共查询到18条相似文献,搜索用时 78 毫秒
1.
Ling Tian TANG Yi WANG Xin Qi LIU Shao Wen HU Tai Wei CHU Xiang Yun WANG* College of Chemistry Molecular Engineering Peking University Beijing 《中国化学快报》2005,16(3):345-348
Benzimidazole compounds have attracted a renewed interest recently owing to theirpotential applications in high-performance composite materials, electronic chemicals,photosensitive materials, and their special potentials in biological and/or medicinalapplication1,2. Typically, aromatic compounds with near planar structures and contain-ing hydrogen-donor groups or groups, which are capable of being protonated, havespecial interactions with DNA via intercalation, hydrogen-bonding, and so on3.Me… 相似文献
2.
JianHU XiaoDaYANG KuiWANG 《中国化学快报》2004,15(10):1197-1200
The fluorescence spectra of Quin 2, (2-[(2-bis-[carboxymethyl] amino-5-methylphenoxy)methyl]-6-methoxy-8-bis [carboxymethyl] aminoquiniline), a Ca^2 probe, were investigated upon incubation with Ca^2 or La^3 . The results showed that binding of La^3 to Quin 2 resulted in different fluorescent spectrum from that of Ca^2 . Based on this observation, a fluorescent method was developed for simultaneously determination of the dissociation rates of Ca^2 and La^3 from a Ca-La- calmodulin complex (Ca2La2CaM). 相似文献
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Chun Xia Tan Ruo Fei Feng Xiao Xia Peng 《中国化学快报》2007,18(5):505-508
By the condensation of 2,6-bis(4-amino-5-mercapto-[1,2,4]-triazoles-2)pyridine with aromatic acid in the presence of phosphorus oxychloride. Compounds of 2,6-bis(6-aryl-[1,2,4]-triazolo[3,4-b][1,3,4]-thiadiazole-3-yl)pyridines were synthesized. Their structures were confirmed by IR, ^1H NMR spectroscopies and elemental analysis. Their electrochemical behavior and cyclic voltammogram also were be studied. The results showed that they have high ionization potentials and good affinity. 相似文献
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The novel ytterbium coordination polymer is a t4wo-dimensional framework in which the central metal ions have four different coordination numbers and form four kinds of coordination poly-hedra,The four kinds of coordination polyhedra connect into infinite chains by sharing oxygen atoms. 相似文献
5.
The title complexes have been synthesized by the reaction of [RhCI(CO)2]2 or [RhCI(COD)]2 (COD = 1,5-cyclooctadiene)with the organic ligand 2,4-dioxo-3-pentyl 4-decyloxy cinnamate 2. The complex 3 based on dicarbonylrhodium(I) shows nematic phase, while the complex 4 containing rhodium(I) bound to a COD ligand is a nonmesogen. The relationship between molecular structures and liquid crystal behavior has also been discussed by means of computer-aided molecular modeling. 相似文献
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1INTRODUCTIONThepyrazolo[3,4-b]pyridineclassofcompoundspossessmanybiologicalandpharmacologicalactivi-ties[1],suchasactiveanti-concretionmedicaments[2]aswellasactiveanti-gramnegativeandpositivebacteriaagents[3].Thereforethesynthesesofsuchcompoundshavearousedgreatattentionofalargenumberofchemists.Themostimportantsyntheticrouteisthecondensationreaction[4~11]ofamino-pyrazoleandα,β-unsaturatedcompounds.Theorganicreactionundermicrowaveirradia-tionhastheadvantagesoffastreactionspeed,shorttime… 相似文献
7.
(NH3CH2CH2NH2)3[Mo(Ⅴ)O2(O2C6H4)2] (1), (NH3CH2CH2NH2)2.5[Mo(Ⅴ)o.sW(Ⅵ)o.502(O2C6H4)2] (2) and(NH3CH2CH2NH2)2[VC(Ⅵ)O2(O2C6H4)2] (3) were synthesized, structurally characterized by X-ray diffraction analysis, and studied on their interactions with ATP, their DNA cleavage activities and antitumor properties. The redox state of molybdenum was not changed on going from crystal to aqueous solutions in complexes 1 and 2, while tungsten underwent reduction from W(VI) to W(V) in complexes 2 and 3. ATP promoted the oxidation of both molybdenum and tungsten from M(Ⅴ) to M(Ⅵ) and the hydrolysis of catecholate ligands in solution consisting of ATP and the complexes. Complex 1 possesses fairly good activity to DNA cleavage and against tumor S180 in mice, and is more effective than the control drug cyclophosphamide under the identical conditions. However, complexes 2 and 3 exhibited marginal effectiveness. The effectiveness of anti-tumor of the complexes was related positively to their DNA cleavage activities and their hydrolysis of catecholate ligands. 相似文献
8.
2-Thioxo-1,2-dihydropyridine derivatives 2a, 2b were reacted with methyl iodide to give 2-methylthiopyridines 3a, 3b, which were reacted with hydrazine hydrate to produce 3-aminopyrazolo[5,4-b]pyridines 4a, 4b. Compounds 4a, 4b were diazotized to afford the corresponding diazonium salts 5a, 5b, which were reacted with some active methylene compounds 6a-6h to give the corresponding pyrido[2′,3′ : 3,4]pyrazole[5,1-c][1,2,4]triazines 7-14. 相似文献
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(Z)-1-[2-(Tri-o-tolylstannyl)vinyl]-1-indanol (1) and (Z)-1-[2-(tri-p-tolylstannyl)vinyl]-l-indanol (2) were synthesized by the addition reaction of 1-ethynylindanol with tri-o-tolyltin and tri-p-tolyltin hydride. The aryl groups in compound 1 and 2 were substituted by Br2 or I2 to yield monohalide derivatives (3-6). The compounds 1-6 were characterized by elemental analysis, ^1H NMR and FT-IR spectroscopy. The crystal structures of 1, 2 and 4 have been determined by single crystal X-ray diffraction analysis. The Sn atom in 1 and 2 exhibits a tetrahedral geometry distorted towards trigonal bipyramid due to a weak intramolecular interaction between Sn and the hydroxyl O atoms [0.2839(4) nm and 0.2744(5) nm], while the Sn atom in 4 adopts a trigonal bipyramidal geometry with a significant O→Sn(1) interaction [0.2552(5) nm]. 相似文献
10.
