Magnetic defects generated by crystal defects

Linear magnetic defects (LMDs), i.e. linear singularities of the fields of magnetic order parameters in ferromagnets (FMs) and antiferromagnets (AFMs) are investigated. It is shown that disclinations in collinear AFM and in cubic FM generate LMDs. These and similar crystallomagnetic singularities are considered from the point of view of the topological theory of defects in ordered media.     

Food seeking in spite of harmful consequences is under prefrontal cortical noradrenergic control

Background  

Eating disorders are multifactorial psychiatric disorders. Chronic stressful experiences and caloric restriction are the most powerful triggers of eating disorders in human and animals. Although compulsive behavior is considered to characterize pathological excessive food intake, to our knowledge, no evidence has been reported of continued food seeking/intake despite its possible harmful consequences, an index of compulsive behavior. Brain monoamine transmission is considered to have a key role in vulnerability to eating disorders, and norepinephrine in medial prefrontal cortex has been shown to be critical for food-related motivated behavior.     

The Relationship Between Chronic Cough and Paradoxical Vocal Fold Movement: A Review of the Literature

SUMMARY: Chronic cough (CC) and paradoxical vocal fold movement (PVFM) are debilitating conditions. PVFM has been given many labels, including vocal cord dysfunction, Munchausen's stridor, functional inspiratory stridor, nonorganic functional or psychogenic upper airway obstruction, factitious asthma, psychogenic stridor, emotional laryngeal wheezing, and episodic laryngeal dyskinesia. Although CC and PVFM have been considered separate entities in many reports, there is preliminary support for the notion that there may be an underlying link between these two conditions. Speech pathologists have become increasingly involved in the treatment of these patients and therefore need to understand the theoretical background of these disorders, the pathophysiological links between the two, and the impact of voice disorders on these populations. The aim of this article is to review the current literature on CC and PVFM from a speech pathology perspective to provide a model for defining and conceptualizing the disorders and to provide a framework for management and future research.     

无人水下航行器势场航路规划方法研究

对运动障碍威胁环境下UUV航路规划问题进行了研究。首先分别对规划过程中固定障碍、运动障碍建立了排斥势场,对目标点建立了吸引势场,将航路规划问题转变为寻找最优势场点问题;然后提出一种改进的粒子群算法(NPSO),在UUV航路规划过程中,寻找距离当前路径点固定步长范围内的最优势场点,将其作为下一路径点,最终实现UUV在运动障碍威胁环境中的航路规划;最后对所提方法进行了仿真验证,UUV可以有效躲避固定障碍与运动障碍威胁,寻找到较优航路,取得了较好的仿真效果。     

Design of potential anti-tumor PARP-1 inhibitors by QSAR and molecular modeling studies

Molecular Diversity - Poly ADP-ribose polymerase-1 (PARP-1) inhibitors have been recognized as new agents for the treatment of patients with breast cancer type 1 (BRCA1) disorders. The quantitative...     

Voice disorders in patients with suspected laryngo-pharyngeal reflux disease

Many symptoms have been recognized in association with laryngo-pharyngealreflux disease (LPRD), but reports of perceptual voice disorders in this condition have been lacking to date. Forty-nine patients with suspected LPRD were studied for five specific perceptual voice characteristics, and these characteristics were compared to the same characteristics in individuals who had never seen an Otolaryngologist for a voice disorder or throat problem (controls). Sixteen of the suspected LPRD patients also underwent 24-hour pH probe studies. All patients with suspected LPRD had significantly increased abnormal perceptual voice characteristics (musculoskeletal tension, hard glottal attack, glottal fry, restricted tone placement, and hoarseness) compared to the controls. Statistical objective differences between the two groups was demonstrated by the presence of increased shimmer in patients with suspected LPRD compared to controls. The differential diagnosis between functional voice disorders and LPRD may be complex, and perceptual parameters may overlap. Interdisciplinary evaluation is advocated.     

Mapping of the roughness exponent for the fuse model for fracture

The roughness exponent for fracture surfaces in the fuse model has been thought to be universal for narrow threshold distributions and has been important in the numerical studies of fracture roughness. We show that the fuse model gives a disorder dependent roughness exponent for narrow disorders when the lattice is influencing the fracture growth. When the influence of the lattice disappears, the local roughness exponent approaches zeta(local)=0.65+/-0.03 for distribution with a tail toward small thresholds, but with large jumps in the profiles giving corrections to scaling on small scales. For very broad disorders the distribution of jumps becomes a Lévy distribution and the Lévy characteristics contribute to the local roughness exponent.     

