), the quenching rate constant for the vibrational
level v′= 0 increases by (13 ±3)% with gas cooling whereas the
quenching rate constant for v′= 1 decreases by (5.0 ±2.5)% in this
temperature range. For quenching by O2 (X), the quenching rate constant
decreases by (3 ±2)% with gas cooling. The temperature variation of
the N2 (C 3Πu v′=0) emission intensity for pure nitrogen
and dry air are calculated using the obtained quenching rate constants and
is compared with the experimental data available in the literature. 相似文献
12.
B. Sitamtze Youmbi Serge Zékeng Samuel Domngang Florent Calvayrac Alain Bulou 《Ionics》2012,18(4):371-377
To date, the fastest lithium ion-conducting solid electrolytes known are the perovskite-type ABO3 oxide, with A = Li, La and B = Ti, lithium lanthanum titanate (LLTO)
Li3x La( 2 \mathord