L 《高等学校化学研究》2005,21(4):480-483
IntroductionThe design of novel DNA photocleavers is of greatsignificance from the standpoints of chemistry,biology,and medicine[1].There have been many reports aboutDNA photocleavers.Usually,they bind to DNAviain-tercalation,electrostatic binding or self-stacking inter-actions[2,3],but under photoirradiation they can initiatesignificant damage to DNA without external chemicalinitiatorsviaa wide variety of ways,such as electrontransfer,the formation of radicals or singlet oxy-gen[4,5].It … 相似文献
11.
To explore new platform for DNA intercalation and potent antitumor agent, a series of 8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters chromophores has been studied. Their intercalation geometries with DNA were rex;ealed through absorption titration, SYBR Green-DNA melt curve, circular dichroism(CD), and docking studies. It was identified that some of the compounds could intercalate into DNA along their long axis parallel to the base-pair long axis, making right-handed B form DNA transform to A-like conformation. Their binding potency varied with the different steric hindrance. Their cytotoxicity(IC50) against MCF-7 cells was found to range between 1.3 to 40.9 umol/L by MTT assay. Interestingly, the IC50 values did not show any obvious correlation to their binding constants with DNA. The chromophore with a carboxyl group exhibited the most potency of intercalating DNA and could be the promising precursor for the future intercalator for DNA, while the bromide demonstrated the highest cytotoxic activity in this series of compounds. 相似文献
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AbstractA series of new N′-(11H-indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazonamides 3a–3j was synthesized in excellent yields from the reaction of N3-substituted benzohydrazonamides 1 and 2-(11H-indeno[1,2-b]quinoxalin-11-ylidene)malononitrile 2 in dichloromethane or with 11H-indeno[1,2-b]quinoxalin-11-one 4 in ethyl acetate at ambient temperature. The new compounds have been characterized and screened for biological activity. Some of them showed significant antibacterial and antifungal activities. In particular, compounds 3c and 3e showed interesting activities as antibacterial agents while compounds 3a 3c, 3e, 3g, and 3i showed high antifungal activities. 相似文献
13.
Shao Ning WANG Ying Kun QIU Hui XU Yi Hui DENG Da Wei CHEN 《中国化学快报》2006,17(2):173-176
Mammalian hepatocytes (parenchymal cells) exclusively possess large number ofasialoglycoprotein receptors (ASGPr), which can recognize terminal D-galactose orN-acetylgalactosamine residues. Lactobionic acid 1, bearing a galactosyl group, isusually used as… 相似文献
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Azza M. Abdel-Fattah Fawzy A. Attaby 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):555-563
Abstract Benzothiophene -2- carbaldehyde 1 reacted with 2-cyanoethanethioamide 2 in 1:2 molar ratios to give the corresponding 6-amino-4-(benzo[b]thiophen-2-yl)-2-thioxo-1, 2-dihydropyridine-3,5-dicarbonitrile 6. The synthetic potentiality of compound 6 was investigated via its reaction with active halogen-containing reagents to afford the corresponding thieno[2,3-b]pyridine derivatives 11a,b, 14, 16, and 19. Also, compound 6 reacted with hydrazine hydrate to give the pyrazolo[3,4-b]pyridine derivative 21. Compound 21 condensed with 4-(2-thienyl)benzaldehyde to afford pyrazolo[3,4-b]pyridine derivative 23. Structural elucidation of all the newly synthesized heterocyclic compounds was based on elemental analyses, IR, 1H NMR, and mass spectra. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
16.
Ru Shu Sun Yang Wang Peng Xia 《中国化学快报》2008,19(7):791-794
The esterifications of 9-(hydroxyimino)-4-methyl-8,9-dihydrofuro[2,3-h]chromen-2-one (4) with acid chlorides afforded normal oxime-esters 3a-e in 35-78% yields in presence of excessive 4-dimethylaminopyridine as the acid scavenger, whereas the reactions gave unexpected 8-substituted products N-(8-chloro-4-methyl-2-oxo-2H-furo-[2,3-h]chromen-9-yl)amides (5a-c) and 4-methyl-2,9-dioxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-ylcarboxyloates (6d-e) by using excessive acid chlorides. The structures of 10 new compounds were determined by 1H NMR, 13C NMR, MS and HRMS, and the possible mechanism for the formation of unexpected products 5a--c and 6d-e was also proposed. 相似文献
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18.
Kolandaivel Prabha 《合成通讯》2014,44(10):1441-1452
Distinction of benzo[h]naphtho[1,2-b][1,6]naphthyridine and its isomeric benzo[b]naphtho[1,2-h][1,6]naphthyridine is well explained on the basis of various spectroscopic techniques. Initially these isomers were prepared from their respective chloroquinolines via anilinoquinolines as potential intermediates. Spectroscopic dissimilarities of their precursors and intermediates have also been considered and compared with the final benzonaphthonaphthyridine isomers. 相似文献