Fully band-resolved scattering rate in MgB2 revealed by the nonlinear hall effect and magnetoresistance measurements

We have measured the normal state temperature dependence of the Hall effect and magnetoresistance in epitaxial MgB2 thin films with variable disorders characterized by the residual resistance ratio RRR ranging from 4.0 to 33.3. A strong nonlinearity of the Hall effect and magnetoresistance have been found in clean samples, and they decrease gradually with the increase of disorders or temperature. By fitting the data to the theoretical model based on the Boltzmann equation and ab initio calculations for a four-band system, for the first time, we derived the scattering rates of these four bands at different temperatures and magnitude of disorders. Our method provides a unique way to derive these important parameters in multiband systems.     

A computer simulation investigation of surface disordering in adsorbed multilayers

Multilayers of methane on a magnesium oxide substrate have been simulated using a model potential. Layer-by-layer disordering was found below the bulk melting point. This disordering is the result of the formation of vacancies by promotion of molecules to overlayers. Both static and dynamic properties show that there is a continuous change in the nature of the disordered layer from solid-like through a lattice liquid to a random liquid as the temperature is raised rather than successive roughening and pre-melting transitions. There is a marked difference in the sharpness of the disordering in the outer layers of multilayers with different exposed faces. In the close packed (111) face the outermost layer disorders over a temperature range of less than 10 K, while the corresponding layers of a (100) or (110) face disorders gradually over a range of 50 K.     

Reflux and vocal disorders in singers with bulimia

Dysphonia associated with bulimia has been described in the literature associated with vocal fold edema and polypoid changes. Laryngopharyngeal reflux (LPR) has been documented to cause reflux vocal fold pathology including edema and polypoid changes. We studied eight singers with bulimia and documented vocal fold pathology, including edema, posterior commissure hypertrophy, ventricular obliteration, and telangiectasia. Reflux was demonstrated in all eight. The results of this study showed that LPR may be a contributing factor to vocal disorders in singers with bulimia.     

Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity

Background  

Stem cells or immune cells targeting the central nervous system (CNS) bear significant promises for patients affected by CNS disorders. Brain or spinal cord delivery of therapeutic cells is limited by the blood-brain barrier (BBB) which remains one of the recognized rate-limiting steps. Osmotic BBB disruption (BBBD) has been shown to improve small molecule chemotherapy for brain tumors, but successful delivery of cells in conjunction with BBBD has never been reported.     

Electrotherapy and the Human Voice: A Literature Review of the Historical Origins and Contemporary Applications

SUMMARY: The present article surveys the literature on the electrotherapy treatment for voice disorders from the mid-18th century to World War I (1914--1918) and the post 1970s reappearance of such therapies. The reappearance of electrotherapy as treatment for voice disorders in the past 20 years has been heralded as a major breakthrough. In light of our reading of the scientific literature of the 19th century, it can be shown to repeat many of the presuppositions of electrotherapists of that time. The current resurgence of interest and research in electrical stimulation of the larynx is buoyed by technological innovations analogous to those in the 19th century. Although the current state of research has enhanced our understanding of vocal fold physiology, it does not necessarily provide a new therapeutic approach as a survey of the most recent literature shows.     

Nondestructive detection of internal bruise and spraing disease symptoms in potatoes using magnetic resonance imaging

Magnetic resonance imaging (MRI) was applied to detect nonvisible internal bruise and spraing symptoms and to get insight on the chemical and anatomical causes of such defects. Cultivar Saturna with internal bruise and cultivar Estima with spraing symptoms were investigated by comparison of different MR images as proton density-, T(1)- and T(2)-weighted images and T(2) maps. In all these types of MR images, it was possible to identify internal bruise and spraing spots in the potatoes, where these phenomena were present. When combining the information in the MR images, the interior of the internal bruise was characterised as being very dry (low signal in the proton-weighted image) with a small amount of highly mobile water in the shell around the bruise (high signal in T(2)-weighted image and high relaxation time in T(2) map). The spraing spots were more diffuse; however, the dry interior and highly mobile water around the spraing dots were somewhat similar to the appearance of internal bruise but resembled more the appearance of human tumour tissue than bruise disorders in, for example, fruits. In conclusion, this study demonstrated that MRI can detect nonvisible internal bruise and spraing symptoms in potatoes, which has not been published before. MRI may, therefore, be an appropriate method for detecting and for studying developmental changes of such disorders and related disorders during postharvest storage in future experiments.     

Microlaryngoscopy: A historical vignette

The development of microlaryngoscopy has been central to modern laryngology and treatment of voice disorders. The history of microlaryngoscopy is interesting and not well known. Various physicians including Rosemarie Albrecht, Oskar Kleinsasser, and Geza Jako made important contributions.     

The Effectiveness of Group Therapy for Students With Mild Voice Disorders: A Controlled Clinical Trial

Previous studies of students studying to be teachers have indicated that these students commonly have voice disorders. Ideally, voice disorders should be treated before students start their work as teachers, but the resources for this treatment are often limited. This study examines whether group voice therapy is effective for teacher students. Accordingly, 20 teacher students with mild voice disorders received group voice therapy (in three small groups), whereas 20 students with similar voice disorders served as a control group and consequently did not receive voice therapy. Two out of three outcome measures (perceptual evaluation of voice quality and a questionnaire on the occurrence of vocal symptoms) indicated significant changes in the treatment group compared with the control group. No differences between groups were noted in the laryngeal status. The results suggest that group voice therapy seems to be an effective method to treat students with mild voice disorders.     

The prevalence of Helicobacter pylori infection in benign laryngeal disorders.

Helicobacter pylori (HP) is an accepted cause of chronic active gastritis and has a major causative role in peptic ulcers. It is a gastric carcinogen. Its role in nonulcer dyspepsia (NUD) is less clear, yet 50% of patients with NUD are infected with HP, and some recent literature demonstrates long-term improvement of symptoms following eradication. HP has been investigated in several other organ systems, but has not been investigated to any major degree in laryngeal disorders, a region that could be directly exposed to the bacterium from pharyngolaryngeal reflux. This study represents one arm of a larger study designed to investigate such a relationship. Of 101 patients with nonmalignant voice disorders presenting to our voice clinics, 54.5% tested positive for the H. pylori organism. Of the controls, 47.1% tested positive. When striated into age groups of < 45 years, 46-61 years, and > 62 years, and then age-matched with the controls, the likelihood of infection with the H. pylori organism was greater in both the experimental middle group, and in the middle group when combined with the elder group, than in the matched controls, and this difference demonstrated a trend approaching statistical significance. This finding is discussed in the light of other studies on HP and on gastroesophageal reflex (GER).     

LEED investigations of the Rh(111)-(2 × 2)-O surface structure: measurements with a video analyser in the presence of some electron beam disordering of the adsorbed layer

A multiple-scattering analysis of LEED intensities has been made for the Rh(111)-(2 × 2)-O surface structure. The measurements were made with a video LEED analyser under conditions where the O layer disorders in 2 min in the incident electron beam. The experimental and calculated intensities were compared with Pendry's reliability index, which was minimised with O atoms adsorbed 1.23 Å above the “expected” hollow sites of three-fold coordination.     

Behavioral therapy for spasmodic dysphonia

This paper presents a general schema for classifying treatment approaches for both functional and organic voice disorders. It's use is illustrated by a review of treatments for Spasmodic Dysphonia. Most behavioral approaches have been found to be unsuccessful except for mild cases. Inhalation speech as a compensatory technique has been reported as somewhat successful for those mild/moderate cases for whom medical/surgical treatment has not been available. The fact that organic treatment levels have been more successful in the treatment of Spasmodic Dysphonia may lend support to an organic etiology     

Translational medicine of the glutamate AMPA receptor

Psychiatric and neurological disorders severely hamper patient’s quality of life. Despite their high unmet needs, the development of diagnostics and therapeutics has only made slow progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are essential structural units of neurotransmission, and neuropsychiatric disorders are considered as “synapse diseases”. Thus, a translational approach with synaptic physiology is crucial to tackle these disorders. Among a variety of synapses, excitatory glutamatergic synapses play central roles in neuronal functions. The glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a principal component of glutamatergic neurotransmission; therefore, it is considered to be a promising translational target. Here, we review the limitations of current diagnostics and therapeutics of neuropsychiatric disorders and advocate the urgent need for the promotion of translational medicine based on the synaptic physiology of AMPAR. Furthermore, we introduce our recent translational approach to these disorders by targeting at AMPARs.